3 research outputs found
Early ultrasound surveillance of newly-created haemodialysis arteriovenous fistula
- Author
- Allen Elisa
- Allsop Karen
- Ansu Kwame
- Aslam Mohammed
- Augustin Martia
- Ayorinde Tobi
- Badhan Rani
- Bagul Atul
- Bajwa Adnan
- Banda Joyce
- Barnett Nicholas
- Bartlett Matthew
- Basnayake Duminda
- Beech Andrew
- Bendle Janet
- Benny Laijee
- Bodneck Caroline
- Bolsworth Amy
- Bond Klaus
- Brand Sarah
- Burney Kashif
- Cai Paris
- Carmichael Sarah-Jane
- Chapman Lianne
- Cheal Darren
- Chipurovski Igor
- Clementoni Laura
- Crane Jeremy
- Crawford Kate
- Daniel Simon
- Dawson Sue
- Dear Karen
- Deary Alison
- Dutta Sam
- Eadie Tom
- Edlin Helena
- Eldridge Philip
- Evans Gail
- Fitzpatrick-Creamer Chloe
- Fleet Ana
- Foley Claire
- Gallagher Karen
- Gardiner Phil
- Gavrila Madita
- Gee Sarah
- Ghazanfar Abbas
- Hardy Elizabeth
- Hare Naomi
- Hopkins Valerie
- Hossain Mohammad Ayaz
- Hossain Mohammed
- Hossain Mohammed Ayaz
- Howson Alexandra
- Hoye Neil
- Hudson Cara
- Hunter James
- Hyndman Samantha
- Irani Natasha
- Jerram Anna
- Kathirvel Manikandan
- Kavanagh Lisa
- Kerr John
- Khosla Nalin
- Knight Simon
- Lafferty Kathryn
- Lagaac Regin
- Lai Jessica
- Laing Emma
- Lawman Sarah
- Lena Midel
- Lochiel Rona
- Long Judith
- MacCormick-Swanson Tara
- Moinuddin Zia
- Morgan Maria
- Motallebzadeh Reza
- Ngwa-Ndifor Naavalah
- Norton Andrew
- Owen William
- Padayachee Soundrie
- Parsons Joseph
- Parsons Karen
- Patel Jashree
- Paul Subhankar
- Pettigrew Gavin J.
- Potter Rachael
- Pugh Elisabeth
- Quashie-Akponeware Mary
- Rabara Ria
- Rabuya May
- Read Kerry
- Richards James
- Rowe Tracey
- Rowe-Leete Louise
- Salter Tracey
- Scott Laura
- Shah-Goodwin Lorraine
- Sidders Anna
- Sivaprakasam Rajesh
- Slater Matthew
- Smith George
- Smith Mel
- Somalanka Subash
- Summers Dominic
- Surendrakumar Veena
- Sutherland Sheera
- Tambyraja Andrew
- Thialli Manoj
- Thomas Helen
- Tiivas Carl
- Toska Valentina
- Trivedi Kate
- Truslove Maria
- Turner Sam
- van Selm Judy
- Walker Alycon
- Waters Kate
- Weerasinghe Thanuja
- Widdup Joanne
- Yuenchang Fernando
- Publication venue
- Elsevier
- Publication date
- 05/01/2024
- Field of study
IntroductionWe assess if ultrasound surveillance of newly-created arteriovenous fistulas (AVFs) can predict nonmaturation sufficiently reliably to justify randomized controlled trial (RCT) evaluation of ultrasound-directed salvage intervention.MethodsConsenting adults underwent blinded fortnightly ultrasound scanning of their AVF after creation, with scan characteristics that predicted AVF nonmaturation identified by logistic regression modeling.ResultsOf 333 AVFs created, 65.8% matured by 10 weeks. Serial scanning revealed that maturation occurred rapidly, whereas consistently lower fistula flow rates and venous diameters were observed in those that did not mature. Wrist and elbow AVF nonmaturation could be optimally modeled from week 4 ultrasound parameters alone, but with only moderate positive predictive values (PPVs) (wrist, 60.6% [95% confidence interval, CI: 43.9–77.3]; elbow, 66.7% [48.9–84.4]). Moreover, 40 (70.2%) of the 57 AVFs that thrombosed by week 10 had already failed by the week 4 scan, thus limiting the potential of salvage procedures initiated by that scan’s findings to alter overall maturation rates. Modeling of the early ultrasound characteristics could also predict primary patency failure at 6 months; however, that model performed poorly at predicting assisted primary failure (those AVFs that failed despite a salvage attempt), partly because patency of at-risk AVFs was maintained by successful salvage performed without recourse to the early scan data.ConclusionEarly ultrasound surveillance may predict fistula maturation, but is likely, at best, to result in only very modest improvements in fistula patency. Power calculations suggest that an impractically large number of participants (>1700) would be required for formal RCT evaluation
Thigh-length compression stockings and DVT after stroke
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- Abbasi S
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- Abdelaziz A
- Abdelfattah M
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- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
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- Abouibrahim M
- Abraham M
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- Abrams J
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- Acharya D
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- Acheson J
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- Adeyeye E
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- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
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- Ahmed L
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- Ahmed M Cecilia
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- Ahmed S Haris
- Ail D
- Ainsley A
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- Wagstaff L
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- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
- Ali S
- Ali S
- Ali S
- Alkhusheh M
- Alkhusheh M
- Allanson A
- Allen L
- Allen R
- Allen S
- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
- Amosun V
- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
- Anderson R
- Andreou P
- Andrews A
- Andrews J
- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
- Appleby S
- Appleyard D
- Archer A
- Ardley C
- Arimoto R
- Arkley C
- Armah C
- Armstrong C
- Armstrong S
- Armtrong P
- Arnison-Newgass C
- Arora D
- Arter A
- Arter A
- Asghar A
- Ashbrook-Raby C
- Ashish A
- Ashish A
- Ashraf S
- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
- Ayaz E
- Azam J
- Aziz G
- Azzopardi G
- Babatunde F
- Babi M
- Babi M
- Babingto G
- Babs-Osibodu A Obaloluwa
- Bacon G
- Bacon J
- Bacon J
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- Bahadori K
- Baijiu G
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- Baillie H
- Baillie JK
- Baillie JK
- Baillie K
- Baird D
- Bajandouh A
- Baker E
- Baker-Moffatt M
- Bakoulas P
- Balachandran N
- Balachandran N
- Balan A
- Balaskas T
- Balasubramaniam M
- Balcombe A
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- Baldwin D
- Baldwin L
- Balfour J
- Ball C
- Bamfo S Danso
- Bamford A
- Bamford A
- Bamford P
- Bamgboye A
- Bancroft H
- Banda J
- Bandi S
- Bandi S
- Bandla N
- Bandyopadhyam S
- Bandyopadhyam S
- Banerjee R
- Banerjee S
- Banks H
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- Bannister O
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- Baqai T
- Barclay A
- Bari S
- Barker D
- Barker J
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- Barker-Williams K
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- Barnett D
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- Belgaumkar A
- Belgaumkar A
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- Bellamy M
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- Benesh N
- Benetti N
- Benham L
- Benison-Horner G
- Benison-Horner G
- Bennett A
- Benson V
- Bentley A
- Benton I
- Beranova E
- Beresford M
- Bergin C
- Bergstrom M
- Bernatoniene J
- Bernatoniene J
- Berriman T
- Best K
- Beuvink Y
- Bexhell H
- Bhadi A
- Bhakta S
- Bhalla R
- Bhalme M
- Bhandal K
- Bhandal K
- Bhatia N
- Bhayani J
- Bhojwani D
- Bhuiyan S
- Bhushan A Kala
- Bibi N
- Biggs S
- Biju A
- Bikov A
- Billingham S
- Billings J
- Birch C
- Birchall K
- Bird S
- Birt M
- Bishop L
- Blachford K
- Black P
- Black P
- Black S
- Blackledge B
- Blackstock C
- Blamey H
- Bland A
- Blane S
- Blazeby J
- Blencowe N
- Bloom B
- Bloss A
- Blundell L
- Bobruk K
- Bodasing N
- Boehmer G
- Bokhari S
- Bokhari S
- Bokhari S Owais
- Boles A
- Boles A
- Bolton M
- Bond H
- Bond T
- Boniface G
- Borbone J
- Borra C
- Boughton H
- Boult Z
- Bourne M
- Bowker P
- Bowman L
- Boyapati G
- Boyle P
- Boyles L
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- Bradley P
- Bradley P
- Bradley-Potts J
- Bradshaw Z
- Brady S
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- Brandl-Salutz E
- Brannigan J
- Brassington L
- Bray F
- Brear L
- Brear T
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- Brend M
- Brewer C
- Bridgwood G
- Brigham S
- Brightling C
- Brightling C
- Britten V
- Broad L
- Broadhurst R
- Broadway M
- Brockelsby C
- Brockley T
- Brogan F
- Brokke F
- Brolly J
- Bromley D
- Brooker V
- Brookes M
- Brooks A
- Brooks N
- Brooks S
- Broomhead N
- Broomhead N
- Broughton N
- Brouns M
- Brown C
- Brown E
- Brown J
- Brown N
- Brown R
- Brown S
- Brown T
- Browne C
- Brownlee S
- Bruce D
- Bruce J
- Bruce M
- Bruce M Schuster
- Brudlo W
- Brunskill N
- Brunton M
- Buch M
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- Buck A
- Buckingham E
- Buckley L
- Buckley P
- Buckman C
- Bugg G
- Bujazia R
- Bull A
- Bull D
- Bungue-Tuble R
- Burchett C
- Burgess M
- Burke E
- Burns A
- Burns K
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- Burston C
- Butler J
- Butler J
- Butler J
- Butler P
- Butterworth-Cowin N
- Buttery R
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- Byrne W
- Byrne-Watts V
- Cade R
- Cadwgan A
- Calderwood C
- Callaghan J
- Callens C
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- Cameron F
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- Campbell H
- Campbell H
- Campbell J
- Campbell M
- Campbell R
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- Cannan R
- Cannon E
- Cannon M
- Cantliff J
- Capp A
- Capstick T
- Carmody M
- Caroline C
- Carrington Z
- Carter J
- Carter P
- Carter P
- Carty C
- Cassimon B
- Caswell M
- Catana A Maria
- Cate H
- Cathie K
- Cave L
- Cawa F
- Cawley K
- Caws C
- Cendl H
- Cernova J
- Cetti E
- Cetti E
- Chabo C
- Chadwick D
- Chadwick D
- Chadwick J
- Chakkarapani E
- Chakraborty M
- Chamberlain S
- Chambers E
- Chambers L
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- Chan C
- Chan C
- Chan C
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- Chandler KJ
- Chandrasekaran B
- Chaplin J
- Chapman G
- Chapman K
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- Chapman L
- Chapman P
- Chapman T
- Chappell L
- Chappell L
- Chappell L
- Chappell L
- Charalambou A
- Charles B
- Charlton D
- Chatar K
- Chaudhary M Yafaa Naveed
- Chaudhry I
- Chaudhry I
- Chauhan A
- Chauhan M
- Chauhan R Singh
- Chavasse N
- Cheaveau J
- Chen F
- Chen H Min
- Chen T
- Cheng L Yin
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- Chengappa A
- Cherian S
- Cheung C Kay
- Cheyne C
- Chhabra S
- Chicano R
- Chimbo P
- Chin K
- Chin W Jie
- Chisnall B
- Chita S
- Chitalia N
- Chitsenga C
- Chivima B
- Choi S
- Chowdhury M
- Christides A
- Christmas D
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- Chudgar D
- Chudgar D
- Chukwulobelu I
- Church S Rebecca
- Cicconi P
- Cipriano B
- Clamp S
- Clapham M
- Clare S
- Clark D
- Clark F
- Clark J
- Clark J
- Clark L
- Clark R
- Clark Z
- Clarke R
- Clarke R
- Clarke S
- Clayton O
- Clayton-Smith J
- Cleaver C
- Clueit S
- Clueit S
- Cobain K
- Cocks S
- Codd R
- Coe A
- Coey D
- Cofie P Foster
- Cohen D
- Colbeck N
- Cole E
- Cole J
- Cole J
- Cole N
- Coleman G
- Coles H
- Colley J
- Collini P
- Collins J
- Collins S
- Collins S
- Collins V
- Colton HE
- Combes E
- Combes E
- Condliffe R
- Connolly G
- Connor E
- Contingency DHSC Med Supply
- Convery R
- Conway G
- Conway G
- Conway R
- Cook E
- Cooke K
- Coombs C
- Cooper J
- Cooper L
- Corbett C
- Corless J
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- Corogeanu D
- Corrigan R
- Cort J
- Cosgrove D
- Coston C
- Cotter R
- Cotterill D
- Cotton C
- Courtney E
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- Cowen L
- Cowman S
- Cowton A
- Cox G
- Coy K
- Craig V
- Crawshaw S
- Cremona J
- Cresswell J
- Cribb M
- Crichton C
- Crisp L
- Crisp N
- Crocombe D
- Crosby H
- Cross T
- Crotty S
- Croysdill R
- Cruise J
- Cryans D
- Cui G
- Cummings-Fosong G
- Cunliffe V
- Cunningham N
- Cunningham N
- Cupitt J
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- D Gilliland
- da Rocha J
- Daggett H
- Daglish J
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- Dale S
- Dalgleish H
- Darbyshire A
- Darbyshire J
- Darton T
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- Daschel M
- Dasgin J
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- Dawa K Kabiru
- Dawe C
- Day A
- Day J
- Day J
- De Berker H
- de Fonseka D
- de la Torre C Clemente
- de Silva T
- de Souza J
- De Soyza A
- De P
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- Dean K
- Deane J
- Dear J
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- Deery J
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- Dell A
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- Dermody S
- Desai A
- Desai P
- Dey P
- Dhaliwal K
- Dhani S
- Dhanoa A
- Dhar M
- Dhillon E
- Dhillon R
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research