Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2V617F-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10−10) and rs2201862 (MECOM; meta-analysis P=1.96 × 10−9). Two additional SNPs, rs2736100 (TERT) and rs9376092 (HBS1L/MYB), achieve genome-wide significance when including JAK2V617F-positive cases. rs9376092 has a stronger effect in JAK2V617F-negative cases with CALR and/or MPL mutations (Breslow–Day P=4.5 × 10−7), whereas in JAK2V617F-positive cases rs9376092 associates with essential thrombocythemia (ET) rather than polycythemia vera (allelic χ2 P=7.3 × 10−7). Reduced MYB expression, previously linked to development of an ET-like disease in model systems, associates with rs9376092 in normal myeloid cells. These findings demonstrate that multiple germline variants predispose to MPN and link constitutional differences in MYB expression to disease phenotype

Fusion Cross Sections for the Proton Drip Line Nucleus 17F at energies below the coulomb barrier

The fusion-fission cross section for the system 17F + 208Pb involving the drip line nucleus 17F has been measured at energies in the vicinity of the Coulomb barrier. No enhancement of the fusion-fission yields due to breakup or to a large interaction radius was observed

Automated Analysis in Feature Modelling and Product Configuration

The automated analysis of feature models is one of the thriving topics of research in the software product line and variability management communities that has attracted more attention in the last years. A recent literature review reported that more than 30 analysis operations have been identi ed and di erent analysis mechanisms have been proposed. Product con guration is a well established research eld with more than 30 years of successful applications in di erent industrial domains. Our hypothesis, that is not really new, is that these two independent areas of research have interesting synergies that have not been fully explored. To try to explore the potential synergies systematically, in this paper we provide a rapid review to bring together these previously disparate streams of work. We de ne a set of research questions and give a preliminary answer to some of them. We conclude that there are many research opportunities in the synergy of these independent areas.Ministerio de Ciencia e Innovación TIN2009- 07366Junta de Andalucía TIC-590

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Experimental study of the Ni56(He3,d)Cu57 reaction in inverse kinematics

Measurements of (He3,d) reactions can provide information on the proton widths of states that play a role in astrophysically important (p,γ) reactions. We report on the first study of the (He3,d) reaction in inverse kinematics with a Ni56(T1/2=6.1 d) ion beam. The Q-value resolution of ~keV achieved in this experiment was sufficient to separate the transitions populating the ground state and the 1/2 - 5/2- doublet at Ex~1.1 MeV in Cu57. Prospects for similar (He3,d) experiments with improved energy resolution are also discussed

Study of the 56Ni(d, p)57 Reaction and the Astrophysical 56Ni(p, γ)57Cu Reaction Rate

The single-particle character of states outside the doubly magic (radioactive) nucleus 56Ni has been determined through a measurement of the (d, p) neutron transfer reaction using inverse kinematics. From the spectroscopic factors of the low-lying states in 57Ni, the astrophysically interesting yield for the 56Ni(p, γ) reaction to the mirror nucleus 57Cu has been calculated, utilizing charge symmetry. The rate for this reaction in the temperature range typical of novae, supernovae, and x-ray bursts is found to be more than 10 times higher than previously assumed