The Journal of the Friends' Historical Society vol. 5 No. 1

1. Notices. 2. Notes and Queries. 3. The Westmorland and Swaledale Seekers in 1651. 4. Extracts from the Minute Book of the Sufferings of Friends in Mansfield. 5. Reminiscences of the Friends' Meeting, Manchester. 6. Women Ministers stopped by Highwaymen. 7. Presentations of Quakers in Episcopal Visitations, 1662-1679. 8. Elisha Bates. 9. Keye-Worsley Marriage Certificate, 1666. 10. Thomas Areskine, Brewer, of Edinburgh. 11. Meeting Records. 12. A Glimpse of Ancient Friends in Dorset I. 13. Distribution of Literature in Cornwall, 1734. 14. William White, M.D. F.R.S. of York. 15. Friends in Barbadoes. 16. Some Quaker Teachers in 1736. 17. Friends in Current Literature. 18. Editors' Note. 19. Anecdote of Obed Cook, Schoolmaster. 20. Early Quaker Booksellers of York

Die transnationale Ordnung globalisierter Finanzmärkte. Was lehrt uns die Krise?

Die Krise der Finanzmärkte, die 2007 begann, hat die meisten Politiker und Wissenschaftler überrascht. In der Soziologie haben, wie in der Wirtschaftswissenschaft, vor 2007 nur Wenige das Krisenpotenzial erkannt, das in der Beschaffenheit des modernen Finanzsystems liegt. Unter dem dominanten Einfluss der liberalen Neoklassik in der ökonomischen Theorie wurde weithin geglaubt, dass Märkte im Allgemeinen und damit auch Finanzmärkte sich selbst regeln. Die Finanzkrise und ihre Folgen haben hier zu einem Umdenken geführt. Inzwischen besteht unter Wissenschaftlern und Politikern ein breiter Konsens, dass Defizite der Regulierung für die krisenhafte Entwicklung im globalen Finanzsystem mit verantwortlich waren. Da die Finanzmärkte globalisiert sind und die Krise als eine globale wahrgenommen wurde, wurde allgemein eine Neuregelung durch Vereinbarungen auf internationaler Ebene verlangt, um künftigen Krisen vorzubauen

Institutional Transplant as Political Opportunity: The Practice and Politics of Indian Electricity Regulation

India has a decade-long experience with independent regulatory agencies in public services as an institutional transplant from the industrialized world. Introduced at the behest of international donor agencies, regulators in India are intended, somewhat naively, to provide an apolitical space for decision making to assuage investor concerns over arbitrary administrative actions, and thereby stimulate private investment. In practice, regulators have had to negotiate a terrain over which the state has continued to exercise considerable control. Regulators have also been been shaped in their functioning by national and sub-national political traditions and by administrative and political practices. The result is a hybrid institutional form that combines politics as usual with intriguing new, and unanticipated, opportunities for political intervention. This paper will explore the origins of electricity regulation as a form of institutional isomorphism. It will then compare the regulatory experience in India\u27s electricity sector across two Indian states to understand the implications of transplanting regulatory agencies in the global south. An examination of the process through which regulatory decisions are reached illustrates how existing bureaucratic and technocratic networks, transplanted procedures, and administrative cultures combine to conservatively manage long-standing political tensions around electricity. In seeking to manage those tensions, regulators often take decisions - on tariff setting, for example - based on a political reading that belies the technocratic narrative on which institutional credibility rests. At the same time, civil society groups ranging from residential associations to professional associations to individuals are using newly created regulatory spaces to structure a more deliberative decision process

Heading for 20 Years of Quasi-Global Precipitation with the New Version 06 IMERG

The U.S. Global Precipitation Measurement mission (GPM) science team is developing a long-term dataset based on intercalibrated estimates from the international constellation of precipitation-relevant satellites and other data. The Integrated Multi-satellitE Retrievals for GPM (IMERG) merged precipitation product (IMERG) is computed at the half hour, 0.1 x 0.1 resolution globally in three "Runs"Early, Late, and Final (4 hours, 14 hours, and 3.5 months after observation time, respectively). GPM is well into computing the new Version 06, which will be the first time IMERG covers the last two decades and routinely provides morphed estimates in polar regions where the surface is snow- and ice-free.A few salient features of the IMERG algorithm will be summarized, then representative examples of IMERG products will be shown. This starts with basic results, such as animations of maps, then extends to preliminary analyses of dataset characteristics. For example, the diurnal cycle demonstrates improvements over V05

Status and Examples for the Version 06 IMERG Multi-Satellite Products

After five years of development following the launch of the Global Precipitation Measurement (GPM) missionCore Observatory, the GPM data products are now being extended across the joint Tropical Rainfall MeasuringMission (TRMM) and GPM eras. Version 06 of the U.S. GPM team's Integrated Multi-satellitE Retrievals forGPM (IMERG) merged precipitation product provides a consistent intercalibration for all precipitation productscomputed from individual satellites with the TRMM and GPM Core Observatory sensors as the TRMM- andGPM-era calibrators, respectively, and incorporates monthly surface gauge data. One major change in the basicIMERG algorithm for V06 is that precipitation motion vectors (used to drive the quasi-Lagrangian interpolation,or "morphing") are computed by tracking vertically integrated vapor (TQV) fields analyzed in MERRA2 andGEOS5. This innovation provides globally complete coverage, expanding IMERG's coverage beyond the 60N-Slatitude band previously provided by IR-based vectors, although precipitation over snowy/icy surfaces is stillmasked out as unreliable. A second innovation is that the Quality Index (QI) data field computed for the half-hourlydatasets has been refined to include estimates of correlation at microwave overpass times.We will summarize the processing status for V06 IMERG, for which the retrospective processing shouldbe actively advancing at meeting time. We will show early examples of performance. For example, the TQVmotion vectors are typically slightly better than the IR-based vectors at all latitudes. The transition across theTRMM/GPM data boundary will be discussed, including the necessity of filling in the TRMM-based calibrationsover the latitude band 35-65 in each hemisphere. The notional schedule for the eventual retirement of thepredecessor TRMM Multi-satellite Precipitation Analysis (TMPA) multi-satellite dataset will be updated as well

A Quick Summary of IMERG Versions and Features

This talk will summarize the shifts in IMERG (Integrated Multi-satellitE Retrievals for GPM (Global Precipitation Measurement)) from Version 03 to 04 in early Spring 2016, and to Version 05 in late Summer 2017. For example, Version 04 replaced approximate pre-launch calibrations with GPM Core Observatory-based calibrations, while Version 05 introduced improved estimates for the primary GPM instrument products (DPR, GMI, and Combined Instrument). In Version 04 the IR estimates were routinely calibrated to the passive microwave estimates. As analysis showed that the Combined Instrument estimates (the IMERG calibration standard) tend to be biased high over land and low over ocean at higher latitudes, in Version 04 we climatologically calibrated IMERG to the Global Precipitation Climatology Project (GPCP) monthly Satellite-Gauge product, except in low- and mid-latitude ocean regions. This calibration leaves the relative time series intact, and only adjusts the mean of the entire series. In Version 05 the primary GPM instrument products have reduced biases, but calibration to GPCP continues to be necessary to achieve the most realistic estimates. Finally, retrospective processing back into the TRMM (Tropical Rainfall Measuring Mission) era is expected in early 2018, after which the legacy TMPA (TRMM Multi-satellite Precipitation Analysis) dataset will be retired

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality with 3009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top 'hits' was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin-mutant cells, and that Wnt-responsive gene expression is highly sensitized in STAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunits stag2b and rad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin-mutant cancers.Health Research Council of New Zealand (15/229) Julia A Horsfield Health Research Council of New Zealand (19/415) Ross D Hannan Julia A Horsfield Associazione Italiana per la Ricerca sul Cancro (IG23284) Antonio Musio The Maurice Wilkins centre for Molecular Biodiscovery (3705733) Jisha Antony Julia A Horsfiel

The twilight of the Liberal Social Contract? On the Reception of Rawlsian Political Liberalism

This chapter discusses the Rawlsian project of public reason, or public justification-based 'political' liberalism, and its reception. After a brief philosophical rather than philological reconstruction of the project, the chapter revolves around a distinction between idealist and realist responses to it. Focusing on political liberalism’s critical reception illuminates an overarching question: was Rawls’s revival of a contractualist approach to liberal legitimacy a fruitful move for liberalism and/or the social contract tradition? The last section contains a largely negative answer to that question. Nonetheless the chapter's conclusion shows that the research programme of political liberalism provided and continues to provide illuminating insights into the limitations of liberal contractualism, especially under conditions of persistent and radical diversity. The programme is, however, less receptive to challenges to do with the relative decline of the power of modern states