42 research outputs found
Larval Survival of Fuller's Rose Weevil, Naupactus cervinus, on Common Groundcover Species in Orchards of New Zealand Kiwifruit
- Publication venue
- University of Wisconsin Library
- Publication date
- Field of study
Get PDFFuller's rose weevil, Naupactus cervinus (Boheman) (Curculionidae: Entiminae), is an important quarantine pest of New Zealand kiwifruit exported to Asian markets. Both adults and larvae are considered to be polyphagous. In this study, the survival of larval N. cervinus was estimated on common groundcover species of kiwifruit (Actinidia spp.) in the Bay of Plenty, the main region in New Zealand where kiwifruit is grown. The botanical composition of groundcover in commercial kiwifruit orchards, characterised by survey, was dominated by ryegrass (Lolium perenne), with white clover (Trifolium repens), creeping buttercup (Ranunculus repens), wild strawberry (Duchesnea indica) and broadleaf dock (Rumex obtusifolius) in lower abundance. Survival to mature larvae or adult was relatively low (·11%) for N. cervinus introduced as neonates to field plots or potted ryegrass, white clover and broadleaf dock. White clover was a more favourable host for survival to adults than ryegrass. This study suggests that increased survival of N. cervinus larvae may occur where white clover and large dock plants are abundant, but that survival is likely to be highly variable because of the heterogeneous availability of preferred host plants and host plant quality. These data suggest that larval polyphagy is a strategy that enables N. cervinus to persist at low densities in kiwifruit orchards despite variation in the quality and diversity of groundcover
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
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- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
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- Ainsworth M.
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- Al Aaraj A.
- Al Balushi A.
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- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
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- Aliberti E.
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- Byrne J.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chan E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
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- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clark R.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
- Coey D.
- Cohen D.
- Coker O.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
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- Connolly G.
- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- De Soyza A.
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- Dear J.
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- Desai A.
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- Dhani S.
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- Dimitri P.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
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- Donohoe A.
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- Duffy H.
- Duggan A.
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- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
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- Elgohary A.
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- Emberson Jonathan R.
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- Essa F.
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- Everden C.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Fenton C.
- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Johnstone D.
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- Jones A.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Logue C. A.
- Lokanathan S.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Get PDFIntroduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
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Full text linkEffect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
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- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
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- Abusamra Yousuf
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- Alessandro Carà Gianmarco
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- Goebeler M.E.
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- Higgins Alisa M.
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- Horvat Christopher M.
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- Williamson James D
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- Winters Lauren
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- Wittenberg Wendy
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- Wong Onyee
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- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
Get PDFIMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
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- Alkhusheh M
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- Allanson A
- Allen L
- Allen R
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- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
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- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
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- Andreou P
- Andrews A
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- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
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- Arnison-Newgass C
- Arora D
- Arter A
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- Asghar A
- Ashbrook-Raby C
- Ashish A
- Ashish A
- Ashraf S
- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
- Ayaz E
- Azam J
- Aziz G
- Azzopardi G
- Babatunde F
- Babi M
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- Babingto G
- Babs-Osibodu A Obaloluwa
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- Publication date
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- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Improved Method for the Determination of Cyanuric Acid in Animal Feed by GC–MS
- Author
- AAM Stolker
- Ashley Y. H. Lai
- C Yu
- CM Karbiwnyk
- Commission decision of 12 August 2002 implementing council directive 96/23/EC concerning the performance of analytical methods the interpretation of results (2002/657/EC)
- DN Heller
- E Pelizzetti
- HG Mol
- Hubert P. O. Tang
- K Patel
- MS Filigenzi
- P Varelis
- R Cantú
- R Cantú
- R Cantú
- R Reimschuessel
- RLM Dobson
- S Ehling
- Shirley S. L. Lai
- W. O. Lee
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- Field of study
No full textTemporal Homogenization of Linear ODEs, with Applications to Parametric Super-Resonance and Energy Harvest
- Author
- B. Despres
- C. Price
- C.C. Mei
- E. Akhmedov
- E. Mathieu
- F. Dohnal
- F. Dohnal
- F. Verhulst
- G. Abraham
- G. Allaire
- G. Mahmoud
- G. Nguetseng
- G.W. Hill
- Houman Owhadi
- J. Berges
- J. Cooper
- J. Garnier
- J. Yang
- J.H. Shirley
- J.P. Blanchard
- M. Devaud
- M. Dobson
- M. Maricq
- M. Skriganov
- M.S. Alam
- Molei Tao
- Q. Zhang
- R. Carlson
- R. Zounes
- R.M. Wilcox
- S. Blanes
- S. Blanes
- S. Fatimah
- S. Rahav
- S.-I. Chu
- T. Grozdanov
- T. Ng
- U. Peskin
- W. Li
- W. Magnus
- W. Paul
- W. Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textMale reproductive tactics to increase paternity in the polygynandrous Columbian ground squirrel (Urocitellus columbianus)
- Author
- A Johnsen
- Adele Balmer
- AP Møller
- B Goossens
- BJ Hatchwell
- C Kvarnemo
- CD Linn
- CD Soulsbury
- CJ Kyle
- DA Dewsbury
- David W. Coltman
- DE Boellstorff
- Dik Heg
- DJ Baumgardner
- DW Foltz
- E Danchin
- EA Lacey
- F. Stephen Dobson
- FJL Kraaijeveld-Smit
- FS Dobson
- FS Dobson
- FS Dobson
- GA Parker
- GA Parker
- GA Parker
- GA Parker
- H Kokko
- J Alcock
- J Hanken
- J Komdeur
- J Martín
- J Zaldivar Rae
- Jamieson C. Gorrell
- JL Hoogland
- JL Hoogland
- JL Koprowski
- JM Waterman
- JO Murie
- JO Murie
- JO Murie
- JO Murie
- JO Wolff
- K Martin
- L Bouchie
- LW Simmons
- M Andersson
- M Festa-Bianchet
- M Gomendio
- M Kohda
- M Lindén
- MA Foster
- MD Jennions
- MJ Norusis
- N Yamamura
- P Hammerstein
- P Neuhaus
- P Neuhaus
- Peter Neuhaus
- PL Schwagmeyer
- PL Schwagmeyer
- PW Sherman
- R Oliveira
- R Pinxten
- RD Cothran
- RD Lisk
- S Hanslik
- S Raveh
- S Stevens
- Shirley Raveh
- SJ Plaistow
- SM Shuster
- ST Emlen
- ST Kalinowski
- T Pizzari
- TC Marshall
- TG Manno
- TG Manno
- TG Manno
- TH Clutton-Brock
- TH Clutton-Brock
- TR Birkhead
- TR Birkhead
- TR Birkhead
- V Jormalainen
- Vincent A. Viblanc
- WD Koenig
- Y Saeki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
