Use of an Online Crowdfunding Platform for Unmet Financial Obligations in Cancer Care.

This cross-sectional study identified characteristics of patients using an online crowdfunding platform for unmet financial obligations associated with cancer care

Use of GoFundMe® to crowdfund complementary and alternative medicine treatments for cancer.

PurposeComplementary and alternative medicine (CAM) use is common amongst cancer patients. However, there is growing concern about its safety and efficacy. Online crowdfunding campaigns represent a unique avenue to understand the cancer patient's perspective for using CAM or declining conventional cancer therapy (CCT).MethodsFive hundred GoFundMe campaigns from 2012 to 2019 detailing financial need for cancer treatment were randomly selected and reviewed for endorsement of CAM use, reasons for using CAM, and reasons for declining CCT. Descriptive statistics were used to compare patient and campaign characteristics between 250 CAM users and 250 non-CAM users.ResultsCompared to non-CAM users, CAM users were more likely to be female (70% vs. 54%, p < 0.01), to report more stage IV cancer (54% vs. 12%, p < 0.01), and to have a history of delayed, missed, or misdiagnosis (10% vs. 4%, p < 0.01). Reasons for using CAM include endorsing curative/therapeutic effects 212 (85%), pain/stress reduction 137 (55%), and dissatisfaction with current or past medical treatment options 105 (42%). 87 (35%) CAM users that declined CCT reported that they wanted to try to fight off cancer using CAM first 57 (61%), that CCT was too "toxic" to the body 39 (42%), and cancer was already too advanced, so that CCT would be futile or too aggressive 25 (27%).ConclusionCancer patients on GoFundMe using CAM highly value quality of life, comfort, and autonomy. Physicians should educate themselves on CAM to set realistic expectations and provide comprehensive counseling of the risks and benefits of CAM usage to patients who choose to use CAM to either augment or completely replace CCT

Can Amazon.com reviews help to assess the wider impacts of books?

University of Wolverhampto

What matters most? Stakeholders’ perceptions of river water quality

The need to integrate stakeholders’ views into environmental policy is increasingly gaining attention because this offers the opportunity to design sustainable and synergistic environmental strategies. Understanding and integrating the views of resource users into policy design and implementation could help address the most important challenges, gain community support, enhance project ownership, and avoid policies being rejected by local people. As a result, research in environmental management has focussed on stakeholders’ perceptions of river water quality and how to integrate such views into policy. While existing studies offer insights into the different ways in which stakeholders evaluate river water quality and potential factors influencing judgements, they appear to be limited in a number of ways. First, most of these studies focus on developed countries and may have limited contextual relevance to the developing world. Moreover, past studies focus on segments of society such as farmers and mainly on wastewater for agriculture. These shortcomings may limit our understanding of the topic and our ability to design effective policies to address water quality problems. Drawing on survey data from the Wenchi municipality in Ghana, we examine public perceptions of what constitute important measures of river water quality as well as factors influencing such judgements. Results suggest that while variables such as taste, colour, smell and litter are important, the presence of faecal matter in and/or around the river was rated the most important measure of river water quality while depth of river was the least important. Results further suggest that education, age, number of years a person had lived in a community, depth of river and the presence of aquatic vegetation influence water quality judgements. The findings of this research provide insights into what policymakers and regulators need to consider when attempting to influence behaviours in relation to water resources. We note, however, that while public perceptions of river water quality could guide water management policies, scientific measurements of water quality must not be replaced with stakeholder perceptions. This is because aspects such as ecological integrity may not be important to segments of the public but are an important aspect of water management. This is reinforced in the present study as there seems to be a lack of concern among the participants regarding river depth – an important factor for habitat provision and pollution dilution

Canine cancer immunotherapy studies: linking mouse and human

Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populations of patients who will respond and who will experience at times significant toxicities. Although advances in cancer immunotherapy depend on preclinical testing, the majority of in-vivo testing currently relies on genetically identical inbred mouse models which, while offering critical insights regarding efficacy and mechanism of action, also vastly underrepresent the heterogeneity and complex interplay of human immune cells and cancers. Additionally, laboratory mice uncommonly develop spontaneous tumors, are housed under specific-pathogen free conditions which markedly impacts immune development, and incompletely model key aspects of the tumor/immune microenvironment. The canine model represents a powerful tool in cancer immunotherapy research as an important link between murine models and human clinical studies. Dogs represent an attractive outbred combination of companion animals that experience spontaneous cancer development in the setting of an intact immune system. This allows for study of complex immune interactions during the course of treatment while also directly addressing long-term efficacy and toxicity of cancer immunotherapies. However, immune dissection requires access to robust and validated immune assays and reagents as well as appropriate numbers for statistical evaluation. Canine studies will need further optimization of these important mechanistic tools for this model to fulfill its promise as a model for immunotherapy. This review aims to discuss the canine model in the context of existing preclinical cancer immunotherapy models to evaluate both its advantages and limitations, as well as highlighting its growth as a powerful tool in the burgeoning field of both human and veterinary immunotherapy

Use of an Online Crowdfunding Platform for Unmet Financial Obligations in Cancer Care.

This cross-sectional study identified characteristics of patients using an online crowdfunding platform for unmet financial obligations associated with cancer care