6 research outputs found
Design and synthesis of a multivalent homing device for targeting to murine CD22.
- Author
- Publication venue
- Publication date
- 01/01/2001
- Field of study
CD22 is a cell-surface glycoprotein uniquely located on mature B-cells and B-cell derived tumour cells. Current evidence suggests that binding of endogenous ligands to CD22 leads to modulation of B-cell activation by antigen. Incidentally, however, B-cell activation may derail. and lead to an undesired immune response, for example in cases of allergy, rheumatoid arthritis and Crohn's disease. In this situation, synthetic high-affinity ligands for CD22 may be of therapeutic value as inhibitors of B-cell activation. Recent studies have revealed that natural ligands for CD22 contain the trisaccharide NeuAc alpha-2,6-Lac as the basic binding motif. In addition, it has been demonstrated that binding to CD22 is strongly enhanced by multivalent presentation of the basic binding motif (cluster effect). In this paper. the stepwise development of a novel multivalent high-affinity ligand for CD22 is described. In the first stage, a series of monovalent NeuAc alpha-2,6-Glc(Y)X type binding motifs was prepared, and their affinity for murine CD22 was monitored, to obtain more insight into the effect of separate structure elements on ligand recognition. In the second stage, we prepared a trivalent cluster, based on the monovalent motif that displayed the highest affinity for CD22, NeuAc alpha-2,6-GlcNBzNO2OMe (7). This cluster, TRIS(NeuAc alpha-2,6-GlcNBzNO2)3 (52), displayed a more than 58-fold higher affinity for CD22 than the reference structure NeuAc alpha-2,6-LacOMe (10). To our knowledge, the cluster 52 is one of the most potent antagonists for CD22 yet synthesised
Stable polyplexes based on arginine-containing oligopeptides for in vivo gene delivery
- Author
- A Domashenko
- B Li
- C Plank
- C Plank
- CH Wu
- D Kalderon
- DL McKenzie
- DV Schaffer
- E Wagner
- H Gausepohl
- HC Chiou
- I Navarro-Quiroga
- J Haensler
- JC Lacey Jr
- JC Perales
- JL Young
- JM Wilson
- JR Merwin
- JT Sparrow
- LA Sliedregt
- M Cotten
- MA Wolfert
- MF Wolschek
- MS Wadhwa
- MS Wadhwa
- O Boussif
- PL Felgner
- PR Dash
- R Kircheis
- RE Lanford
- RI Mahato
- RI Mahato
- RJ Cristiano
- S Armeanu
- S Gottschalk
- SL Commerford
- SM Van Rossenberg
- T Niidome
- VM Guillem
- Y Zou
- YK Oh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Crimes de guerre des soci�t�s: Condamner le pillage des ressources naturelles (Corporate War Crimes: Prosecuting Pillage of Natural Resources)
- Author
- &
- &
- (� L
- A G R�s
- A G R�s
- A G R�s
- A G R�s
- A G R�s
- A G R�s
- A Nuremberg
- Activit�s Arm�es Sur Le Territoire Du
- Affaire Bommer
- Affaire Bommer
- Affaire Flick
- Affaire Krupp
- Affaire Krupp
- Affaire Krupp
- Affaire Niyonteze
- Affaire R�chling
- Affaire R�chling
- Allan Gerson
- Amrit Singh
- Andrew Clapham
- Anita Ramastray
- Antony Anghie
- Arr�t Tadi?
