The Future of the Jews: Planning for the Postwar Jewish World, 1939-1946

This dissertation examines a key transformation in the history of Jewish nationalism in the 1940s - the decline of autonomist visions in Jewish national thought oriented toward Jewish life as a minority community in Eastern Europe, and the emergence of a Jewish ethnic-nation state in Palestine as the dominant mode of Jewish national expression. The main argument advanced in this dissertation is that this shift cannot be explained exclusively as a Jewish response to the Holocaust, but ought to situated as part of the larger process of the homogenization of the nation- state in East Central Europe during the war and in its immediate aftermath through genocide and ethnic cleansing, population transfers and the rejection of international norms regarding the protection of minorities. Drawing on a variety of archival and published sources in Hebrew, Yiddish and English, this study reconstructs the vibrant Jewish postwar planning scene in New- York, Palestine and London. From the start of the war tens of Jewish leaders and scholars, many whom had bee recent refugees from Europe, turned to plan for the Jewish future after the war. This dissertation examines how these Jewish leaders and thinkers grappled with the question of the future of the Jews as they debated whether Jews would be able reintegrate into Eastern Europe after the war, learned about the extermination of European Jewry and observed the ethnic transformation of the multiethnic East Central European landscape through wartime and postwar population transfers and ethnic cleansing

Molecular gas in NUclei of GAlaxies (NUGA). XI. A complete gravity torque map of NGC4579: new clues on bar evolution

We create a complete gravity torque map of the disk of the LINER/Seyfert 1.9 galaxy NGC4579. We quantify the efficiency of angular momentum transport and search for signatures of secular evolution in the fueling process from r~15kpc down to the inner r~50pc around the Active Galactic Nucleus (AGN). We use both the 1-0 and 2-1 line maps of CO obtained with the Plateau de Bure Interferometer (PdBI) as part of the NUclei of Galaxies-(NUGA)-project. We derive the stellar potential from a NIR (K band) wide field image of the galaxy. The K-band image, which reveals a stellar bar, together with a high resolution HI map of NGC4579 obtained with the Very Large Array (VLA), allow us to extend the gravity torque analysis to the outer disk. The bulk of the gas response traced by the CO PdBI maps follows the expected gas flow pattern induced by the bar potential in the presence of two Inner Lindblad Resonances (ILR). We also detect an oval distortion in the inner r~200pc of the K-band image. The oval is not aligned with the large-scale bar, a signature of dynamical decoupling. The morphology of the outer disk suggests that the neutral gas is currently piling up in a pseudo-ring formed by two winding spiral arms that are morphologically decoupled from the bar structure. In the outer disk, the decoupling of the spiral allows the gas to efficiently produce net gas inflow on intermediate scales. The corotation barrier seems to be overcome due to secular evolution processes. The gas in the inner disk is efficiently funneled by gravity torques down to r~300pc. Closer to the AGN, the two m=2 modes (bar and oval) act in concert to produce net gas inflow down to r~50pc, providing a clear smoking gun evidence of fueling with associated short dynamical time-scales.Comment: Submitted for publication in A&A. 21 pages, 21 figure

Molecular Gas in NUclei of GAlaxies (NUGA) XIV. The barred LINER/Seyfert 2 galaxy NGC 3627

We present CO(1-0) and CO(2-1) maps of the interacting barred LINER/Seyfert 2 galaxy NGC 3627 obtained with the IRAM interferometer at resolutions of 2.1" x 1.3" and 0.9" x 0.6", respectively. The molecular gas emission shows a nuclear peak, an elongated bar-like structure of ~18" (~900 pc) diameter in both CO maps and, in CO(1-0), a two-arm spiral feature from r~9" (~450 pc) to r~16" (~800 pc). The inner ~18" bar-like structure, with a north/south orientation (PA = 14{\deg}), forms two peaks at the extremes of this elongated emission region. The kinematics of the inner molecular gas shows signatures of non-circular motions associated both with the 18" bar-like structure and the spiral feature detected beyond it. The 1.6 micron H-band 2MASS image of NGC 3627 shows a stellar bar with a PA = -21{\deg}, different from the PA (= 14{\deg}) of the CO bar-like structure, indicating that the gas is leading the stellar bar. The torques computed with the HST-NICMOS F160W image and our PdBI maps are negative down to the resolution limit of our images, ~60 pc in CO(2-1). If the bar ends at ~3 kpc, coincident with corotation (CR), the torques are negative between the CR of the bar and the nucleus, down to the resolution limit of our observations. This scenario is compatible with a recently-formed rapidly rotating bar which has had insufficient time to slow down because of secular evolution, and thus has not yet formed an inner Lindblad resonance (ILR). The presence of molecular gas inside the CR of the primary bar, where we expect that the ILR will form, makes NGC 3627 a potential smoking gun of inner gas inflow. The gas is fueling the central region, and in a second step could fuel directly the active nucleus.Comment: 24 pages, 28 figures, 2 tables. Accepted for publication in Astronomy and Astrophysic

Results from PAMELA, ATIC and FERMI : Pulsars or Dark Matter ?

It is well known that the dark matter dominates the dynamics of galaxies and clusters of galaxies. Its constituents remain a mystery despite an assiduous search for them over the past three decades. Recent results from the satellite-based PAMELA experiment detect an excess in the positron fraction at energies between 10-100 GeV in the secondary cosmic ray spectrum. Other experiments namely ATIC, HESS and FERMI show an excess in the total electron (\ps + \el) spectrum for energies greater 100 GeV. These excesses in the positron fraction as well as the electron spectrum could arise in local astrophysical processes like pulsars, or can be attributed to the annihilation of the dark matter particles. The second possibility gives clues to the possible candidates for the dark matter in galaxies and other astrophysical systems. In this article, we give a report of these exciting developments.Comment: 27 Pages, extensively revised and significantly extended, to appear in Pramana as topical revie

Prospects for K+→π+ννˉK^+ \to \pi^+ \nu \bar{ \nu } at CERN in NA62

The NA62 experiment will begin taking data in 2015. Its primary purpose is a 10% measurement of the branching ratio of the ultrarare kaon decay $K^+ \to \pi^+ \nu \bar{ \nu }$, using the decay in flight of kaons in an unseparated beam with momentum 75 GeV/c.The detector and analysis technique are described here.Comment: 8 pages for proceedings of 50 Years of CP

Indication for the disappearance of reactor electron antineutrinos in the Double Chooz experiment

The Double Chooz Experiment presents an indication of reactor electron antineutrino disappearance consistent with neutrino oscillations. A ratio of 0.944 $\pm$ 0.016 (stat) $\pm$ 0.040 (syst) observed to predicted events was obtained in 101 days of running at the Chooz Nuclear Power Plant in France, with two 4.25 GW$_{th}$ reactors. The results were obtained from a single 10 m$^3$ fiducial volume detector located 1050 m from the two reactor cores. The reactor antineutrino flux prediction used the Bugey4 measurement as an anchor point. The deficit can be interpreted as an indication of a non-zero value of the still unmeasured neutrino mixing parameter \sang. Analyzing both the rate of the prompt positrons and their energy spectrum we find \sang = 0.086 $\pm$ 0.041 (stat) $\pm$ 0.030 (syst), or, at 90% CL, 0.015 $<$ \sang $\ <$ 0.16.Comment: 7 pages, 4 figures, (new version after PRL referee's comments

AMP-Activated Kinase AMPK Is Expressed in Boar Spermatozoa and Regulates Motility

The main functions of spermatozoa required for fertilization are dependent on the energy status and metabolism. AMP-activated kinase, AMPK, acts a sensor and regulator of cell metabolism. As AMPK studies have been focused on somatic cells, our aim was to investigate the expression of AMPK protein in spermatozoa and its possible role in regulating motility. Spermatozoa from boar ejaculates were isolated and incubated under different conditions (38,5°C or 17°C, basal medium TBM or medium with Ca2+ and bicarbonate TCM, time from 1–24 hours) in presence or absence of AMPK inhibitor, compound C (CC, 30 µM). Western blotting reveals that AMPK is expressed in boar spermatozoa at relatively higher levels than in somatic cells. AMPK phosphorylation (activation) in spermatozoa is temperature-dependent, as it is undetectable at semen preservation temperature (17°C) and increases at 38,5°C in a time-dependent manner. AMPK phosphorylation is independent of the presence of Ca2+ and/or bicarbonate in the medium. We confirm that CC effectively blocks AMPK phosphorylation in boar spermatozoa. Analysis of spermatozoa motility by CASA shows that CC treatment either in TBM or in TCM causes a significant reduction of any spermatozoa motility parameter in a time-dependent manner. Thus, AMPK inhibition significantly decreases the percentages of motile and rapid spermatozoa, significantly reduces spermatozoa velocities VAP, VCL and affects other motility parameters and coefficients. CC treatment does not cause additional side effects in spermatozoa that might lead to a lower viability even at 24 h incubation. Our results show that AMPK is expressed in spermatozoa at high levels and is phosphorylated under physiological conditions. Moreover, our study suggests that AMPK regulates a relevant function of spermatozoa, motility, which is essential for their ultimate role of fertilization

A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles

Poly(MePEG2000cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA) nanoparticles have demonstrated their capacity to reach the rat central nervous system after intravenous injection. For insight into the transport of colloidal systems across the blood-brain barrier (BBB), we developed a relevant in vitro rat BBB model consisting of a coculture of rat brain endothelial cells (RBECs) and rat astrocytes. The RBECs used in our model displayed and retained structural characteristics of brain endothelial cells, such as expression of P-glycoprotein, occludin and ZO-1, and immunofluorescence studies showed the specific localization of occludin and ZO1. The high values of transendothelial electrical resistance and low permeability coefficients of marker molecules demonstrated the functionality of this model. The comparative passage of polyhexadecylcyanoacrylate and PEG-PHDCA nanoparticles through this model was investigated, showing a higher passage of PEGylated nanoparticles, presumably by endocytosis. This result was confirmed by confocal microscopy. Thanks to a good in vitro/in vivo correlation, this rat BBB model will help in understanding the mechanisms of nanoparticle translocation and in designing new types of colloidal carriers as brain delivery systems

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Phosphatidylserine Increases IKBKAP Levels in Familial Dysautonomia Cells

Familial Dysautonomia (FD) is an autosomal recessive congenital neuropathy that results from abnormal development and progressive degeneration of the sensory and autonomic nervous system. The mutation observed in almost all FD patients is a point mutation at position 6 of intron 20 of the IKBKAP gene; this gene encodes the IκB kinase complex-associated protein (IKAP). The mutation results in a tissue-specific splicing defect: Exon 20 is skipped, leading to reduced IKAP protein expression. Here we show that phosphatidylserine (PS), an FDA-approved food supplement, increased IKAP mRNA levels in cells derived from FD patients. Long-term treatment with PS led to a significant increase in IKAP protein levels in these cells. A conjugate of PS and an omega-3 fatty acid also increased IKAP mRNA levels. Furthermore, PS treatment released FD cells from cell cycle arrest and up-regulated a significant number of genes involved in cell cycle regulation. Our results suggest that PS has potential for use as a therapeutic agent for FD. Understanding its mechanism of action may reveal the mechanism underlying the FD disease