Perspectives of youth and reading - a case-study of youth beliefs regarding reading at 10th grade

Mastergradsoppgave i kultur- og språkfagenes didaktikk, Avdeling for lærerutdanning og naturvitenskap, Høgskolen i Hedmark, 2014.Norsk: I denne masteroppgaven har jeg undersøkt åtte ungdommers forhold til egen lesing. Lesing er en vesentlig del av vår hverdag og vi lever hektiske liv som krever mer og mer av vår lesekompetanse og leseforståelse. I vårt samfunn blir gode leseferdigheter ofte regnet som en inngangsbillett til viktig informasjonshenting og tilegnelse av ny kunnskap, noe som gjelder på stort sett alle arenaer. Som lesere må vi igjennom mange situasjoner der vi bruker tekster som vi leser til flere ulike formål. Jeg har gjennomført en kvalitativ undersøkelse og innsamlingen av empiriske data har primært foregått gjennom halvstrukturerte, åpne intervjuer. Sekundært har jeg gjort observasjoner av elevene i forskjellige undervisningssituasjoner. Jeg har valgt et flerkasusdesign, siden hvert av individene må ses på som et eget kasus. Det mest fremtredende funnet i undersøkelsen er at elever på tiende trinn har et variert syn på hva lesing er, samt ulike oppfatninger av leseopplevelser. Et annet funn sier at samtlige elever uttrykker at de verdsetter lesing høyt og ser på det som betydningsfullt. Kjønnsforskjellene er også vesentlige. Grovt sett kan vi si at guttene leser for å tilegne seg mer kunnskap som kan bedre karakterene i skolen, mens jentene stort sett leser for å oppnå optimale leseopplevelser. Observasjonene forteller at guttene er mer aktive enn jentene i tradisjonell undervisning og i diskusjoner i klasserommet. Jentene foretrekker først og fremst gruppearbeid som undervisningsmetode. Min undersøkelse kan forhåpentligvis være et bidrag til en bedre forståelse av ungdoms syn på lesing, deres lesevaner og forholdet de har til sin egen leseutvikling og leseforståelse. Den kan også ses på som en utfordrer til andre undersøkelser som fokuserer dypere på hvert enkelt individ. Benyttelsen av flerkasusdesignet har ført til en bedre forståelse av min problemstilling. Jeg håper dermed at denne masteroppgaven kan bidra til videre forskning innenfor emnet ungdom og lesing.English: In this master thesis I have studied eight youth beliefs regarding their own reading. Reading is a significant part of our everyday life. We live hectic lives which require more and more of our understanding of literacy and skills in reading. Strong reading abilities are often considered as an important admission to essential information and acquisition of new knowledge in any level of our society. As readers, we need to recognise countless situations in use of texts in a large number of different purposes. I have conducted a qualitative study, and the collection of empirical data has primarily been obtained through semi-structured and open interviews. Secondary, I have localised observations of my pupils in different learning situations. I have chosen a multiple-casedesign, considering the fact of each individual being a separate case. The most prominent finding in my study is that students at 10th grade possessing a varied possess of reading and various perceptions of reading experiences. An other finding is the fact that all the respondents are expressing the value and significant of reading. The gender differences are also important. On a general basis, the boys read to acquire more knowledge to achieve higher grades at school, while the girls mainly seek the optimal reading experiences. The observations show higher activity among the boys in the more traditional classes. The girls prefer working in groups. My study will hopefully contribute as a more profound understanding of the youth beliefs about - and habits of reading. Reading development and reading comprehension are also essential topics of my study. My master thesis may challenge similar studies focusing on individuals. The use of the multiple-case-design is leading towards a higher understanding of my research question. I sincerely hope this master thesis will be considered as a contribution to future research within the area of youth and reading

Stochastic master surgery scheduling

The aim of the Master Surgery Scheduling Problem (MSSP) is to schedule the medical specialties to the different operating rooms available, such that surgeries may be performed efficiently. We consider a MSSP where elective and emergency patients can be treated in the same operating rooms. In addition to elective-dedicated operating room slots, flexible operating room slots are introduced to handle the fluctuating demand of emergency patients. To solve the MSSP, we propose a simulation-optimization approach consisting of a two-stage stochastic optimization model and a discrete-event simulation model. For the two-stage stochastic optimization model, uncertain arrivals of emergency patients are represented by discrete scenarios. The discrete-event simulation model is developed to address uncertainty related to the surgery duration and the length of stay at the hospital, and to test the Master Surgery Schedule (MSS) developed by the optimization model in a stochastic operational-level environment. In addition, the simulation model is used to generate scenarios for the optimization model. We present some general advice for surgery scheduling based on testing the optimization model in a numerical study. The simulation-optimization approach is applied to a case study from a hospital department that treats both elective and emergency patients. The optimized MSS outperforms the manually generated MSS, both in terms of emergency waiting time for surgery, and emergency interruptions to the flow of electives.acceptedVersio

Offering a Free Online Program to Maintain Weight Over the Holiday Season

The Holiday Challenge is a free weight maintenance program offered from Thanksgiving to New Year\u27s Eve. Ninety-three percent of participants maintained or lost weight during the 2014 Holiday Challenge, and 99% said they were very likely to somewhat likely to participate again in the 2015 Holiday Challenge

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions

SummaryAge can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging—reduced endocytosis and protein aggregation—are interconnected and regulated by Vac17

AGRICOH: A Consortium of Agricultural Cohorts

AGRICOH is a recently formed consortium of agricultural cohort studies involving 22 cohorts from nine countries in five continents: South Africa (1), Canada (3), Costa Rica (2), USA (6), Republic of Korea (1), New Zealand (2), Denmark (1), France (3) and Norway (3). The aim of AGRICOH, initiated by the US National Cancer Institute (NCI) and coordinated by the International Agency for Research on Cancer (IARC), is to promote and sustain collaboration and pooling of data to investigate the association between a wide range of agricultural exposures and a wide range of health outcomes, with a particular focus on associations that cannot easily be addressed in individual studies because of rare exposures (e.g., use of infrequently applied chemicals) or relatively rare outcomes (e.g., certain types of cancer, neurologic and auto-immune diseases). To facilitate future projects the need for data harmonization of selected variables is required and is underway. Altogether, AGRICOH provides excellent opportunities for studying cancer, respiratory, neurologic, and auto-immune diseases as well as reproductive and allergic disorders, injuries and overall mortality in association with a wide array of exposures, prominent among these the application of pesticides

The CRCbiome study : a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants

Background: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary screening methods. To aid in the development of a non-invasive screening test with improved sensitivity and specificity, we have initiated a prospective biomarker study (CRCbiome), nested within a large randomized CRC screening trial in Norway. We aim to develop a microbiome-based classification algorithm to identify advanced colorectal lesions in screening participants testing positive for an immunochemical fecal occult blood test (FIT). We will also examine interactions with host factors, diet, lifestyle and prescription drugs. The prospective nature of the study also enables the analysis of changes in the gut microbiome following the removal of precancerous lesions. Methods: The CRCbiome study recruits participants enrolled in the Bowel Cancer Screening in Norway (BCSN) study, a randomized trial initiated in 2012 comparing once-only sigmoidoscopy to repeated biennial FIT, where women and men aged 50-74 years at study entry are invited to participate. Since 2017, participants randomized to FIT screening with a positive test result have been invited to join the CRCbiome study. Self-reported diet, lifestyle and demographic data are collected prior to colonoscopy after the positive FIT-test (baseline). Screening data, including colonoscopy findings are obtained from the BCSN database. Fecal samples for gut microbiome analyses are collected both before and 2 and 12 months after colonoscopy. Samples are analyzed using metagenome sequencing, with taxonomy profiles, and gene and pathway content as primary measures. CRCbiome data will also be linked to national registries to obtain information on prescription histories and cancer relevant outcomes occurring during the 10 year follow-up period. Discussion: The CRCbiome study will increase our understanding of how the gut microbiome, in combination with lifestyle and environmental factors, influences the early stages of colorectal carcinogenesis. This knowledge will be crucial to develop microbiome-based screening tools for CRC. By evaluating biomarker performance in a screening setting, using samples from the target population, the generalizability of the findings to future screening cohorts is likely to be high.Peer reviewe

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Do-not-attempt-cardiopulmonary-resuscitation decisions : an evidence synthesis

Background: Cardiac arrest is the final common step in the dying process. In the right context, resuscitation can reverse the dying process, yet success rates are low. However, cardiopulmonary resuscitation (CPR) is a highly invasive medical treatment, which, if applied in the wrong setting, can deprive the patient of dignified death. Do-not-attempt-cardiopulmonary-resuscitation (DNACPR) decisions provide a mechanism to withhold CPR. Recent scientific and lay press reports suggest that the implementation of DNACPR decisions in NHS practice is problematic. Aims and objectives: This project sought to identify reasons why conflict and complaints arise, identify inconsistencies in NHS trusts’ implementation of national guidelines, understand health professionals’ experience in relation to DNACPR, its process and ethical challenges, and explore the literature for evidence to improve DNACPR policy and practice. Methods: A systematic review synthesised evidence of processes, barriers and facilitators related to DNACPR decision-making and implementation. Reports from NHS trusts, the National Reporting and Learning System, the Parliamentary and Health Service Ombudsman, the Office of the Chief Coroner, trust resuscitation policies and telephone calls to a patient information line were reviewed. Multiple focus groups explored service-provider perspectives on DNACPR decisions. A stakeholder group discussed the research findings and identified priorities for future research. Results: The literature review found evidence that structured discussions at admission to hospital or following deterioration improved patient involvement and decision-making. Linking DNACPR to overall treatment plans improved clarity about goals of care, aided communication and reduced harms. Standardised documentation improved the frequency and quality of recording decisions. Approximately 1500 DNACPR incidents are reported annually. One-third of these report harms, including some instances of death. Problems with communication and variation in trusts’ implementation of national guidelines were common. Members of the public were concerned that their wishes with regard to resuscitation would not be respected. Clinicians felt that DNACPR decisions should be considered within the overall care of individual patients. Some clinicians avoid raising discussions about CPR for fear of conflict or complaint. A key theme across all focus groups, and reinforced by the literature review, was the negative impact on overall patient care of having a DNACPR decision and the conflation of ‘do not resuscitate’ with ‘do not provide active treatment’. Limitations: The variable quality of some data sources allows potential overstatement or understatement of findings. However, data source triangulation identified common issues. Conclusion: There is evidence of variation and suboptimal practice in relation to DNACPR decisions across health-care settings. There were deficiencies in considering, discussing and implementing the decision, as well as unintended consequences of DNACPR decisions being made on other aspects of patient care. Future work: Recommendations supported by the stakeholder group are standardising NHS policies and forms, ensuring cross-boundary recognition of DNACPR decisions, integrating decisions with overall treatment plans and developing tools and training strategies to support clinician and patient decision-making, including improving communication. Study registration: This study is registered as PROSPERO CRD42012002669. Funding: The National Institute for Health Research Health Services and Delivery Research programme

The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C

Functional significance of the taper of vertebrate cone photoreceptors

© The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of General Physiology 139 (2012): 159-187, doi:10.1085/jgp.201110692.Vertebrate photoreceptors are commonly distinguished based on the shape of their outer segments: those of cones taper, whereas the ones from rods do not. The functional advantages of cone taper, a common occurrence in vertebrate retinas, remain elusive. In this study, we investigate this topic using theoretical analyses aimed at revealing structure–function relationships in photoreceptors. Geometrical optics combined with spectrophotometric and morphological data are used to support the analyses and to test predictions. Three functions are considered for correlations between taper and functionality. The first function proposes that outer segment taper serves to compensate for self-screening of the visual pigment contained within. The second function links outer segment taper to compensation for a signal-to-noise ratio decline along the longitudinal dimension. Both functions are supported by the data: real cones taper more than required for these compensatory roles. The third function relates outer segment taper to the optical properties of the inner compartment whereby the primary determinant is the inner segment’s ability to concentrate light via its ellipsoid. In support of this idea, the rod/cone ratios of primarily diurnal animals are predicted based on a principle of equal light flux gathering between photoreceptors. In addition, ellipsoid concentration factor, a measure of ellipsoid ability to concentrate light onto the outer segment, correlates positively with outer segment taper expressed as a ratio of characteristic lengths, where critical taper is the yardstick. Depending on a light-funneling property and the presence of focusing organelles such as oil droplets, cone outer segments can be reduced in size to various degrees. We conclude that outer segment taper is but one component of a miniaturization process that reduces metabolic costs while improving signal detection. Compromise solutions in the various retinas and retinal regions occur between ellipsoid size and acuity, on the one hand, and faster response time and reduced light sensitivity, on the other.This work was funded by the Natural Sciences and Engineering Research Council of Canada Discovery Grant 238886 and a Grass-Marine Biological Laboratory Sabbatical Fellowship in Neurosciences to I. Novales Flamarique.2012-07-1