DRUG INDUCED PROTEIN BIOSYNTHESIS AND ITS INFLUENCE UPON SULFHYDRIL GROUP AMOUNT IN SOME ORGANS WITH CASES OF ACUTE MERCURY INTOXICATION

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Gerstmann syndrome in a young man: a case report

Gerstmann syndrome is a classical cerebral syndrome in neurology, named after Joseph Gerstmann, a Jewish Austrian-born American neurologist. Patients present with a tetrad of cognitive symptoms, including agraphia, acalculia, finger agnosia and left-right disorientation. The syndrome is known to result from a lesion of the posterior portion of the dominant parietal lobe and is usually due to stroke or to developmental problems. We describe the case of a 35-year-old man whose illness debuted about 9 months before the initial presentation to the neurology clinic, with memory complaints, anxiety, verbal aggression, sleeping problems, as well as subjective word finding difficulty and depressed mood. The patient had 3 out of the 4 classic symptoms of Gerstmann syndrome, among other, mostly neuropsychiatric symptoms. Initially, structural lesions were sought for, but were not found on magnetic resonance imaging. Psychiatric conditions were discussed but not confirmed by the consulting psychiatrist. We are prone to accepting a non-organic reason for the condition of the patient, but follow-up of the clinical course and repeated assessments, including neuropsychological and psychiatric evaluations, structural and possibly functional neuroimaging will be required to verify and confirm this presumption

Characterization of MHz pulse repetition rate femtosecond laser-irradiated gold-coated silicon surfaces

In this study, MHz pulse repetition rate femtosecond laser-irradiated gold-coated silicon surfaces under ambient condition were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction analysis (XRD), and X-ray photoelectron spectroscopy (XPS). The radiation fluence used was 0.5 J/cm2 at a pulse repetition rate of 25 MHz with 1 ms interaction time. SEM analysis of the irradiated surfaces showed self-assembled intermingled weblike nanofibrous structure in and around the laser-irradiated spots. Further TEM investigation on this nanostructure revealed that the nanofibrous structure is formed due to aggregation of Au-Si/Si nanoparticles. The XRD peaks at 32.2°, 39.7°, and 62.5° were identified as (200), (211), and (321) reflections, respectively, corresponding to gold silicide. In addition, the observed chemical shift of Au 4f and Si 2p lines in XPS spectrum of the irradiated surface illustrated the presence of gold silicide at the irradiated surface. The generation of Si/Au-Si alloy fibrous nanoparticles aggregate is explained by the nucleation and subsequent condensation of vapor in the plasma plume during irradiation and expulsion of molten material due to high plasma pressure

Results of Monitoring over and Biological Properties of <I>Vibrio cholerae</I> Isolated from Ambient Environment Objects in the Khabarovsk Territory

genotype and a unique MLVA profile. The results of the monitoring indicated that there were optimal for V. cholerae accumulation in surface water reservoirs conditions and it was necessary to enhance measures for cholera prophylaxis in the post-flood period

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Анализ потерянных лет жизни в результате преждевременной смертности от злокачественных новообразований в Российской Федерации

Background. Burden of disease estimation allows analyses to be carried out integrally, including cause and effect assessment. the rate of life years lost due to premature mortality is part of the burden of disease analysis. given that the burden of cancer is steadily increasing, analysis of the number of years lost makes it possible to identify new strategic directions, as well as to adjust decisions already made, in the health care of cancer patients.Purpose: to estimate the loss of life expectancy as a result of premature mortality from cancer in the population of the Russian Federation.Material and Methods. the analysis was carried out using international statistical databases for disease burden estimation, databases of the Federal state statistics service (Rosstat). to determine the target groups of priority reduction of mortality from neoplasms in the Russian Federation, an estimation of the lost years of life expectancy as a result of premature mortality in the form of the e† (e-dagger) indicator was carried out. the analyzed period of the study was 2010–2019.Results. the Russian Federation is characterized by the smallest share of losses from cancer in the structure of losses from all causes of death compared to the analyzed countries (Japan, France, germany, latvia, lithuania, estonia). However, the share of losses has been intensively increasing for 10 years (in 2010 – 14.79 %, in 2019 – 17.54 %). in comparison with the analyzed countries, Russia is more characterised by losses from cancer at a younger age, with the highest value of life years lost in the age group 60–64 years. the age-standardized number of years lost in men in Russia is 67.1 % higher than in women. in the age group from 25 to 49 years of age, the loss of life expectancy due to cancer in women is higher and accounts for 0.4 years (or 19 %) of all losses, which is not typical of other age groups in which losses in men prevail. A significant regional differentiation of mortality in the constituent entities of the Russian Federation has been revealed, which is also reflected in the number of years lost.Conclusion. the potential of preventive strategies in the Russian Federation has not been fully realized – the loss of life years in young and middle age requires the correction of measures to improve preventive services and oncological care. the revealed regional differentiation allows us to identify regions with high losses for priority solutions.Актуальность. Оценка бремени болезни позволяет проводить анализ интегрально, включая оценку причин и последствий. Показатель потерянных лет жизни в результате преждевременной смертности является частью анализа бремени болезни. Учитывая, что бремя злокачественных новообразований (ЗНО) неуклонно растет, анализ числа потерянных лет позволяет определить новые стратегические направления, а также скорректировать уже принятые решения в области здравоохранения онкологических пациентов.Цель исследования – оценить потери продолжительности жизни в результате преждевременной смертности от ЗНО населения Российской Федерации (РФ).Материал и методы. Анализ проведен с использованием международных статистических баз данных для оценки бремени заболеваний, баз данных Федеральной службы государственной статистики (Росстат). Для определения целевых групп приоритетного снижения смертности от новообразований в РФ проведена оценка потерянных лет продолжительности жизни в результате преждевременной смертности в виде показателя e† (e-dagger). Анализируемый период исследования – 2010–2019 гг.Результаты. Для Российской Федерации характерна наименьшая доля потерь от ЗНО в структуре потерь от всех причин смерти по сравнению с анализируемыми странами (Япония, Франция, Германия, Латвия, Литва, Эстония). Однако доля потерь интенсивно растет на протяжении 10 лет (в 2010 г. – 14,79 %, в 2019 г. – 17,54 %). В сравнении с анализируемыми странами для России в большей степени характерны потери от ЗНО в более молодом возрасте с наибольшим значением потерянных лет жизни в возрастной группе 60–64 года. Стандартизованное по возрасту число потерянных лет у мужчин в РФ на 67,1 % выше, чем у женщин. В возрастной группе от 25 до 49 лет потери ожидаемой продолжительности жизни от ЗНО у женщин выше и составляют 0,4 года (или 19 %) от всех потерь, что не характерно для других возрастных групп, в которых у мужчин потери превалируют. Выявлена значительная региональная дифференциация смертности в субъектах РФ, что также отражается в количестве потерянных лет.Заключение. Потенциал профилактических стратегий в РФ не реализован в полной мере – потери лет жизни в молодом и среднем возрасте требуют коррекции мероприятий по улучшению профилактической службы и онкологической помощи. Выявленная региональная дифференциация позволяет определить регионы с высокими потерями для первоочередных решений

Recent improvements in the development of A2B adenosine receptor agonists

Adenosine is known to exert most of its physiological functions by acting as local modulator at four receptor subtypes named A1, A2A, A2B and A3 (ARs). Principally as a result of the difficulty in identifying potent and selective agonists, the A2B AR is the least extensively characterised of the adenosine receptors family. Despite these limitations, growing understanding of the physiological meaning of this target indicates promising therapeutic perspectives for specific ligands. As A2B AR signalling seems to be associated with pre/postconditioning cardioprotective and anti-inflammatory mechanisms, selective agonists may represent a new therapeutic group for patients suffering from coronary artery disease. Herein we present an overview of the recent advancements in identifying potent and selective A2B AR agonists reported in scientific and patent literature. These compounds can be classified into adenosine-like and nonadenosine ligands. Nucleoside-based agonists are the result of modifying adenosine by substitution at the N6-, C2-positions of the purine heterocycle and/or at the 5′-position of the ribose moiety or combinations of these substitutions. Compounds 1-deoxy-1-{6-[N′-(furan-2-carbonyl)-hydrazino]-9H-purin-9-yl}-N-ethyl-β-D-ribofuranuronamide (19, hA1Ki = 1050 nM, hA2AKi = 1550 nM, hA2B EC50 = 82 nM, hA3Ki > 5 μM) and its 2-chloro analogue 23 (hA1Ki = 3500 nM, hA2AKi = 4950 nM, hA2B EC50 = 210 nM, hA3Ki > 5 μM) were confirmed to be potent and selective full agonists in a cyclic adenosine monophosphate (cAMP) functional assay in Chinese hamster ovary (CHO) cells expressing hA2B AR. Nonribose ligands are represented by conveniently substituted dicarbonitrilepyridines, among which 2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-ylsulfanyl]acetamide (BAY-60–6583, hA1, hA2A, hA3 EC50 > 10 μM; hA2B EC50 = 3 nM) is currently under preclinical-phase investigation for treating coronary artery disorders and atherosclerosis

Морфологические аспекты применения полусинтетического антиоксиданта диборнола при инволюционной центральной хориоретинальной дегенерации у крыс линии OXYS

Retina of rats OXYS 6 months of age by treatment of 4-methyl-2,6-diisobornylphenol (dibornol) was researched. Mainly, rats OXYS have of vascular disturbances such as reduction open functional vasculars of choroidea, destruction of retinal pigmental epithelium and retinal neurons. Dibornol was protected of retina increased area of open vascular and safety of retinal neurons. Besides dibornol was prevented thrombosis in retinal vasculars.Изучены сетчатки глаз крыс OXYS в возрасте 6 мес на фоне коррекции 4-метил-2,6-диизоборнилфенолом (диборнолом). У крыс OXYS преобладают сосудистые нарушения - снижение числа открытых функционирующих сосудов хориоидеи, деструктивные изменения пигментного эпителия и нейронов сетчатки. Показан ретинопротекторный эффект диборнола, выражающийся в увеличении площади открытых сосудов, снижении площади тромбированных сосудов и высокой сохранности нейронов сетчатки крыс OXYS