Diseño de pozos multilaterales para las condiciones de la Cuenca costa afuera de la Guajira en el Caribe Colombiano

This article proposes the design of a multilateral well on the Tayrona area conditions located in the Guajira Offshore basin that belongs to the Colombian Caribbean. This zone has a strategic importance for Colombia, because is where the Orca-1 well was drilled, integrating a substantial gas reservoir detection in 2014, which is a project with great development potential, that can help meet the energy needs of the country, where Ecopetrol, Petrobras, and Repsol are contributing. Reviewed to know about the technique of drilling multilateral wells, perform an analysis of the conventional and modern existing alternatives and both the environmental and operational variables influencing the drilling of this kind of offshore wells. In addition, a research study of environmental and geological conditions of the interest area, the Colombian Guajira offshore, was carried out to determine the feasibility of the application of this technology. The design of the multilateral well UIS-OFF-MO1 was proposed, with two opposite branches to increase production in the reservoir in which Orca-1 well is situated, to increase the drainage area and contact an area of the reservoir, which is separated by a normal no-flow fault. © 2022 Academic Publishing House. All rights reserved

Diseño de metodología para la conformación y secuenciación de lotes no idénticos en máquinas paralelas en una empresa de vidrios de seguridad

La programación es una de las estrategias a corto plazo más importantes para mejorar el uso de los recursos de una empresa. Esta aplicación en American Glass Products (AGP) Colombia, una fabricación de vidrios de seguridad que en la búsqueda de una mejor solución para su complejo programa NP-hard de sus productos en la estación de trabajo crítica de la línea de producción, convergió en el diseño de una técnica, para generar un cronograma de trabajos cuya disponibilidad no sea igual en lotes con tamaño variable y asignarlos en máquinas de procesamiento de lotes paralelos no relacionados con tiempos de configuración dependientes de la secuencia para minimizar la tardanza promedio y evaluar otros indicadores de interés de la empresa. Se ha encontrado que este entorno de producción no tiene muchos estudios asociados. De esta manera, fue necesaria la caracterización de los tiempos a lo largo de la producción para que los productos definan los tiempos de liberación de los mismos a la estación en estudio para comprender su distribución probabilística y generar los parámetros determinísticos para desarrollar un Algoritmo Genético (AG). Basado en una regla de despacho dinámico para la resolución del problema teniendo en cuenta la interacción entre la conformación de los lotes y la programación de los mismos. Su desempeño es evaluado con el método actual de la empresa. Los resultados mostraron que el algoritmo propuesto mejora los indicadores principales. Sin embargo, la variabilidad de la distribución y su efecto en la programación generaron la necesidad de evaluar la solución en un contexto estocástico. En consecuencia, los resultados expresaron la importancia de tomar acciones en las estaciones anteriores para disminuir la dispersión y el impacto directamente en el problema principal.Scheduling is one of the most important short-term strategies to improve the use of resources of a company. This application in American Glass Products (AGP) Colombia, a safety glass manufacturing which in the searching of a better solution to their complex NP-hard schedule of their products in the critical work station of the production line, converged in the design of a technique to generate a schedule of jobs whose availability are not equal in batches with variable size and asign them in a unrelated parallel batch processing machines with sequence- dependent setup times to minimize the average tardiness and evaluate other indicators of interest of the company. It has been found that this production environment docs not have many studies associated. In this way, it was necessary the characterization of the times throughout the production for the products to define the release times of them to the station under study in order to comprehend their probabilistic distribution and generate the deterministic parameters to develop a Genetic Algorithm (GA) based in a dynamic dispatch rule for the resolution of the problem taking into account the interaction between the batches conformation and the scheduling of them. Its performance is evaluated with the actual method of the company. The results showed that the proposed algorithm improves the main indicators. However, the variability of the distribution and his effect in the scheduling generated the need of evaluate the solution in a stochastic context. In consequence, the results expossed the importance of take actions in the previous stations to decrease the dispersion and impact directly in the main problem.Ingeniero (a) IndustrialPregrad

Memorias : Coloquio Vida Cotidiana y Diseño

1 archivo PDF (259 páginas)Memorias del coloquio realizado en noviembre de 2007 en las instalaciones de la UAM Azcapotzalco en donde la temática, incluyó investigaciones variadas que iban desde utensilios para comer hasta las librerías y vecindades en el siglo XIX, pasando por el diseño japonés, empaques y embalajes, cooperativas y la España Musulmana, todo esto relacionado con la vida cotidiana ya que dicho concepto está modificando la manera en que los científicos sociales se acercan a la realidad

Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; MéxicoFil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; MéxicoFil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; MéxicoFil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; MéxicoFil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; MéxicoFil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Yu, Neng. American Red Cross; Estados UnidosFil: Lebedeva, Tatiana V.. American Red Cross; Estados UnidosFil: Alosco, Sharon M.. American Red Cross; Estados UnidosFil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; MéxicoFil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; MéxicoFil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; MéxicoFil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino UnidoFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Yunis, Edmond. Dana Farber Cancer Institute; Estados UnidosFil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; Méxic

Cultura de investigación para la innovación y el emprendimiento

El libro se encuentra dividido en tres ejes temáticos : el primero trata temas de Investigación aplicada con dos capítulos, el segundo eje contiene los capítulos tres al seis y aborda temas de innovación en procesos con temas de software y competitividad empresarial; el eje tres innovación en servicios y en producción, del capítulo siete al doce aborda temas tan interesantes como las realidades de la internacionalización de servicios, logística hospitalaria, modelo de diagnóstico para el desarrollo socio-económico y modelo de microcréditos.The book is divided into three thematic axes: the first deals with issues of applied research with two chapters, the second axis contains chapters three to six and addresses issues of innovation in processes with issues of software and business competitiveness; axis three innovation in services and production, from chapter seven to twelve, addresses such interesting topics as the realities of the internationalization of services, hospital logistics, a diagnostic model for socio-economic development and a microcredit model.Cómo fomentar la investigación científica y la innovación empresarial desde una unidad de emprendimiento / Carlos Andres Zamudio Delgado, Johemir Pérez Pertuz -- Cambio y variabilidad cognitiva en el desarrollo de competencias financieras en niños y niñas de 7 años / Luis Guillermo Rojas Gómez -- FINEVA: el software para el análisis financiero de la internacionalización empresarial / Guillermo Rafael Angulo Vega, Lissette Salomé Ortíz Gallardo, Johel Andrés García Vargas -- Responsabilidad social del contador público desde su proceso de formación para fortalecer la gestión contable de microempresarios en la localidad de suba upz rincón Bogotá Colombia / Nadia Ávila, Ana C. Pinzón Vargas -- Competitividad e innovación en el aprendiz SENA: perspectivas de formación / René Alexander Guerrero Vergel, Ferly Antonio Valencia Serna, Elizabeth Tuberquia Vanegas -- Diseño y desarrollo de una aplicación de escritorio para la homologación contable de módulos sap systeme anwendungen und produkte / Nelson Giovanni Agudelo Cristancho, Ángela María Montoya, Juan Carlos Amezquita Tovar -- Realidades de la internacionalización de servicios en Colombia: una revisión de literatura (1994-2017) / Campo Elías López Rodríguez, Juan Carlos Ligarreto Parra, Haroldo Enrique Puerta Cabarcas -- Logística hospitalaria: caracterización de la operación de una sala de urgencias en la ciudad de Ibagué / Julián Alonso Garzón Quiroga, Jaime Alberto Villada Garcés -- Estudio de la evolución de la huella ocular como mecanismo de seguridad para las entidades financieras / Laura Valentina García Pérez, Karen Valentina Cetina Huérfano, Ashly Valeria Mercado Rojas, Ana C Pinzón Vargas -- Cómo vincular la información que brinda la contabilidad de gestión ambiental con los proyectos de emprendimiento / Daniel Isaac Roque -- Modelo diagnóstico para el desarrollo socio- productivo de la chamba en la post cosecha / Marina Casallas Silva, Jimmy Daniel Gamba Casallas, Wilson Ferney Molano -- Modelo de microcréditos para el sistema financiero / José Gerardo Vaca Lombanana232 página

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat