An inventory model for multiple items assuming time-varying demands and limited storage

Producción CientíficaA model for inventory systems with multiple products is studied. Demands of items are time-dependent and follow power patterns. Shortages are allowed and fully back logged. For this inventory system, our findings provide the efficient inventory policy that helps decision-makers to obtain the initial inventory levels and the reorder points that maximize the profit per unit time. Moreover, when it is assumed that the warehouse used for the storage of products has a limited capacity, the optimal inventory policy is also developed. The model presented here extends some inventory systems studied by other authors. Numerical examples are introduced to illustrate the applicability of the theoretical results presented.Ministerio de Ciencia, Innovación y Universidades cofinanciado por la Comunidad Europea (FEDER) (project MTM2017-84150-P)Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Optimal price and lot size for an EOQ model with full backordering under power price and time dependent demand

Producción CientíficaIn this paper, we address an inventory system where the demand rate multiplicatively combines the effects of time and selling price. It is assumed that the demand rate is the product of two power functions, one depending on the selling price and the other on the time elapsed since the last inventory replenishment. Shortages are allowed and fully backlogged. The aim is to obtain the lot sizing, the inventory cycle and the unit selling price that maximize the profit per unit time. To achieve this, two efficient algorithms are proposed to obtain the optimal solution to the inventory problem for all possible parameter values of the system. We solve several numerical examples to illustrate the theoretical results and the solution methodology. We also develop a numerical sensitivity analysis of the optimal inventory policy and the maximum profit with respect to the parameters of the demand function.Ministerio de Ciencia, Innovación y Universidades y Fondo Europeo de Desarrollo Regional (FEDER) - (Project MTM2017-84150-P

An inventory system with time-dependent demand and partial backordering under return on inventory investment maximization

Producción CientíficaIn this article, we study an inventory system for items that have a power demand pattern and where shortages are allowed. We suppose that only a fixed proportion of demand during the stock-out period is backordered. The decision variables are the inventory cycle and the ratio between the initial stock and the total quantity demanded throughout the inventory cycle. The objective is to maximize the Return on Inventory Investment (ROII) defined as the ratio of the profit per unit time over the average inventory cost. After analyzing the objective function, the optimal global solutions for all the possible cases of the inventory problem are determined. These optimal policies that maximize the ROII are, in general, different from those that minimize the total inventory cost per unit time. Finally, a numerical sensitivity analysis of the optimal inventory policy with respect to the system input parameters and some useful managerial insights derived from the results are presented.Ministerio de Ciencia, Innovación y Universidades - Fondo Europeo de Desarrollo Regional (project MTM2017-84150-P

Profitability index maximization in an inventory model with a price- and stock-dependent demand rate in a power-form

Producción CientíficaThis paper presents the optimal policy for an inventory model where the demand rate potentially depends on both selling price and stock level. The goal is the maximization of the profitability index, defined as the ratio income/expense. A numerical algorithm is proposed to calculate the optimal selling price. The optimal values for the depletion time, the cycle time, the maximum profitability index, and the lot size are evaluated from the selling price. The solution shows that the inventory must be replenished when the stock is depleted, i.e., the depletion time is always equal to the cycle time. The optimal policy is obtained with a suitable balance between ordering cost and holding cost. A condition that ensures the profitability of the financial investment in the inventory is established from the initial parameters. Profitability thresholds for several parameters, including the scale and the non-centrality parameters, keeping all the others fixed, are evaluated. The model with an isoelastic price-dependent demand is solved as a particular case. In this last model, all the optimal values are given in a closed form, and a sensitivity analysis is performed for several parameters, including the scale parameter. The results are illustrated with numerical examples.Ministerio de Ciencia, Innovación y Universidades y Fondo Europeo de Desarrollo Regional (FEDER) - (project MTM2017-84150-P

Optimal policy for multi-item systems with stochastic demands, backlogged shortages and limited storage capacity

Producción CientíficaIn this paper, an inventory model for multiple products with stochastic demands is developed. The scheduling period or inventory cycle is known and prescribed. Demands are independent random variables and they follow power patterns throughout the inventory cycle. For each product, an aggregate cycle demand is realized first and then the demand is released to the inventory system gradually according to power patterns within a cycle. These demand patterns express different ways of drawing units from inventory and can be a good approach to modelling customer demands in inventory systems. Shortages are allowed and they are fully backlogged. It is assumed that the warehouse where the items are stored has a limited capacity. For this inventory system, we determine the inventory policy that maximizes the expected profit per unit time. An efficient algorithmic approach is proposed to calculate the optimal inventory levels at the beginning of the inventory cycle and to obtain the maximum expected profit per unit time. This inventory model is applicable to on-line sales of a wide variety of products. In this type of sales, customers do not receive the products at the time of purchase, but sellers deliver goods a few days later. Also, this model can be used to represent inventories of products for in-shop sales when the withdrawal of items from the inventory is not at the purchasing time, but occurs in a period after the sale of the products. This inventory model extends various inventory systems studied by other authors. Numerical examples are introduced to illustrate the theoretical results presented in this work.Ministerio de Ciencia, Innovación y Universidades - Fondo Europeo de Desarrollo Regional (project MTM2017-84150-P

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings

Profitability ratio maximization in an inventory model with stock-dependent demand rate and non-linear holding cost

Producción CientíficaThis paper studies a deterministic inventory model with a stock-dependent demand pattern where the cumulative holding cost is a non-linear function of both time and stock level. When the monetary resources are limited and the inventory manager can invest his/her money in buying different products, it seems reasonable to select the ones that provide a higher profitability. Thus, a new approach with the aim of maximizing the profitability ratio (defined as the profit/cost quotient) is considered in this paper. We prove that the profitability ratio maximization is equivalent to minimizing the inventory cost per unit of an item. The optimal policy is obtained in a closed form, whose general expression is a generalization of the classical EOQ formula for inventory models with a stock-dependent demand rate and a non-linear holding cost. This optimal solution is different from the other policies proposed for the problems of minimum cost or maximum profit per unit time. A complete sensitivity analysis of the optimal solution with respect to all the parameters of the model is developed. Finally, numerical examples are solved to illustrate the theoretical results and the solution methodology.This work is partially supported by the Spanish Ministry of Economy and Competitiveness through the research projects MTM2017-84150-P and AGL2014-51964-C2-1-R

An inventory system with demand dependent on both time and price assuming backlogged shortages

Producción CientíficaIn this work we analyze an inventory model for items whose demand is a bivariate function of price and time. It is supposed that the demand rate multiplicatively combines the effects of a time-power function and a price-logit function. The aim is to maximize the profit per time unit, assuming that the inventory cost per time unit is the sum of the holding, shortage, ordering and purchasing costs. An algorithm is developed to find the optimal price, the optimal lot size and the optimal replenishment cycle. Several numerical examples are introduced to illustrate the solution procedure.This work is partially supported by the Spanish Ministry of Science and Innovation (MCI) and European FEDER funds through the research Project MTM2013-43396-P