Arsenic Exposure and Motor Function among Children in Bangladesh

Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

The pragmatic-semiotic construction of male identities in contemporary advertising of male grooming products

[EN] This article aims to unveil how male identities are constructed in a corpus of male toiletry TV ads through a pragmatic and multimodal analysis of a set of implicit assumptions conveyed about the male participants in the ads. The validity of these assumptions is first empirically tested with a group of 10 male informants and then those implied meanings are bundled into thematic cores for their qualitative and quantitative description. Findings reveal that these ads still rely on stereotypical constructs and traditional discourses of what it takes to be a man. For example, men are invited to consume grooming products but reminded to do it the men's way. Men are also reminded of their sexual power to seduce and attract women with the aid of the product. Likewise, by portraying male ad personae in traditional manly activities while emphasizing their toughness and body strength, or their resourcefulness when faced with challenging situations, the ads portray a rather skewed view of contemporary men, which fails to take into account the myriad roles a modern man can play in contemporary societies.I am really grateful to the reviewers for their insightful comments and also to the editor of the journal.Saz Rubio, MMD. (2019). The pragmatic-semiotic construction of male identities in contemporary advertising of male grooming products. Discourse & Communication. 13(2):192-227. https://doi.org/10.1177/1750481318817621S192227132Alexander, S. M. (2003). Stylish Hard Bodies: Branded Masculinity in Men’s Health Magazine. Sociological Perspectives, 46(4), 535-554. doi:10.1525/sop.2003.46.4.535Attwood, F. (2005). ‘Tits and ass and porn and fighting’. International Journal of Cultural Studies, 8(1), 83-100. doi:10.1177/1367877905050165Rubio, M. D. S. (2018). A multimodal approach to the analysis of gender stereotypes in contemporary British TV commercials: «women and men at work». Poznan Studies in Contemporary Linguistics, 54(2), 185-221. doi:10.1515/psicl-2018-0008Del Saz-Rubio, M. M. (2018). Female identities in TV toiletries ads: A pragmatic and multimodal analysis of implied meanings. Journal of Pragmatics, 136, 54-78. doi:10.1016/j.pragma.2018.07.009Barthel, D. (s. f.). When Men put on Appearances: Advertising and the Social Construction of Masculinity. Men, Masculinity, and the Media, 138-153. doi:10.4135/9781483326023.n10Benwell, B. (2003). Introduction: Masculinity and men’s Lifestyle Magazines. The Sociological Review, 51(1_suppl), 6-29. doi:10.1111/j.1467-954x.2003.tb03600.xBrandth, B. (1995). Rural masculinity in transition: Gender images in tractor advertisements. Journal of Rural Studies, 11(2), 123-133. doi:10.1016/0743-0167(95)00007-aBrandth, B., & Haugen, M. S. (2000). From lumberjack to business manager: masculinity in the Norwegian forestry press. Journal of Rural Studies, 16(3), 343-355. doi:10.1016/s0743-0167(00)00002-4Caldas-Coulthard, C. R., & van Leeuwen, T. (2002). 4. Stunning, shimmering, iridescent. Discourse Approaches to Politics, Society and Culture, 91-108. doi:10.1075/dapsac.2.05calCarrigan, T., Connell, B., & Lee, J. (1985). Toward a new sociology of masculinity. Theory and Society, 14(5), 551-604. doi:10.1007/bf00160017Connell, R. W., & Messerschmidt, J. W. (2005). Hegemonic Masculinity. Gender & Society, 19(6), 829-859. doi:10.1177/0891243205278639Craig, S. (s. f.). Considering Men and the Media. Men, Masculinity, and the Media, 2-7. doi:10.4135/9781483326023.n1An, D., & Kim, S. (2007). Relating Hofstede’s masculinity dimension to gender role portrayals in advertising. International Marketing Review, 24(2), 181-207. doi:10.1108/02651330710741811Dick, A., Chakravarti, D., & Biehal, G. (1990). Memory-Based Inferences during Consumer Choice. Journal of Consumer Research, 17(1), 82. doi:10.1086/208539Feasey, R. (2009). Spray more, get more: masculinity, television advertising and the Lynx effect. Journal of Gender Studies, 18(4), 357-368. doi:10.1080/09589230903260027Featherstone, M. (s. f.). The Body in Consumer Culture. The Body: Social Process and Cultural Theory, 170-196. doi:10.4135/9781446280546.n6Firat, A. F., & Venkatesh, A. (1993). Postmodernity: The age of marketing. International Journal of Research in Marketing, 10(3), 227-249. doi:10.1016/0167-8116(93)90009-nFollo, G. (2002). A hero’s journey: young women among males in forestry education. Journal of Rural Studies, 18(3), 293-306. doi:10.1016/s0743-0167(02)00006-2Franzoi, S. L. (1995). The body-as-object versus the body-as-process: Gender differences and gender considerations. Sex Roles, 33(5-6), 417-437. doi:10.1007/bf01954577Gill, R. (2003). Power and the Production of Subjects: A Genealogy of the New Man and the New Lad. The Sociological Review, 51(1_suppl), 34-56. doi:10.1111/j.1467-954x.2003.tb03602.xGill, R., Henwood, K., & McLean, C. (2005). Body Projects and the Regulation of Normative Masculinity. Body & Society, 11(1), 37-62. doi:10.1177/1357034x05049849Grisot, C. (2017). A quantitative approach to conceptual, procedural and pragmatic meaning: Evidence from inter-annotator agreement. Journal of Pragmatics, 117, 245-263. doi:10.1016/j.pragma.2017.06.020Hakala U (2003) Quantitative and qualitative methods of analysing advertising: Content analysis and semiotics. Series Discussion and Working Papers 5. Turku: Turku School of Economics and Business Administration, p. 51.Hall, M., Gough, B., & Seymour-Smith, S. (2012). «I’m METRO, NOT Gay!»: A Discursive Analysis of Men’s Accounts of Makeup Use on YouTube. The Journal of Men’s Studies, 20(3), 209-226. doi:10.3149/jms.2003.209Halliwell, E., & Dittmar, H. (2003). A Qualitative Investigation of Women’s and Men’s Body Image Concerns and Their Attitudes Toward Aging. Sex Roles, 49(11/12), 675-684. doi:10.1023/b:sers.0000003137.71080.97Hanke, R. (1998). Theorizing Masculinity With/In the Media. Communication Theory, 8(2), 183-201. doi:10.1111/j.1468-2885.1998.tb00217.xHarrison, C. (2008). Real men do wear mascara: advertising discourse and masculine identity. Critical Discourse Studies, 5(1), 55-74. doi:10.1080/17405900701768638Holt, D. B., & Thompson, C. J. (2004). Man-of-Action Heroes: The Pursuit of Heroic Masculinity in Everyday Consumption: Figure 1. Journal of Consumer Research, 31(2), 425-440. doi:10.1086/422120Jackson, P. (1994). Black male: Advertising and the cultural politics of masculinity. Gender, Place & Culture, 1(1), 49-59. doi:10.1080/09663699408721200Kacen, J. J. (2000). Girrrl power and boyyy nature: the past, present, and paradisal future of consumer gender identity. Marketing Intelligence & Planning, 18(6/7), 345-355. doi:10.1108/02634500010348932Kervin, D. (1990). Advertising Masculinity: The Representation of Males in Esquire Advertisements. Journal of Communication Inquiry, 14(1), 51-70. doi:10.1177/019685999001400106Kress, G. (2006). Reading Images. doi:10.4324/9780203619728Lee, D. H., & Olshavsky, R. W. (1995). Conditions and Consequences of Spontaneous Inference Generation: A Concurrent Protocol Approach. Organizational Behavior and Human Decision Processes, 61(2), 177-189. doi:10.1006/obhd.1995.1014Levinson, S. C. (2000). Presumptive Meanings. doi:10.7551/mitpress/5526.001.0001Luyt, R. (2012). Constructing hegemonic masculinities in South Africa: The discourse and rhetoric of heteronormativity. Gender and Language, 6(1). doi:10.1558/genl.v6i1.47McNeill, L. S., & Douglas, K. (2011). Retailing masculinity: Gender expectations and social image of male grooming products in New Zealand. Journal of Retailing and Consumer Services, 18(5), 448-454. doi:10.1016/j.jretconser.2011.06.009McNeill, L. S., & Firman, J. L. (2014). Ideal body image: A male perspective on self. Australasian Marketing Journal (AMJ), 22(2), 136-143. doi:10.1016/j.ausmj.2014.04.001Moeschler, J. (s. f.). 15. Conversational and conventional implicatures. Cognitive Pragmatics. doi:10.1515/9783110214215.405Morrison, T. G., Morrison, M. A., & Hopkins, C. (2003). Striving for bodily perfection? An exploration of the drive for muscularity in Canadian men. Psychology of Men & Masculinity, 4(2), 111-120. doi:10.1037/1524-9220.4.2.111Nixon, S. (1996). Hard Looks. doi:10.1007/978-1-349-61442-4Olivardia, R., Pope, H. G., Borowiecki, J. J., & Cohane, G. H. (2004). Biceps and Body Image: The Relationship Between Muscularity and Self-Esteem, Depression, and Eating Disorder Symptoms. Psychology of Men & Masculinity, 5(2), 112-120. doi:10.1037/1524-9220.5.2.112Pascoe, C. J. (2003). Multiple Masculinities? American Behavioral Scientist, 46(10), 1423-1438. doi:10.1177/0002764203046010009Patterson, M., & Elliott, R. (2002). Negotiating Masculinities: Advertising and the Inversion of the Male Gaze. Consumption Markets & Culture, 5(3), 231-249. doi:10.1080/10253860290031631Pennock-Speck, B., & del Saz-Rubio, M. M. (2013). A multimodal analysis of facework strategies in a corpus of charity ads on British television. Journal of Pragmatics, 49(1), 38-56. doi:10.1016/j.pragma.2012.12.010Plakoyiannaki, E., & Zotos, Y. (2009). Female role stereotypes in print advertising. European Journal of Marketing, 43(11/12), 1411-1434. doi:10.1108/03090560910989966Pope, H. G., Gruber, A. J., Mangweth, B., Bureau, B., deCol, C., Jouvent, R., & Hudson, J. I. (2000). Body Image Perception Among Men in Three Countries. American Journal of Psychiatry, 157(8), 1297-1301. doi:10.1176/appi.ajp.157.8.1297Renkema, J. (2004). Introduction to Discourse Studies. doi:10.1075/z.124Ringrow, H. (2016). The Language of Cosmetics Advertising. doi:10.1057/978-1-137-55798-8Rohlinger, D. A. (2002). Sex Roles, 46(3/4), 61-74. doi:10.1023/a:1016575909173Rudy, R. M., Popova, L., & Linz, D. G. (2010). The Context of Current Content Analysis of Gender Roles: An Introduction to a Special Issue. Sex Roles, 62(11-12), 705-720. doi:10.1007/s11199-010-9807-1Schroeder, J. E., & Zwick, D. (2004). Mirrors of Masculinity: Representation and Identity in Advertising Images. Consumption Markets & Culture, 7(1), 21-52. doi:10.1080/1025386042000212383Tashakkori, A., & Creswell, J. W. (2007). Editorial: The New Era of Mixed Methods. Journal of Mixed Methods Research, 1(1), 3-7. doi:10.1177/2345678906293042Thompson, C. J., & Hirschman, E. C. (1995). Understanding the Socialized Body: A Poststructuralist Analysis of Consumers’ Self-Conceptions, Body Images, and Self-Care Practices. Journal of Consumer Research, 22(2), 139. doi:10.1086/209441THOMPSON, E. H., & PLECK, J. H. (1986). The Structure of Male Role Norms. American Behavioral Scientist, 29(5), 531-543. doi:10.1177/000276486029005003Van Dijk, T. A. (2001). Discourse, Ideology and Context. Folia Linguistica, 35(1-2). doi:10.1515/flin.2001.35.1-2.11Van Dijk, T. A. (2005). War rhetoric of a little ally. The Soft Power of War, 4(1), 65-91. doi:10.1075/jlp.4.1.04dijVan Dijk, T. A. (2006). Politics, Ideology, and Discourse. Encyclopedia of Language & Linguistics, 728-740. doi:10.1016/b0-08-044854-2/00722-7Van Leeuwen, T. (2008). Discourse and Practice. doi:10.1093/acprof:oso/9780195323306.001.0001Wernick, A. (1991). Promotional Culture. Ideology and Power in the Age of Lenin in Ruins, 260-281. doi:10.1007/978-1-349-22346-6_17Wheaton, B. (2003). Lifestyle Sport Magazines and the Discourses of Sporting Masculinity. The Sociological Review, 51(1_suppl), 193-221. doi:10.1111/j.1467-954x.2003.tb03612.xWodak, R. (2007). Pragmatics and Critical Discourse Analysis. Pragmatics & Cognition, 15(1), 203-225. doi:10.1075/pc.15.1.13wo

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. Analysis of CRISPR/Cas9 loss-of-function gene deletion screens identified PIK3CA and MTOR as targetable molecular dependencies across patient derived models of DIPG, highlighting the therapeutic potential of the blood-brain barrier–penetrant PI3K/Akt/mTOR inhibitor, paxalisib. At the human-equivalent maximum tolerated dose, mice treated with paxalisib experienced systemic glucose feedback and increased insulin levels commensurate with patients using PI3K inhibitors. To exploit genetic dependence and overcome resistance while maintaining compliance and therapeutic benefit, we combined paxalisib with the antihyperglycemic drug metformin. Metformin restored glucose homeostasis and decreased phosphorylation of the insulin receptor in vivo, a common mechanism of PI3K-inhibitor resistance, extending survival of orthotopic models. DIPG models treated with paxalisib increased calcium-activated PKC signaling. The brain penetrant PKC inhibitor enzastaurin, in combination with paxalisib, synergistically extended the survival of multiple orthotopic patient-derived and immunocompetent syngeneic allograft models; benefits potentiated in combination with metformin and standard-of-care radiotherapy. Therapeutic adaptation was assessed using spatial transcriptomics and ATAC-Seq, identifying changes in myelination and tumor immune microenvironment crosstalk. Collectively, this study has identified what we believe to be a clinically relevant DIPG therapeutic combinational strategy

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI

Genome-wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small individual magnitude. Modelling polygenic risk scores may be a powerful way of identifying disrupted brain regions whose genetic architecture is related to that of BD. We determined the extent to which common genetic variation underlying risk to BD affected neural activation during an executive processing/language task in individuals at familial risk of BD and healthy controls. Polygenic risk scores were calculated for each individual based on GWAS data from the Psychiatric GWAS Consortium Bipolar Disorder Working Group (PGC-BD) of over 16 000 subjects. The familial group had a significantly higher polygene score than the control group (P=0.04). There were no significant group by polygene interaction effects in terms of association with brain activation. However, we did find that an increasing polygenic risk allele load for BD was associated with increased activation in limbic regions previously implicated in BD, including the anterior cingulate cortex and amygdala, across both groups. The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD

TNF-α is involved in activating DNA fragmentation in skeletal muscle

Intraperitoneal administration of 100 μg kg−1 (body weight) of tumour necrosis factor-α to rats for 8 consecutive days resulted in a significant decrease in protein content, which was concomitant with a reduction in DNA content. Interestingly, the protein/DNA ratio was unchanged in the skeletal muscle of the tumour necrosis factor-α-treated animals as compared with the non-treated controls. Analysis of muscle DNA fragmentation clearly showed enhanced laddering in the skeletal muscle of tumour necrosis factor-α-treated animals, suggesting an apoptotic phenomenon. In a different set of experiments, mice bearing a cachexia-inducing tumour (the Lewis lung carcinoma) showed an increase in muscle DNA fragmentation (9.8-fold) as compared with their non-tumour-bearing control counterparts as previously described. When gene-deficient mice for tumour necrosis factor-α receptor protein I were inoculated with Lewis lung carcinoma, they were also affected by DNA fragmentation; however the increase was only 2.1-fold. These results suggest that tumour necrosis factor-α partly mediates DNA fragmentation during experimental cancer-associated cachexia

The Restriction of Zoonotic PERV Transmission by Human APOBEC3G

The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation. Here, long-term co-culture experiments were used to show that porcine endogenous retrovirus (PERV) transmission from pig to human cells is reduced to nearly undetectable levels by expressing human APOBEC3G in virus-producing pig kidney cells. Inhibition occurred by a deamination-independent mechanism, likely after particle production but before the virus could immortalize by integration into human genomic DNA. PERV inhibition did not require the DNA cytosine deaminase activity of APOBEC3G and, correspondingly, APOBEC3G-attributable hypermutations were not detected. In contrast, over-expression of the sole endogenous APOBEC3 protein of pigs failed to interfere significantly with PERV transmission. Together, these data constitute the first proof-of-principle demonstration that APOBEC3 proteins can be used to fortify the innate anti-viral defenses of cells to prevent the zoonotic transmission of an endogenous retrovirus. These studies suggest that human APOBEC3G-transgenic pigs will provide safer, PERV-less xenotransplantation resources and that analogous cross-species APOBEC3-dependent restriction strategies may be useful for thwarting other endogenous as well as exogenous retrovirus infections

The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio