Alamu al Jinni : fi Dho`i al kitabi wa al sunnati

621 hlm,; 25 c

<i>linc00673 (ERRLR01)</i> is a prognostic indicator of overall survival in breast cancer

<p>LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (<i>ERRLR01</i>) as a marker of overall survival (OS) in breast cancer patients. Specifically, <i>ERRLR01</i> levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. <i>ERRLR01</i> levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα⁻ tumors correlated with negative overall survival, while in ERα⁺ tumors, <i>ERRLR01</i> correlated with positive outcomes. This suggests <i>ERRLR01</i> is modulated by hormone signaling in breast cancer. Gene-network analysis revealed <i>ERRLR01</i> correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest <i>ERRLR01</i> operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.</p

Serotypes, antimicrobial profiles, and public health significance of Salmonella from camels slaughtered in Maiduguri central abattoir, Nigeria

Aim: This study aimed at determining the serotypes, antimicrobial profiles, and public health importance of Salmonella strains from camels slaughtered at Maiduguri central abattoir, Nigeria. Materials and Methods: Two hundred samples were obtained from camel comprising of intestines, feces, liver, and spleen (n=50 each). Non-lactose fermenting dark center Salmonella colonies were identified using standard biochemical techniques, serotyped and subjected to antimicrobial susceptibility test using minimum inhibition concentration method. Results: Out of the 200 samples collected, 17 were Salmonella positive (spleen=7, intestine=6, feces=3, and liver=1) with a prevalence of 8.5%. Five serotypes comprising Salmonella Eko, 7 (3.5%), Salmonella Uganda, 4 (2.0%), Salmonella Amager, 2 (1.0%), Salmonella Westhampton, 2 (1.0%), and Salmonella Give, 2 (1.0%) were incriminated. Majority of the serotypes were sensitive to the antimicrobials, but one Salmonella Amager exhibited resistance to streptomycin, and one each of Salmonella Uganda and Salmonella Eko were resistant to sulfamethoxazole. Conclusion: This study revealed the prevalence and the antibiotic resistance profile of newly emerging Salmonella from camels in the northeast of Nigeria, which can serve as a means for the transmission of Salmonella to human. Therefore, there is a need for the establishment of national Salmonella surveillance and control programs