Peritoneal carcinomatosis of colorectal origin

Peritoneal carcinomatosis is, after liver metastases, the second most frequent cause of death in colorectal cancer patients and at the present time, is commonly inserted and treated as a stage IV tumour. Because there is no published data that outlines the impact of new therapeutic regimens on survival of patients with peritoneal surface diffusion, the story of carcinomatosis can be rewritten in light of a new aggressive approach based on the combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Also if these treatment perhaps allow to obtain better results than standard therapies, we suggest, that a large prospective randomised control trial is needed to compare long-term and progression-free survival under the best available systemic therapy with or without cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Meteonetwork: An Open Crowdsourced Weather Data System

Citizen science has shown great potential for bringing large groups of people closer to science, thanks in part to cooperation with universities and research centers. In this context, amateur weather networks played a major role in the last few decades thanks to a constant growth in technology. An example is given by the Meteonetwork association, born in 2002, and mainly composed by atmospheric science enthusiasts, who built up in time a huge weather station network in Italy. In recent years, they have enlarged their horizons over Europe, displaying real time observations and daily maps coming from both personal weather stations and official networks. This study described how Meteonetwork has set up an open crowdsourced weather data system, how data are validated, and which products are generated and freely accessible for scientists and stakeholders for their own purposes. Two concrete use cases were described as examples: the Weatherness Project, which selects a subnet of Meteonetwork data for biometeorological and health purposes and the data assimilation process implemented to improve the initial conditions into the WRF meteorological model for daily weather forecasts

Erythropoiesis-stimulating agents: dose and mortality risk

Hypo-responsiveness to erythropoiesis-stimulating agents (ESAs) has been associated with increased mortality in end-stage renal disease patients. It is not clear if this effect is related to the elevated ESAs dosage for targeting hemoglobin levels or underlying morbid conditions that lead to ESA resistance. We retrospectively evaluated from 2008 to death or December 2011, 28 consecutive incident hemodialysis patients. We identified 2 cohort of patients based on their mean annual ESAs dosage. The correlation between data was evaluated with the Spearman's rho test. Kaplan-Meier curves were generated to assess survival in subjects with high and low ESAs mean dose. Median ESAs dosage, used as a cutoff point between patients at high and low ESAs dose, was at 11.000 IU/week for epoetin alfa and beta, 55 mcg/week for darbopoietin, and 220 mcg/month for cera. Mean hemoglobin (Hb) level was 10.58\ua0\ub1\ua00.13\ua0g/dL. Of 28 patients, during follow-up, 6 (21,4%) died of all causes. High-dose ESA therapy was associated with increased all-cause mortality (P\ua0=\ua0.047). Moreover, there was a negative correlation between ESAs dose and Hb levels (rho\ua0=\ua0-0.825; P\ua0<\ua0.001). Higher ESAs dose for the treatment of anemia in incident hemodialysis patients was associated with higher mortality risk. ESAs and Hb serum levels were inversely correlated with mortality. Together, these findings suggest that ESAs dosage and Hb level may play a role through an independent manner or an interactive effect that adversely affects mortality

Variability in the mountain environment at Melka Kunture archaeological site, Ethiopia, during the Early Pleistocene (~1.7 Ma) and the Mid-Pleistocene Transition (0.9–0.6 Ma)

In this paper, we present and discuss pollen data from the Early Pleistocene (1.8 to 1.6 Ma) – we use the revised timescale approved by IUGS, in which the base of the Pleistocene is defined by the GSSP of the Gelasian Stage at 2.588 (2.6) Ma (Gibbard et al. 2010) – and from the Mid-Pleistocene Transition (0.9 to 0.6 Ma) at Melka Kunture (Upper Awash, Ethiopia). At 2000 m asl in the Ethiopian highlands, these deposits yield many rich and successive archaeological sites, notably documenting the late Oldowan, the emergence of the Acheulean and the middle Acheulean. The stratigraphic position of the fifteen pollen samples is checked by 40Ar/39Ar dating and by geological investigation. Furthermore, they are now correlated to archaeological layers whose excavated lithic industries have been reinterpreted. Our study shows that mountain forest trees belonging to the present-day Afromontane complex were already established in Ethiopia at ~1.8 Ma and that the knappers of the Oldowan and early Acheulean could cope with mountain climatic conditions that had a large diurnal temperature range. Moreover, the new interpretation of pollen results emphasizes changes that occurred in the vegetation cover at 200- or 300-thousand-year snapshot intervals, one during the Early Pleistocene and another one later on, during the Mid-Pleistocene Transition. These changes concerned plant species and their respective abundance and appear to have been related to rainfall and temperature variability. The proportion of forest trees increased during wet episodes, whereas the influence of Afroalpine grassland indicators increased during cool and dry episodes. Variations in Early Pleistocene pollen data from Melka Kunture at ~1.8–1.6 Ma are consistent with isotopic evidence of precession variability as recorded at Olduvai and Turkana archaeological sites at ~2–1.8 Ma. For the Mid-Pleistocene Transition, variations in pollen data seem to match the climatic variability of isotopic and long pollen records from the Mediterranean region, notably upon the onset of dominant 100 ka-long glacial/interglacial cycles