DEVELOPMENT OF INTERACTIVE MULTIMEDIA-BASED GYMNASTICS FLOOR TECHNIQUES LEARNING MODEL FOR JUNIOR HIGH SCHOOL STUDENTS

Abstract Based on preliminary observations conducted on teachers and students of SMP Negeri in Malang Regency: (1) students can not and do not like the material gymnastics floor, and tend to like the material of big ball game (92%); (2) students state that educators have never done teaching with media in the form of interactive multimedia, 100%; and (3) students agree when done an development of interactive multimedia media for learning basic technique of gymnastic floor 100%. The purpose of this research and development is to develop an effective model of basic techniques of floor gymnastics for junior high school students using interactive multimedia. In this study is using development research methods from Borg and Gall (1983: 775), and researchers did not use the whole but only using 7 steps. The 7 steps chosen by the researchers are as follows: (1) collecting information, (2) initial product design, (3) expert evaluation, (4) trial in phase I , (5) product revision (6) trials in phase II, (7) revisions and final products. Based on the result of data analysis of the evaluation of the learning expert is very valid, the evaluation of expert gymnastics is very valid, the evaluation of media expert is very valid. From the data analysis result of small group trial is valid enough (73,1% ), while large group trial is very valid (85,75%), thus it can be concluded that the development of interactive multimedia-based floor gymnastic basic technique for junior high school student can be used. Keywords: development, learning, gymnastics floor, interactive multimedi

DEVELOPMENT OF INTERACTIVE MULTIMEDIA-BASED GYMNASTICS FLOOR TECHNIQUES LEARNING MODEL FOR JUNIOR HIGH SCHOOL STUDENTS

Based on preliminary observations conducted on teachers and students of SMP Negeri in Malang Regency: (1) students can not and do not like the material gymnastics floor, and tend to like the material of big ball game (92%); (2) students state that educators have never done teaching with media in the form of interactive multimedia, 100%; and (3) students agree when done an development of interactive multimedia media for learning basic technique of gymnastic floor 100%. The purpose of this research and development is to develop an effective model of basic techniques of floor gymnastics for junior high school students using interactive multimedia. In this study is using development research methods from Borg and Gall (1983: 775), and researchers did not use the whole but only using 7 steps. The 7 steps chosen by the researchers are as follows: (1) collecting information, (2) initial product design, (3) expert evaluation, (4) trial in phase I , (5) product revision (6) trials in phase II, (7) revisions and final products. Based on the result of data analysis of the evaluation of the learning expert is very valid, the evaluation of expert gymnastics is very valid, the evaluation of media expert is very valid. From the data analysis result of small group trial is valid enough (73,1% ), while large group trial is very valid (85,75%), thus it can be concluded that the development of interactive multimedia-based floor gymnastic basic technique for junior high school student can be used.. Keywords: Development, learning, gymnastics floor, interactive multimedi

Perancangan 2D Game Design Animasi di Studio Re-Anoman

Penulis mendapatkan kesempatan menjalani program kerja magang di Studio Re- Anoman dengan jobdesk sebagai UI/UX designer dan animator selama 3 bulan dari 9 April sampai 29 Juni 2018. Selama menjalankan program magang di divisi tersebut, penulis mendapatkan tiga projek game baru yang perlu diselesaikan untuk acara pameran di Bekraf 2018 dan kompetisi yang diselenggarakan di Universitas Indonesia. Game ini dibuat oleh rekan magang lainnya dengan bantuan supervisor. Dari proses pengerjaan tugas-tugas yang diberikan, penulis mampu mengerjakan tugas yang diberikan oleh supervisor dan mendapat pengalaman dan wawasan baru mengenai dunia kerja game digital. Penulis juga mendapat keuntungan yaitu memperluas perkenalan dengan komunitas game developer

Development Model Training Shooting based on Multiple Unit Offense for Basketball Athletes 16-18 Years of Age Groups

The goal of this research and development is to produce and develop the effectiveness of the model of drills shooting basketball for basketball athletes 16-18 years age group. This research and development uses qualitative and quantitative approaches and uses development research methods Research and Development (R & D)that adopt the theory of Borg W. R and Gall. M. D which uses 10 stages of development. The steps in this development research start from the following: (1) Research and information collecting, (2) Planning, (3) Develop preliminary form of product, (4) Preliminary field testing, (5) Main product revision, (6) ) Main field testing, (7) Operational product revision, (8) Operational field testing, (9) Final product revision, (10) Dissemination and implementation. This development research resulted in practice model products shooting with practice manuals shooting and practice videos shooting. The results of processing normality test data with Kolmogorov-Smirnov and Shapiro-Wilk obtained the Sig or the p-value of all data for Kolmogorov-Smirnov> 0.05, H0 is accepted or not significant, means the population data is distributed normally. In addition, the results of the t-test value of the post-test experimental group and the control post-test, with the mean (mean) test results of technique shooting the basketball given the based training model multiple unit offense (experimental group) of 103.27 and The standard deviation is 12.556, which means that descriptively the ability of the technique shooting given the based training model multiple unit offense is higher and more developed than the based training model multiple unit offense. In addition, the average N-Gain Score for the experimental class is 158.71%, this value is included in the "effective" category, with a minimum value of 20.69% and a maximum value of 750.00%. While the average N-Gain Score for the control class is 38.76%, this value is included in the "ineffective" category, with a minimum value of 5.00% and a maximum value of 200.00%. Thus it can be concluded that the use of techniques for shooting basketball athletes in the 16-18 year age group based on multiple unit offense is effective in improving the skills of techniques shooting

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo

Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently been subject to in-depth proteomic analysis. Surprisingly, the most abundant secreted protein of adult Brugia malayi is triose phosphate isomerase (TPI), a glycolytic enzyme usually associated with the cytosol. We now show that while TPI is a prominent target of the antibody response to infection, there is little antibody-mediated inhibition of catalytic activity by polyclonal sera. We generated a panel of twenty-three anti-TPI monoclonal antibodies and found only two were able to block TPI enzymatic activity. Immunisation of jirds with B. malayi TPI, or mice with the homologous protein from the rodent filaria Litomosoides sigmodontis, failed to induce neutralising antibodies or protective immunity. In contrast, passive transfer of neutralising monoclonal antibody to mice prior to implantation with adult B. malayi resulted in 60–70% reductions in microfilarial levels in vivo and both oocyte and microfilarial production by individual adult females. The loss of fecundity was accompanied by reduced IFNγ expression by CD4+ T cells and a higher proportion of macrophages at the site of infection. Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections

Mapping recent shoreline changes spanning the lateral collapse of Anak Krakatau Volcano, Indonesia

We use satellite imagery to investigate the shoreline changes associated with volcanic activity in 2018–2019 at Anak Krakatau, Indonesia, spanning a major lateral collapse and period of regrowth through explosive activity. The shoreline changes have been analyzed and validated through the adaptation of an existing methodology based on Sentinel-2 multispectral imagery and developed on Google Earth Engine. This work tests the results of this method in a highly dynamic volcanic environment and validates them with manually digitized shorelines. The analysis shows that the size of the Anak Krakatau Island increased from 2.84 km2 to 3.19 km2 during 15 May 2018–1 November 2019 despite the loss of area in the 22 December 2018 lateral collapse. The lateral collapse reduced the island area to ~1.5 km2 but this was followed by a rapid increase in area in the first two months of 2019, reaching up to 3.27 km2. This was followed by a period of little change as volcanic activity declined and then by a net decrease from May 2019 to 1 November 2019 that resulted from erosion on the SW side of the island. This history of post-collapse eruptive regrowth and coastal erosion derived from the shoreline changes illuminates the potential for satellite-based automated shoreline mapping to provide databases for monitoring remote island volcanoes

Downward-propagating eruption following vent unloading implies no direct magmatic trigger for the 2018 lateral collapse of Anak Krakatau

The lateral collapse of Anak Krakatau volcano, Indonesia, in December 2018 highlighted the potentially devastating impacts of volcanic edifice instability. Nonetheless, the trigger for the Anak Krakatau collapse remains obscure. The volcano had been erupting for the previous six months, and although failure was followed by intense explosive activity, it is the period immediately prior to collapse that is potentially key in providing identifiable, pre-collapse warning signals. Here, we integrate physical, microtextural and geochemical characterisation of tephra deposits spanning the collapse period. We demonstrate that the first post-collapse eruptive phase (erupting juvenile clasts with a low microlite areal number density and relatively large microlites, reflecting a crystal-growth dominated regime) is best explained by instantaneous unloading of a relatively stagnant upper conduit. This was followed by the second post-collapse phase, on a timescale of hours, which tapped successively hotter and deeper magma batches, reflected in increasing plagioclase anorthite content and more mafic glass compositions, alongside higher calculated ascent velocities and decompression rates. The characteristics of the post-collapse products imply downward propagating destabilisation of the magma storage system as a response to collapse, rather than pre-collapse magma ascent triggering failure. Importantly, this suggests that the collapse was a consequence of longer-term processes linked to edifice growth and instability, and that no indicative changes in the magmatic system could have signalled the potential for incipient failure. Therefore, monitoring efforts may need to focus on integrating short- and long-term edifice growth and deformation patterns to identify increased susceptibility to lateral collapse. The post-collapse eruptive pattern also suggests a magma pressurisation regime that is highly sensitive to surface-driven perturbations, which led to elevated magma fluxes after the collapse and rapid edifice regrowth. Not only does rapid regrowth potentially obscure evidence of past collapses, but it also emphasises the finely balanced relationship between edifice loading and crustal magma storage

Interaction forces and membrane charge tunability: Oleic acid containing membranes in different pH conditions

Oleic acid is known to interact with saturated lipid molecules and increase the fluidity of gel phase lipid membranes. In this work, the thermodynamic properties of mixed monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and oleic acid at the air-water interface were determined using Langmuir isotherms. The isotherm study revealed an attractive interaction between oleic acid and DPPC. The incorporation of oleic acid also monotonically decreased the elastic modulus of the monolayer indicative of higher fluidity with increasing oleic acid content. Using the surface force apparatus, intermembrane force-distance profiles were obtained for substrate supported DPPC membranes containing 30mol% oleic acid at pH5.8 and 7.4. Three different preparation conditions resulted in distinct force profiles. Membranes prepared in pH5.8 subphase had a low number of nanoscopic defects ≤1% and an adhesion magnitude of ~0.6mN/m. A slightly higher defect density of 1-4% was found for membranes prepared in a physiological pH7.4 subphase. The presence of the exposed hydrophobic moieties resulted in a higher adhesion magnitude of 2.9mN/m. Importantly, at pH7.4, some oleic acid deprotonates resulting in a long-range electrostatic repulsion. Even though oleic acid increased the DPPC bilayer fluidity and the number of defects, no membrane restructuring was observed indicating that the system maintained a stable configuration

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial

Background Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI. Methods This randomised, placebo-controlled trial was done in 175 hospitals in 29 countries. Adults with TBI who were within 3 h of injury, had a Glasgow Coma Scale (GCS) score of 12 or lower or any intracranial bleeding on CT scan, and no major extracranial bleeding were eligible. The time window for eligibility was originally 8 h but in 2016 the protocol was changed to limit recruitment to patients within 3 h of injury. This change was made blind to the trial data, in response to external evidence suggesting that delayed treatment is unlikely to be effective. We randomly assigned (1:1) patients to receive tranexamic acid (loading dose 1 g over 10 min then infusion of 1 g over 8 h) or matching placebo. Patients were assigned by selecting a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was head injury-related death in hospital within 28 days of injury in patients treated within 3 h of injury. We prespecified a sensitivity analysis that excluded patients with a GCS score of 3 and those with bilateral unreactive pupils at baseline. All analyses were done by intention to treat. This trial was registered with ISRCTN (ISRCTN15088122), ClinicalTrials.gov (NCT01402882), EudraCT (2011-003669-14), and the Pan African Clinical Trial Registry (PACTR20121000441277). Results Between July 20, 2012, and Jan 31, 2019, we randomly allocated 12 737 patients with TBI to receive tranexamic acid (6406 [50·3%] or placebo [6331 [49·7%], of whom 9202 (72·2%) patients were treated within 3 h of injury. Among patients treated within 3 h of injury, the risk of head injury-related death was 18·5% in the tranexamic acid group versus 19·8% in the placebo group (855 vs 892 events; risk ratio [RR] 0·94 [95% CI 0·86-1·02]). In the prespecified sensitivity analysis that excluded patients with a GCS score of 3 or bilateral unreactive pupils at baseline, the risk of head injury-related death was 12·5% in the tranexamic acid group versus 14·0% in the placebo group (485 vs 525 events; RR 0·89 [95% CI 0·80-1·00]). The risk of head injury-related death reduced with tranexamic acid in patients with mild-to-moderate head injury (RR 0·78 [95% CI 0·64-0·95]) but not in patients with severe head injury (0·99 [95% CI 0·91-1·07]; p value for heterogeneity 0·030). Early treatment was more effective than was later treatment in patients with mild and moderate head injury (p=0·005) but time to treatment had no obvious effect in patients with severe head injury (p=0·73). The risk of vascular occlusive events was similar in the tranexamic acid and placebo groups (RR 0·98 (0·74-1·28). The risk of seizures was also similar between groups (1·09 [95% CI 0·90-1·33]). Interpretation Our results show that tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death. Patients should be treated as soon as possible after injury. Funding National Institute for Health Research Health Technology Assessment, JP Moulton Charitable Trust, Department of Health and Social Care, Department for International Development, Global Challenges Research Fund, Medical Research Council, and Wellcome Trust (Joint Global Health Trials scheme)

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe