Spatiotemporal dynamics of ticks and tick-borne disease at NEON sites across a sub-continental scale

Tick-borne diseases in humans such as Lyme disease cases in the United States have doubled between 2004 and 2016. Understanding the dynamics of infectious diseases has long been of interest for ecologists. Tick and tick-borne diseases are influenced by temperature and precipitation at local scales, indirectly through mast seeding in forest trees which increases the abundance of tick hosts (e.g., small mammals), as well as direct effects on survival. Most tick studies occur at local scales that comprise only a small part of their range. The aim of my thesis is to characterize spatiotemporal dynamics of ticks and tick-borne diseases in the eastern United States. I used datasets from National Ecological Observatory Network (NEON) from 2014 to 2021 to quantify the level of synchrony in tick dynamics in seven NEON Domains, representing different ecoregions, and spanning distances up to 2,000 km. I used multiple regression matrices (MRM) to examine patterns of synchrony across sites in regional to sub-continental patterns of host-seeking ticks, and climatic variation. I found that spatial synchrony in temporal patterns of nymph abundance for both Amblyomma americanum and Ixodes scapularis declined with increasing distance between NEON sites. Weather variables associated with the spatiotemporal dynamics and key predictors of ticks and tick-borne diseases vary between the two species. A. americanum was driven by lags in July temperature differences, ∆T3 (difference in mean July temperatures in year t-3 and t-4) and ∆T4 (difference in mean July temperatures in year t-4 and t-5); and January conditions impacted tick survival for I. scapularis. The proportion of nymph-infected ticks was explained by environmental factors for the genus A. americanum. Whereas, for I. scapularis proportion of infected nymphs we were unable to explain. Nymph abundance and tick-borne diseases could be understood by identifying environmental variables influencing tick spatiotemporal patterns, allowing for potential prediction of a future tick outbreak

Lima Eco-Star Wash: Servicio de lavado ecológico de autos a domicilio

Durante estos últimos meses hemos sido testigos de grandes cambios donde negocios y personas han buscado adaptarse rápidamente a los nuevos tiempos, reinventando las formas de poder llegar a un nuevo público de una manera eficiente y efectiva. Es así que presentamos a Lima Eco-Star Wash un servicio de limpieza de autos, dirigido a un mercado que busca gestionar sus tiempos de la mejor manera posible con el fin de obtener un equilibrio entre la vida profesional, familiar y social. Nuestra propuesta principal es ofrecer un servicio para nuestros clientes basado en la distinción y calidad de nuestros productos ecológicos de origen natural los cuales brindan como resultado un auto limpio, preservado por productos naturales que no afectan la pintura con el paso del tiempo, no contaminan el medio ambiente y están respaldados por un sólido equipo de trabajo enfocado en la limpieza, detalles y personalización del servicio para que cada experiencia sea única. Lima Eco-Star Wash promueve el uso responsable del agua. Somos conscientes de la gran importancia que esto tiene, ya que muchas personas en el mundo no tienen acceso al agua potable salubre, siendo esto un atentado contra la salud pública. El proyecto nos permitió comprender a profundidad una variable importante en la actual coyuntura que vivimos, el tiempo que demandan las actividades de hogar y trabajo son complejas y generamos un aporte en la solución de esta disyuntiva para generar valor a nuestro entorno y ser empáticos con la realidad que vivimos hoy en día.During these last months we have witnessed great changes where businesses and people have sought to adapt quickly to the new times, reinventing the ways to reach a new audience in an efficient and effective way. This is how we present to Lima Eco-Star Wash a car cleaning service, aimed at a market that seeks to manage its times in the best possible way to achieve a balance between professional, family, and social life. Our main proposal is to offer a service for our clients based on the distinction and quality of our ecological products of natural origin which result in a clean car, preserved by natural products that do not affect the paint over time, do not pollute the environment and are backed by a solid work team focused on cleaning, details and personalization of the service so that each experience is unique. Lima Eco-Star Wash promotes the responsible use of water. We are aware of the great importance that this has, since many people in the world do not have access to safe drinking water, this being an attack against public health. The project allowed us to understand in depth an important variable in the current situation in which we live, the time that home and work activities demand are complex, and we generate a contribution in the solution of this dilemma to generate value to our environment and be empathetic with the reality that we live today.Trabajo de investigació

The benefits and costs of adjusting bank capitalisation: evidence from Euro Area countries

El artículo propone un marco para evaluar el impacto de los colchones de capital a nivel de todo el sistema y a nivel bancario. La evaluación se basa en un modelo FAVAR (Factor-Augmented Vector Autoregression) que relaciona los ajustes bancarios individuales con la dinámica macroeconómica. El modelo FAVAR se estima individualmente para once economías de la zona del euro y se identifican impactos estructurales, lo que permite diagnosticar las principales vulnerabilidades de los sistemas bancarios nacionales y al mismo tiempo estimar los costes económicos a corto plazo del aumento de capital de los bancos. Sobre esta base, se realiza una evaluación completa de la relación coste-beneficio de un incremento en los colchones de capital. Los beneficios están relacionados con un aumento en la capacidad de resistencia de los bancos a perturbaciones adversas. Una mayor capitalización permite a los bancos hacer frente a impactos negativos y modera la reducción del crédito a economía real que se produce en circunstancias adversas. Los costes se relacionan con pérdidas transitorias de crédito y producción que son evaluadas tanto a nivel agregado como bancario. Se obtiene que un aumento en los ratios de capital tienen un impacto muy diferente en la actividad crediticia y económica, dependiendo de la forma en que los bancos se ajustan, es decir, bien a través de cambios en los activos o en capital.The paper proposes a framework for assessing the impact of system-wide and bank-level capital buffers. The assessment rests on a factor-augmented vector autoregression (FAVAR) model that relates individual bank adjustments to macroeconomic dynamics. We estimate FAVAR models individually for eleven euro area economies and identify structural shocks, which allow us to diagnose key vulnerabilities of national banking systems and estimate short-run economic costs of increasing banks’ capitalisation. On this basis, we run a fullyfledged cost-benefit assessment of an increase in capital buffers. The benefits are related to an increase in bank resilience to adverse shocks. Higher capitalisation allows banks to withstand negative shocks and moderates the reduction of credit to the real economy that ensues in adverse circumstances. The costs relate to transitory credit and output losses that are assessed both on an aggregate and bank level. An increase in capital ratios is shown to have a sharply different impact on credit and economic activity depending on the way banks adjust, i.e. via changes in assets or equity

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection