A novel strong coupling expansion of the QCD Hamiltonian

Introducing an infinite spatial lattice with box length a, a systematic expansion of the physical QCD Hamiltonian in \lambda = g^{-2/3} can be obtained. The free part is the sum of the Hamiltonians of the quantum mechanics of spatially constant fields for each box, and the interaction terms proportional to \lambda^n contain n discretised spatial derivatives connecting different boxes. As an example, the energy of the vacuum and the lowest scalar glueball is calculated up to order \lambda^2 for the case of SU(2) Yang-Mills theory.Comment: Talk given at the 6th International Workshop on "Critical Point and Onset of Deconfinement (CPOD)", Dubna, Russia, 23-29 August 201

Dyson-Schwinger Equations: Density, Temperature and Continuum Strong QCD

Continuum strong QCD is the application of models and continuum quantum field theory to the study of phenomena in hadronic physics, which includes; e.g., the spectrum of QCD bound states and their interactions; and the transition to, and properties of, a quark gluon plasma. We provide a contemporary perspective, couched primarily in terms of the Dyson-Schwinger equations but also making comparisons with other approaches and models. Our discourse provides a practitioners' guide to features of the Dyson-Schwinger equations [such as confinement and dynamical chiral symmetry breaking] and canvasses phenomenological applications to light meson and baryon properties in cold, sparse QCD. These provide the foundation for an extension to hot, dense QCD, which is probed via the introduction of the intensive thermodynamic variables: chemical potential and temperature. We describe order parameters whose evolution signals deconfinement and chiral symmetry restoration, and chronicle their use in demarcating the quark gluon plasma phase boundary and characterising the plasma's properties. Hadron traits change in an equilibrated plasma. We exemplify this and discuss putative signals of the effects. Finally, since plasma formation is not an equilibrium process, we discuss recent developments in kinetic theory and its application to describing the evolution from a relativistic heavy ion collision to an equilibrated quark gluon plasma.Comment: 103 Pages, LaTeX, epsfig. To appear in Progress in Particle and Nuclear Physics, Vol. 4

Proton stability in grand unified theories, in strings, and in branes

A broad overview of the current status of proton stability in unified models of particle interactions is given which includes non - supersymmetric unification, SUSY and SUGRA unified models, unification based on extra dimensions, and string-M-theory models. The extra dimensional unification includes 5D and 6D and universal extra dimensional (UED) models, and models based on warped geometry. Proton stability in a wide array of string theory and M theory models is reviewed. These include Calabi-Yau models, grand unified models with Kac-Moody levels $k>1$, a new class of heterotic string models, models based on intersecting D branes, and string landscape models. The destabilizing effect of quantum gravity on the proton is discussed. The possibility of testing grand unified models, models based on extra dimensions and string-M-theory models via their distinctive modes is investigated. The proposed next generation proton decay experiments, HyperK, UNO, MEMPHYS, ICARUS, LANNDD (DUSEL), and LENA would shed significant light on the nature of unification complementary to the physics at the LHC. Mathematical tools for the computation of proton lifetime are given in the appendices. Prospects for the future are discussed.Comment: Published in Physics Reports. 258 pages, 11 figure

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Towards Future Oriented Collaborative Policy Development for Rural Areas and People

Rural areas in Europe are at risk due to depopulation, failing generation renewal, and a multitude of influences ranging from market-based, regulatory, to societal and climate changes. As a result, current rural policy is no longer keeping pace with these changes. We propose an advanced rural policy development framework in order to deliver more accurate foresight for rural regions, contributing to new and enhanced policy interventions. The proposed framework combines new quantitative and qualitative epistemological approaches, previously unused unstructured data with traditional research information, grassroot perspective with expert knowledge, current situation analysis with forward looking activities. We argue that by using the proposed methods, policy teams will be able to enhance the effectiveness of their policy making processes, while rural stakeholders will be given the opportunity to become valuable policy influencers and solution co-creators. The ability to quickly experiment and understand the impact of a variety of policy solutions will result in saved time and costs. The framework is part of an ongoing experimental verification and testing in twelve pilot regions across Europe and Israel

Folding of guanine quadruplex molecules \u2013 funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies

Background Guanine quadruplexes (GQs) play vital roles in many cellular processes and are of much interest as drug targets. In contrast to the availability of many structural studies, there is still limited knowledge on GQ folding. Scope of review We review recent molecular dynamics (MD) simulation studies of the folding of GQs, with an emphasis paid to the human telomeric DNA GQ. We explain the basic principles and limitations of all types of MD methods used to study unfolding and folding in a way accessible to non-specialists. We discuss the potential role of G-hairpin, G-triplex and alternative GQ intermediates in the folding process. We argue that, in general, folding of GQs is fundamentally different from funneled folding of small fast-folding proteins, and can be best described by a kinetic partitioning (KP) mechanism. KP is a competition between at least two (but often many) well-separated and structurally different conformational ensembles. Major conclusions The KP mechanism is the only plausible way to explain experiments reporting long time-scales of GQ folding and the existence of long-lived sub-states. A significant part of the natural partitioning of the free energy landscape of GQs comes from the ability of the GQ-forming sequences to populate a large number of anti-syn patterns in their G-tracts. The extreme complexity of the KP of GQs typically prevents an appropriate description of the folding landscape using just a few order parameters or collective variables. General significance We reconcile available computational and experimental studies of GQ folding and formulate basic principles characterizing GQ folding landscapes

Study of strange matter production in the heavy ion collisions at NUCLOTRON

It is proposed to install an experimental setup in the fixed-target hall of the Nuclotron with the final goal to perform a research program focused on the production of strange matter in heavyion collisions at beam energies between 2 and 6 A GeV. The basic setup will comprise a large acceptance dipole magnet with inner tracking detector modules based on double-sided Silicon micro-strip sensors and GEMs. The outer tracking will be based on the drift chambers and straw tube detector. Particle identification will be based on the time-of-flight measurements. This setup will be sufficient perform a comprehensive study of strangeness production in heavy-ion collisions, including multi-strange hyperons, multi-strange hypernuclei, and exotic multi-strange heavy objects. These pioneering measurements would provide the first data on the production of these particles in heavy-ion collisions at Nuclotron beam energies, and would open an avenue to explore the third (strangeness) axis of the nuclear chart. The extension of the experimental program is related with the study of in-medium effects for vector mesons decaying in hadronic modes. The studies of the NN and NA reactions for the reference is assumed