Intravenous Continuous Infusion of Lidocaine for Treatment of Equine Ileus

Objective—To determine if intravenous lidocaine is useful and safe as a treatment for equine ileus. Study Design—Prospective double-blinded placebo-controlled trial. Study Population—Horses (n¼32) with a diagnosis of postoperative ileus (POI) or enteritis and that had refluxed 420L or had been refluxing for 424 hours. Methods—Refluxing horses were administered lidocaine (1.3mg/kg intravenously [IV] as a bolus followed by a 0.05mg/kg/min infusion) or saline (0.9% NaCl) solution placebo for 24 hours. Variables evaluated included volume and duration of reflux, time to 1st fecal passage, signs of pain, analgesic use, heart rate and arrhythmias, respiratory rate, temperature, days of hospitalization, outcome (survival to discharge), and complications. Results—Of the lidocaine-treated horses, 65% (11/17) stopped refluxing within 30 hours (mean SD, 15.2 2.4 hours) whereas 27% (4/15) of the saline-treated horses stopped within 30 hours. Fecal passage was significantly correlated with response to treatment; horses that responded to lidocaine passed feces within 16 hours of starting the infusion. Compared with placebo treatment, lidocaine treatment resulted in shorter hospitalization time for survivors, equivalent survival to discharge, no clinically significant changes in physical or laboratory variables, and no difference in the rate of incisional infections, jugular thrombosis, laminitis, or diarrhea. Muscle fasciculations occurred in 3 lidocaine-treated horses (18%). Conclusion—IV lidocaine significantly improved the clinical course in refluxing horses with minimal side effects. Clinical Relevance—At the infusion rate studied, IV lidocaine is safe and should be considered for the treatment of equine ileus

Knowledge, attitudes and other factors associated with assessment of tobacco smoking among pregnant Aboriginal women by health care providers: a cross-sectional survey

<p>Abstract</p> <p>Background</p> <p>As with many Indigenous peoples, smoking rates among Aboriginal Australians are considerably higher than those of the non-Indigenous population. Approximately 50% of Indigenous women smoke during pregnancy, a time when women are more motivated to quit. Antenatal care providers are potentially important change agents for reducing the harms associated with smoking, yet little is known about their knowledge, attitudes or skills, or the factors associated with providing smoking cessation advice.</p> <p>Methods</p> <p>This paper aimed to explore the knowledge and attitudes of health care providers caring for pregnant Australian Aboriginal women with regard to smoking risks and cessation; and to identify factors associated with self-reported assessment of smoking. A cross-sectional survey was undertaken with 127 staff providing antenatal care to Aboriginal women from two jurisdictions: the Northern Territory and New South Wales, Australia. Measures included respondents' estimate of the prevalence of smoking among pregnant women; optimal and actual assessment of smoking status; knowledge of risks associated with antenatal smoking; knowledge of smoking cessation; attitudes to providing cessation advice to pregnant women; and perceived barriers and motivators for cessation for pregnant women.</p> <p>Results</p> <p>The median provider estimate of the smoking prevalence was 69% (95%CI: 60,70). The majority of respondents considered assessment of smoking status to be integral to antenatal care and a professional responsibility. Most (79%) indicated that they assess smoking status in 100% of clients. Knowledge of risks was generally good, but knowledge of cessation was poor. Factors independently associated with assessing smoking status among all women were: employer service type (<it>p </it>= 0.025); cessation knowledge score (<it>p </it>= 0.011); and disagreeing with the statement that giving advice is not worth it given the low level of success (<it>p </it>= 0.011).</p> <p>Conclusions</p> <p>Addressing knowledge of smoking risks and cessation counselling is a priority and should improve both confidence and ability, and increase the frequency and effectiveness of counselling. The health system must provide supports to providers through appropriate policy and resourcing, to enable them to address this issue.</p

Genetic and neurological foundations of customer orientation: field and experimental evidence

We explore genetic and neurological bases for customer orientation (CO) and contrast them with sales orientation (SO). Study 1 is a field study that establishes that CO, but not SO, leads to greater opportunity recognition. Study 2 examines genetic bases for CO and finds that salespeople with CO are more likely to have the 7R variant of the DRD4 gene. This is consistent with basic research on dopamine receptor activity in the brain that underlies novelty seeking, the reward function, and risk taking. Study 3 examines the neural basis of CO and finds that salespeople with CO, but not SO, experience greater activation of their mirror neuron systems and neural processes associated with empathy. Managerial and research implications are discussed

Assuming Identities Online: How Linguistics Is Helping the Policing of Online Grooming and the Distribution of Abusive Images

In this chapter we seek to elucidate the potential of linguistic analysis in the undercover pursuit of criminals online. We examine the relationship between language and online identity performance and address the question of what linguistic analysis is necessary and sufficient to describe an online linguistic persona to the extent it could be successfully assumed by another individual. We compare the performance of trainee undercover officers (UCOs) at online impersonation of a specific individual before receiving any linguistic training to their performance after such input. We also report on a series of experiments in which participants engaged with each other over Instant Messaging (IM), before an impersonation situation was engineered. Information was collected about what level of accuracy and confidence individuals can detect the substitution of one interlocutor with another, what linguistic criteria give rise to such suspicions, and how individuals prepare for impersonation tasks. We also draw on other data sets including from police training and operational settings where identity disguise is employed online in the context of investigations into child grooming and the distribution of abusive images

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease