Using VO tools to investigate distant radio starbursts hosting obscured AGN in the HDF(N) region

A 10-arcmin field around the HDF(N) contains 92 radio sources >40 uJy, resolved by MERLIN+VLA at 0".2-2".0 resolution. 55 have Chandra X-ray counterparts including 18 with a hard X-ray photon index and high luminosity characteristic of a type-II (obscured) AGN. >70% of the radio sources have been classified as starbursts or AGN using radio morphologies, spectral indices and comparisons with optical appearance and MIR emission. Starbursts outnumber radio AGN 3:1. This study extends the VO methods previously used to identify X-ray-selected obscured type-II AGN to investigate whether very luminous radio and X-ray emission originates from different phenomena in the same galaxy. The high-redshift starbursts have typical sizes of 5--10 kpc and star formation rates of ~1000 Msun/yr. There is no correlation between radio and X-ray luminosities nor spectral indices at z>~1.3. ~70% of both the radio-selected AGN and the starburst samples were detected by Chandra. The X-ray luminosity indicates the presence of an AGN in at least half of the 45 cross-matched radio starbursts, of which 11 are type-II AGN including 7 at z>1.5. This distribution overlaps closely with the X-ray detected radio sources which were also detected by SCUBA. Stacked 1.4-GHz emission at the positions of radio-faint X-ray sources is correlated with X-ray hardness. Most extended radio starbursts at z>1.3 host X-ray selected obscured AGN. Radio emission from most of these ultra-luminous objects is dominated by star formation but it contributes less than 1/3 of their X-ray luminosity. Our results support the inferences from SCUBA and IR data, that at z>1.5, star formation is an order of magnitude more extended and more copious, it is closely linked to AGN activity and it is triggered differently, compared with star formation at lower redshifts.Comment: 24 pages, 12 figures, uses graphicx, rotating, natbib, supertabular packages and aa.cls. Accepted for publication in A&

Proceedings of a Conference on Agricultural Education in Our Public Schools

Vocational Agriculture has played an important role in helping young men become established in farming. Much of our success in more than meeting the food and fiber needs of our rapidly growing population today can b~ attributed to Vocational Agriculture. But, questions are being raised about the need for cominuation of such an extensive program of preparation for farming in view of the reduced number of farming opportunities each year. Furthermore, questions are being raised about the adeqwacy of preparation for farming by a program that is terminal at the high school level, and about the adequacy of preparation for college if a student devotes much of his high school time to Vocational Agriculture.https://lib.dr.iastate.edu/card_reports/1000/thumbnail.jp

A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources.

OBJECTIVE: The Genomic Medicine Working Group of the National Advisory Council for Human Genome Research virtually hosted its 13th genomic medicine meeting titled Developing a Clinical Genomic Informatics Research Agenda . The meeting\u27s goal was to articulate a research strategy to develop Genomics-based Clinical Informatics Tools and Resources (GCIT) to improve the detection, treatment, and reporting of genetic disorders in clinical settings. MATERIALS AND METHODS: Experts from government agencies, the private sector, and academia in genomic medicine and clinical informatics were invited to address the meeting\u27s goals. Invitees were also asked to complete a survey to assess important considerations needed to develop a genomic-based clinical informatics research strategy. RESULTS: Outcomes from the meeting included identifying short-term research needs, such as designing and implementing standards-based interfaces between laboratory information systems and electronic health records, as well as long-term projects, such as identifying and addressing barriers related to the establishment and implementation of genomic data exchange systems that, in turn, the research community could help address. DISCUSSION: Discussions centered on identifying gaps and barriers that impede the use of GCIT in genomic medicine. Emergent themes from the meeting included developing an implementation science framework, defining a value proposition for all stakeholders, fostering engagement with patients and partners to develop applications under patient control, promoting the use of relevant clinical workflows in research, and lowering related barriers to regulatory processes. Another key theme was recognizing pervasive biases in data and information systems, algorithms, access, value, and knowledge repositories and identifying ways to resolve them

The twilight of the Liberal Social Contract? On the Reception of Rawlsian Political Liberalism

This chapter discusses the Rawlsian project of public reason, or public justification-based 'political' liberalism, and its reception. After a brief philosophical rather than philological reconstruction of the project, the chapter revolves around a distinction between idealist and realist responses to it. Focusing on political liberalism’s critical reception illuminates an overarching question: was Rawls’s revival of a contractualist approach to liberal legitimacy a fruitful move for liberalism and/or the social contract tradition? The last section contains a largely negative answer to that question. Nonetheless the chapter's conclusion shows that the research programme of political liberalism provided and continues to provide illuminating insights into the limitations of liberal contractualism, especially under conditions of persistent and radical diversity. The programme is, however, less receptive to challenges to do with the relative decline of the power of modern states

Constitutivism

A brief explanation and overview of constitutivism

Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus

Although disease remission can frequently be achieved for patients with neuroblastoma, relapse is common. The cancer stem cell theory suggests that rare tumorigenic cells, resistant to conventional therapy, are responsible for relapse. If true for neuroblastoma, improved cure rates may only be achieved via identification and therapeutic targeting of the neuroblastoma tumor initiating cell. Based on cues from normal stem cells, evidence for tumor populating progenitor cells has been found in a variety of cancers.Four of eight human neuroblastoma cell lines formed tumorspheres in neural stem cell media, and all contained some cells that expressed neurogenic stem cell markers including CD133, ABCG2, and nestin. Three lines tested could be induced into multi-lineage differentiation. LA-N-5 spheres were further studied and showed a verapamil-sensitive side population, relative resistance to doxorubicin, and CD133+ cells showed increased sphere formation and tumorigenicity. Oncolytic viruses, engineered to be clinically safe by genetic mutation, are emerging as next generation anticancer therapeutics. Because oncolytic viruses circumvent typical drug-resistance mechanisms, they may represent an effective therapy for chemotherapy-resistant tumor initiating cells. A Nestin-targeted oncolytic herpes simplex virus efficiently replicated within and killed neuroblastoma tumor initiating cells preventing their ability to form tumors in athymic nude mice.These results suggest that human neuroblastoma contains tumor initiating cells that may be effectively targeted by an oncolytic virus

Clinical outcomes and response to treatment of patients receiving topical treatments for pyoderma gangrenosum: a prospective cohort study

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. Objective: to estimate the effectiveness of topical therapies in the treatment of PG. Methods: prospective cohort study of UK secondary care patients with a clinical diagnosis of PG suitable for topical treatment (recruited July 2009 to June 2012). Participants received topical therapy following normal clinical practice (mainly Class I-III topical corticosteroids, tacrolimus 0.03% or 0.1%). Primary outcome: speed of healing at 6 weeks. Secondary outcomes: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality-of-life; treatment failure and recurrence. Results: Sixty-six patients (22 to 85 years) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28/66 (43.8%) of ulcers healed by 6 months. Median time-to-healing was 145 days (95% CI: 96 days, ∞). Initial ulcer size was a significant predictor of time-to-healing (hazard ratio 0.94 (0.88;80 1.00); p = 0.043). Four patients (15%) had a recurrence. Limitations: No randomised comparator Conclusion: Topical therapy is potentially an effective first-line treatment for PG that avoids possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone

Philosophy of action

The philosophical study of human action begins with Plato and Aristotle. Their influence in late antiquity and the Middle Ages yielded sophisticated theories of action and motivation, notably in the works of Augustine and Aquinas.1 But the ideas that were dominant in 1945 have their roots in the early modern period, when advances in physics and mathematics reshaped philosophy