35 research outputs found
Pathological complete response in advanced gastric stromal tumor after imatinib mesylate therapy: a case report
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Introduction</p> <p>Gastrointestinal stromal tumors are a rare neoplasm exhibiting, in most cases, mutations of <it>c-kit</it>. Imatinib mesylate is the standard treatment for patients who have advanced gastrointestinal stromal tumors. Although the response rate in patients treated with imatinib mesylate in prospective clinical studies is above 50%, a complete response is very rare. We report the case of a patient with a gastric gastrointestinal stromal tumor who had a pathological complete response after neoadjuvant treatment with imatinib mesylate.</p> <p>Case presentation</p> <p>We report the case of a 54-year-old Arab woman with a gastrointestinal stromal tumor who had a pathological complete response after neoadjuvant treatment with imatinib mesylate.</p> <p>Conclusion</p> <p>The pathological examination of our patient documented a complete pathological response after imatinib therapy. Recently, it has been confirmed that the kinase genotype of <it>KIT </it>and <it>platelet-derived growth factor receptor α </it>can accurately predict a good response to imatinib mesylate therapy. We propose that this patient had a mutation conferring high sensitivity to imatinib mesylate.</p
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
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- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
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- Akoto Elliot
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- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
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- Al-Saqqa Sara W.
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- Ingabire J. C. Allen
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- Irwin Gareth
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- Kabariti Rakan
- Kabariti Rakan
- Kabongo Kalangu
- Kache Stephen
- Kaci Amir Ait
- Kadiwar Suraj
- Kalakouti Eliana
- Kalles Vasileios
- Kalles Vasileios
- Kalles Vassilis
- Kamarajah Sivesh K.
- Kamarulzamil Siti Nur Alia
- Kamya Sylvia
- Kanani Arezo
- Kandil Ahmedali M.
- Kandil Hend
- Kanta Tasnia Hamid
- Karabelias Georgios
- Karabulut Kagan
- Karahan Servet Rustu
- Karandikar Sharad
- Kariem Nazmie
- Karim Rezaul
- Karim Sabbir
- Karismaningtyas Herlin
- Karjiker Parveen
- Karkeet Mohamed
- Karlo Robert
- Kaselis Nerijus
- Kasem Esraa Abdalmageed
- Kasputyte Simona
- Kaul Anil
- Kedar Asaf
- Keke Kpemahouton Rene
- Kelany Mohamed
- Keogh Kenneth
- Kershaw Suzanne
- Khafagy Toqa
- Khalifah Eyad
- Khallaf Salwa
- Khamajeet Arvin
- Khan Maryam Ali
- Khan Roaa
- Khan Zain Ali
- Khatri Chetan
- Khoja Ahmad
- Khokha Dzianis
- Khokha Vladimir
- Khosla Shivun
- Khreishi Reem
- Khreishi Rose
- Khulu Lawrence Bongani
- Kidd Thomas
- Kinandu Kamau
- King Sebastian
- Kiran Ravi P.
- Kirby Andrew
- Kiudelis Mindaugas
- Klappenbach Roberto
- Knight Stephen
- Koay Kean Leong
- Kobal Berna Buse
- Koh Pei Ying
- Koh Sharon
- Kojo Anyomih Theophilus Teddy
- Kojo Anyomih Theophilus Teddy
- Kondrotas Paulius
- Kong Chia
- Kong Shu Ning
- Kong Victor
- Konstantina Kolonia
- Kordorwu Hope Edem Kofi
- Korkolis Dimitrios
- Kosai Nik Ritza
- Kose Emin
- Koskenvuo Laura
- Koto Modise Zacharia
- Kotobi Henri
- Kourdouli Amar
- Kourdouli Amar
- Kufeji Dorothy
- Kuliavas Justas
- Kumar Basant
- Kumar Basant
- Kumar Basant
- Kumar Sandip
- Kumar Sunil
- Kumar Sunil
- Kumwenda Dayson
- Kushwaha Sameer
- Kusi Kwasi
- Kutkevicius Juozas
- Kwakyeafriyie Prince
- Kwatiwani Chimwemwe
- Kwizera Sandrine
- Kwok Stephanie Hiu-wai
- Kyereh Martin
- Kyriazanos Ioannis
- Kyrou Georgios
- Kyziridis Dimitrios
- L'Heveder Ariadne
- La Brocca Antonella
- Ladukas Adomas
- Lagunavicius Karolis
- Lai Anthony Chuk-Him
- Lam Justin Chak Yiu
- Lam Wai Him
- Lanau Maria Isabel Villegas
- Lando Justus
- Landolfo Giovanni
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- Paulouski Dzmitry
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- Pellino Gianluca
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- Perenyei Miklos
- Perera James
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- Picardo Antonio
- Picciariello Arcangelo
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- Pinkney Thomas
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- Pinnagoda Kalitha
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- Prudhomme Thomas
- Psarianos Kyriakos
- Pugliesi Thays Brunelli
- Pujol-Cano Natalia
- Purwaningsih Nurlaila Ayu
- Puyana Juan
- Qaissieh Ahmad
- Qawasmi Israa
- Qenawy Mostafa
- Quek Roy
- Qureshi Ahmad Uzair
- Qureshi Ahmad Uzair
- Qureshi Mobeen
- Qurie Khalid
- Rackauskas Rokas
- Radkowiak Dorota
- Radojkovic Milan
- Rahantasoa Finaritra Casimir Fleur Prudence
- Rahmah Dina Faizatur
- Rajan Reynu
- Rajmohan Shivanchan
- Rakha Ibrahim
- Ramadan Menna Tallah
- Ramos Perez Virginia
- Ramos-De la Medina Antonio
- Ramos-De la Medina Antonio
- Ramos-De la Medina Antonio
- Raptis Dimitri Aristotle
- Raptis Dmitri
- Rashad Eman
- Rashed Ahmed M.
- Rasoaherinomenjanahary Fanjandrainy
- Rath Max
- Ravishankar Ramanish
- Rayne Sarah
- Rayne Sarah
- Rayne Sarah
- Rayne Sarah
- Raza Ahmed
- Raza Awais
- Raza Ibrahim
- Razuri Cesar
- Razzaque Joyeta
- Reali Claudia
- Recinos Gustavo
- Recinos Gustavo
- Reda Amira
- Reda Aya
- Redgrave Natalie
- Redota Menold Archee P.
- Reece-Smith Alex
- Reinisch Katharina
- Reinsoo Arvo
- Rekhis Syrine
- Renaux-Petel Mariette
- Restrepo Ivan Mendoza
- Reunis Elke
- Rezq Asmaa
- Riauka Romualdas
- Riaz Muhammed Masood
- Ribaldi Sergio
- Rickard Jennifer
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- Riente Francesco
- Rinaldi Anna
- Ringressi Maria Novella
- Ripa Matteo
- Riswan Nur Zulaika
- Rob Zakaria
- Robert Elsa
- Robledo-Rabanal Alina
- Rocke Alistair
- Rod Julien
- Rod Julien
- Rodicio Joseluis
- Rodriguez Xianelle
- Roman Velasquez Armando Jose
- Romani Diego
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- Rommaneh Muna
- Roodt Liana
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- Rossi Davide
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- Ruiz Panez Walter
- Ruiz-Tova Jaime
- Rulie Anthonius Santoso
- Runigamugabo Emmy
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- Ruzzenente Andrea
- Saad Abdalla Gamal
- Saad Hala
- Saad Hanan Adel
- Saad Mahmoud M.
- Saad Reham
- Saadeh Rana
- Saami Mahmoud
- Saar Sten
- Sabe Ahmad
- Sabe Ahmad Khaled
- Sabour Fahd Abdel
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- Sacco Rosario
- Saeed Manar
- Sahbaz Nuri Alper
- Sahel Sarah
- Saidbadr Ahmed
- Sakr Ahmad
- Salah Asmaa
- Salah Maram
- Salah Mohamed
- Salah Osama Mohamed
- Salama Mahmoud
- Salama Yahya
- Salamone Giuseppe
- Salcedo Jannin
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- Salem Menatalla
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- Salma Mahmoud
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- Salusso Paola
- Sam Zi Hao
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- Samison Luc Herve
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- Segovia Lohse Helmut Alfredo
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- Selvaggi Lucio
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- Senanayake Kithsiri J.
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- Shaw Catherine A.
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- Sii Samuel S. Y.
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- Soliman Abdelrahman
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- Soliman Yasmin
- Sollazzo Viviana
- Soon Wai Cheong
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- Souaibou Yacoubou Imorou
- Soulou Vasiliki
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- Sproule Lorraine
- Srinivasan Ravi
- Sroor Fathy
- Sruogiene Elena Zdanyte
- Steccanella Francesca
- Stefanopoulos Anastasios
- Stock Simon
- Stoddart Michael
- Stoddart Michael
- Stourton Frederick
- Strupas Kestutis
- Stuva Jessica
- Styles Kristian
- Suarez Aida
- Subocius Andrejus
- Sund Malin
- Suresh Sukrit
- Sutandi Nathania
- Suyadi Arlindawati
- Swaroop Mamta
- Syibrah Khuzaimah Zahid
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tackie Enoch
- Taddei Antonio
- Tahboub Haya
- Taher Ayman
- Taher Mustafa Mohammed
- Taieb Chouikh
- Taiwo Agboola
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- Talaat Muhammed
- Tale Luis
- Talving Peep
- Talving Peep
- Tan Charlene
- Tan Choy Ling
- Tan Joel Kin
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- Tan Ryan Choon Kiat
- Tan Yee Wen
- Tan Yi Koon
- Tang Lingshan
- Tani Sobhana Iftekhar
- Tansoker Ilkan
- Tarek Adham
- Tarek Dina
- Targa Simone
- Tariq Sherif
- Tata Mahadevan Deva
- Tawfik Badreldin Adel
- Tawfik Gehad
- Teasdale Ella
- Teasdale Ella
- Teasdale Ella
- Tedeschi Umberto
- Tembo Thelma
- Tennakoon Athula
- Teo Shuang Yi
- Ter Eunice Zuling
- Tew Yong Yong
- Tew Yong Yong
- Thabet Waleed
- Thalgaspitiya S. P. B.
- Theodosopoulos Theodosios
- Thollot Aurore
- Thorarinsdottir Hildur
- Thorell Anders
- Timothy Oyediran Kehinde
- Ting Jesse Ron Swire
- To Kathleen
- Tolonen Matti
- Tolotra Todisoa Emmanuella Christina
- Tomas Kadir
- Tori Sayeeda Aktar
- Toribio Orbegozo Pedro Angel
- Torrance Hew D.
- Torres Cardozo Jorge
- Torres Rodriguez Servio Tulio
- Toto Omer Faruk
- Townsend Dominic
- Trompetto Mario
- Tselos Angelos
- Tshisola Serge Kapenda
- Tugnoli Gregorio
- Tun Myint
- Turati Luca
- Turkustani Sondos
- Turpo Espinoza Kenny
- Turpo Espinoza Kevin
- Tutino Roberta
- Tverskis Zygimantas
- Tyler Robert
- Tze R. Goh Ern
- Tzikos Georgios
- Ubiali Paolo
- Ukwenya Yahaya
- ul Razi Syed Asaat
- Ulusahin Mehmet
- Upadhyaya Vijaid
- Urbonas Tomas
- Urniezius Zigmantas
- Uscinas Laimonas
- Uzabumwana Norbert
- Vaicius Arturas
- Valcarcel-Saldana Maria
- Valioulis Ioannis
- Van Der Naald Niels
- Van Niekerk Michael
- Van Straten Stephanie
- Vargas Marvin
- Vartanoglu Talar
- Vartic Mihaela
- Vasquez Giorgio
- Vasquez Idelso
- Veen Torhild
- Velasquez Ricardo
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venskutonis Donatas
- Verbeek Anna
- Vergara Mejia Angelica Genoveva
- Verjee Azmina
- Vermaas Maarten
- Vicario Erika
- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Ademuyiwa Adesoji O
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
- Al Barraw Fayez Elian
- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
- Alcca Ticona Willy
- Alejos Bermudez Ysabel Esthefany
- Alexander Philip
- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
- Alis Halil
- Aliyu Halima
- Aliyu Mohammad
- Aliyu Shamsudeen
- Aljboor Khaled
- Aljiffry Murad
- Alkaaki Aroub
- Alkelani Muhammad
- Allam Meran
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- Alnaby Mohamed Hassab
- Alnusairat Aseel
- Alqahtani Saleh
- Alsaggaf Mohammed Ubaid
- Alser Osaid H
- Alshareef Reham
- Altaf Abdulmalik
- Altamimi Abdullah
- Altamimi Afnan
- Altamini Afnan
- Altarayra Marwa
- Altibi Ahmed
- Altinel Yuksel
- Altinel Yuksel
- Altwijri Abdulaziz
- Alvi Abdul Rehman
- Aly Mohammed Yahia Mohamed
- Alyacoubi Said
- Alyahya Reem
- Alzahrani Ahmed
- Aman Nowrin F
- Amandito Radhian
- Amandito Radhian
- Ambrona-Zafra David
- Amin Hager Abdul Aziz
- Amjad Mohammadasim
- Amoah Michael
- Amoako Joachim
- Amoako Philip Taah
- Amoako-Boateng Mabel
- Amole Isaac
- Amreia Mahmoud
- Anderson Frank
- Andika Ferry Fitriya Ayu
- Andreotti Dario
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- Ang Yun Lin
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- Ansaloni Luca
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- Anthoulakis Christos
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- Anwar Nourhan
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- Azizeldine Mohammed G
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- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
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- Antonarakis Stylianos E.
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- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
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- Itoh Takehiko
- Iwakawa Shinobu
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
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- Jia Jia
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- Nwokenkwo Stanley
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- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Olarnpunsagoon Alisa
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- Olson Maynard V.
- Omotosho Bamidele
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- Ow David
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- Paul Heidie A.
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- Perez Agapito
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- Sonnhammer Erik
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- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
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- Zhang Jiuchun
- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
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- Zhang Ruhua
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- Zhang Tiezhen
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- Zhang Wei
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- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
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- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
- Akoua-Koffi Chantal G.
- Akpede George O.
- Al Onifade Fattah
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- Alaoui Afaf
- Alaoui-Amine Sanaa
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- Albert Mélanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
- Ali Wael
- Alkarim Mona O.A.
- Allam Loubna
- Allam Mushal
- Allam Mushal
- Altamura Settimia
- Amar Narjis
- Amenga-Etego Lucas N.
- Amer K. E.
- Amer Khaled
- Amira Souissi
- Amoako Daniel G.
- Amoo Olufemi Samuel
- Amoth Patrick
- Amougou Marie
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- Amuzu Dominic S. Y.
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- Andika Brian
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- Andriam Soa Fy
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- Anga Latifa
- Ange Dossou
- Angelov Angel
- Anna-Lena Sander
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- Antwerpen Markus H.
- Anu Campbell
- Anyaneji Ugochukwu J.
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- Arena Fabio
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- Armanious Riad Mounir
- Armoo Samuel
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- Arrouchi Housna
- Artesi Maria
- Aryeetey Sherihane
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- Asante Ivy A.
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- Ashton Phillip
- Asiedu Ernest
- Asiedu-Bekoe Franklyn Egbe
- Asiimwe Stephen
- Askander Omar
- Asmamaw Kominist
- Assane Hamadi
- Assoumou Samira Zoa
- Atiga N.
- Attiku Keren Okyerebea
- Audu Rosemary A.
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- Awandare Gordon A.
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- Awunyo Sena
- Ayansola Oyeronke
- Ayei James
- Ayekaba Mitoha Ondo’o
- Ayivor-Djanie Reuben
- Aymane Bouzidi
- Ayo-Ale B.
- Ayoade F.
- Ayoola Joy
- Ayouba Ahidjo
- Aziz Ramy Karam
- Aziza Amuri
- Azman Andrew
- Aïssi Melchior A. Joël
- Ba-Diallo Awa
- Babatunde Sunday
- Baboo S. B.
- Badjo Ange
- Badou Yvette
- Bagaya Bernard Ssentalo
- Bah Mamadou Saliou
- Bahadoor B. S.
- Bahnassy A.A.
- Bajjou Tahar
- Baker David
- Baker Noah
- Bakhash Shah Mohamed
- Bakry U.
- Balde Aladje
- Balde Aladje
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- Bamourou Diané
- Banda R.
- Bane S.
- Barasa Edwine
- Barbet Marion
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- Barilar Ivan
- Barkat Amina
- Barnes Kayla
- Barreh Guedi Ali
- Bashein Abdulla
- Bassène Hubert
- Batchi-Bouyou Armel L.
- Batchi-Bouyou Armel L.
- Bates Matthew
- Batra Dhwani
- Batra R.
- Bauer Peter
- Baxter Cheryl
- Bayih Abebe Genetu
- Bbosa Nicholas
- Bedford Trevor
- Bediako Yaw
- Bedié
- Bedri Shahinaz.A.
- Behillil Sylvie
- Bejon Philip
- Belarbi Essia
- Belfquih Bouchra
- Belkhir A.B.
- Bellefquih Abdelkrim Meziane
- Beloufa Mohamed Amine
- Belournou Grace Angong
- Ben Alaya Nissaf
- Ben Ayed I.
- Ben Boubaker Ilhem Boutiba
- Ben Boubaker Ilhem Boutiba
- Ben Kahla Alia
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- Bestehorn-Willmann Malena S.
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- Beyene Getachew Tesfaye
- Bhiman Jinal N.
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- Biscornet Leon
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- Bitrou S.M.
- Bizard Méline
- Bióté Simão Tchuda
- Blackmore Timothy
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- Bloomfield Max
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- Boatemaa Linda
- Bolajoko Bankole
- Bonney Evelyn Y.
- Bonney Joseph H. K.
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- Bootsma Sacha
- Borrmann Steffen
- Boter Marjan
- Boujemla Bouchra
- Bours Vincent
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- Bouzid Amal
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- Brechar Ludivine
- Bridges Daniel J.
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- Brisebarre Angela
- Brook Cara
- Bssaibis Fatna
- Budiaki Sylvie L.
- BUHARI Mikhail Olayinka
- Bulimo Wallace D
- Bunga Sudhir
- Butel Christelle
- Butera Yvan
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- Camara Alimou
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- Campbell Allan
- Campbell Julian
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- Candé Adul
- Capel Camille
- Carey Omondi Francis
- Carniel Elisabeth
- Carr Rosina A. A.
- Carri Valeria Delli
- Carvalho Kevin S.
- Cassama Faatu
- Cedola Donatella
- Cer Regina Z.
- Chabert-Consen Marie Madeleine
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- Chammam Sara
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- Chenaoui Mohamed
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- Chipimo P.J.
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- Christoffels Alan
- Chtourou A.
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- Chukwu G.
- Cigolo Jean-Claude Makangara
- Cisse Barada
- Clarisse Murebwayire
- Colson Philippe
- Comas Iñaki
- Combe Patrice
- Corman Victor Max
- Cortes Carlos
- Cotten Matthew
- Crawford M.
- Crespin Xavier
- Cá Milanca Agostinho
- D'Amore N.
- D'Aprile Annamaria
- Dadi Hailu
- Daghfous Riadh
- Dagnran Anoumou
- Dakka Hanae
- Dal Monego Simeone
- Damaris Matoke-Muhia
- Damena D.
- Damilari Dabiri
- Daniels Rodney S.
- Dao Sounkalo
- Daou Amadou
- Dara Antoine
- Daubenberger Claudia
- David Kumbelembe
- Davids Micheala
- Davies Mary-Ann
- Dawood R.M.
- Dawood Reham
- de Laurent Zaydah R.
- de Ligt Joep
- De Nittis Rosella
- de Oliveira Filho Edmilson F.
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- De Sanctis R.
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- DeAlmeida Mary
- Debela Alemu Tike
- Delaney Kayla
- Delaporte Eric
- Delerce Jeremy
- Dellagi Koussay
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- Deschenes Michael V.
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- Devaux Christian A.
- Dhaala Beatrice
- Dia Aminata
- Dia Ndongo
- Dia Yacine Amet
- Diab A.
- Diagne Diabou
- Diagne Moussa M.
- Diakite Mandiou
- Diallo Amadou
- Diallo Haby
- Diallo Penda Malhado
- Diallo Sada
- Diarra B.
- Diarra Bassirou
- Diaw Papa Alassane
- Diawara Idrissa
- Dieng Alle Baba
- Dieng Assane
- Diergaardt Azaria
- Diop Mamadou
- Diop Oumy
- Djimde Abdoulaye
- Djingarey Mamoudou Harouna
- Djomsi Dowbiss Meta
- Djontu Jean Claude
- Dobi Paul
- Donati Flora
- Dorkenoo Ameyo
- Doudou Fetouma
- Douffan Messanh
- Doumbia Seydou
- Draper C.
- Dratibi Fred A.
- Drinkovic Dragana
- Drosten Christian
- Duedu Kwabena O.
- Durkin Keith
- Dussart Philippe
- Dussart Philippe
- Dürr Kouriba
- Ebied Fatma
- Ebong Ofonime
- Eckstein Simone
- Edu Emame
- Eggan Stephen M.
- Egli Adrian
- Egoh Ifunanya
- Egyir B.
- Ehlan Amivi
- El Amin Ghizlane
- El ansari Fatima Zahra
- El Atar Jalil
- El Fahime Elmostafa
- El Falaki Fatima
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- El Hady Yassine
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- Elgahzaly Hesham
- Elgohary Mohamed Abdel-Salam
- Elguindy Nancy
- Elhadidi Mohamed
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- Elisabeth Carniel
- Elkhateeb S.M.
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- Elnakib Mostfa
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- Elouennass Mostafa
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- Embaló Bubacar Delgado Pinto
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- Engelbrecht Susan
- Ennibi H.
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- Erhart Annette
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- Farawyla H.
- Fares Wasfi
- Farghaly Ayman
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- Feasey Nicholas
- Fedorov A.V.
- Fekkak Jamal
- Femi Ayoade
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- Fwoloshi Somda Soro Georgina
- Gaaloul I.
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- Garcia Guillermo
- Gardoul Mouhcine
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- Gaseitsiwe Simani
- Gatare Swaibu
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- Gdoura Mariem
- Gedeon Jude
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- George Uwem E.
- Gerard Izuwayo
- GeurtsvanKessel Corine H.
- Gevao Sahr
- Gharmaz Hamza
- Ghassan Adib
- Ghedira Kais
- Ghita Amalou
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- Giandhari Jennifer
- Gideon Nsubuga
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- Girgis Samia Abdou
- Gismondo Maria Rita
- Githii Rachid
- Githinji George
- Gnimadi Thibaut Armel Cherif
- Goba Augustine
- Godwe Celestin
- Goedhals Dominique
- Goldstone R.
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- Grantz Kyra
- Grayo Solène
- Greninger Alexander
- Guedouar Houssem
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- Gueye Khadim
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- Hassan W.
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- Hayette Marie-Pierre
- Heikel Jaafar
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- Helmy Sherine
- Hemlali Mouhssine
- Henson Sondes
- Heraud Jean-Michel
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- Hicham Charoute
- Hicham Elannaz
- Hihi Nardjes
- Hilali Abderraouf
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- Hoornaert Laurien
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- Hsiao Nei-yuan
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- Jain Komal
- Jalal D.
- Jalal Nourlil
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- Jamal Fekkak
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- Jefferies Sarah
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- Johane Shirley
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- Joseph Rageema
- Jouali Farah
- Jumaa A.B.
- Juru Agnes
- Kabamba Gabriel
- Kabanda Alice
- Kabatesi Francisca
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- Kandeil Ahmed
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- Kane Mouhamed
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- Lako Richard Lino Loro
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- Lamboni Lallepak
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- Langat Sombo
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- Rubin Sarah
- Rudder Steven
- Rufael Tesfaye
- Ruhweza Simon Peter
- Rujeni Nadine
- Rumunu John
- Rutayisire Robert
- Saad M.A.
- Saasa Ngonda
- Sabeti Pardis C.
- Sadeuh-Mba Serge Alain
- Sadji
- Sadji Adodo
- Sadji Y.A.
- Safer Mouna
- Safietou Sankhe
- Sahr Dumbuya Foday
- Sahr P.F.
- Saibu J.O.
- Saiid S.
- Saiid Samirah
- Saizonou Raoul
- Sakho Moustapha
- Salah D.
- Salah Djimabi
- Salah H.
- Salako Babatunde L.
- Salama Abdullah
- Saleh A.A.
- Saleh M.
- Salifou Sourakatou
- Sall Amadou A.
- Sall Amadou Alpha
- Salma Loukman
- Salou M.
- Salou Mounerou
- Salu O.B.
- Samaté Dianke
- Sambou Masse
- Samir M.
- Samir O.
- San James E.
- Sanaa-amine Alaoui
- Sander Anna-Lena
- Sanders Kevin
- Sandi John D.
- Sangare Abdoul K.
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- Sankhe Safietou
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- Sanyang Bakary
- Sathees Saraswathi
- Sathyendran Vani
- Savaliya Nitin
- Sawa H.
- Sawadogo Yacouba
- Sayed Ahmed
- Sayed Salma
- Sbabou Laila
- Schaffner Stephen F.
- Scharnberg Jasmin
- Scheepers Cathrine
- Schindler Tobias
- Schlotterbeck Jasmin
- Schneider Julia
- Schubert Grit
- Seadawy M.G.
- Seadawy Mohamed
- Seadawy Mohamed G.
- Seadawy Mohamed Gomaa
- Sedjro Eclou
- Seffar Myriam
- Sekhsokh Yassmin
- Selekon Benjamin
- Semanda Patrick
- Sena Awunyo
- Sene Pauline Yacine
- Serrano Laetitia
- Seru Kedumetse
- Sesay Abdul K.
- Seth-Smith Helena
- Seyoum Tamrayehu
- Shabaan Abd Elazeez
- Shaffer Jeffrey G.
- Shaibu Joseph Ojonugwa
- Shalaby L.
- Shama Abo
- Shamel Mohamed
- Shapiro Roger
- Shawky Shereen
- Shcherbakova S.A.
- Shehata Mahmoud
- Shemis Mohamed
- Sherwood Jill
- Shevtsova A.P.
- Shibemba Aaron L.
- Shiningavamwe Andreas
- Shipingana Loide
- Shobayo Bode
- Shoka Abd Moniem Ain
- Shrestha Lasata
- Shumba Edwin
- Si Huiqing
- Siawaya Joel Fleury Djoba
- Siddle Katherine J.
- Siedner Mark
- Siegfried Nandi
- Sigei Faith
- Sijuwola Ayotunde E.
- Sikkema Reina
- Silander Olin
- Siliadin Akoele
- Silochi Nelson Boricó
- Simbi Rajiha
- Simon-Loriere Etienne
- Simons Lacy M.
- Simulundu Edgar
- Singh Lavanya
- Sinyange N.
- Sisay Abay
- Sitharam Nikita
- Sitoe Nadia
- Sivro Aida
- Skarwan Emilio
- Skidmore Peter T.
- Smeti Ibtihel
- Smit Erasmus
- Smith-Lawrence Pamela
- Smyej Imane
- Soara Nabila
- Sobajo Tope
- Soglo Philip M.
- Sogodogo Heitzer
- Sogodogo Sokhna
- Sokei Judith
- Sokhna Cheikh
- Soliman Hany K.
- Soliman May Sherif
- Soliman Shaimaa
- Somboro Anou M.
- Somé Arsène
- Sonoo Janaki
- Sorie Foday Sahr Samuel
- Sorie Samuel
- Sosedova E.A.
- Souiri Amal
- Souissi Amal
- Souma Zein
- Soumah Abdoul Karim
- Souopgui Jacob
- Sourakatou Salifou
- Sow Abdourahmane
- Sow Mamadou Saliou
- Ssemwanga Deogratius
- Ssewanyana Isaac
- Ssuuna Charles
- Stambouli Nejla
- Stander Tania
- Stange Madlen
- Stanley Sarah
- Stefanov Emily K.
- Stoecker Kilian
- Storey Matt
- Strydom Amy
- Subramoney Kathleen
- Sujeewon C.
- SULAIMAN Mariam Kehinde
- Sule Waidi
- Sun Fengming
- Swanson Kena
- Sylvanus Okogbenin
- Sylverken Augustina A.
- Symeker S.L.
- Symekher Samwel Lifumo
- Tagajdid Rida
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- Taloa K.A.
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- Tarnagda Zekiba
- Tarupiwa Andrew
- Tatfeng Mirabeau Y.
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- Tato Cristina M.
- Taweh Fahn M.
- Tayachew Adamu
- Tayimetha Carolle Yanique
- Taylor Susan
- Tchibozo Carine
- Tchoudjin Herve Christian Paho
- Tebeje Yenew K.
- Tefelo Thela
- Tefera D.A.
- Tefera Dessalegn Abeje
- Tegally Houriiyah
- Tegomoh Bryan
- Tegueni Kokou
- Tei-Maya
- Teka Gizaw
- Tembo John
- Tesfaye Abraham
- Tesfaye Gelanew
- Tesfaye Kassahun
- Tessema Sofonias K.
- Testimony Olumade
- Thiam Aminata Sileymane
- Thilliez Gaetan
- Thiongo K.
- Thomas Van L.
- Tia Alie
- Tinto Halidou
- Tollera Getachew
- Tombolomako T. B.
- Tomkins-Tinch C.
- Tomori Oyewale
- Tongo Marcel
- Top Ndeye Marieme
- Tordo Noël
- Toure Abdoulaye
- Touré Bamba Fatoumata
- Touzani Charifa Drissi
- Touzani Otmane
- Trabelsi Sameh
- Traoré
- Traoré Adjaratou
- Treurnicht Florette
- Triki H.
- Triki Henda
- Trotter Alexander J.
- Tsegay Yao
- Tshiabuila Derek
- Tsiry R.
- Tsofa Benjamin
- Tuki Keyru
- Tumedi Kefentse A.
- Turki M.
- Tushabe Phionah
- Tuyisenge Patrick
- Tyers Lynn
- Uche Peace O.
- Ugwu C.A.
- Ulrich M.
- Umumararungu Esperance
- Umuringa Jeanne d’Arc
- Upton Arlo
- Ushijima Yuri
- Ussher James
- Utpatel Christian
- Uwanibe Jessica N.
- Uwituze Arlene
- van der Eijk Annemiek
- van der Linden Anne
- van der Linden Antje
- van der Werf Sylvie
- Van Rooyen G.
- van Rooyen Gerhard
- van Wyk Stephanie
- van Zyl Gert U.
- Vanaerschot M.
- Vanmechelen Bert
- Vanpeene Maud
- Velavan Thirumalaisamy P.
- Venter Marietjie
- Vernet Marie-Astrid
- Viana R.
- Vickos U.
- Victoir Kathleen
- Vida Ahyong
- Vidal Nicole
- Viegas Sofia
- Vincent Grace
- Vinze Anika
- Voegtly Logan J.
- von Gottberg Anne
- Waberi Zeinab Ali
- Wadi Amira Suliaman
- Wadonda N.
- Wadula J.
- Wagner Philipp
- Wahab Kolawole Wasiu
- Waitumbi John
- Walter Mathias C.
- Wamala Joseph F.
- Wandera Dennis N.
- Wang Jing
- Wang Xiuhua
- Wani Gregory
- Wanjohi Dorcas W.
- Wanok Stephen
- Waruhiu C.N.
- Waruhiu Cecilia
- Wasfi Fares
- Watters Chaselynn M.
- Wawina-Bokalanga Tony
- Wayengera Misaki
- Wayoro Oby
- Webby R.
- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
- Wolh S.
- Wolter Nicole
- Wuduri Zara
- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.
- Author
- Aberson Christopher
- Aczel Balazs
- Adamkovic Matus
- Adamus Sylwia
- Adetula Adeyemi
- Adetula Gabriel Agboola
- Adiguzel Arca
- Adoric Vera Cubela
- Afhami Reza
- Agadullina Elena
- Agesin Bamikole Bamikole
- Ahlgren Lina
- Ahmed Afroja
- Ahn El Rim
- Akgoz Aysegul
- Akkas Handan
- Alaei Ravin
- Albayrak-Aydemir Nihan
- Allred Tara Bulut
- Almeida Inês
- Alper Sinan
- Alvarez Daniela Serrato
- Alves Sara
- Andreychik Michael
- Anjum Gulnaz
- Ankushev Vladislav
- Anne Michele
- Antazo Benedict
- Antfolk Jan
- Anton-Boicuk Lisa
- Antoniadi Maria
- Anvari Farid
- Arinze Azuka Ikechukwu
- Arinze Nwadiogo
- Arinze Nwadiogo Chisom
- Ariyabuddhiphongs Kris
- Armstrong Marie
- Arnal Jack
- Arriaga Patrícia
- Artner Richard
- Aruta John Jamir Benzon
- Arvanitis Alexios
- Ashworth Logan
- Ask Karl
- Askelund Adrian Dahl
- Atari Mohammad
- Azab Habiba
- Azevedo Flavio
- Azouaghe Soufian
- Babincak Peter
- Badidi Touhami
- Bai Hui
- Baklanova Ekaterina
- Balas Benjamin
- Balci Busra Bahar
- Ballada Christine Joy
- Ballantyne Tonia
- Balt Nina
- Baník Gabriel
- Barba-Sánchez Alan
- Barbosa Sergio
- Barzykowski Krystian
- Basabe Nekane
- Baskin Ernest
- Basnight-Brown Dana
- Batres Carlota
- Bavolar Jozef
- Beaudry Jennifer
- Becker Maja
- Behzadnia Behzad
- Beitner Julia
- Belaus Anabel
- Belhaj Abdelkarim
- Bennett-Day Brooke
- Berkessel Jana
- Bernardo Márcia
- Beshears Julie
- Betlehem Ruben
- Bhushan Braj
- Bialek Michal
- Bialobrzeska Olga
- Białek Michał
- Bijlstra Gijsbert
- Blake Khandis
- Blaut Agata
- Bloxsom Nicholas
- Bobowik Magdalena
- Bogatyreva Natalia
- Bokkour Ahmed
- Bonick Judson
- Borras-Guevara Martha Lucia
- Bosch Jasmijn
- Bosma Minke Jasmijn
- Boucher Leanne
- Boudesseul Jordane
- Bozdoc Andreea Ioana
- Bradford Maria
- Bran Alexandre
- Brandt Mark
- Bravo Olalla Niño
- Brohmer Hilmar
- Buchanan Erin
- Bundt Carsten
- Burak Elif Gizem Demirag
- Burin Debora
- Butt Muhammad Mussaffa
- Bylinina Lisa
- Caballero Amparo
- Cai Sun Jun
- Calin-Jageman Robert
- Calvillo Dustin
- Campos Olatz
- Capizzi Mariagrazia
- Carpentier Joelle
- Carrera Pilar
- Carvalho Lilian
- Ceary Chris
- Cellini Nicola
- Chandel Priyanka
- Chartier Christopher
- Charyate Abdelilah
- Chatard Armand
- Chen Sau-Chin
- Chen Zhang
- Chevallier Coralie
- Chittham Phakkanun
- Chiu Faith
- Choi Eunsoo
- Chopik William
- Chou Weilun
- Christopherson Cody
- Chuan-Peng Hu
- Coelho Gabriel Lins de Holanda
- Coetzee Vinet
- Cohen Noga
- Coles Nicholas
- Collins W. Matthew
- Colloff Melissa
- Cook Corey
- Corral-Frías Nadia
- Correa Pablo Sebastián
- Correia Rita
- Crawford Matthew
- Cruz Vásquez Julio
- Cubillas Carmelo
- Cyrus-Lai Wilson
- Czamanski-Cohen Johanna
- Czarnek Gabriela
- Cárcamo Rodrigo
- Daches Shimrit
- Dalgar Ilker
- Damnjanović Kaja
- Daniels Judith
- Danvers Alexander
- Davis William
- Day Chris
- De La Rosa-Gómez Anabel
- de Lima Tiago Jessé Souza
- de Souza Luana Elayne Cunha
- DeBruine Lisa
- del Carmen Espinoza Maria
- Delgado Lady Grey Javela
- Desai Kermeka
- Dixson Barnaby
- Dixson Barnaby James Wyld
- Djamai Ikhlas
- Djordjevic Jasna Milosevic
- Dodaj Arta
- Domurat Artur
- Dorison Charles
- Doğan Uğur
- Drexler Shira Meir
- Du Hongfei
- Du Xinkai
- Dubrov Dmitrii
- Dujols Olivier
- Dumont Kitty
- Dunham Yarrow
- Dunleavy Daniel
- Dursun Pinar
- Ebersole Charles
- Ebert Tobias
- El Arabi Kanza Ait
- Elouafa Jamal
- Escobar María Josefina
- Espinoza Barría Mauricio
- Esteban-Serna Celia
- Estrada-Mejia Catalina
- Etabari Zahra
- Eudave Luis
- Evans Kortnee
- Evans Thomas
- Eşkisu Mustafa
- FatahModarres Saiedeh
- Fedotov Maksim
- Feinberg David
- Feldman Gilad
- Fernandez Ana Maria
- Ferreira Ana
- Ferreira Diogo
- Ferreira Paulo
- Filip Katarzyna
- Findor Andrej
- Flake Jessica
- Floerke Victoria
- Flowe Heather
- Forbes Paul
- Foroni Francesco
- Forscher Patrick
- Freeman Jonathan
- Friedemann Maja
- Frizzo Thomas
- Frohlich Brooke
- Frías-Armenta Martha
- Galindo-Caballero Oscar
- Garcia Adolfo
- Garcia Elkin Oswaldo Luis
- Gardiner Gwendolyn
- Gawryluk Katarzyna
- Geiger Sandra
- Geniole Shawn
- Gialitaki Zoi
- Gilboa-Schechtman Eva
- Gilead Michael
- Gill Tripat
- Giolla Erik Mac
- Gjoneska Biljana
- Godbersen Hendrik
- Gogan Taylor
- Goldenberg Amit
- Golik Karolina
- González-Santoyo Isaac
- Gordon-Finlayson Alasdair
- Gourdon-Kanhukamwe Amélie
- Grano Caterina
- Gračanin Asmir
- Greenburgh Anna
- Grigoryev Dmitry
- Grinberg Maurice
- Gross James
- Groyecka-Bernard Agata
- Grzech Karolina
- Götz Friedrich
- Gülgöz Sami
- Habib Sumaiya
- Hahn Amanda
- Hajdu Nandor
- Hanel Paul
- Haque Shamsul
- Hareli Shlomo
- Hartanto Andree
- Harutyunyan Mikayel
- Hatami Javad
- Hedgebeth Mattie
- Hehman Eric
- Hofer Gabriela
- Holford Dawn Liu
- Hostler Thomas
- House Thea
- Hoyer Karlijn
- Hricova Monika
- Hristova Evgeniya
- Hruška Matej
- Hsu Rafael
- Hsu Tsuyueh
- Hu Chuan-Peng
- Hubena Barbora
- Ibanez Agustin
- Idzikowska Katarzyna
- Ihaya Keiko
- IJzerman Hans
- Inzlicht Michael
- Irrazabal Natalia
- Isager Peder Mortvedt
- Ishii Tatsunori
- Ishkhanyan Byurakn
- Ito Kenichi
- Ivanov Aleksandr
- Ivory James
- Iyer Aishwarya
- Izquierdo Sara Morales
- Jackson Emily
- Jaeger Bastian
- Janak Allison
- Jang Chaning
- Janjić Kristina
- Janssen Steve
- Jaremka Lisa
- Jarukasemthawee Somboon
- Jaworska Katarzyna
- Jernsäther Teodor
- Jiang Zhongqing
- Jimenez-Leal William
- Johannes Niklas
- Jones Benedict
- Jones Marc
- Jose Paul
- Joy-Gaba Jennifer
- Jurković Anita Penić
- Jzerman Hans
- Kadreva Veselina Hristova
- Kaliska Lada
- Kamburidis Julia
- Kaminski Gwenaël
- Kappes Heather
- Kapucu Aycan
- Karaarslan Cemre
- Karaaslan Aslan
- Karababa Alper
- Karashiali Christiana
- Kardum Igor
- Karekla Maria
- Karsten Julie
- Kassianos Angelos
- Kačmár Pavol
- Khaoudi Ahmed
- Khosla Meetu
- Kielińska Julita
- Kirgizova Komila
- Klein Richard
- Klevjer Kristoffer
- Kocalar Halil Emre
- Kocsel Natália
- Kocsor Ferenc
- Koehn Monica
- Kohlová Markéta Braun
- Kolen Anouk
- Konova Irina
- Koptjevskaja-Tamm Maria
- Korbmacher Max
- Kossowska Małgorzata
- Kovic Vanja
- Kowal Marta
- Kozma Luca
- Kołodziej Sabina
- Krafnick Anthony
- Kraus Sue
- Kremer Inbal
- Križanić Valerija
- Krupić Dajana
- Krupić Dino
- Kruse Elliott
- Kujur Pratibha
- Kung Chun-Chia
- Kung Franki
- Kunisato Yoshihiko
- Kunst Jonas
- Kurfali Merve
- Kurfalı Murathan
- Kushnir Elizaveta
- Kuzminska Anna
- Kácha Ondřej
- Kökönyei Gyöngyi
- Körner Anita
- Lamm Claus
- Landry Anais Thibault
- Law Wilbert
- Lazarevic Ljiljana
- Lee Ai-Suan
- Lee Jeong Min
- Lee Kean Mun
- Legate Nicole
- Lekkou Eleimonitria
- Leongómez Juan David
- Leonis Trinity
- Lerner Jennifer
- Levitan Carmel
- Levy Neil
- Lewis David
- Lewis Neil
- Lewis Savannah
- Li Manyu
- Li Ranran
- Li Yansong
- Lima Tiago
- Lin Hause
- Lin Yijun
- Lindemans Jan
- Lins Samuel
- Liu Qing-Lan
- Liuzza Marco Tullio
- Lu Jackson
- Lucas Marc
- Lutz Johannes
- Macapagal Paulo Manuel
- Maeura Nao
- Majeed Nadyanna
- Maldonado Mónica Alarcón
- Malik Sadia
- Mallik Peter
- Manavalan Mathi
- Manley Harry
- Manunta Efisio
- Marcu Gabriela
- Marcu Gabriela Mariana
- Marinova Evelina
- Markiewicz Łukasz
- Marko Dafne
- Marszalek Magdalena
- Martinez-Zelaya Gonzalo
- Martins Diogo
- Martončik Marcel
- Massoni Sébastien
- Mateo Nino Jose
- Maturan Princess Lovella G.
