Temperature evolution of domains and intradomain chirality in 1T- TaS2

We use scanning tunneling microscopy to study the temperature evolution of the atomic-scale properties of the nearly commensurate charge density wave (NC-CDW) state of the low-dimensional material 1T-TaS2. Our measurements at 203, 300, and 354 K, roughly spanning the temperature range of the NC-CDW state, show that while the average CDW periodicity is temperature independent, domaining and the local evolution of the CDW lattice within a domain are temperature dependent. Further, we characterize the temperature evolution of the displacement field associated with the recently discovered intradomain chirality of the NC-CDW state by calculating the local rotation vector. Intradomain chirality throughout the NC-CDW phase is likely driven by a strong coupling of the CDW lattice to the atomic lattice. © 2023 American Physical Society

‘You understand me, right?’.:Health research among the Moroccan community in the Netherlands

Based on a secondary analysis of three qualitative studies, we describe three tensions that arose when conducting health research within the Moroccan community in the Netherlands. Namely, the tension between (1) the need for an informal recruitment approach and preventing participation as a social obligation, (2) building a relationship of trust and breaking taboos and (3) immersing into respondents’ life world and keeping a distant perspective. The current scientific practice provides limited space to align with ethnic minority’s experience that professional and formal institutes have little attention for their perspectives and needs. Research teams, consisting of researchers from different backgrounds, who take time to continuously reflect collectively on the research process are necessary to recognize such tensions and find ways to deal with these tensions

Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection:an international, multi-centre, prospective audit

Introduction: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation (MBP+Abx) was associated with a reduced risk of anastomotic leak when compared to mechanical bowel preparation alone (MBP) or no bowel preparation (NBP). Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 Left Sided Colorectal Resection audit was performed. Patients undergoing elective left sided colonic or rectal resection with primary anastomosis between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 3676 patients across 343 centres in 47 countries, 618 (16.8%) received MBP+ABx, 1945 MBP (52.9%) and 1099 patients NBP (29.9%). Patients undergoing MBP+ABx had the lowest overall rate of anastomotic leak (6.1%, 9.2%, 8.7% respectively) in unadjusted analysis. After case-mix adjustment using a mixed-effects multivariable regression model, MBP+Abx was associated with a lower risk of anastomotic leak (OR 0.52, 0.30–0.92, P = 0.02) but MBP was not (OR 0.92, 0.63–1.36, P = 0.69) compared to NBP. Conclusion: This non-randomised study adds ‘real-world’, contemporaneous, and prospective evidence of the beneficial effects of combined mechanical bowel preparation and oral antibiotics in the prevention of anastomotic leak following left sided colorectal resection across diverse settings. We have also demonstrated limited uptake of this strategy in current international colorectal practice

Evaluating the incidence of pathological complete response in current international rectal cancer practice

The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials

‘You understand me, right?’.:Health research among the Moroccan community in the Netherlands

Based on a secondary analysis of three qualitative studies, we describe three tensions that arose when conducting health research within the Moroccan community in the Netherlands. Namely, the tension between (1) the need for an informal recruitment approach and preventing participation as a social obligation, (2) building a relationship of trust and breaking taboos and (3) immersing into respondents’ life world and keeping a distant perspective. The current scientific practice provides limited space to align with ethnic minority’s experience that professional and formal institutes have little attention for their perspectives and needs. Research teams, consisting of researchers from different backgrounds, who take time to continuously reflect collectively on the research process are necessary to recognize such tensions and find ways to deal with these tensions

Lattice-driven chiral charge density wave state in 1T-TaS2

We use scanning tunneling microscopy to study the domain structure of the nearly commensurate charge density wave (NC-CDW) state of 1T-TaS2. In our subangstrom characterization of the state, we find a continual evolution of the CDW lattice from domain wall to domain center, instead of a fixed CDW arrangement within a domain. Further, we uncover an intradomain chirality characterizing the NC-CDW state. Unlike the orbital-driven chirality previously observed in related transition-metal dichalcogenides, the chiral nature of the NC-CDW state in 1T-TaS2 appears driven by a strong coupling of the NC-CDW state to the lattice

Characterizing the active tectonics in the Oran region (Algeria) and recasting the 1790 earthquake

