23 research outputs found
Finite elements with h -adaptation for momentum, heat and mass transport with application to environmental flow
- Author
- Publication venue
- Digital Scholarship@UNLV
- Publication date
- 01/01/1999
- Field of study
Self-adaptive algorithms for 2 and 3-dimensional unstructured finite element grids are recent to the solution of partial differential equations, particularly those equations describing environmental transport. An h-adaptive grid embedding method is developed to solve the incompressible Navier-Stokes equations for fluid flow and scalar transport. An application to atmospheric mass transport is presented; This h-adaptive algorithm, in combination with the finite element method, has been designed to solve 2 and 3-dimensional problems on Pentium PC\u27s, including problems involving complex geometry on high end PC\u27s, workstations and mainframes. The Galerkin finite element solver is a 2 point Gauss-Legendre integration scheme which employs mass lumping, Cholesky skyline L-U decomposition, and Petrov-Galerkin upwinding; This dissertation introduces and explains the application of the Galerkin weighted residual finite element method. Development of the weak statements for the non-dimensional primitive variable Navier-Stokes equations is presented along with a Poisson formulation for resolving pressure. The semi-implicit solution process of this Poisson formulation is described in detail. Various adaptive methods are presented with emphasis on grid embedDing Finally the application of the adaptive process coupled with the finite element solver is applied to the solution of the Navier-Stokes equations along with the species transport equation; Adaptive methods are becoming common place in the solution of partial differential equations. In this thesis, an algorithm employing h-adaptation is developed for the solution of the non-linear Navier-Stokes equations for incompressible flow and its application to environmental fluid dynamics. Improvements in computational requirements are discussed including comparison with solutions on globally refined domains. Comparison of solutions is provided by using benchmark problems that provide a means for assuring the verification and validation of the computer code. Implementation of the algorithm for environmental species transport is an effective method to improve the accuracy of transport prediction
A 3-dimensional h-adaptive algorithm for species transport prediction
- Author
- Publication venue
- Digital Scholarship@UNLV
- Publication date
- 01/01/1995
- Field of study
Development of 3-dimensional self-adaptive algorithms for unstructured finite element grids is recent to the solution of partial differential equations. An h-adaptive grid embedding method is employed to help solve the Navier-Stokes equations for fluid flow and scalar transport; This h-adaptive algorithm, in combination with the finite element solver, has been designed to solve simple to moderately complex 3-dimensional problems on high-end PC\u27s with at least 16 megabytes of ram, and more complex geometries on workstations and mainframes. The finite element solver is a one point Gauss-Legendre integration scheme which employs mass lumping, Cholesky skyline L-U decomposition, and Petrov-Galerkin upwinding; This thesis introduces and explains the Galerkin weighted residual finite element solution process with the use of the Laplace heat conduction equation. Development of the weak statements for the non-dimensional primitive variable Navier-Stokes equations is presented with a Poisson formulation for pressure. The explicit solution process of this Poisson formulation is described in detail. Various adaptive methods are presented with emphasis on grid embedDing Single element division or grid embedding allows for the use of the one point quadrature integration scheme used in the solution process. Finally the application of the adaptive process coupled with the finite element solver is applied to the solution of the Navier-Stokes equations along with the species transport equations
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
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- Youens J.
- Younes Ibrahim A.
- Young E.
- Young G.
- Young L.
- Young R.
- Yousafzar A.
- Youssouf S.
- Yousuf A.
- Yu C.
- Yung B.
- Yusef D.
- Yusef S.
- Yusuf I.
- Zafar A.-S.
- Zagalo S.
- Zaher S.
- Zahoor A.
- Zaki K.
- Zakir N.
- Zalewska K.
- Zamalloa A.
- Zaman M.
- Zaman R.
- Zaman S.
- Zamikula J.
- Zammit L.
- Zammit-Mangion M.
- Zarb L.
- Zebracki E.
- Zehnder D.
- Zeidan L.
- Zelman M.
- Zhao X.
- Zheng D.
- Zhu D.
- Zia M.
- Zibdeh O.
- Zill-E-Huma R.
- Zin E.T.
- Zindonda V.
- Zinkin E.
- Zinyemba V.
- Zipitis C.
- Zmierczak A.
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- Zuhra N.
- Zulaikha R.
- Zulfikar S.
- Zullo C.
- Zuriaga-Alvaro A.
- Zuurbier W.
- Zyengi S.
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/05/2021
- Field of study
Background:
Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
Findings:
Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79).
Interpretation:
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
- Arora P
- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
- Aviles R
- Awasty V
- Axelsson U
- Ayers S
- Ayub H
- Babar G
- Babington G
- Backlund M
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Acton C.
- Adam F.
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- Adedeji O.
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- Aggarwal S.
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- Byrne J.
