215 research outputs found
Congenital contractural arachnodactyly (Beals syndrome)
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
Congenital contractural arachnodactyly (Beals syndrome) is an autosomal dominantly inherited connective tissue disorder characterized by multiple flexion contractures, arachnodactyly, severe kyphoscoliosis, abnormal pinnae and muscular hypoplasia. It is caused by a mutation in FBN2 gene on chromosome 5q23. Although the clinical features can be similar to Marfan syndrome (MFS), multiple joint contractures (especially elbow, knee and finger joints), and crumpled ears in the absence of significant aortic root dilatation are characteristic of Beals syndrome and rarely found in Marfan syndrome. The incidence of CCA is unknown and its prevalence is difficult to estimate considering the overlap in phenotype with MFS; the number of patients reported has increased following the identification of FBN2 mutation. Molecular prenatal diagnosis is possible. Ultrasound imaging may be used to demonstrate joint contractures and hypokinesia in suspected cases. Management of children with CCA is symptomatic. Spontaneous improvement in camptodactyly and contractures is observed but residual camptodactyly always remains. Early intervention for scoliosis can prevent morbidity later in life. Cardiac evaluation and ophthalmologic evaluations are recommended
Edge-Related Loss of Tree Phylogenetic Diversity in the Severely Fragmented Brazilian Atlantic Forest
- Author
- A Purvis
- A Purvis
- AMM Santos
- AV Lopes
- BA Santos
- Bráulio A. Santos
- C Murcia
- CJ Humphries
- Claudia E. Moreno
- CO Webb
- CO Webb
- DP Faith
- GJ Russell
- J Cavender-Bares
- J Fischer
- J Silvertown
- JC Vamosi
- Jerome Chave
- JL Harper
- JMC Silva
- KG Smith
- L Fahrig
- LC Girão
- M Martínez-Ramos
- M Tabarelli
- MA González
- MA Oliveira
- Marcelo Tabarelli
- MC Ribeiro
- ML Mckinney
- MW Cadotte
- MW Cadotte
- N Myers
- PM Bennett
- RM Ewers
- RM May
- S Nee
- S Pavoine
- SM Vamosi
- SN Stuart
- TJ Davies
- V Arroyo-Rodríguez
- Víctor Arroyo-Rodríguez
- WF Laurance
- WF Laurance
- WF Laurance
- Publication venue
- Public Library of Science
- Publication date
- 08/09/2010
- Field of study
Deforestation and forest fragmentation are known major causes of nonrandom extinction, but there is no information about their impact on the phylogenetic diversity of the remaining species assemblages. Using a large vegetation dataset from an old hyper-fragmented landscape in the Brazilian Atlantic rainforest we assess whether the local extirpation of tree species and functional impoverishment of tree assemblages reduce the phylogenetic diversity of the remaining tree assemblages. We detected a significant loss of tree phylogenetic diversity in forest edges, but not in core areas of small (<80 ha) forest fragments. This was attributed to a reduction of 11% in the average phylogenetic distance between any two randomly chosen individuals from forest edges; an increase of 17% in the average phylogenetic distance to closest non-conspecific relative for each individual in forest edges; and to the potential manifestation of late edge effects in the core areas of small forest remnants. We found no evidence supporting fragmentation-induced phylogenetic clustering or evenness. This could be explained by the low phylogenetic conservatism of key life-history traits corresponding to vulnerable species. Edge effects must be reduced to effectively protect tree phylogenetic diversity in the severely fragmented Brazilian Atlantic forest
Differences between men and women in self-reported body mass index and its relation to drug use
- Author
- A Cardone
- A Castro
- A Zárate
- AE Pujolar
- Annemieke van Straten
- BG Tabachnick
- C Filozof
- C Morales-Ruan Mdel
- Consejo Nacional para el Control de Estupefacientes (CONACE)
- CP McLean
- D Barry
- D Carrasco
- DM Huebner
- E MdSeINd
- E Moreno
- F Gillison
- F Mediano-Stoltze
- F Vio
- G Flores
- H Aránguiz
- HM Al-Hazzaa
- I Elfeddali
- I Galan
- I Teva
- J Alfonso
- J Aranceta
- J Gutiérrez-Fisac
- J Kain
- J Perz
- J Rehm
- J Vioque
- JA Piqueras
- JA Piqueras
- José A Piqueras
- JW Twisk
- KE Pasch
- L Ruiz-Arregui
- LE Bautista
- LJ Nolan
- LJ Nolan
- LJ Nolan
- LL Calderon
- LM Gomez
- M Arroyo
- M Bes-Rastrollo
- M Gómez
- M Pimentel
- M Romero
- M Vargas-Zárate
- M Warren
- MA Gonzalez
- MC Beltrán
- MR Yeomans
- NM Petry
- P Arroyo
- P Vera-Villaroel
- Pablo Vera-Villarroel
- Pim Cuijpers
- PT Williams
- R Araya
- R Jessor
- R Lowry
- RP Pickering
- S Micin
- S-I Baek
- T Shamah Levy
- V Blüml
- V Ramos
- W López-López
- Walter Kuhne
- World Health Organization
- Y Liao
- Z Antúnez
- Z Satalic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inactivation of a Single Copy of Crebbp Selectively Alters Pre-mRNA Processing in Mouse Hematopoietic Stem Cells
- Author
- A Giordano
- A Partanen
- A Subramanian
- A von Mikecz
- AG Arroyo
- AL Kung
- AM Broske
- Andrew L. Kung
- AS Chuck
- AV Terskikh
- C Kanellopoulou
- C Lois
- C Murre
- CF Webb
- CL Willman
- DC Bedford
- DC Hargreaves
- DK Nam
- E Kalkhoven
- F Arai
- F Bex
- G Dennis Jr
- G Karlsson
- GA Blobel
- H Iwasaki
- H Yamamoto
- H Zeng
- HC Suh
- HW Song
- I Kim
- IE Schor
- JC Bryne
- JN Hutchinson
- John Cornell
- JS Byun
- KA Kovacs
- Kevin D. Bunting
- KJ Hope
- KJ Hope
- KJ Livak
- KJ McManus
- KM Lang
- LJ Core
- M Hauses
- M Hu
- M Pritsker
- M Reich
- M Sultan
- M von Lindern
- M Voulgarelis
- MA Essers
- Madeleine E. Lemieux
- MC Frith
- MG Kharas
- MG Kharas
- N Cloonan
- NB Ivanova
- O Tliba
- O Wessely
- P Zhang
- Qing Zhou
- RC Gentleman
- RH Goodman
- Ruth White
- S Rozen
- S Tsai
- SF Altschul
- SH Orkin
- SJ Morrison
- SL Finstad
- SM Chambers
- SM Uptain
- T Almlof
- T Cheng
- T Enver
- T Hisa
- T Shimazu
- TP Yao
- TV Bowman
- U Schwarze
- U Testa
- V Matys
- V Tripathi
- VI Rebel
- VI Rebel
- VI Rebel
- Vivienne I. Rebel
- W Huang
- X Jiang
- Y Piao
- Y Sun
- YF Ramos
- Z Liu
- Ziming Cheng
- ZJ Ye
- Publication venue
- Public Library of Science
- Publication date
- 25/08/2011
- Field of study
Global expression analysis of fetal liver hematopoietic stem cells (FL HSCs) revealed the presence of unspliced pre-mRNA for a number of genes in normal FL HSCs. In a subset of these genes, Crebbp+/− FL HSCs had less unprocessed pre-mRNA without a corresponding reduction in total mRNA levels. Among the genes thus identified were the key regulators of HSC function Itga4, Msi2 and Tcf4. A similar but much weaker effect was apparent in Ep300+/− FL HSCs, indicating that, in this context as in others, the two paralogs are not interchangeable. As a group, the down-regulated intronic probe sets could discriminate adult HSCs from more mature cell types, suggesting that the underlying mechanism is regulated with differentiation stage and is active in both fetal and adult hematopoiesis. Consistent with increased myelopoiesis in Crebbp hemizygous mice, targeted reduction of CREBBP abundance by shRNA in the multipotent EML cell line triggered spontaneous myeloid differentiation in the absence of the normally required inductive signals. In addition, differences in protein levels between phenotypically distinct EML subpopulations were better predicted by taking into account not only the total mRNA signal but also the amount of unspliced message present. CREBBP thus appears to selectively influence the timing and degree of pre-mRNA processing of genes essential for HSC regulation and thereby has the potential to alter subsequent cell fate decisions in HSCs
Worldwide molecular epidemiology of HIV
- Author
- Adetunji J
- Anderson JP
- Arroyo MA
- Artenstein AW
- Ayouba A
- Badea CL
- Bailes E
- Bobkov A
- Bobkov A
- Bobkov A
- Bobkov A
- Bobkov A
- Bongertz V
- Buonaguro L
- Caride E
- Carr JK
- Carr JK
- Casado C
- Casado G
- Cassol S
- Castro E
- Chakrabarti S
- Charneau P
- Cheingsong-Popov R
- Chen YMA
- Clapham PR
- Corbet S
- Couto-Fernandez JC
- Csillag C
- Delwart EL
- Delwart EL
- Deroo S
- Eigen M
- Eigen M
- Esparza J
- Espinosa A
- Esteves A
- Fischetti L
- Gadelha SR
- Gao F
- Gao F
- Gardner EJ
- Gardner MB
- Gelderblom HR
- Gojobori T
- Guyader M
- Hahn BH
- Henry I Z Requejo
- Herring BL
- Heyndrickx L
- Heyndrickx L
- Hierholzer M
- Hirsch VM
- Hirsch VM
- Holguin A
- Howard TM
- Hu DJ
- Huet T
- Hwang SS
- Janini LM
- Jonassen TO
- Kalish ML
- Kanki PJ
- Kanki PJ
- Kato K
- Kijak GH
- Kitsutani PT
- Klevytska AM
- Kliks S
- Koch N
- Korber B
- Kostrikis LG
- Koulinska IN
- Kurle S
- Laukkanen T
- Leitner T
- Liitsola K
- Ljungberg K
- Louwagie J
- Louwagie J
- Luciw PA
- Lukashov VV
- Mamadou S
- Mandal D
- McCutchan FE
- McCutchan FE
- Mellquist JL
- Menu E
- Menu E
- Milich L
- Monno L
- Montavon C
- Moore JP
- Morgado MG
- Morgado MG
- Motomura K
- Muller-Trutwin MC
- Myers G
- Nabatov AA
- Naganawa S
- Nakasone T
- Nasioulas G
- Nkengasong JN
- Oh M
- Op de Coul E
- Papa A
- Paraskevis D
- Peeters M
- Peeters M
- Peeters M
- Piyasirisilp S
- Poignard P
- Price DA
- Quarleri JF
- Ramos A
- Renjifo B
- Rios M
- Robertson DL
- Roudinskii NI
- Rutebemberwa A
- Sabino EC
- Sabino EC
- Se-Thoe SY
- Sherefa K
- Shieh B
- Simon F
- Snoeck J
- Soares MA
- Sreepian A
- Srisuphanunt M
- Stanojevic M
- Stoeckli TC
- Su L
- Takehisa J
- Tatt ID
- Tee KK
- Tripathy SP
- Vachot L
- Vallejo A
- Van der Loeff MFS
- Vaughan HE
- Vidal N
- Viputtijul K
- Visco-Comandini U
- Wainberg MA
- Wei M
- Weniger BG
- Wilbe K
- Williams KJ
- Womack C
- Yahi N
- Yamaguchi J
- Yamaguchi J
- Yerly S
- Yirrell DL
- Yu XF
- Zetterberg V
- Zhu T
- Zhu T
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Biased-corrected richness estimates for the Amazonian tree flora
- Author
- Ahuite Reategui MA
- Albuquerque BW
- Alexiades MN
- Alonso A
- Amaral IL
- Andrade A
- Araujo-Murakami A
- Arroyo L
- Assis RL
- Aymard C. GA
- Baider C
- Baker TR
- Balslev H
- Baraloto C
- Barbosa EM
- Barbosa FR
- Barlow J
- Berenguer E
- Brienen R
- Bánki OS
- Camargo JL
- Cano A
- Carrero Márquez YA
- Carvalho FA
- Casas LF
- Castaño Arboleda N
- Castellanos H
- Castilho CV
- Casula KR
- Cerón C
- Chave J
- Cintra BBL
- Comiskey JA
- Cornejo Valverde F
- Correa DF
- Costa FRC
- Costa JBP
- Cárdenas López D
- Cárdenas S
- da Silva Guimarães JR
- Dallmeier F
- Daly D
- Damasco G
- de Aguiar DPP
- de Andrade Lima Filho D
- de Andrade Miranda IP
- de Jesus Rodrigues D
- de Jesus Veiga Carim M
- de Leão Novo EMM
- de Lima RAF
- de Matos Bonates LC
- de Medeiros MB
- de Oliveira EA
- de Queiroz HL
- de Sousa Farias E
- de Souza Coelho L
- de Souza FC
- de Sá Carpanedo R
- de Toledo JJ
- Demarchi LO
- Dexter KG
- Di Fiore A
- Dionízia de Almeida Matos F
- do Amaral DD
- Doza HPD
- Draper F
- Duivenvoorden JF
- Duque A
- Dávila N
- Engel J
- Farfan-Rios W
- Farfan-Rios W
- Feeley KJ
- Feitosa YO
- Feldpausch TR
- Ferreira C
- Ferreira J
- Ferreira LV
- Fine PVA
- Flores BM
- Fonty É
- Fuentes A
- Galbraith D
- Gamarra LV
- Garcia-Cabrera K
- García-Villacorta R
- Gomes VHF
- Gonzales GPG
- Gonzales T
- Gribel R
- Guedes MC
- Guevara JE
- Gómez RZ
- Henkel TW
- Hernandez L
- Hilário RR
- Hoffman B
- Holmgren M
- Honorio Coronado EN
- Huamantupa-Chuquimaco I
- Irume MV
- Jimenez EM
- Junqueira AB
- Kalamandeen M
- Killeen TJ
- Klitgaard B
- Laurance SGW
- Laurance WF
- Levesley A
- Licona JC
- Linares-Palomino R
- Lloyd J
- Lopes A
- Lopes MA
- Lozada JR
- Luize BG
- Maas P
- Magalhães JLL
- Magnusson WE
- Malhi Y
- Manzatto AG
- Marimon BS
- Marimon-Junior BH
- Melgaço K
- Mendoza C
- Mesones I
- Milliken W
- Mogollón HF
- Molino J-F
- Monteagudo Mendoza A
- Montero JC
- Mostacedo B
- Nascimento HEM
- Nascimento MT
- Neill D
- Noronha JC
- Núñez Vargas P
- Oliveira AA
- Palacios Cuenca W
- Pansini S
- Pansonato MP
- Paredes MR
- Pauletto D
- Pena JLM
- Pennington T
- Peres CA
- Petronelli P
- Peñuela Mora MC
- Phillips JF
- Phillips OL
- Pickavance G
- Piedade MTF
- Pinto LFM
- Pires Martins M
- Pitman NCA
- Pos E
- Prado PI
- Prieto A
- Quaresma A
- Ramirez Arevalo F
- Ramirez-Angulo H
- Ramos JF
- Reis NFC
- Revilla JDC
- Rincón LM
- Rivas-Torres G
- Rocha M
- Rudas A
- Ruschel AR
- Sabatier D
- Salomão RP
- Sampaio AF
- Schietti J
- Schöngart J
- Scudeller VV
- Sierra R
- Silman MR
- Silva N
- Silva TSF
- Silveira M
- Simon MF
- Sousa TR
- Stevenson PR
- Stropp J
- Tello JS
- ter Steege H
- Terborgh J
- Thomas R
- Tirado M
- Torres-Lezama A
- Umaña MN
- Urrego Giraldo LE
- Valderrama Sandoval EH
- van Andel TR
- van der Heijden G
- Vasquez R
- Vela CIA
- Venticinque EM
- Vicentini A
- Vieira ICG
- Vilanova Torre E
- Villa B
- Villarroel D
- von Hildebrand P
- Vos VA
- Vriesendorp C
- Wang O
- Wittmann F
- Young KR
- Zagt R
- Zartman CE
- Zent EL
- Zent S
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
Amazonian forests are extraordinarily diverse, but the estimated species richness is very much debated. Here, we apply an ensemble of parametric estimators and a novel technique that includes conspecific spatial aggregation to an extended database of forest plots with up-to-date taxonomy. We show that the species abundance distribution of Amazonia is best approximated by a logseries with aggregated individuals, where aggregation increases with rarity. By averaging several methods to estimate total richness, we confirm that over 15,000 tree species are expected to occur in Amazonia. We also show that using ten times the number of plots would result in an increase to just ~50% of those 15,000 estimated species. To get a more complete sample of all tree species, rigorous field campaigns may be needed but the number of trees in Amazonia will remain an estimate for years to come
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
- Carreiro De Freitas AV
- Castro Mollo M
- Cengiz Y
- Cengiz Y
- Ceriani C
- Chachulski W
- Chambers A
- Chan E
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
- Chiu SMY
- Choi J
- Chong BFHK
- Chong CL
- Chong HY
- Chowdhury A
- Chun A
- Chun T
- Chung S
- Cirocchi R
- Clark DJ
- Clark T
- Clement KD
- Clements JM
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Cocker DM
- Collaborative G
- Colombani J-F
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Coomber R
- Corro-Diaz Gonzalez S
- Costa-Maia J
- Court E
- Cragg J
- Cross K
- Cruz H
- Cucumazzo S
- Currow C
- D'aguzan N
- D'amours SK
- D'cruz R
- D'Souza R
- Da Silva LA
- Dabessa D
- Dablouk M
- Dablouk MO
- Dal Canto M
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daqeeq A
- Dar M
- Darweesh M
- Das A
- Das K
- Das S
- Davenport R
- Davies J
- Dawnay G
- Dawoud H
- De Bono P
- De Sousa AV
- Dean R
- Deckelbaum DL
- Decker E
- Deichsel F
- Dempster E
- Deputy M
- Dervenis C
- Despotidis V
- Desta S
- Devadasar GH
- Dharamshi HA
- Di Franco F
- Di Saverio S
- Diab A
- Diaconescu I-B
- Dias S
- Diaz-Zorrilla C
- Dickfos M
- Dickson L
- Dindyal S
- Domini E
- Donoghue D
- dos Santos DV
- Doughan S
- Doughty J
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- Driscoll A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Multi-messenger observations of a binary neutron star merger
- Author
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- Aartsen MG
- Abbott BP
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- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
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- Al Samarai I
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- Albuquerque IFM
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- Alcaniz JS
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- Alighieri S Di Serego
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- Allekotte I
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- Arcavi I
- Arceo R
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- Argan A
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- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
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- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
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- Bae S
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- Bai X
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- Balasubramanian A
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- Boom BA
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- Botticella MT
- Bouffanais Y
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- Brillet A
- Brinkmann M
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- Bulik T
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- Cabero M
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- Canepa M
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- Canizares P
- Cannella C
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- Cannon KC
- Cano Z
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- Cao XL
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- Chu Q
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- Cordero-Carrion I
- Corley KR
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- Costa E
- Costa-Duarte MV
- Costantin D
- Costantini H
- Cotti U
- Cotzomi J
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- Coughlin MW
- Coughlin SB
- Coulon J-P
- Coulter DA
- Countryman ST
- Courvoisier TJ-L
- Coutu S
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- Covault CE
- Covino S
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- Coward DM
- Coward DM
- Cowart MJ
- Cowen DF
- Cowperthwaite P
- Coyle P
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- Doctor Z
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- Eikenberry SS
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- El Bojaddaini I
- El Khayati N
- El Moursli R Cherkaoui
- Elias-Rosa N
- Elipe G Torralba
- Eller P
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- Elmer E
- Elsasser D
- Emery G
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- Feicht J
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- Fejer MM
- Feldbusch F
- Felde J
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- Fender RP
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- Fenu F
- Fermi GBM
- Fernandes MV
- Fernandez D
- Fernandez E
- Fernandez G Rodriguez
- Fernandez-Galiana A
- Feroci M
- Ferrante I
- Ferrari A
- Ferreira EC
- Ferrigno C
- Ferrini F
- Fiasson A
- Fick B
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- Fioretti V
- Fiori I
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- Firth RE
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- Fosalba P
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- Fox OD
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- Fraija N
- Frail DA
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- Franzen T
- Frasca S
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- Fremling C
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- Frey V
- Friedman E
- Frieman JA
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- Fritschel P
- Frohmaier C
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- Frolov VV
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- Fssling M
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- Fuchs T
- Fujii T
- Fujii YI
- Fujiyoshi T
- Fukazawa Y
- Fulda P
- Funk S
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- Furusawa H
- Fuschino F
- Fusco LA
- Fusco P
- Fuster A
- Fyffe M
- Fynbo JPU
- Gabbard H
- Gabici S
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- Gadre BU
- Gaebel SM
- Gaensler BM
- Gaior R
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- Gaisser TK
- Gal-Yam A
- Galbany L
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- Gallagher J
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- Gate F
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- Ghia PL
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- Ghosh Abhirup
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- Ghosh S
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- Giang W
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- Gianotti F
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- Goetz E
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- Goldschmidt A
- Goldstein A
- Goldstein DA
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- Golup G
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- Gu YD
- Guan J
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- Guelbenzu A Nicuesa
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- Guiriec S
- Guo CC
- Guo X
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- Gupta MK
- Gurovich S
- Gusai V
- Gushwa KE
- Gustafson EK
- Gustafson R
- Gutierrez CP
- Gutierrez G
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- Zimnukhov DS
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
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- Zhuang H
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
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- Abozeid K
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- Arevalo Azmitia JR
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- Leal A
- Leal M
- Leanne Almanon C
- Lecompte J-F
- Lee C
- Lee EX
- Lee F
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- Lee KY
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- Leone N
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- Leppaniemi A
- Leppaniemi A
- Leroux J
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- Leung MF
- Leusink A
- Lewis J
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- Liew I
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- Lilford R
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- Lim G
- Lim H
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- Lim PJ
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- Limaye N
- Limoges B
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- lo Conte A
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Machain Vega GM
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- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
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- Magdy H
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- Magee C
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- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
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- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
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- Mano MJB
- Manrique Sila G
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- Mansor EY
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- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
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- Mas R
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- Mathew SW
- Matos-Puig R
- Mattar O
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- Menegussi J
- Mensah E
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- Mentula P
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- Merlo MS
- Mesbah N
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- Metwally MM
