176 research outputs found
Photography in the Marketplace
Photography in the Marketplace is not only a matter of industrial advertising photography, or corporate branding, but is a political, material and above all, commercial enterprise that inflects the taking, circulating, collection and recirculation of photographs. The materiality of the markets in which photography takes part, the communications networks in which they circulate, and the circumstances in which they are preserved as history enrich the narratives of ‘industry’ beyond its current confines
Left versus right subcallosal cingulate deep brain stimulation for treatment-resistant depression
Deep brain stimulation (DBS) of the subcallosal cingulate has emerged as a promising therapy for treatment-resistant depression (TRD). To date, all studies have employed bilateral stimulation; however, the physiology of affect and pathophysiology of depression are known to be asymmetric across hemispheres. Unilateral stimulation may provide efficacy while decreasing risk. Five patients were exposed to unilateral open-label DBS to the subcallosal cingulate for 12 weeks each to the left and then right hemispheres in a double-blind, crossover fashion. After 12 weeks of stimulation to each hemisphere, bilateral stimulation was initiated, and patients were followed for 12 additional weeks. Additionally, nine months of long-term follow up data were collected. Left, but not right, unilateral stimulation was associated with significant decrease in depression scores; with bilateral stimulation, all patients improved and one patient remitted. No serious adverse events were associated with surgery or acute or chronic stimulation. This small study suggests that unilateral DBS to the subcallosal cingulate may be an effective treatment for TRD. All patients improved with bilateral stimulation, though antidepressant effects following 12 weeks were modest. These findings contrast somewhat with prior open-label trials, though duration of bilateral stimulation was shorter in this trial. The current study continues to confirm safety of implantation and use of DBS to the subcallosal cingulate for patients with TRD and highlights the importance of personalization of therapy, for example by hemisphere, in future trials
Optimal clinical management of children receiving dietary therapies for epilepsy : Updated recommendations of the International Ketogenic Diet Study Group
Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years
Flash! A Literary and Visual Culture of Performative Technology
Roundtable article
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.In Flash! Photography, Writing, & Surprising Illumination Kate Flint presents a technology history in the fullness of its literary and visual culture as it plays out over more than a century. Her narrative is not about inventions, firsts or the sort of exceptionalism of individual geniuses that often populate the stories of photography or photographically related technology. It is instead about presenting the technological, literary and visual cultures of the flash as mutually productive, inseparable entities
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