Misandria

Hoy en día las redes sociales se han vuelto parte del día a día de las personas, una forma rápida de estar conectados unos con otros y de tener a la mano las noticias más importantes del mundo. Así mismo, ya no es necesario llegar a casa para ver una serie porque gracias a los smartphones y las aplicaciones tenemos todo este contenido a cualquier hora y en cualquier lugar. En el siguiente trabajo, presentaremos una serie web la cual está pensada y realizada para distribuir por la red social instagram. La primera temporada consta de 10 capítulos, cada uno de una duración de entre un minuto a un minuto y medio como máximo, los cuales serán publicados en el feed de nuestra cuenta oficial. Nuestra historia es un thriller, que nos muestra capítulo tras capítulo como traumas del pasado afectan directamente a la salud mental de las personas y esto desencadena una serie de comportamientos tóxicos que afectan no solo a sus relaciones intrapersonales sino también interpersonales. Hemos elegido la imagen femenina como protagonista de esta historia y quien será la mente maestra detrás de todos los hechos que ocurrirán

Feature selection for chemical sensor arrays using mutual information

We address the problem of feature selection for classifying a diverse set of chemicals using an array of metal oxide sensors. Our aim is to evaluate a filter approach to feature selection with reference to previous work, which used a wrapper approach on the same data set, and established best features and upper bounds on classification performance. We selected feature sets that exhibit the maximal mutual information with the identity of the chemicals. The selected features closely match those found to perform well in the previous study using a wrapper approach to conduct an exhaustive search of all permitted feature combinations. By comparing the classification performance of support vector machines (using features selected by mutual information) with the performance observed in the previous study, we found that while our approach does not always give the maximum possible classification performance, it always selects features that achieve classification performance approaching the optimum obtained by exhaustive search. We performed further classification using the selected feature set with some common classifiers and found that, for the selected features, Bayesian Networks gave the best performance. Finally, we compared the observed classification performances with the performance of classifiers using randomly selected features. We found that the selected features consistently outperformed randomly selected features for all tested classifiers. The mutual information filter approach is therefore a computationally efficient method for selecting near optimal features for chemical sensor arrays

Control interno en la gestión de cuentas por cobrar

El estudio titulado “CONTROL INTERNO EN LA GESTIÓN DE CUENTAS POR COBRAR” deL distrito de Magdalena del Mar, tiene como fin analizar si la carencia del “control interno” influye en la gestión de las “cuentas por cobrar”. Para mejorar ello se requiere de normas, procedimientos y política aprobados por la gerencia. Por consiguiente, la compañía debe constantemente realizar “control interno” a las “cuentas por cobrar” buscando que sean cobradas y no tener una cartera alta en morosidad. Así mismo, las “cuentas por cobrar” son los créditos que se da a clientes que se comprometen a pagar en un futuro, esto debido a la obtención de un producto o prestaciones de servicio de la entidad ofertante. Los créditos se dan a clientes para conserva a los clientes y atraer otros nuevos, sin embargo, se debe evaluar a quien otorgar crédito y a quienes se le debe negar. Las “cuentas por cobrar” inician por la “venta a crédito” que normalmente existen condiciones para la otorgación de ello y siempre sustentado con comprobante de pago o en contrato de servicios. Toda compañía le presta mucha atención a la “cuenta por cobrar” porque es un activo circulante que se convierte en coto tiempo en efectivo por ello se requiere en esa área personal calificado que gestione la cobranza y entregue informes para que el área contable lo registre en los Estados financieros y los directivos tomen decisiones en base de ellas. El objetivo que se busca este estudio es aplicar un “control interno” efectivo a las “cuentas por cobrar” de la empresa dedicada a brindar servicios de ingeniería y arquitectura.The study entitled “CONTROL INTERNO EN LA GESTIÓN DE CUENTAS POR COBRAR” Magdalena del Mar District aims to analyze whether the lack of "internal control" influences the management of "Accounts Receivable". To improve this requires standards, procedures and policy approved by management. In order to properly manage the “accounts receivable”, either in their nature, registration and evaluation, their control must be taken into account to ensure effective administration. Therefore, the company must constantly carry out “internal control” to the “accounts receivable” seeking that they are collected and not have a high delinquent portfolio. Likewise, “accounts receivable” are the credits that are given to customers who agree to pay in the future, this due to obtaining a product or service benefits from the offering entity. Credits are given to customers to keep customers and attract new ones; however, they should be evaluated to whom to grant credit and who should be denied. The origin of the “accounts receivable” is due to the “sale on credit” that there are normally conditions for the granting of this and always supported by proof of payment or service contract. Every company pays a lot of attention to the “account receivable” because it is a current asset that becomes a cash time, so it is required in that qualified personal area that manages the collection and delivers reports for the accounting area to record in Financial statements and managers make decisions based on them. The objective of this study is to apply an effective internal control to the “accounts receivable” of the company dedicated to providing engineering and architecture services

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability

Oral administration of camptothecin (Cm) derivatives and other antitumoral agents is being actively developed in order to improve the quality of life of patients with cancer. Though several lipophilic derivatives of CPT have shown interesting oral bioavailability in preclinical and clinical studies, only Topotecan has been approved for this route of administration. Semisynthesis, antitumor activity, biological inhibition mechanism, and in situ intestinal permeability of 9, 10-[1,3]-Dioxinocamptothecin (CDiox), an unexplored CPT derivative, have been studied in this paper. The hexacyclic analog was as effective as Topotecan and CPT in different tumor cell lines, showing an expected similar apoptosis cell mechanism and high ability to inhibit DNA synthesis in HeLa, Caco-2, A375 and MDA-MB-231 cell lines. Furthermore, in vitro and in situ pharmacokinetics transport values obtained for CDiox displayed more favorable absorption profile than CPT and Topotecan. (C) 2014 Elsevier Masson SAS. All rights reserved.G.R.-B. acknowledges Instituto de Tecnologia Quimica for a scholarship; Consolider-Ingenio 2010 (proyecto MULTICAT), Sub-programa de Apoyo a Centros de Excelencia Severo Ochoa, and Agencia de Gestico, d'Ajuts Universiteris i de Recerca (2009 SGR 758, to S.S.) I.G.-A., V.M.-S., M.G.-A. and M. B. acknowledge financial support from the European Financial Commission (Red bioFarma DCI-ALA/19.09.01/10/21526/245-297/ALFA III (2010)). J.L.G.-G. acknowledges the financial support of the CIBERER (Biomedical Network Research Center for Rare Diseases) ISCIII.Rodríguez Berna, G.; Mangas Sanjuan, V.; Gonzalez Alvarez, M.; Gonzalez Álvarez, I.; Garcia Gimenez, JL.; Díaz Cabañas, MJ.; Bermejo, M.... (2014). A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. European Journal of Medicinal Chemistry. 83:366-373. doi:10.1016/j.ejmech.2014.06.050S3663738

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

It's getting hot in here – Microcontextual study of a potential pit hearth at the Middle Paleolithic site of El Salt, Spain

By studying combustion structures, which conceal information about anthropogenic activity, we might learn about their makers. This is especially important for remote time periods like the Middle Paleolithic, whose archaeological record comprises numerous combustion structures. The majority of these are simple, flat, open hearths, although a small number of features situated in pit-like depressions have been recorded. Given that hearths built on a flat surface can result in pit-like color alteration of the underlying sediment, accurate identification of pit hearths is a crucial step prior to behavioral interpretation. Here we present a comprehensive study of a possible pit hearth from the Middle Paleolithic site of El Salt, Spain, using a microcontextual approach combining micromorphology, lipid biomarker analysis, archaeomagnetism and zooarchaeology. This pit hearth involves a true depression containing a thick plant ash deposit. It reached very high temperatures, possibly multiple burning events and long combustion times. Morphologically distinct combustion structures in a single archaeological context may indicate different functions and thus a diverse fire technology, pointing to Neanderthal behavioral variability.ERC Consolidator Grant project PALEOCHAR – 648871 https://erc.europa.eu/funding/consolidator-grants, I + D Project HAR2008-06117/HIST, HAR2015-68321-P (MINECO-FEDER/UE), and the Cultural Heritage Department of the Valencia Government and the Archaeological Museum Camil Visedo of Alcoy, under the direction of Professor Bertila Galván of Universidad de La Laguna, Junta de Castilla y León (project BU235P18), the European Fund for Economic and Regional Development (EFRD) and the project PID2019-105796 GB-I00 of the Agencia Estatal de Investigación (AEI/10.13039/501100011033

Electronic Noses and Tongues: Applications for the Food and Pharmaceutical Industries

The electronic nose (e-nose) is designed to crudely mimic the mammalian nose in that most contain sensors that non-selectively interact with odor molecules to produce some sort of signal that is then sent to a computer that uses multivariate statistics to determine patterns in the data. This pattern recognition is used to determine that one sample is similar or different from another based on headspace volatiles. There are different types of e-nose sensors including organic polymers, metal oxides, quartz crystal microbalance and even gas-chromatography (GC) or combined with mass spectroscopy (MS) can be used in a non-selective manner using chemical mass or patterns from a short GC column as an e-nose or “Z” nose. The electronic tongue reacts similarly to non-volatile compounds in a liquid. This review will concentrate on applications of e-nose and e-tongue technology for edible products and pharmaceutical uses

Surfactants-based remediation as an effective approach for removal of environmental pollutants—A review

Deterioration of environmental quality and equilibrium by rampant industrial expansion, accelerated urbanization and unchecked population growth has become a high-priority concern. The release of an alarming number of toxic polluting agents such as volatile organic compounds, dyes, heavy metals, pharmaceuticals, pesticides, industrial wastes, and personal care products due to natural or anthropogenic activities pose direct adverse effects on human health and living entities. This issue is inescapably increased because of the lack of efficient technologies for the proper disposal, management, and recycling of waste. It is of paramount importance to track alternative solutions to address these pollution problems for an eco-sustainable environment. Conventional remediation techniques are either inefficient, cumbersome or restricted due to certain techno-economic limitations. Environmental compatibility and high pollutant-removal efficacy make surfactants valuable for removal of organic pollutants and toxic heavy metal ions from different mediums. In this review, we present recent and up-to-date information on micelles/surfactants-assisted abatement of a vast number of toxic agents of emerging concern from water/wastewater including volatile organic compounds, personal care products, pharmaceutically active residues, toxic metals, dye pollutants, pesticides, and petroleum hydrocarbons. Based on the literature survey, it can be concluded that micelles-assisted water and soil treatment technology can have a better future on large-scale decontamination of wastewater. Though bio-surfactants are environmentally friendlier matrices and have successfully been employed for environmental decontamination; their large-scale applicability is challenging owing to high costs. Additional research efforts on the development and employment of novel bio-surfactants might render wastewater treatment technology greener, smarter and economical

STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs

STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticulum (ER) and regulate store-operated Ca2+ entry (SOCE). The function of STIMs in the brain is only beginning to be explored, and the relevance of SOCE in nerve cells is being debated. Here we identify STIM2 as a central organizer of excitatory synapses. STIM2, but not its paralogue STIM1, influences the formation of dendritic spines and shapes basal synaptic transmission in excitatory neurons. We further demonstrate that STIM2 is essential for cAMP/PKA-dependent phosphorylation of the AMPA receptor (AMPAR) subunit GluA1. cAMP triggers rapid migration of STIM2 to ER–plasma membrane (PM) contact sites, enhances recruitment of GluA1 to these ER-PM junctions, and promotes localization of STIM2 in dendritic spines. Both biochemical and imaging data suggest that STIM2 regulates GluA1 phosphorylation by coupling PKA to the AMPAR in a SOCE-independent manner. Consistent with a central role of STIM2 in regulating AMPAR phosphorylation, STIM2 promotes cAMP-dependent surface delivery of GluA1 through combined effects on exocytosis and endocytosis. Collectively our results point to a unique mechanism of synaptic plasticity driven by dynamic assembly of a STIM2 signaling complex at ER-PM contact sites

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

[EN] Twenty-(S)-camptothecin is a strongly cytotoxic molecule with excellent antitumor activity over a wide spectrum of human cancers. However, the direct formulation is limited by its poor water solubility, low plasmatic stability and severe toxicity, which currently limits its clinical use. As a consequence, two strategies have been developed in order to achieve safe and efficient delivery of camptothecin to target cells: structural analogues and nanomedicines. In this review, we summarize recent advances in the design, synthesis and development of camptothecin molecular derivatives and supramolecular vehicles, following a systematic classification according to structure-activity relationships (structural analogues) or chemical nature (nanomedicines). A series of organic, inorganic and hybrid materials are presented as nanoplatforms to overcome camptothecin restrictions in administration, biodistribution, pharmacokinetics and toxicity. Nanocarriers which respond to a variety of stimuli endogenously (e.g., pH, redox potential, enzyme activity) or exogenously (e.g., magnetic field, light, temperature, ultrasound) seem the best positioned therapeutic materials for optimal spatial and temporal control over drug release. The main goal of this review is to be used as a source of relevant literature for others interested in the field of camptothecin-based therapeutics. To this end, final remarks on the most important formulations currently under clinical trial are provided. (C) 2016 Elsevier B.V. All rights reserved.Financial support of the Spanish Ministry of Economy and Competitiveness (projects MAT2012-39290-C02-02 and SEV-2012-0267) is gratefully acknowledged. Dr. E.M. Rivero thanks the Cursol Foundation for a post-doctoral scholarship.Botella Asuncion, P.; Rivero-Buceta, EM. (2017). Safe approaches for camptothecin delivery: Structural analogues and nanomedicines. Journal of Controlled Release. 247:28-54. https://doi.org/10.1016/j.jconrel.2016.12.023S285424