Methodological Approach to the Study of Sustainable and Safe Social and Economic Development of the Territories

The problems of social and economic development of the country under conditions of the world financial crisis are discussed in the paper. Methodological basics are proposed for the research of sustainable and safe social and economic development (SSSED) of the territories of different levels. Major components in the scheme of research of SSSED are characterized. For the territories of the regional level a methodological approach to differentiate SSSED is proposed and discussed. Algorithms evaluating the state of the economy from the viewpoint of providing SSSED and from the viewpoint of the indicators of sustainability of the direction of social and economic development are also proposed. An example of the use of elaborated methodological tools as applied to the state and forecasting of the indicators of the Ural Federal Region territories SSSED is given

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Research and assessment of competitiveness of large engineering complexes

The urgency of the problem of ensuring the competitiveness of manufacturing and high-tech sectors is shown. Substantiated the decisive role of the large industrial complexes in the formation of the results of the national economy; the author’s interpretation of the concept of “industrial complex” with regard to current economic systems. Current approaches to assessing the competitiveness of enterprises and industrial complexes are analyzed; showing their main advantages and disadvantages. Provides scientific-methodological approach to the study and management of competitiveness of a large industrial complex; the description of its main units is provided. As a Central element of the scientific methodology approach proposed the methodology for assessing the competitiveness of a large industrial complex based on the Pattern-method; a modular system of indicators of competitiveness is developed and its adaptation to a large engineering complexes is made. Using the developed methodology the competitiveness of one of the largest engineering complexes of the group of companies Uralelectrotyazhmash, which is the leading enterprises in electrotechnical industry of Russia is assessed. The evaluation identified the main problems and bottlenecks in the development of these enterprises, and their comparison with leading competitors is provided. According to the results of the study the main conclusions and recommendations are formed

THE CONDITION AND THE DYNAMICS OF CHANGES OF REGIONAL ENERGETIC SAFETY LEVEL

On the basis of indicative analysis method use, the dynamic processes of changes of energetic safety condition of federal districts and subjects of Russian Federation for last 5 years are investigated. The results of diagnosing safety levels for separate indicators, their blocks and the results of situation evaluation as a whole are discussed. The comparison of regions’ energetic safety condition is given, the causes of crisis situations appearance are discovered, and on this basis the suggestions for regions’ safety levels increasing are formulated

THE CONDITION OF THE URALS METALLURGICAL COMPLEX BEFORE THE INTRODUCTION OF RUSSIA INTO WTO

The problem of readiness of the enterprises of a metallurgical complex of Russia and Urals Mountains to work in conditions of connection to WTO is mentioned in the work. The analysis of a modern condition of a complex in Russia and Ural federal district is lead, tendencies of its change during last years are investigated. The methodical approach to an estimation of a condition of the enterprises and their competitiveness on the basis of which it is possible to reveal "narrow" places and the "weak" parties in their activity and to estimate a degree of readiness of the enterprise to work in conditions of WTO is offered. With use of the developed methodical device the estimation of a condition and readiness of the enterprises of the Ural mountain-metallurgical company for the introduction of Russia in WTO is executed

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion