8 research outputs found
Comportamento a campo de cultivares de algodão colorido no norte do Paraná.
- Author
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Get PDFCaracterísticas tecnológicas de fibra de algodão colorido no Paraná.
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- Publication venue
- Publication date
- 01/01/2011
- Field of study
Get PDFUso de fontes de nitrogênio visando retardar a senescência em girassol ornamental
- Author
- Publication venue
- Universidade Estadual do Oeste do Parana - UNIOESTE
- Publication date
- 01/01/2000
- Field of study
Get PDFOrnamental sunflowers present senescence of the basal leaves, which is a negative factor from the viewpoint of commercialization. Even though being the fourth in production of grains in the world, the sunflower has some genotypes that are used with ornamental purpose for pot and cut flower. The study aimed to evaluate the effect of different nitrogen sources on some parameters of growth and development, and on the retardation of the senescence of the basal leaves in pot sunflower. The experiment was carried out with the variety cv. Sunflower F1 Sumbrite Supreme, planted in pots with a volume of 1,3 L, under controlled cultivation, at the Department of Vegetal Production of the State University of the North of Paraná, Luiz Meneghel Campus, in Bandeirantes (Paraná, Brazil). The experimental design was entirely in randomized blocks, with seven treatments and five repetitions. The pots had been filled with 50% of the commercial substratum Plantmax® and 50% of earthworm castings. The following treatments were done: control, fertilizer Super N ®, sulfamide®, urea, ammonium nitrate, ammonium sulphate and calcium nitrate at 100 mg L-1 of N, in two weekly applications, with 100 mL each pot. Two evaluations were performed, one at 30 days after planting (DAP), when the number of leaves and plant height (cm) were examined, and another at harvest, when the number of leaves, plant height, diameter of inflorescences and number of days between harvest and senescence of inflorescences where examined. There were no significant differences between the nitrogen sources used in the experiment, which allows the conclusion that all sources of nitrogen fertilizers examined in the experiment can be used to improve the quality of sunflower plants. O girassol ornamental apresenta senescência das folhas basais que é um fator negativo do ponto de vista da comercialização, mesmo sendo a quarta oleaginosa em produção de grãos no mundo, alguns genótipos são usados com finalidade ornamental para flor de corte e de vaso. O objetivo do trabalho foi o de avaliar o efeito de diferentes fontes de nitrogênio sobre alguns parâmetros de crescimento, desenvolvimento e no retardamento da senescência das folhas basais em girassol de vaso. O experimento foi conduzido em vaso, com volume de 1,3 L sob cultivo protegido, no Departamento de Produção Vegetal da Universidade Estadual do Norte do Paraná, Campus Luiz Meneghel, município de Bandeirantes–PR, utilizando do girassol cv. Sunflower F1 Sumbrite Supreme. O delineamento experimental foi em blocos ao acaso, composto por sete tratamentos com cinco repetições. Os vasos foram preenchidos com 50% de substrato comercial Plantmax ® e 50% de húmus de minhoca. Os tratamentos foram: testemunha (adubação realizada pelo produtor), adubo Super N ®, sulfammo®, uréia, nitrato de amônio, sulfato de amônio e nitrato de cálcio na dose 100 mg L-1 de N, em duas aplicações semanais, com volume de 100 mL por vaso. Foram realizadas duas avaliações, uma aos 30 dias após plantio (DAP), sendo avaliado o número de folhas e altura plantas (cm) e outra na colheita, quando os capítulos estavam totalmente abertos, sendo avaliados o número de folhas, altura de plantas, diâmetro das inflorescências e número de dias entre a colheita e a senescência das inflorescências. Não houve diferença significativa entre as fontes de nitrogênio utilizadas, permitindo concluir que todas as fontes de adubos nitrogenadas avaliadas no experimento podem ser utilizadas na melhoria da qualidade das plantas de girassol
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
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- Zuriaga-Alvaro A.
- Zuurbier W.
- Zyengi S.
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/05/2021
- Field of study
Get PDFBackground:
Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
Findings:
Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79).
Interpretation:
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Get PDFBackground:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Thigh-length compression stockings and DVT after stroke
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
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Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Using Information and Communication Technologies to teach and learn mathematics in South African schools: A snapshot view of its impact
- Author
- Antony G.
- Bester Chimbo
- Bingimlas K.A
- Campuzano L.
- Chigona A.
- DoBE (Department of Basic Education)
- DoBE (Department of Basic Education).
- DoE (Department of Education)
- Drew P.
- Forgasz H
- Hasselbring T. S.
- Hennessy S.
- Huang T. H.
- Isaacs S.
- Jones A.
- Keong C. C.
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- Spradlin K. D.
- Sullivan P.
- Tella A
- Tshiredo L. L.
- Van der Berg S.
- Way J.
- Woodward J.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Get PDFBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