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- Mihaljevic AL
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- Mircea H
- Mirghani D
- Mironescu A
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- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Mizzi C
- Mizzi S
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- Moaty M
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- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
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- Mok YT
- Mokhtar A
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- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
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- Morsi A
- Morsi M
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
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- Mshelbwala P
- Msiska N
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- Muktar U
- Mukuzunga C
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- Nanthakumaran S
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- Narayanan R
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- Perez Velasquez CI
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- Samaraweera DI
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- Senanayake KJ
- Senanayake WSMKJ
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- Shillito S
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- Smedley A
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
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- Soliman A
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- Soliman AR
- Soliman N
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- Soliman S
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- Sollazzo V
- Soltani N
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- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
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- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
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- Stewart D
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- Suarez A
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- Summerour V
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- Sundstrom SM
- Suresh S
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- Sutanto EPR
- Sutton P
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- Suyadi A
- Swann J
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- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
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- Tabiri S
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- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
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- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
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- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
- Ting JRS
- To K
- To K
- Todd KO
- Toeema AG
- Tolba H
- Tolg C
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- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola SK
- Tugnoli G
- Tugnoli G
- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
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- Velasquez R
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- Venskutonis D
- Venskutonis D
- Venskutonis D
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- Venugopal C
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- Vergara Mejia AG
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- Wold TB
- Wolf B
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- Wredberg C
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- Yahaya MT
- Yakubu M
- Yallop L
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- Yaseen TM
- Yau JD
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- Yeang LJ
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- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
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- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
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- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
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- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
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- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
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- Zorrilla CD
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- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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