51 research outputs found
Compactons versus Solitons
We investigate whether the recently proposed PT-symmetric extensions of
generalized Korteweg-de Vries equations admit genuine soliton solutions besides
compacton solitary waves. For models which admit stable compactons having a
width which is independent of their amplitude and those which possess unstable
compacton solutions the Painleve test fails, such that no soliton solutions can
be found. The Painleve test is passed for models allowing for compacton
solutions whose width is determined by their amplitude. Consequently these
models admit soliton solutions in addition to compactons and are integrable.Comment: 4 page
Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis.
BACKGROUND: Mammography is less effective in detecting cancer in dense than in fatty breasts. METHODS: We undertook a systematic search in PubMed to identify studies on women with dense breasts who underwent screening with mammography supplemented with ultrasound. A meta-analysis was undertaken on the proportion of cancers detected only by ultrasound, out of all screen-detected cancers, and the proportion of women with negative mammography who were referred for assessment following ultrasound screening. RESULTS: Twenty-nine studies satisfied our inclusion criteria. The proportion of total cancers detected only by ultrasound was 0.29 (95% CI: 0.27-0.31), consistent with an approximately 40% increase in the detection of cancers compared to mammography. In the studied populations, this translated into an additional 3.8 (95% CI: 3.4-4.2) screen-detected cases per 1000 mammography-negative women. About 13% (32/248) of cancers were in situ from 17 studies with information on this subgroup. Ultrasound approximately doubled the referral for assessment in three studies with these data. CONCLUSIONS: Studies have consistently shown an increased detection of breast cancer by supplementary ultrasound screening. An inclusion of supplementary ultrasound into routine screening will need to consider the availability of ultrasound and diagnostic assessment capacities.Department of Health Policy Research Programme (106/0001).
Cancer Research UK (grants C8162/A16892 and C569/A16891)
CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting
Nuclear detection, segmentation and morphometric profiling are essential in
helping us further understand the relationship between histology and patient
outcome. To drive innovation in this area, we setup a community-wide challenge
using the largest available dataset of its kind to assess nuclear segmentation
and cellular composition. Our challenge, named CoNIC, stimulated the
development of reproducible algorithms for cellular recognition with real-time
result inspection on public leaderboards. We conducted an extensive
post-challenge analysis based on the top-performing models using 1,658
whole-slide images of colon tissue. With around 700 million detected nuclei per
model, associated features were used for dysplasia grading and survival
analysis, where we demonstrated that the challenge's improvement over the
previous state-of-the-art led to significant boosts in downstream performance.
Our findings also suggest that eosinophils and neutrophils play an important
role in the tumour microevironment. We release challenge models and WSI-level
results to foster the development of further methods for biomarker discovery
Newly Discovered Occurrences and Gene Tree of the Extracellular Globins and Linker Chains from the Giant Hexagonal Bilayer Hemoglobin in Metazoans
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Impact of Virtual Reality Experience on Accessibility of Cultural Heritage
Accessibility plays a main role among the aspects that contribute to the conservation of Cultural Heritage sites. Seismic stability, fragility of the artefacts, conflicts, deterioration, natural disasters, climate change and visitors’ impact are only some of the possible causes that might lead to the inaccessibility of a heritage site for both researchers and visitors.
The increasing potential of Information and Communication Technologies (ICT) in the conservation field has resulted in the development of Augmented and Virtual reality (AR and VR) experiences. These ones can be very effective for what concerns the description of the visual experience, but also improve the understanding of a site and even became analytic research tools.
This paper presents an inaccessible Buddhist temple in the Myanmar city of Bagan as a case study for the realization of a VR experience that aims at providing accessibility to knowledge and therefore a better understanding of the cultural value. In order to evaluate the effectiveness of the VR for this purpose, a user study has been conducted and its results are reported.status: Published onlin
Carbon-13 NMR spectra of coumarin and methoxycoumarins—a reinvestigation of charge density/Chemical Shift Relations
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