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- Cale E.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Chilvers A.
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- Chineka R.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
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- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
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- Coe A.
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- Coker O.
- Cole J.
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- Collini Paul
- Collins J.
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- Colton H.
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- Connell E.
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- Connolly G.
- Connor E.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- De Soyza A.
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- Desai A.
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- Dhani S.
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- Dobbie L.
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- Dolan D.
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- Duffy H.
- Duggan A.
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- Dunn A.
- Duran B.
- Durrans L.
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- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
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- Elgohary A.
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- Everden C.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
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- Zafar A-M
- Zaher S
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- Zdanaviciene A
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
- Author
- Addo Marylyn M.
- Agan Brian
- Agarwal Shanu
- Ahern Richard L.
- Allen Brady L.
- Allen Todd M.
- Altfeld Marcus
- Altidor Sherly
- Altschuler Eric L.
- Alvino Donna Marie L.
- Ambardar Sujata
- Anastos Kathryn
- Anderson Ben
- Anderson Val
- Andrady Ushan
- Antoniskis Diana
- Baker Brett
- Bangsberg David
- Barbaro Daniel
- Barrie William
- Bartczak J.
- Barton Simon
- Basden Patricia
- Basgoz Nesli
- Bazner Suzane
- Beattie Nicole
- Bellos Nicholaos C.
- Benson Anne M.
- Berger Judith
- Bernard Annette M.
- Bernard Nicole F.
- Birch Christopher
- Block Brian
- Bodner Stanley J.
- Bolan Robert K.
- Boudreaux Emilie T.
- Bradley Meg
- Braun James F.
- Brndjar Jon E.
- Brown Katherine
- Brown Sheldon T.
- Brown Stephen J.
- Brumme Chanson J.
- Burack Jedidiah
- Burtt Noël P.
- Bush Larry M.
- Cafaro Virginia
- Camargo Amy
- Campbell John
- Campbell Omobolaji
- Carlson Jonathan M.
- Carlson Robert H.
- Carmichael J. Kevin
- Carrington Mary
- Carrington Mary
- Casey Kathleen K.
- Cavacuiti Chris
- Celestin Gregory
- Chambers Steven T.
- Chez Nancy
- Chirch Lisa M.
- Cimoch Paul J.
- Cohen Daniel
- Cohn Lillian E.
- Conway Brian
- Cooper David A.
- Cornelson Brian
- Cox David T.
- Crawford Gabriel
- Crenshaw Andrew
- Cristofano Michael V.
- Cuchural George
- Cutrell Emily
- Czartoski Julie L.
- Daar Eric S.
- Dahman Joseph M.
- Daly Jennifer S.
- Davies Leela
- Davis Benjamin T.
- Davis Kristine
- Davod Sheila M.
- de Bakker Paul I.W.
- de Bakker Paul I.W.
- de Bakker Paul I.W.
- Deeks Steven G.
- Deeks Steven G.
- DeJesus Edwin
- Dietz Craig A.
- Dunham Eleanor
- Dunn Michael E.
- Ellerin Todd B.
- Eron Joseph J.
- Fangman John J.W.
- Farel Claire E.
- Ferlazzo Helen
- Fidler Sarah
- Fleenor-Ford Anita
- Frankel Renee
- Freedberg Kenneth A.
- French Neel K.
- Fuchs Jonathan D.
- Fuller Jon D.
- Gaberman Jonna
- Gallant Joel E.
- Gandhi Rajesh T.
- Gao Xiaojiang
- Garcia Efrain
- Garmon Donald
- Gathe Joseph C.
- Gaultier Cyril R.
- Gebre Wondwoosen
- Gianniny Lauren
- Gilman Frank D.
- Gilson Ian
- Goepfert Paul A.
- Gonzalez Elena
- Gottlieb Michael S.
- Goulston Claudia
- Graham Robert R.
- Groger Richard K.
- Guiducci Candace
- Gulick Roy M.
- Gupta Namrata
- Gupta Supriya
- Gurley T. Douglas
- Haas David W.
- Haber Stuart
- Hardwicke Robin
- Hardy W. David
- Harrigan P. Richard
- Haubrich Richard
- Hawkins Trevor N.
- Heath Sonya
- Hecht Frederick M.
- Heckerman David
- Henn Matthew R.
- Henry W. Keith
- Hladek Melissa
- Hoffman Robert P.
- Horton James M.
- Hsu Ricky K.
- Huhn Gregory D.
- Hunt Peter
- Hupert Mark J.
- Illeman Mark L.
- Jaeger Hans
- Jellinger Robert M.
- Jia Xiaoming
- Jia Xiaoming
- John Mina
- Johnson Heather
- Johnson Jennifer A.
- Johnson Kay
- Johnson Kristin L.
- Joly Jennifer
- Jordan Wilbert C.