- Bernd Sch�nemann
- Blum C
- Brent Fisse
- Britannique Manuel Militaire
- Britannique Manuel Militaire
- Britannique Manuel Militaire
- Bruno Proc�s De
- C Peter
- Chapitre Voir
- Chidi Odinkalu
- Coffee
- Consolata Mukangango
- Conventions De Gen�ve
- Cristina Chiomenti
- De La Belgique
- De Riard V Medoro
- Delgamuukw V. British
- Dinstein
- Donald Rumsfeld
- Doris Voir
- Edward R Cummings
- Elihu Lauterpacht
- Elise Van Sliedregt
- Emerka Duruigbo
- Erik Castr�ns
- Erik Kennes
- Eser Voir Albin
- F R G
- Fafo Enqu�te
- Feilchenfeld Voir Aussi
- Fisse &
- Georg Schwarzenberger
- Gerhard Von Glahn
- Glahn
- Greenspan
- H R Ct
- I G Affaire
- I G Affaire
- I G Affaire
- I G Affaire
- I G Affaire
- Iain Scobbie
- Ian Brownlie
- Id
- Id
- Id
- Id
- Id
- Id
- Internationale Cour P�nale
- J Coffee
- J G Voir
- J M Spaight
- Jacques-Henri Robert
- James Crawford
- James G. Stewart
- Jan G Laitos
- Jean-Marie Henckaerts
- John Westlake
- Johnson Claggett
- Johnson Eva Liedholm
- Joseph Voir Aussi Le Proc�s Du Dr
- Jugement Brima
- Jugement Delali?
- Jugement Marti?
- Jugement Voir
- Jugement Voir Par Exemple
- Julia Harrington Reddy
- Julius Stone
- Kamal Hossain
- Karl Proc�s
- Karol N Gess
- Kelly Askin
- Ken Hurwitz
- Krupp
- Krupp Voir Affaire
- La Haye De
- La M�me Jurisprudence Semble Traiter � Une Conscience D&apos
- La Qu
- La Statut De
- La Statut De
- Lafave
- Le
- Le Code
- Le Procureur
- Le Procureur
- Le Procureur C. Thomas Lubanga
- Le Terme
- Leiv Lunde
- Luis Moreno-Ocampo
- M Brice
- Mabo V Queensland
- Manuel Militaire Britannique De
- Michael Bohlander
- Minist�res Affaire Des
- Minist�res Affaire Des
- Minist�res Affaire Des
- Morris Greenspan
- Morris Voir Steven
- Mr Luis Moreno-Ocampo
- N V De
- P V A G Voir
- Par Voir
- Par Voir
- Patrick Daillier
- Prosecutor V Brima
- Prosecutor V Delali?
- Prosecutor V Katanga
- Prosecutor V Kouwenhoven
- Prosecutor V Limaj
- Prosecutor V Limaj
- Prosecutor V Naletili?
- Q C Lester
- Rdc Affaire
- Rdc C Affaire
- S/Res
- S/Res/1457
- S/Res/1499
- Sandra Coliver
- Scotti V Garbagnati
- Singapore Oil Stocks
- Supra Sch�nemann
- S�nat Belge
- T J Lawrence
- Tracy Gurd
- U S
- U S Navy
- Ugolovnyi Kodeks
- Uni Au Royaume
- Uni Au Royaume
- Voir
- Voir Al Nawar V
- Voir Douglas
- Voir Ernst
- Voir Global Witness
- Voir Infra
- Voir Infra
- Voir Juan Carlos Abella V. Argentina
- Voir Statut
- Wayne Voir
- William Whewell
- Yutaka Arai-Takahashi
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Tissue Engineering
- Author
- A Bader
- A Castaldini
- A Castaldini
- A Castaldini
- A Chang
- A Domb
- A Nanci
- A Sliedregt van
- A Sliedregt van
- ADO Levi
- AGM Dorp van
- AGM Dorp van
