Sleep is required to consolidate odor memory and remodel olfactory synapses

Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear if, in any system, sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures

The chemical evolution of a Milky Way-like galaxy: the importance of a cosmologically motivated infall law

We aim at finding a cosmologically motivated infall law to understand if the LambdaCDM cosmology can reproduce the main chemical characteristics of a Milky Way-like spiral galaxy. In this work we test several different gas infall laws, starting from that suggested in the two-infall model for the chemical evolution of the Milky Way by Chiappini et al., but focusing on laws derived from cosmological simulations which follows a concordance LambdaCDM cosmology. By means of a detailed chemical evolution model for the solar vicinity, we study the effects of the different gas infall laws on the abundance patterns and the G-dwarf metallicity distribution. The cosmological gas infall law predicts two main gas accretion episodes. By means of this cosmologically motivated infall law, we study the star formation rate, the SNIa and SNII rate, the total amount of gas and stars in the solar neighbourhood and the behaviour of several chemical abundances. We find that the results of the two-infall model are fully compatible with the evolution of the Milky Way with cosmological accretion laws. A gas assembly history derived from a DM halo, compatible with the formation of a late-type galaxy from the morphological point of view, can produce chemical properties in agreement with the available observations.Comment: This paper has 26 pages, 19 figures and 5 table

JASMINE: Near-infrared astrometry and time-series photometry science

The Japan Astrometry Satellite Mission for INfrared Exploration (JASMINE) is a planned M-class science space mission by the Institute of Space and Astronautical Science, the Japan Aerospace Exploration Agency. JASMINE has two main science goals. One is Galactic archaeology with a Galactic Center survey, which aims to reveal the Milky Way’s central core structure and formation history from Gaia-level (∼25 ${\mu}$as) astrometry in the near-infrared (NIR) Hw band (1.0–1.6 ${\mu}$m). The other is an exoplanet survey, which aims to discover transiting Earth-like exoplanets in the habitable zone from NIR time-series photometry of M dwarfs when the Galactic Center is not accessible. We introduce the mission, review many science objectives, and present the instrument concept. JASMINE will be the first dedicated NIR astrometry space mission and provide precise astrometric information on the stars in the Galactic Center, taking advantage of the significantly lower extinction in the NIR. The precise astrometry is obtained by taking many short-exposure images. Hence, the JASMINE Galactic Center survey data will be valuable for studies of exoplanet transits, asteroseismology, variable stars, and microlensing studies, including discovery of (intermediate-mass) black holes. We highlight a swath of such potential science, and also describe synergies with other missions

Early galaxy formation and its large-scale effects

Galaxy formation is at the heart of our understanding of cosmic evolution. Although there is a consensus that galaxies emerged from the expanding matter background by gravitational instability of primordial fluctuations, a number of additional physical processes must be understood and implemented in theoretical models before these can be reliably used to interpret observations. In parallel, the astonishing recent progresses made in detecting galaxies that formed only a few hundreds of million years after the Big Bang is pushing the quest for more sophisticated and detailed studies of early structures. In this review, we combine the information gleaned from different theoretical models/studies to build a coherent picture of the Universe in its early stages which includes the physics of galaxy formation along with the impact that early structures had on large-scale processes as cosmic reionization and metal enrichment of the intergalactic medium

\u3ci\u3eC. elegans\u3c/i\u3e avoids toxin-producing \u3ci\u3eStreptomyces\u3c/i\u3e using a seven transmembrane domain chemosensory receptor

Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator–prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to Streptomyces at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of Streptomyces secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation represents an important strategy for the nematode, which utilizes specialized sensory organs and a chemoreceptor that is tuned to recognize the bacteria. These findings provide a window into the molecules and organs used in the coevolutionary arms race between predator and potential prey