24 research outputs found
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
- Author
- Alda Martin
- Alliey-Rodriguez Ney
- Anand Amit
- Balaraman Yokesh
- Berrettini Wade H.
- Bertram Holli
- Burdick Katherine E.
- Calabrese Joseph R.
- Calkin Cynthia V.
- Conroy Carla
- Coryell William H.
- Craig David
- DeModena Anna
- Donovan Claire O’
- Eyler Lisa T.
- Feeder Scott
- Fisch Kathleen M.
- Fisher Carrie
- Frazier Nicole
- Frye Mark A.
- Gage Fred H.
- Gao Keming
- Garnham Julie
- Gershon Elliot S.
- Goes Fernando S.
- Goto Toyomi
- Harrington Gloria J.
- Jakobsen Petter
- Kamali Masoud
- Kelly Marisa
- Kelsoe John R.
- Leckband Susan G.
- Lohoff Falk W.
- Maihofer Adam X.
- Marchetto Maria C.
- McCarthy Michael J.
- McInnis Melvin G.
- Millett Caitlin E.
- Mondimore Francis
- Morken Gunnar
- Niemsiri Vipavee
- Nievergelt Caroline M.
- Nurnberger John I.
- Rosenthal Sara Brin
- Ryan Kelly
- Santos Renata
- Schinagle Martha
- Shekhtman Tatyana
- Shilling Paul D.
- Slaney Claire
- Stapp Emma K.
- Stautland Andrea
- Tarwater Bruce
- Zandi Peter P.
- Ødegaard Ketil Joachim
- Publication venue
- Nature
- Publication date
- 01/01/2023
- Field of study
Get PDFLithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless of lithium exposure. In the PGBD, post-GWAS gene prioritization using the GWA-boosting (GWAB) approach identified 1119 candidate genes. Following DE-derived network propagation, there was a highly significant overlap of genes between the top 500- and top 2000-proximal gene networks and the GWAB gene list (Phypergeometric = 1.28E–09 and 4.10E–18, respectively). Functional enrichment analyses of the top 500 proximal network genes identified focal adhesion and the extracellular matrix (ECM) as the most significant functions. Our findings suggest that the difference between LR and NR was a much greater effect than that of lithium. The direct impact of dysregulation of focal adhesion on axon guidance and neuronal circuits could underpin mechanisms of response to lithium, as well as underlying BD. It also highlights the power of integrative multi-omics analysis of transcriptomic and genomic profiling to gain molecular insights into lithium response in BD.publishedVersio
Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: a multi-level study of Australian registry data
- Author
- A Gelman
- A Judge
- A Majeed
- AIHW
- AM Foruria
- Anita E. Wluka
- AOANJRR
- Australian Bureau of Statistics
- Australian Bureau of Statistics
- Australian Bureau of Statistics
- Australian Orthopaedic Association National Joint Replacement Registry
- D Bryant
- D Melzer
- H Ruckstuhl
- J Baum Vegini
- J Iannotti
- J Skinner
- JA Singh
- JF Haines
- JS Day
- Julie A. Pasco
- JV Rasmussen
- Kerrie M. Sanders
- M Dudzinski
- MA Wirth
- MG Peterson
- Michelle Lorimer
- ML Francis
- MW Maier
- N Agabiti
- N Steel
- NN Mahomed
- P Boileau
- Peter R. Ebeling
- PJ Millett
- Rachelle Buchbinder
- Richard H. Osborne
- Richard S. Page
- RM Orfaly
- RS Churchill
- RS Page
- SH Kim
- Sharon L. Brennan-Olsen
- SL Brennan
- SL Brennan
- SL Brennan
- StanDevelopmentTeam
- Stephen E. Graves
- Stephen E. Lane
- T Dixon
- T Dixon
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Full text linkDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abdul Rasheed A.
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- Al Aaraj A.
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- Al-Saadi Z.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Dicks P.
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- Dimitri P.
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- Duran B.
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- Duru I.
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- D’Mello A.
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- Emberson Jonathan R.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Jeebun V.
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- Johnstone E.
- Jones A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lodhia K.
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- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
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No full textThigh-length compression stockings and DVT after stroke
- Author
- Abbas M
- Abbasi S
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- Abdelaziz A
- Abdelfattah M
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- Wood T
- Woodford J
- Woodhead L
- Woodland P
- Woodward Z
- Wooldridge G
- Woollen L
- Woosey D
- Wootton D
- Worton S
- Wright D
- Wright R
- Wroe C
- Wu P
- Wyness K
- Wynter I
- Xavier B
- Xia Z
- Yan M
- Yanney M
- Yasmin S
- Yates B
- Yates B
- Yates D
- Yates H
- Yein K
- Yelnoorkar F
- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
- Zafar A-M
- Zaher S
- Zalewska K
- Zaman M
- Zaman S
- Zammit L
- Zammit-Mangion M
- Zdanaviciene A
- Zehnde D
- Zhixin J
- Zhu D
- Zia M
- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Incidence and antibiotic prescribing for clinically diagnosed urinary tract infection in older adults in UK primary care, 2004-2014
- Author
- AK Schweizer
- Ana Paula Arez
- C Costelloe
- C Llor
- Christopher C. Butler
- Daniel Farewell
- DM Drekonja
- E Herrett
- EI Benchimol
- ER Millett
- ER Millett
- Haroon Ahmed
- HI McDonald
- Hywel M. Jones
- J McQuiston Haslund
- JE Anderson
- JE Simmering
- K Hood
- L Rossignol
- L Wilson
- M Bardsley
- M Juthani-Mehta
- M Loeb
- M Loeb
- M Lutters
- MA Caljouw
- MAA Caljouw
- Nick A. Francis
- P McClean
- P McClean
- S Walker
- Shantini Paranjothy
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
No full textThe Memory of Slavery at Saint Louis University
- Author
- Abe Takao
- Alden Dauril
- Arenson Adam
- Arenson Adam
- Bannon John Francis
- Bannon John Francis
- Bannon John Francis
- Berlin Ira
- Blackburn Carole
- Brockey Liam Matthew
- Chapple Christopher
- Cleary Patricia
- Clossey Luke
- Cushner Nicholas
- Cushner Nicholas
- Davis David Brion
- DuVal Kathleen
- Faherty William S. J.
- Faherty William S. J.
- Faherty William S. J.
- Faherty William S. J.
- Farrell Thomas
- Fehrenbacher Don
- Frazier Harriet
- Gagliamo Joseph
- Ganson Barbara
- Garraghan Gilbert S.J.
- Gerteis Louis
- Gollar C. Walker.
- Gordon Colin
- Greer Allan
- Greer Allan
- Heithaus Claude
- Hill Walter
- Howe Daniel Walker
- Johnson Walter
- Killoren John S. J.
- Leavelle Tracy
- Maltz Earl
- McNaspy C. J.
- Morgan M. J.
- Murphy Thomas S. J.
- Nathaniel Millett
- O'Malley John
- Ong Walter
- Primm James Neal
- Rothman Adam
- Schroth Roman S. J.
- Traub George W. S. J.
- Wilder Craig Steven
- Winch Julie
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textThe 'feminisation of schooling' or 're-masculinising' primary education?[1]
- Author
- Adler S.
- Al-Khalifa E.
- Arnot M.
- Ashley M.
- Aspinwall K.
- Biddulph S.
- Blackmore J.
- Christine Skelton
- Clarricoates K.
- Coffey A.
- Connell R. W.
- Connell R. W.
- Connell R. W.
- Davies B.
- Francis B.
- Francis B.
- Fraser N.
- Gilbert R.
- Gurian M.
- Haywood C.
- Hoff-Sommers C.
- Kanter R. M.
- Lahelma E.
- Lingard B.
- Littlewood M.
- Mahony P.
- Mahony P.
- Martino W.
- Millett A.
- Moir A.
- Morris E.
- Noble C.
- O'connor M.
- Pollack W.
- Powney J.
- Redwood F.
- Skelton C.
- Skelton C.
- Stones R.
- Thompson B.
- Walford G.
- Walkerdine V.
- Walkerdine V.
- Weiner G.
- Wilkinson H.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textDevelopment of Prototype Filovirus Recombinant Antigen Immunoassays
- Author
- Abigail B. Jones
- Augustine Goba
- Becker
- Dafna M. Abelson
- Darin Oottamasathien
- Dhillon
- Diana S. Nelson
- Donald S. Grant
- Erica Ollmann Saphire
- Francis Baimba
- Jeffery G. Shaffer
- Jessica N. Hartnett
- Joan B. Geisbert
- John S. Schieffelin
- Kelly R. Pitts
- Ksiazek
- Lansana Kanneh
- Luis M. Branco
- Mambu Momoh
- Marjan Akdag
- Marnie L. Fusco
- Matt L. Boisen
- Megan L. Heinrich
- Megan M. Rowland
- Michael Gbakie
- Mohammed Fullah
- Molly M. Millett
- Peter C. Kulakosky
- Richard Fonnie
- Robert F. Garry
- Robert W. Cross
- Russell B. Wilson
- S. Humarr Khan
- Sadiki Safa
- Shun-ichiro Oda
- Thomas W. Geisbert
- Zachary A. Bornholdt
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
No full text