- AH Reddi
- AM Radder
- AM Radder
- AM Rodriguez
- AR Harvey
- AS Breitbart
- AT Caplan
- AU Daniels
- B Battiston
- B Coulomb
- B Coulomb
- B Garner
- B. Nusgens
- BAM Venhoven
- C Compton
- C Doyle
- C Klein
- CA Blitterswijk van
- CA Blitterswijk van
- CA Vacanti
- CCP Verheyen
- CCP Verheyen
- CCP Verheyen
- CE Schmidt
- CT Laurencin
- CT Laurencin
- CT Laurencin
- D Bakker
- D Dean
- D Heimbach
- DA Peleo
- DA Peleo
- DA Puleo
- DE Steflik
- DF Shriver
- DJ Bryan
- DM Ferris
- DM Toriumi
- DW Grijpma
- DW Jones
- E Bell
- E Bell
- E Furnish
- EP Plueddemann
- F Langone
- FJ Schoen
- FR Rozema
- G Guida
- G Lundborg
- GGI Gallico
- GJ Meijer
- GJ Meijer
- H Green
- H Molander
- H Ohgushi
- H Ohgushi
- H Ohgushi
- H Oonishi
- HB Wen
- HB Wen
- HC Li
- HM Lazarus
- HR Allcock
- HR Allcock
- HR Allcock
- IA Small
- IV Yannas
- IV Yannas
- IV Yannas
- IV Yannas
- IV Yannas
- IV Yannas
- J Black
- J Devin
- J Gearhart
- J Kohn
- J Teumer
- JA Jansen
- JA Thomson
- JC Behiri
- JC Knowles
- JD Bruijn de
- JD Bruijn de
- JF Burke
- JF Hansbrough
- JF Hansbrough
- JF Hansbrough
- JG Rheinwald
- JH Collier
- JHL Crommen
- JHL Crommen
- JM Antonucci
- JM Pachence
- JO Hollinger
- K Endo
- K Groot de
- K Groot de
- K Sinibaldik
- KK Wang
- KK Wang
- KS Tenhuisen
- KW Weadock
- LA Prezyna
- LD Couves
- LJ Bonassar
- LJ Marden
- LL Hench
- LL Miller
- LR Williams
- M Lind
- M Lind
- M Merle
- M Nimni
- M Wang
- MA Attawia
- MC Shin
- MF Meek
- MJ Yaszemski
- MJ Yaszemski
- MJ Yaszemski
- MS Widmer
- MS Widmer
- N Dagalaskis
- NR Boeree
- O Cataltepe
- OA Sadik
- P Aebischer
- P Aebischer
- P Aebischer
- P Aebischer
- P Chistolini
- P Ducheyne
- PG Cordeiro
- PH Robinson
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Liu
- Q Ye
- R Hulspas
- R Kuijer
- R Labella
- R Skalak
- R Sodian
- R Zhang
- RC Thomson
- RC Thomson
- RF Valentini
- RL Bowen
- RL Dunn
- RL Scheridan
- RL Walton
- RZ Geros Le
- S Deb
- S Higashi
- S Kadiyala
- SA Eming
- SAT Meer van der
- SC Cook
- SH Li
- SH Li
- SJ Peter
- SJ Peter
- SJ Peter
- SL Ishaug-Riley
- SN Nazhat
- SP Bruder
- SP Hoerstrup
- ST Boyce
- ST Boyce
- T Albrektsson
- T Kokubo
- T Livingston
- T Shinoka
- T Shinoka
- T Terjesen
- U Ripamonti
- U Ripamonti
- UA Stock
- V Zacchi
- VR Shastri
- W Bonfield
- W Bonfield
- W Colin
- W Raemdonck van
- WFA Dunnen den
- WFA Dunnen den
- WFA Dunnen den
- WR Lacefield
- Y Li
- Y Restrepo
- YL Xiao
- ZB Luklinska
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update covering the period 2001–2002
- Author
- Ackloo
- Afiyatullov
- Ahrazem
- Akaji
- Akbay
- Akita
- Aksenova
- Albach
- Alisi
- Alpe
- Altmann
- Aly
- Amano
- An
- Ando
- Ando
- Araki
- Arbatsky
- Ashida
- Aussel
- Bacher
- Bahrke
- Baigude
- Baker
- Bakker
- Barberá
- Barkley
- Bashir
- Batrakov
- Batrakov
- Belgacem
- Belmont
- Benaissa-Trouw
- Berggren
- Bergh
- Bergh
- Betancourt
- Bewley
- Bezouška
- Bhattacharyya
- Biemann
- Biondi
- Birken
- Blume
- Boehm
- Boisson
- Boivin
- Bonnin
- Boraston
- Botek
- Bothner
- Botting
- Bourcier
- Bringhurst
- Brodsky
- Bryan
- Bublitz
- Buchanan
- Böhme
- Büttner
- Cai
- Calabozo
- Calis
- Callewaert
- Callewaert
- Capon
- Careri
- Caroff
- Castric
- Cencic
- Charlwood
- Charlwood
- Charlwood
- Charlwood
- Chaurand
- Chen
- Cheng
- Cherif
- Chernyak
- Chevalier
- Chitlaru
- Chitlaru
- Chiu
- Chong
- Christians
- Cid
- Cipolla
- Cipollo
- Cipollo
- Cipollo
- Cipollo
- Clausen
- Cogez
- Cogez
- Cohen
- Cohen
- Colangelo
- Constant
- Cooper
- Coppin
- Corsaro
- Courel
- Creaser
- Cruz
- Csávas
- Csávás
- Cudic
- Cudic
- Czichocki
- Dalluge
- Daniel
- Darewicz
- Davis
- de la Fuente
- de Paz
- de Vries
- Dean
- Deery
- Dell
- Delplace
- Deng
- Deng
- Di Patrizi
- Dicko
- DiGiandomenico
- Dirnberger
- Dolashka-Angelova
- Dondoni
- Dondoni
- Dondoni
- Dondoni
- Dondoni
- Dondoni
- Dondoni
- Dondoni
- Driedger
- Du
- Du
- Du
- Dubber
- Duclos
- Duelli
- Duraisamy
- Dvoráková
- Eichler
- Elbers
- Elsayed
- Escalante
- Eserstam
- Ethier
- Faber
- Faber
- Fabini
- Farid
- Faull
- Fernández-Fernández
- Florea
- Fournier
- Franz
- Franz
- Freeman
- French
- Frison
- Frison-Norrie
- Frison-Norrie
- Fryksdale
- Fu
- Fujiwaki
- Fujiwaki
- Fukuoka
- Fukushima
- Fukushima
- Fukuyama
- Fulton
- Fulton
- Gabriele-Schuette
- Gallego
- Galán
- Gao
- García-Barrientos
- Garner
- Garner
- Garner
- Garton
- Gege
- Gege
- Geng
- George
- Gerwig
- Geurtsen
- Geurtsen
- Geyer
- Geyer
- Gibbons
- Glomski
- Glückmann
- Gobbo
- Gohlke
- Gotoh
- Gouw
- Grathwohl
- Gronow
- Grozdanov
- Gu
- Gu
- Gu
- Guerrini
- Guo
- Guo
- Guérardel
- Gyémánt
- Gèze
- Hada
- Hada
- Halkes
- Haller
- Haneda
- Hanessian
- Hanisch
- Hanisch
- Hanrahan
- Hansske
- Harding
- Harhangi
- Harrison
- Harvey
- Harvey
- Harvey
- Harvey
- Harvey
- Harvey
- Harvey
- Hashimoto
- Haslam
- He
- Heise
- Hendrix
- Henriksson
- Hepbildikler
- Hiki
- Hills
- Hirabayashi
- Hoffmann
- Hoja-Lukowicz
- Hojo
- Hollister
- Homer
- Hong
- Horibata
- Horiuchi
- Horiuchi
- Hossain
- Hricovíniová
- Hrmova
- Huang
- Huang
- Huang
- Hui
- Hui
- Huisman
- Humeny
- Hunnam
- Hurlbert
- Hussein
- Höög
- Hülsmeier
- Ichiyanagi
- Iida
- Inamura
- Inoue
- Iriko
- Ito
- Ivanchina
- Iwai
- Iwase
- Jacobs
- Jacobs
- Jacobs
- Jacobs
- Janusch
- Jemth
- Jeyaretnam
- Jiang
- Jones
- Josephson
- Kabel
- Kabel
- Kabel
- Kakehi
- Kandil
- Kandra
- Kandra
- Kanipes
- Kannan
- Kantelhardt
- Karlsson
- Karumanchi
- Kato
- Kato
- Kato
- Kawachi
- Kawahara
- Kawahara
- Keiser
- Kemminer
- Khodair
- Kida
- Kilz
- Kim
- Kim
- Kislinger
- Kissel
- Kitamura
- Knirel
- Knochenmuss
- Knuhr
- Kobayashi
- Koike
- Komba
- Kooistra
- Korduláková
- Kornilov
- Kotake
- Kotani
- Kovács
- Kozlov
- Kragol
- Kranz
- Krause
- Kreuger
- Kubanek
- Kubanek
- Kubasch
- Kuroda
- Kurokawa
- Kuroyama
- Kushi
- Kwan
- Kéki
- Küster
- Küster
- Lahmann
- Landersjö
- Landersjö
- Lapolla
- Lapolla
- Lapolla
- Lapolla
- Lavanant
- Lazarevic
- Lecourt
- Lee
- Lee
- Lee
- Lefeber
- Leppänen
- Lerouxel
- Li
- Liedtke
- Lin
- Lindhorst
- Linnerborg
- Lipinski
- Liptak
- Litynska
- Liu
- Liu
- Liu
- Liu
- Liu
- Liu
- Loureiro y Penha
- Ludwiczak
- Ludwiczak
- Luo
- López-Marín
- Magnadóttir
- Mahoney
- Malkar
- Manabe
- Manna
- Manzo
- Matamoros-Fernández
- Matsumoto
- Matsuoka
- Mattei
- Mattei
- Mawas
- McCoy
- McGowen
- McWatt
- Mechref
- Mehlert
- Melean
- Meng
- Menge
- Merchant
- Merry
- Mills
- Mills
- Mills
- Minchiotti
- Mirgorodskaya
- Mischnick
- Miura
- Molinaro
- Molinaro
- Molinaro
- Morath
- Mourad
- Mukherjee
- Mäki
- Müller
- Müller
- Naderer
- Nakamura
- Natunen
- Navazio
- Naven
- Nemeth
- Neretina
- Neubert
- Niedziela
- Nimtz
- Nitz
- Nonami
- Nonami
- Nonami
- Nørbæk
- O'Connor
- Ohanessian
- Ohno
- Ohta
- Ohtsuka
- Ojha
- Okamoto
- Ouchi
- Pacios-Bras
- Papac
- Papantonakis
- Park
- Pasch
- Patel
- Pauly
- Pauly
- Pedersen
- Peoc'h
- Peri
- Pfenninger
- Pihko
- Plettenburg
- Pojasek
- Post
- Powell
- Prior
- Prior
- Putalun
- Qian
- Qin
- Rabenstein
- Radcliffe
- Rafty
- Raju
- Raju
- Ramamurthy
- Ratner
- Recht
- Reddy
- Reiner
- Reis
- Reiter
- Roberts
- Rodríguez
- Roussel
- Rowley
- Roy
- Royle
- Rudd
- Russell
- Rutschow
- Saba
- Sahu
- Sahu
- Sakaguchi
- Salo
- Samyn-Petit
- Saskiawan
- Sassi
- Sato
- Satomaa
- Scaloni
- Schilling
- Schilling
- Schilling
- Schmid
- Schmid
- Schuette
- Schwientek
- Schwientek
- Schäffer
- Schäffer
- Sei
- Semenuk
- Shafer
- Shahgholi
- Shangguan
- Shashkov
- Sherman
- Sherman
- Shields
- Shields
- Shimizu
- Sievi
- Silipo
- Silipo
- Sliedregt
- Soulemanov
- Spengler
- St Michael
- Steiner
- Stelmach
- Stoeva
- Strasser
- Sturiale
- Su
- Su
- Sukegawa
- Sumida
- Sun
- Sutton
- Suzuki
- Suzuki
- Sweet
- Sörme
- Takano
- Takasu
- Taketomi
- Takeuchi
- Takeuchi
- Talaga
- Tanimoto
- Teleman
- Tetaert
- Tetaert
- Thoma
- Thomson
- Thomsson
- Thérisod
- Thérisod
- Thérisod
- Toivonen
- Toyoda
- Trent
- Trent
- Trent
- Tseng
- Tseng
- Tseng
- Tsvetanova
- Tubbs
- Tufvesson
- Tull
- Tullius
- Turnbull
- Turnbull
- Tzeng
- Tzeng
- Tømmeraas
- Urashima
- van Alebeek
- van Alebeek
- van Bommel
- Van der Kleij
- van der Wel
- Varga
- Verhoef
- Vielhaber
- Vierhuis
- Vierhuis
- Viladot
- Vincent
- Vinogradov
- Vinogradov
- Viseux
- Volc
- von Bonsdorff
- von der Ohe
- Vorachek-Warren
- Vorachek-Warren
- Wagner
- Walton
- Wang
- Wang
- Wang
- Warren
- Wasylnka
- Wehofsky
- Westmacott
- Wheeler
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wing
- Wirth
- Wittmann
- Wittmann
- Woller
- Woller
- Wondrak
- Wu
- Wuhrer
- Wuhrer
- Wuttke
- Xie
- Yamada
- Yamagaki
- Yamagaki
- Yamagaki
- Yamagaki
- Yamagaki
- Yang
- Yang
- Yang
- Yang
- Yang
- Yaoi
- Yeboah
- Ylönen
- Ylönen
- Yoon
- Yoon
- Yu
- Yudina
- Zaia
- Zamze
- Zeng
- Zhan
- Zhang
- Zhang
- Zhang
- Zhao
- Zhou
- Zhu
- Zhu
- Zinecker
- Zoellner
- Zähringer
- Zídková
- Ágoston
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2008
- Field of study
Synthesis Of Nucleosides
- Author
- Abdel-Megied
- Abdel-Megied
- Abdel-Megied
- Abdel-Megied
- Abdel-Megied
- Abdelal
- Absalon
- Abushanab
- Acevedo
- Acevedo
- Adachi
- Adams
- Agathocleous
- Agrofoglio
- Agyei-Aye
- Ajinomoto Inc.
- Akhrem
- Akhrem
- Akhrem
- Akhrem
- Akhrem
- Akita
- Al-Masoudi
- Al-Masoudi
- Al-Masoudi
- Al-Masoudi
- Alaoui-Jamali
- Almond
- Almond
- Alonso
- Altermatt
- Altmann
- Altmann
- Aly
- An
- Andersen
- Andersen
- Andersen
- Anderson
- Anderson
- Anderson
- Andrés
- Anzai
- Anzai
- Aoyama
- Araki
- Asakura
- Ashton
- Auberson
- Augustyns
- Augustyns
- Augustyns
- Austin
- Autenrieth
- Avasthi
- Averett
- Azhaev
- Azhayev
- Azmy
- Azuma
- Azuma
- Azuma
- Azymah
- Azymah
- Azymah
- Bailey
- Bailey
- Baker
- Baker
- Baker
- Bambury
- Bamford
- Banijamali
- Baraldi
- Barascut
- Barascut
- Barascut
- Barbas
- Barchi
- Bardos
- Barker
- Barr
- Barrett
- Bartholomew
- Barton
- Basnak
- Basnak
- Bassindale
- Baud
- Baud
- BaŠnák
- Beach
- Beach
- Beard
- Beattie
- Beauchamp
- Bednarski
- Bednarski
- Beer
- Beigel'man
- Beigel'mann
- Beigelman
- Bellon
- Ben-Hattar
- Benhaddou
- Bennua-Skalmowski
- Benson
- Berkowitz
- Bessodes
- Bessodes
- Betbeder
- Betbeder
- Bhadti
- Bhan
- Billich
- Binkley
- Birkofer
- Birkofer
- Björsne
- Bobek
- Bobek
- Bobek
- Bobek
- Bolitt
- Bontems
- Borthwick
- Boryski
- Boryski
- Boryski
- Boryski
- Botta
- Bou
- Bouali
- Boudjouk
- Bourgeois
- Bowles
- Branalt
- Branalt
- Bravo
- Bravo
- Breining
- Brink
- Brink
- Brink
- Brink
- Brossmer
- Brossmer
- Brown
- Bräuniger
- Bräuniger
- Bräuniger
- Bräuniger
- Brånalt
- Bubbar
- Buchanan
- Buchanan
- Buchanan
- Burns
- Bärwolff
- Bévierre
- Böhringer
- Cadet
- Camarasa
- Camerman
- Cameron
- Camplo
- Cao
- Cao
- Cao
- Capaldi
- Carbon
- Carson
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