In this work, we reappraise the seismogenic potential of the geologic structures in the western Tell Atlas of Algeria, considered active host to moderate to low magnitude earthquakes. The direct identification of active faults is generally a difficult task in northern Algeria. The active tectonics in the Oran Plio- Quaternary age basin (Northwestern Algeria) is ana- lyzed and characterized through a morpho-structural study combining topographic, geomorphologic, geolog- ical, and neotectonic data. Folds and fault scarps affect- ing Quaternary deposits show that the region is affected by compressional deformation still active nowadays, as shown by the recorded seismic activity. Our new obser- vations enable a better understanding of the present seismotectonic context of the Oran region, particularly with regard to the magnitude and source of the 1790 Oran damaging event. The obtained result helps to shed some light on the elusive active tectonics characterizing this coastal area, and to assess regional seismic hazard, particularly in coastal zones where large seismogenic areas straddle the onshore–offshore zones.Published1549–15612T. Deformazione crostale attivaJCR Journa

An international assessment of the adoption of enhanced recovery after surgery (ERAS®) principles across colorectal units in 2019–2020

AimThe Enhanced Recovery After Surgery (ERAS®) Society guidelines aim to standardize perioperative care in colorectal surgery via 25 principles. We aimed to assess the variation in uptake of these principles across an international network of colorectal units.MethodAn online survey was circulated amongst European Society of Coloproctology members in 2019–2020. For each ERAS principle, respondents were asked to score how frequently the principle was implemented in their hospital, from 1 (‘rarely’) to 4 (‘always’). Respondents were also asked to recall whether practice had changed since 2017. Subgroup analyses based on hospital characteristics were conducted.ResultsOf hospitals approached, 58% responded to the survey (195/335), with 296 individual responses (multiple responses were received from some hospitals). The majority were European (163/195, 83.6%). Overall, respondents indicated they ‘most often’ or ‘always’ adhered to most individual ERAS principles (18/25, 72%). Variability in the uptake of principles was reported, with universal uptake of some principles (e.g., prophylactic antibiotics; early mobilization) and inconsistency from ‘rarely’ to ‘always’ in others (e.g., no nasogastric intubation; no preoperative fasting and carbohydrate drinks). In alignment with 2018 ERAS guideline updates, adherence to principles for prehabilitation, managing anaemia and postoperative nutrition appears to have increased since 2017.ConclusionsUptake of ERAS principles varied across hospitals, and not all 25 principles were equally adhered to. Whilst some principles exhibited a high level of acceptance, others had a wide variability in uptake indicative of controversy or barriers to uptake. Further research into specific principles is required to improve ERAS implementation.AimThe Enhanced Recovery After Surgery (ERAS®) Society guidelines aim to standardize perioperative care in colorectal surgery via 25 principles. We aimed to assess the variation in uptake of these principles across an international network of colorectal units.MethodAn online survey was circulated amongst European Society of Coloproctology members in 2019–2020. For each ERAS principle, respondents were asked to score how frequently the principle was implemented in their hospital, from 1 (‘rarely’) to 4 (‘always’). Respondents were also asked to recall whether practice had changed since 2017. Subgroup analyses based on hospital characteristics were conducted.ResultsOf hospitals approached, 58% responded to the survey (195/335), with 296 individual responses (multiple responses were received from some hospitals). The majority were European (163/195, 83.6%). Overall, respondents indicated they ‘most often’ or ‘always’ adhered to most individual ERAS principles (18/25, 72%). Variability in the uptake of principles was reported, with universal uptake of some principles (e.g., prophylactic antibiotics; early mobilization) and inconsistency from ‘rarely’ to ‘always’ in others (e.g., no nasogastric intubation; no preoperative fasting and carbohydrate drinks). In alignment with 2018 ERAS guideline updates, adherence to principles for prehabilitation, managing anaemia and postoperative nutrition appears to have increased since 2017.ConclusionsUptake of ERAS principles varied across hospitals, and not all 25 principles were equally adhered to. Whilst some principles exhibited a high level of acceptance, others had a wide variability in uptake indicative of controversy or barriers to uptake. Further research into specific principles is required to improve ERAS implementation.A