Diseño y construcción de un almacén de productos fitosanitarios

En el proyecto propuesto se ha realizado diseño de un establecimiento para albergar productos fitosanitarios con arreglo a la vigente normativa que regula el almacenamiento de este tipo de productos. Desde el almacén proyectado se distribuirá la mercancía para dar servicio a toda la provincia de Huesca, tanto en productos específicos de cultivos extensivos, como de arboricultura. La ubicación del almacén se establece en Sariñena (Huesca) dado que es un punto céntrico, de gran actividad agraria y desde el que se puede acometer la distribución de los productos a todas las comarcas de la provincia de Huesca. El diseño estructural estará compuesto de pórticos y pilares de hormigón prefabricado, cerramientos de fachada del mismo material y la cubierta se ejecutara a dos aguas en panel sándwich, todo ello de acuerdo con el CTE. Las instalaciones interiores de fontanería, saneamiento contra incendios y eléctrica, se ejecutaran para que la edificación cumpla los requeridos requisitos de seguridad y funcionamiento marcados por la normativa de obligado cumplimiento que atañe a esta actividad Cumpliendo la normativa municipal urbana en vigor para la edificación del almacén. El proyecto constara de los siguientes documentos: Memoria Anejos a la memoria Planos Pliego de condiciones Presupuesto Estudio de seguridad y salud

Correction: Core-substituted naphthalenediimides anchored on BiVO4 for visible light-driven water splitting

Correction for 'Core-substituted naphthalenediimides anchored on BiVO4 for visible light-driven water splitting' by Simelys Hernández et al., Green Chem., 2017, 19, 2448–2462

EVIDENCIA DE ESTRÉS CARBONÍLICO EN PACIENTES CON DIABETES MELLITUS TIPO 2 DE UNA UNIDAD MÉDICA DE PRIMER NIVEL DE ATENCIÓN DE HERMOSILLO, SONORA

En la diabetes mellitus tipo 2 (DM2), la carbonilación proteica está asociada con la hiperglicemia crónica. Es una modificación química espontánea que altera la estructura y funciones nativas de las proteínas, por lo que podría ser un estimador del control metabólico de los pacientes. En México no es utilizado en la práctica clínica, por lo que no es posible saber si los pacientes con DM2 presentan una concentración alta de proteínas carboniladas. En este trabajo, de tipo transversal analítico, se incluyeron 68 pacientes con diabetes mellitus tipo 2 de una unidad médica de primer nivel de Hermosillo, Sonora, para determinar la concentración de proteínas séricas carboniladas y estimar su relación con los marcadores de control metabólico de la DM2. Los resultados demostraron el incremento significativo en la concentración de proteínas séricas carboniladas que correlacionó positivamente con la glicemia y con la concentración de albúmina carbonilada. Estos sugieren que el estrés carbonílico de los pacientes está asociado con el descontrol glicémico y que la albúmina es una de las principales fracciones proteicas modificadas. Se recomiendan futuros estudios para determinar el valor clínico de las proteínas séricas carboniladas como marcador de control metabólico en los pacientes estudiados

Synthesis of fluorosugar reagents for the construction of well-defined fluoroglycoproteins.

2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-β-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such β-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.We thank the European Commission (Marie Curie CIG, O.B. and G.J.L.B.), MICINN, Spain (Juan de la Cierva Fellowship, O.B.), MINECO, Spain (CTQ2011-22872BQU) and Generalitat de Catalunya (M.S.) for generous financial support. We also thank Mr. Adrià Cardona-Benages (URV) for technical assis-tance. G.J.L.B. thanks the Royal Society (University Research Fellowship), Fundação para a Ciência a Tecnologia, Portugal (FCT Investigator), and the EPSRC for funding.This is the final version of the article. It first appeared from ACS via http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b01259

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Central scaffold topology and carbohydrate density are important features in determining both the binding mechanism and potency of synthetic multivalent, polydisperse vs. monodisperse carbohydrate systems to a model plant toxin (RCA120). We found lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations as determined by surface plasmon resonance (SPR) and dynamic light scattering (DLS)

Metal-free and VOC-free Synthesis of O-Glycosides in Supercritical CO2

Supercritical carbon dioxide (scCO2) is a suitable medium to perform transition metal-free glycosylations in the absence of volatile organic solvents (VOCs) using glycosyl halides as glycosyl donors. The methodology here described can be applied for obtaining O-glycosides in a totally green reaction, as well as orthoesters, depending on the reaction conditions. The process is much more sensitive to temperature changes than to pressure modification, glycosyl chlorides requiring higher temperatures to be activated than glycosyl bromides. Pivaloyl groups act as good CO2-philic units and showed to be the best choice to obtain good stereoselectivities. The relevance of the fluid nature and supercritical conditions was also evidenced