- Kadie Carl M.
- Kauffman Carol A.
- Khanlou Homayoon
- Killian Robert K.
- Kim Arthur Y.
- Kim David D.
- Kinder Clifford A.
- Kirchner Jeffrey T.
- Kogelman Laura
- Kojic Erna Milunka
- Korthuis P. Todd
- Kurisu Wayne
- Kuritzkes Daniel R.
- Kwon Douglas S.
- LaMar Melissa
- Lampiris Harry
- Lanzafame Massimiliano
- Le Gall Sylvie
- Lederman Michael M.
- Lee David M.
- Lee Edward T.Y.
- Lee Jean M.L.
- Lee Marah J.
- Lemay Paul
- Lemoine Janice
- Levy Jay A.
- Lian Jeffrey
- Liguori Michael A.
- Little Susan J.
- Liu Anne Y.
- Llibre Josep M.
- Lopez Alvaro J.
- Loutfy Mono R.
- Loy Dawn
- Man Alan
- Mansour Michael K.
- Marconi Vincent C.
- Markowitz Martin
- Marques Rui
- Martin Harold L.
- Martin Jeffrey N.
- Mayer Kenneth Hugh
- McElrath M. Juliana
- McGhee Theresa A.
- McGovern Barbara H.
- McGowan Katherine
- McIntyre Dawn
- McLaren Paul J.
- McLaren Paul J.
- Mcleod Gavin X.
- Menezes Prema
- Mesa Greg
- Metroka Craig E.
- Meyer-Olson Dirk
- Miller Andy O.
- Mohammed Debbie Y.
- Montgomery Kate
- Moore Jamie M.
- Moss Kristin L.
- Mounzer Karam C.
- Nagami Ellen H.
- Nagin Iris
- Nahass Ronald G.
- Nelson Margret O.
- Nielsen Craig
- Norene David L.
- Ojikutu Bisola O.
- Okulicz Jason
- Oladehin Olakunle O.
- Oldfield Edward C.
- Olender Susan A.
- Ostrowski Mario
- Owen William F.
- O’Connor David H.
- O’Leary Jessica
- Pae Eunice
- Parsonnet Jeffrey
- Pavlatos Andrew M.
- Pereyra Florencia
- Pereyra Florencia
- Pereyra Florencia
- Perlmutter Aaron M.
- Piechocka-Trocha Alicja
- Pierce Michael N.
- Pincus Jonathan M.
- Pisani Leandro
- Plenge Robert M.
- Price Lawrence Jay
- Proia Laurie
- Prokesch Richard C.
- Proudfoot Jacqueline
- Pujet Heather Calderon
- Pulit Sara L.
- Qi Ying
- Ramgopal Moti
- Rathod Almas
- Rausch Michael
- Ravishankar J.
- Rhame Frank S.
- Ribaudo Heather J.
- Richards Constance Shamuyarira
- Richman Douglas D.
- Riddler Sharon
- Ripke Stephan
- Robbins Gregory K.
- Robbins Gregory K.
- Rodes Berta
- Rodriguez Milagros
- Rose Richard C.
- Rosenberg Eric S.
- Rosenberg Rachel
- Rosenthal Daniel
- Ross Polly E.
- Rothchild Alissa
- Rubin David S.
- Rumbaugh Elease
- Saenz Luis
- Salvaggio Michelle R.
- Sanchez William C.
- Sanjana Veeraf M.
- Santiago Steven
- Sax Paul E.
- Schaefer Todd
- Schmidt Wolfgang
- Schuitemaker Hanneke
- Sestak Philip M.
- Shafer Robert W.
- Shalit Peter
- Shay William
- Shikuma Cecilia M.
- Shirvani Vivian N.
- Silebi Vanessa I.
- Sizemore James M.
- Skolnik Paul R.
- Sokol-Anderson Marcia
- Sosman James M.
- Stabile Paul
- Stapleton Jack T.
- Starrett Sheree
- Stein Francine
- Stellbrink Hans-Jurgen
- Sterman F. Lisa
- Stone David R.
- Stone Valerie E.
- Streeck Hendrik
- Sullivan Jordan
- Tambussi Giuseppe
- Taplitz Randy A.
- Tedaldi Ellen M.
- Telenti Amalio
- Telenti Amalio
- Telenti Amalio
- Theisen William
- Torres Richard
- Tosiello Lorraine
- Toth Ildiko
- Tremblay Cecile
- Tribble Marc A.
- Trinh Phuong D.
- Tsao Alice
- Ueda Peggy
- Vaccaro Anthony
- Valadas Emilia
- Vanig Thanes J.
- Vecino Isabel
- Vega Vilma M.
- Veikley Wenoah
- Verma Pranshu
- Vine Seanna
- Wade Barbara H.
- Walker Bruce D.
- Walker Bruce D.
- Walker Bruce D.
- Walworth Charles
- Wanidworanun Chingchai
- Ward Douglas J.
- Warner Daniel A.
- Weber Robert D.
- Webster Duncan
- Weis Steve
- Wheeler David A.
- White David J.
- Wilkins Ed
- Winston Alan
- Wlodaver Clifford G.
- Wout Angelique van’t
- Wright David P.
- Yang Otto O.
- Yuki Yuko
- Yurdin David L.
- Zabukovic Brandon W.
- Zachary Kimon C.
- Zeeman Beth
- Zhao Meng
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2010
- Field of study
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection
‘This Community Which Nobody Can Define’: Meanings of Commonwealth in the Late 1940s and 1950s
- Author
- Allen H. C.
- Arnold Guy.
- Attlee Clement.
- Bailkin Jordanna.
- Berger Carl.
- Bradley Kenneth
- Brady Alexander.
- Brebner J. Bartlet.
- Brock W. R.
- Brookes Edgar H.
- Buckner Philip
- Buckner Philip
- Carrington Charles
- Carrington Charles.
- Carrington Charles.
- Carrington Charles.
- Carter E. H.
- Christopher Prior
- Copland Sir Douglas.
- Creighton Donald.
- Davidson Jim.
- De Smith Stanley A.
- Digby Margaret.
- Eden Anthony.
- Fawcett J. E. S.
- Hancock W. K.
- Hancock W. K.
- Hancock W. K.
- Hancock W. K.
- Heinlein Frank.
- Hyam Ronald
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Jennings Ivor.
- Knaplund Paul.
- Koebner Richard.
- Kumarasingham Harshan
- Listowel Lord.
- Low D. A.
- Maitland Patrick.
- Mansergh Nicholas.
- Mansergh Nicholas.
- Mansergh Nicholas.
- Mansergh Nicholas.
- Mansergh Nicholas.
- Mansergh Nicholas.
- Mansergh Nicholas.
- May Alex.
- McIntyre W. David.
- Metcalf Thomas.
- Miller J. D. B.
- Miller J. D. B.
- Muir Ramsay.
- Newton A. P.
- Parsloe Guy.
- Rayner Robert.
- Simnett W. E.
- Somervell D. C.
- Somervell D. C.
- Somervell D. C.
- Soper Tom.
- Southgate George W.
- Southgate George W.
- Stamp L. Dudley.
- Strachey John.
- Taylor Don.
- Tennyson Charles.
- Underhill Frank
- Underhill Frank.
- Webster Wendy.
- Westad Odd Arne.
- Wheare K. C.
- Wilkes George
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Professionals or Politicians: The Uncertain Empirical Case for an Elected Rather Than Appointed Judiciary
- Author
- . R Cass
- Adam B Cox
- Adam B Cox
- Alexander M Bickel
- Alexander Tabarrok
- Aman L Mcleod
- Anup Malani
- Anup Malani
- B Adam
- B Adam
- Bernard E Harcourt
- Bernard E Harcourt
- Bernard E Harcourt
- Bernard E Harcourt
- Bradley Canon
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Charles G Geyh
- Damon Cann
- Daniel Kahneman
- Daniel R Pinello
- David A Weisbach
- David A Weisbach
- David A Weisbach
- David Gilo
- David S Abrams
- David S Abrams
- David S Abrams
- Deborah Goldberg
- Douglas Lichtman
- E Bernard
- Eric A Posner
- Eric A Posner
- Eric A Posner
- Eric A Posner
- Eric A. Posner
- Eugene Kontorovich
- Eugene Kontorovich
- F Hanssen
- F Hanssen
- Frank B Cross
- Frank Cross
- Frank Cross
- G A Tarr
- G Douglas
- G. Mitu Gulati
- H Albert
- Henry Glick
- J Lior
- J Stephen
- Jacob E Gersen
- Jacob Lior
- Jacob Lior
- Jeffrey A Segal
- Joanna Shepherd
- John F Bibby
- Jon O Newman
- Kenneth W Dam
- Kenneth W Dam
- Larry Aspin
- M
- M William
- Matthew Adler
- Melinda Hall
- Michael Abramowicz
- Michael Abramowicz
- Mita Bhattacharya
- Paul Brace
- Paul Brace
- Paul Brace
- Paul Brace
- Paul Brace
- Paul D Carrington
- R Christopher
- Randal C Picker
- Randal C Picker
- Randal C Picker
- Randal C Picker
- Robert Cooter
- Robert L Dudley
- Scott Baker
- Stephen J Choi
- Stephen J Choi
- Stephen J. Choi
- Steven P Croley
- Timothy Besley
- Tracey E George
- W Dennis
- Wayne Hsiung
- William D Berry
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2007
- Field of study