- Mburu Georgina
- McCarthy Randy
- Mefoh Philip
- Menon Madhavi
- Mensink Michael
- Mentser Sari
- Messerschmidt Johanna
- Metin-Orta Irem
- Michalak Nicholas
- Micheli Leticia
- Miller Jeremy
- Mioni Giovanna
- Miranda Jacob
- Misiak Michal
- Mokady Aviv
- Mola Débora
- Monajem Arash
- Monteiro Renan
- Moon Karis
- Moreau David
- Morey Richard
- Morvinski Coby
- Mosannenzadeh Farnaz
- Moshontz Hannah
- Muchembled Fany
- Mues Chiel
- Muminov Abdumalik
- Musser Erica
- Muñoz-Reyes Jose Antonio
- Nadif Khaoula
- Nakayama Masataka
- Nauman Rafia
- Ndukaihe Izuchukwu
- Nedelcheva-Datsova Mina
- Neyroud Lison
- Ng Wee Qin
- Nielsen Tonje
- Nilsonne Gustav
- Nock Nora
- Noone Chris
- Norton James
- Novak Sarah
- Nussinson Ravit
- Ogbonnaya Chisom Esther
- Oh Dong Won
- Okan Ceylan
- Oldmeadow Julian
- Oliveira Raquel
- Olofsson Jonas
- Olsen Jerome
- Ong Chew Wei
- Oosterlinck Marlies
- Orjiakor Charles
- Ortiz Manuel
- Ortiz María Victoria
- Ostermann Thomas
- Ouherrou Nihal
- Owsley Nicholas
- Ozery Daphna Hausman
- Očovaj Sanja Batić
- O’Mara Kunz Erin
- Pande Babita
- Pantazi Myrto
- Papachristopoulos Konstantinos
- Papadatou-Pastou Marietta
- Parashar Neha
- Parganiha Arti
- Paris Bastien
- Paruzel-Czachura Mariola
- Parveen Noorshama
- Parzuchowski Michal
- Pati Atanu Kumar
- Pavlacic Jeffrey
- Peltola Henna-Riikka
- Perillo Jennifer
- Peters Kim
- Pfuhl Gerit
- Philipp Michael
- Pich Olivia
- Pilecka Natalia
- Pineda Lina Maria Sanabria
- Pinto Isabel
- Pit Ilse
- Pizarro José
- Polo Pablo
- Pourafshari Razieh
- Pradhan Sraddha
- Primbs Maximilian
- Pronizius Ekaterina
- Protzko John
- Prusova Irina
- Przybylski Andrew
- Putz Ádám
- Páez Darío
- Pálfi Bence
- Pérez Laura Calderón
- Pöntinen Sara
- Qi Yue
- Quirin Markus
- Rachev Nikolay
- Radtke Theda
- Rahal Rima-Maria
- Rana Kafeel
- Razza Timothy
- Reeck Crystal
- Reggev Niv
- Reips Ulf-Dietrich
- Ren Dongning
- Rentfrow Peter
- Reyna Cecilia
- Ribeiro Gianni
- Ribeiro Matheus Fernando Felix
- Ribeiro Rafael
- Ricaurte Danilo Zambrano
- Richard Karley
- Ritchie Kay
- Ritchie Stuart
- Roczniewska Marta
- Rojas-Berscia Luis Miguel
- Romanova Marina
- Ropovik Ivan
- Rosa Anna Dalla
- Ross Robert
- Ruiz-Dodobara Fernando
- Ruiz-Fernández Susana
- Rule Nicholas
- Röer Jan Philipp
- Sacakli Asli
- Samojlenko Lara
- Sampaio Waldir
- Santos Anabela Caetano
- Santos Diana
- Sarda Elisa
- Saribay S. Adil
- Sarieva Irena
- Sarıoğuz Eylül
- Sato Wataru
- Saunders Blair
- Sawicki Przemysław
- Say Nicolas
- Schei Vidar
- Schild Christoph
- Schmid Irina
- Schmidt Kathleen
- Schmidt Nadya-Daniela
- Schorch Sebastian
- Schrover Elke
- Schrötter Jana
- Schubert Thomas
- Schwerdtfeger Andreas
- Schönefeld Victoria
- Schütz Astrid
- Searston Rachel
- Seehuus Martin
- Sesar Kristina
- Shani Yaniv
- Shankland Rebecca
- Sharifian MohammadHasan
- Sharman Leah
- Shiramazu Victor
- Sikka Pilleriin
- Silan Miguel
- Silva Jaime
- Simchon Almog
- Simonovic Nicolle
- Singer Gage
- Singh Margaret
- Sinkolova Sladjana
- Sirota Miroslav
- Sleegers Willem
- Sloane Guyan
- Solas Sara Álvarez
- Solorzano Claudio Singh
- Song Xin
- Sorokowska Agnieszka
- Sorokowski Piotr
- Soto Jose
- Sousa Daniela
- Sparacio Alessandro
- Stadel Marie
- Stanke Franziska
- Steffens Niklas
- Stephen Ian
- Stern Julia
- Sternglanz R. Weylin
- Stevens Laura
- Stewart Suzanne L.K.
- Stieger Stefan
- Stojanovska Dragana
- Stojanovska Marija
- Stolier Ryan
- Storage Daniel
- Stoyanova Alina
- Studzinska Anna
- Su-May Terri Tan
- Suavansri Panita
- Suchow Jordan
- Sullivan Gavin Brent
- Sunami Naoyuki
- Suter Lilian
- Sutherland Clare
- Sverdrup Therese
- Szabelska Anna
- Szala Anna
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- Szecsi Peter
- Szwed Paulina
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- Taber Jennifer
- Taephant Nattasuda
- Tajchman Zuzanna
- Tamnes Christian
- Tan Chrystalle
- Tan Kok Wei
- Tatachari Srinivasan
- Tcherkassof Anna
- Tejada Rivera María del Carmen M. C.
- Terskova Maria
- Theodoropoulou Andriana
- Thirkettle Martin
- Thomas Andrew
- Thommesen Katrine Krabbe
- Thorstenson Christopher
- Tiantian Dong
- Tidwell Natasha
- Todsen Anna Louise
- Topor Marta
- Tops Mattie
- Toro Mónica
- Torres Adriana Olaya
- Torunsky Nathan
- Tran Ulrich
- Travaglino Giovanni
- Tressoldi Patrizio
- Tullett Alexa
- Turiegano Enrique
- Tümer Murat
- Uchida Yukiko
- Uittenhove Kim
- Urban Jan
- Urooj Anum
- Urry Heather
- Uttley Jim
- Uusberg Andero
- Vadillo Miguel
- Vaidis David
- Valderrama Eugenio
- Valentova Jaroslava
- Valentova Jaroslava Varella
- Vally Zahir
- van de Ven Niels
- Van der Linden Nicolas
- Van Doren Natalia
- van Schie Kevin
- van Steenkiste I.
- van Zyl Casper
- Vanman Eric
- Vanpaemel Wolf
- Varella Marco
- Vargas-Nieto Juan Camilo
- Vasilev Martin
- Vatakis Argiro
- Vaughn Leigh Ann
- Vazire Simine
- Vdovic Milica
- Vega Diego
- Verbruggen Frederick
- Vergauwe Evie
- Verharen Jeroen
- Verschuere Bruno
- Vezirian Kevin
- Vianello Michelangelo
- Vieira Luc
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- Vilares Iris
- Villar Sergio
- Vilsmeier Johannes
- Vingerhoets Ad
- Vintr Jáchym
- Volz Leonhard
- von Bastian Claudia
- Voracek Martin
- Vranka Marek
- Vuoskoski Jonna
- Vásquez-Amézquita Milena
- Wagemans Fieke
- Walczak Radoslaw
- Wang Chunhui
- Wang Hsiao-Hsin
- Wang Ke
- Warmelink Lara
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- Weissgerber Sophia
- Westerlund Minja
- Westgate Erin
- White David
- Whitt Cassie
- Wichman Aaron
- Wielgus Magdalena
- Willis Megan
- Wilson John
- Wilson John Paul
- Wissink Joeri
- Wlodarczyk Anna
- Wolf Daniel
- Wolfe Kelly
- Wu Qi
- Wu Yang
- Xiao Qinyu
- Xie Sally
- Yamada Yuki
- Yan Wen-Jing
- Yang Xin
- Yao Elvin
- Yeung Siu Kit
- Yu Karen
- Zabel Chelsea
- Zakharov Ilya
- Zdybek Przemysław
- Zettler Ingo
- Zheng Michelle Xue
- Ziano Ignazio
- Zickfeld Janis
- Zorjan Saša
- Zrimsek Miha
- Zsido Andras
- Álvarez-Solas Sara
- Çoksan Sami
- Çolak Tuğba Seda
- Özdoğru Asil
- Özdoğru Asil Ali
- Čadek Martin
- Ścigała Karolina
- Śmieja Magdalena
- Šakan Dušana
- Šebeňa René
- Štrukelj Eva
- Žuro Barbara
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world
Orbital Turning of the upper Albian from the site U1513D - Palaeoenvironmental implications
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
International audienc
Orbital Turning of the upper Albian from the site U1513D - Palaeoenvironmental implications
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
International audienc
Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1variants in Moroccan population
- Author
- A Sabbagh
- A Tostmann
- Abdelaziz Sefiani
- AJ Fretland
- Amina Barkat
- B Roy
- B Yang
- BH Lauterburg
- C Bouchardy
- D Lucas
- DE Ryan
- DP Parkin
- EJ Forget
- F Marra
- Fatima Zahra Laarabi
- HJ Lin
- I Cascorbi
- Ilham Ratbi
- Imane Cherkaoui Jaouad
- J Azuma
- JFE Sambrook
- JG Chamorro
- JJ Saukkonen
- JR Mitchell
- JR Mitchell
- K Bendjemana
- K Kolble
- L Ait Moussa
- M Brocic
- M Ohno
- MO Tanira
- P Neafsey
- RL Teixeira
- S Garte
- SC Kunak
- SI Hamdy
- Siham Chafai Elalaoui
- SK Sharma
- Soukaina Guaoua
- T Neuhaus
- V Leiro-Fernandez
- WHO
- Y Shimizu
- Y Zang
- YS Huang
- Z Hussain
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Surgical site infection after gastrointestinal surgery in children : an international, multicentre, prospective cohort study
- Author
- A A Essam
- A B Jayathilake
- Abbas Chabok
- Abd Elkhalek Sallam
- Abdalla Gamal Saad
- Abdelaziz Abdelaal
- Abdelaziz Elhendawy
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Soliman
- Abdelrhman Kz Darwish
- Abdul Rehman Alvi
- Abdulaziz Altwijri
- Abdullah Altamimi
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulrahman Abdel-Aty
- Abdulrasheed Nasir
- Abdulrazzaq Lawal
- Abdulshafi Khaled AbdRabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abeer Esam
- Abhishek Sharma
- Abiboye Yifieyeh
- Abobaker Younis
- Abrar Nawawi
- Adam Boggon
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B Hassanein
- Adel Denewer
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji O Ademuyiwa
- Adewale Adeniyi
- Adewale O Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian Palma
- Adrienne Ho
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahed Ghaben
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Ashour
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd El-Sameea
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Adamu
- Ahmed Al-Bahrani
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Alkhatib
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Dahy
- Ahmed El Kashash
- Ahmed El-Sehily
- Ahmed Essam
- Ahmed Farag
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed M Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed Mohamed Ibrahim
- Ahmed Moustafa
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Raza
- Ahmed Said Badr
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M Kandil
- Ahmedglal Elnagar
- Ahmet Murat Pektaş
- Aia Mehdi
- Aida Suarez
- Aidan Haslegrave
- Ainhoa Costas-Chavarri
- Aized Raza Shahbaz
- Akin Olaolorun
- Akinlabi Ajao
- Al Faifi Jubran
- Ala Shamasneh
- Alaa Al-Buhaisi
- Alaa Bowabsak
- Alaa El Jamassi
- Alaa Elazab
- Alaa Elhadad
- Alaa Fergany
- Alaa Shaheen
- Alaba Adesina
- Alberto Miyar de León
- Alberto Realis Luc
- Alejandro Matheu
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alex Makupe
- Alex Reece-Smith
- Alexander Canta Calua
- Alexander Smedley
- Alexandra Gerosa
- Alexia Farrugia
- Alexis Arnaud
- Alexis Pierre Arnaud
- Alfio Alessandro Russo
- Alfredo Gulielmi
- Ali Ababneh
- Ali Abo El Dahab
- Ali Adam
- Ali Guner
- Ali Khan Niazi
- Ali Mussad
- Aliaksandr Filatau
- Aliang Latif
- Alibeth Andres Baquero Suarez
- Alice Murray
- Alina Robledo-Rabanal
- Aline Broch
- Alissa Gübeli
- Alistair Rocke
- Aliyu Ndajiwo
- Alphonse Zeta Mutabazi
- Alvaro Enrique Mendoza Beleño
- Alvin Ee Zhiun Cheah
- Aly Abd-Elrazek
- Aly Sanad
- Alyaa Halim Elgendy
- Amal Ibrahim
- Amany Eldosouky Mohammed
- Amar Kourdouli
- Amgad Al Meligy
- Amina Abdelhamid
- Aminah Hanum Haji Abdul Majid
- Aminu Mohammad
- Amir Ait Kaci
- Amira Elsawy
- Amira Hassan Bekhet
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- Amjad Abu Qumbos
- Amjad Elmashala
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- Amna Mamdouh Mohamed
- Amna Mohamed
- Amr Ahmed Saleh
- Amr Hassaan
- Amr Hossameldin
- Amreen Faruq
- Amro Aglan
- Ana Lucia Contreras-Vergara
- Ana Maria Sandoval Barrantes
- Anahita Mansuri
- Anan Rady Abdelazeam
- Anass Majbar
- Anastasios Stefanopoulos
- Anders Thorell
- Andre L Mihaljevic
- Andre Navarro
- Andrea Armellini
- Andrea Belli
- Andrea Bondurri
- Andrea Craus-Miguel
- Andrea Natili
- Andrea Ruzzenente
- Andrea Simioni
- Andreass Haloho
- Andrejus Subocius
- Andrew Kirby
- Andrey Litvin
- Andrius Burmistrovas
- Angel David Pérez Rojas
- Angela Dell
- Angela Mazzella
- Angelica Genoveva Vergara Mejia
- Angeline Charles
- Angelo Antoniozzi
- Angelo Benevento
- Angelos Tselos
- Anil Kaul
- Anil Semiz
- Ankur Bhatnagar
- Anmar Homeida
- Anna Jeffery
- Anna Lasek
- Anna Maffioli
- Anna Rinaldi
- Anna Verbeek
- Annalisa Lo Conte
- Annamaria Bigaran
- Annisa Dewi Fitriana Mukin
- Antanas Gulbinas
- Antanas Zadoroznas
- Anthonius Santoso Rulie
- Anthony Ajiboye
- Anthony Avoka
- Anthony Chuk-Him Lai
- Anthony Davor
- Anthony Sander
- Antoinette Bediako-Bowan
- Antonella La Brocca
- Antonio Nocito
- Antonio Picardo
- Antonio Ramos-De la Medina
- Antonio Taddei
- Anwar Atiyeh
- Anyomih Theophilus Teddy Kojo
- April Camilla Roslani
- Aram Abdelhaq
- Arazzelly Del Pilar Paucar
- Arcangelo Picciariello
- Arestis Sokratous
- Arezo Kanani
- Ari Leppäniemi
- Ariadne L'Heveder
- Arianna Birindelli
- Arij Ibrahim
- Arjun Paramasivan
- Arlindawati Suyadi
- Armando José Román Velásquez
- Arnav Agarwal
- Aroub Alkaaki
- Arturas Vaicius
- Arvin Khamajeet
- Arvo Reinsoo
- Arwa Abouzaid
- Arwa Elfarargy
- Arwa Ibrahim
- Arwa Mohamed
- Asad Choudhry
- Asaf Kedar
- Asdaq Ahmed
- Aseel Alnusairat
- Aseel Hamarshi
- Aseel Musleh
- Ashish Gupta
- Ashish Minocha
- Ashraf Maghrabi
- Ashrafun Nessa
- Ashrarur Rahman Mitul
- Ashwath Bandi
- Asmaa Rezq
- Asmaa Salah
- Asnel Dorismé
- Aspasia Papailia
- Astrid Leusink
- Ataa Ahmed
- Athanasia Bamicha
- Athar Abbas
- Athirah Zulkifli
- Athula Tennakoon
- Attia Attia
- Audrey Clarissa
- Audrius Dulskas
- Audrius Parseliunas
- Augusto Zani
- Aurel Mironescu
- Aurel Sandu Mironescu
- Aurelien Scalabre
- Aurora Mariani
- Aurore Haffreingue
- Aurore Thollot
- Awais Raza
- Aya Abdelfatah Ibraheem
- Aya Adel Elsharkawy
- Aya El-Sawy
- Aya Firwana
- Aya Hammad
- Aya Mohamed Fathy
- Aya Reda
- Aya Yehia Ata
- Ayah Hamdan
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- Ayman And Taher
- Ayman Salman
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- Azher Herebat
- Babajide Adenekan
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- Bakeer Mohamed
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- Bashir Bello
- Basma Mahmoud
- Basmah Alhassan
- Bassant Mowafy
- Beatrice Brunoni
- Behrad Barmayehvar
- Belen Sanchez
- Benogreît Parmentier
- Berk Baris Ozmen
- Berna Buse Kobal
- Bernard Limoges
- Bernhard Wolf
- Bertrand Dousset
- Besmir Grizhja
- Bettina Lieske
- Betty Maillot
- Bogdan Diaconescu
- Britta Dedekind
- Bruno Noukpozounkou
- Busra Murutoglu
- Bárbara Málaga
- Calogero Iacono
- Calvin Eng
- Cameron Fairfield
- Camila Sanchez Samaniego
- Camilla Cona
- Can Adiyaman
- Carla Soldevila-Verdeguer
- Carlo Corbellini
- Carlos Nsengiyumva
- Carlos Paz Galvez
- Carly Bisset
- Carmen Capito
- Carmen Fernández
- Carmen García Bernardo
- Carmina Diaz Zorrilla
- Carolina Guzmán Dueñas
- Caroluce K Musyoka
- Catherine A Shaw
- Catrin Jones
- Catrin Morgan
- Cecile Muller
- Cecilia Costa
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- Charles Dally
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- Chelise Currow
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- Chi Chung Foo
- Chi Ying Jacquelyn Fok
- Chia Kong
- Chimwemwe Kwatiwani
- Chingwan Yip
- Chloe Roy
- Choon Seng Chong
- Chouikh Taieb
- Choy Ling Tan
- Chris Bode
- Christel Leanne Almanon
- Christian Lari Coompson
- Christina Panteli
- Christine Mizzi
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- Christopher Owen
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- Chu-Ann Chai
- Chui Yee Wong
- Cicilia Viany Evajelista
- Ciskje Zarb
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- Claire Sharpin
- Clare Skerritt
- Claudia Reali
- Claudio Arcudi
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- Clement Onuoha
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- Cornelius Mukuzunga
- Corrado Bottini
- Cristina Fernandes
- Cristina Pineño-Flores
- Crystal Yern Nee Chow
- Céline Grosos
- D C Grobler
- Damir Ljuhar
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- Daniela Magri
- Daniele Angelieri
- Daniele Gui
- Danilo Herrera Cruz
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- Dansou Gaspard Gbessi
- Dario Andreotti
- David Ambrona-Zafra
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- Dayang Nita Abdul Aziz
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- Ernest Yemalin Stephane Ahounou
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- Eyad Khalifah
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- Giedrius Lauzikas
- Giles Bond-Smith
- Gintaras Simutis
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- Giovanni Landolfo
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- Giuliano Borda-Luque
- Giuseppe Clerico
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- Greg Padmore
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- Greta Wood
- Greta Žiubrytė
- Grzegorz Zuk
- Guillaume Podevin
- Guillermo Sanchez Rosenberg
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- Tariq Alhammali
- Tasneem Idress
- Tasnia Hamid Kanta
- Tatsiana Shachykava
- Tebian Hassanein Ahmed Ali
- Tewodros Worku
- Thamer Nouh
- Thandinkosi Madiba
- Tharindra Dissanayake
- Thays Brunelli Pugliesi
- Thea Dimech
- Thelma Tembo
- Theodore Pezas
- Theodosios Theodosopoulos
- Therese Duane
- Thierry Alihonou
- Thomas Feidantsis
- Thomas Kidd
- Thomas M Drake
- Thomas Mann
- Thomas Olagboyega Olajide
- Thomas Pinkney
- Thomas Prudhomme
- Thomas Tetens Moe
- Tien Seng Bryan Lee
- Tina Gaarder
- Tobias Schuetz
- Todisoa Emmanuella Christina Tolotra
- Tolg Cecilia
- Tom Abbott
- Tom Arthur
- Tomas Abaliksta
- Tomas Jankus
- Tomas Poskus
- Tomas Poškus
- Tomas Urbonas
- Tommaso Bocchetti
- Tommaso Campagnaro
- Tommaso Fontana
- Toqa Khafagy
- Torhild Veen
- Tsz-Yan Katie Chan
- Tuan Nur'Azmah Tuan Mat
- Tunde Sholadoye
- Turgut Bora Cengiz
- Twc Mak
- Tyler Rouse
- Tzu-Ling Chen
- Uday Muddebihal
- Umar Muktar
- Umberto Tedeschi
- Umme Salma
- Usama Hantour
- Uttaran Datta
- Vahit Mutlu
- Valdemaras Jotautas
- Valeria Andriola
- Vanessa Msosa
- Vania Guglielmo
- Vania Silvestri
- Vasileios Kalles
- Vasiliki Soulou
- Vassilis Kalles
- Vedatcan Işler
- Veeranna Shatkar
- Venerand Barendegere
- Veronica Lazzari
- Vicky Jennings
- Victor Dassah
- Victor Etwire
- Victor Kong
- Victor Nwinee
- Vijaid Upadhyaya
- Viktorija Nevieraite
- Ville Sallinen
- Vincas Jonas Banaitis
- Virginia Jiménez Carneros
- Virginia Ramos Pérez
- Viviana Sollazzo
- Vladimir Khokha
- Volkan Ozben
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wadah Ali
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Weihei Dao
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wiktor Rutkowski
- William Appeadu-Mensah
- William Bonney
- William English
- Willy Alcca Ticona
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yasmin Elfouly
- Yasmin Soliman
- Ye Ru Chin
- Yee Wen Tan
- Yehia Zakaria
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yoshan Moodley
- Yousef Abuowda
- Ysabel Esthefany Alejos Bermúdez
- Yucel Cengiz
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yun Lin Ang
- Yung Kok Ng
- Yuri Macchitella
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zakaria Rob
- Zhan Herr Ng
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Ömer Faruk Toto
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings. Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI). Results Of 1159 children across 181 hospitals in 51 countries, 523 (45 center dot 1%) children were from high HDI, 397 (34 center dot 2%) from middle HDI and 239 (20 center dot 6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12 center dot 8% (51/397) in middle HDI and 24 center dot 7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI. Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.Peer reviewe