Darfur - Making a Difference

The Tenth Jacoby-Lunin Humanitarian Lectureship underwritten by the Frank Jacoby Foundation in collaboration with the Carl and Dorothy Bennett Center for Judaic Studies of the College of Arts and Sciences and University College\u27s Open VISIONS Forum presents... Nicholas Kristof, Political scientist, author, and two-time Pulitzer Prize-winning journalist specializing in East Asia. Currently a columnist for The New York Times.https://digitalcommons.fairfield.edu/bennettcenter-posters/1254/thumbnail.jp

2014 Commencement Program (Morning Ceremony)

The program for the Portland State University 2014 Commencement, Morning Ceremony: College of Liberal Arts and Sciences, held June 15, 2014. Lorry I. Lokey and Nicholas D. Kristof received honorary degrees; Kristof delivered the commencement address.https://pdxscholar.library.pdx.edu/commencement_2010s/1004/thumbnail.jp

Measurements of the pp → ZZ production cross section and the Z → 4ℓ branching fraction, and constraints on anomalous triple gauge couplings at √s = 13 TeV

Four-lepton production in proton-proton collisions, pp -> (Z/gamma*)(Z/gamma*) -> 4l, where l = e or mu, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The ZZ production cross section, sigma(pp -> ZZ) = 17.2 +/- 0.5 (stat) +/- 0.7 (syst) +/- 0.4 (theo) +/- 0.4 (lumi) pb, measured using events with two opposite-sign, same-flavor lepton pairs produced in the mass region 60 4l) = 4.83(-0.22)(+0.23) (stat)(-0.29)(+0.32) (syst) +/- 0.08 (theo) +/- 0.12(lumi) x 10(-6) for events with a four-lepton invariant mass in the range 80 4GeV for all opposite-sign, same-flavor lepton pairs. The results agree with standard model predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ. couplings at 95% confidence level: -0.0012 < f(4)(Z) < 0.0010, -0.0010 < f(5)(Z) < 0.0013, -0.0012 < f(4)(gamma) < 0.0013, -0.0012 < f(5)(gamma) < 0.0013

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

A data science roadmap for open science organizations engaged in early-stage drug discovery

The Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, believe that artificial intelligence (AI) is poised to be a main accelerator in the field. The question is then how to best benefit from recent advances in AI and how to generate, format and disseminate data to enable future breakthroughs in AI-guided drug discovery. We present here the recommendations of a working group composed of experts from both the public and private sectors. Robust data management requires precise ontologies and standardized vocabulary while a centralized database architecture across laboratories facilitates data integration into high-value datasets. Lab automation and opening electronic lab notebooks to data mining push the boundaries of data sharing and data modeling. Important considerations for building robust machine-learning models include transparent and reproducible data processing, choosing the most relevant data representation, defining the right training and test sets, and estimating prediction uncertainty. Beyond data-sharing, cloud-based computing can be harnessed to build and disseminate machine-learning models. Important vectors of acceleration for hit and chemical probe discovery will be (1) the real-time integration of experimental data generation and modeling workflows within design-make-test-analyze (DMTA) cycles openly, and at scale and (2) the adoption of a mindset where data scientists and experimentalists work as a unified team, and where data science is incorporated into the experimental design

DEVILS/MIGHTEE/GAMA/DINGO: The Impact of SFR Timescales on the SFR-Radio Luminosity Correlation

The tight relationship between infrared luminosity (L$_\mathrm{TIR}$) and 1.4 GHz radio continuum luminosity (L$_\mathrm{1.4GHz}$) has proven useful for understanding star formation free from dust obscuration. Infrared emission in star-forming galaxies typically arises from recently formed, dust-enshrouded stars, whereas radio synchrotron emission is expected from subsequent supernovae. By leveraging the wealth of ancillary far-ultraviolet - far-infrared photometry from the Deep Extragalactic VIsible Legacy Survey (DEVILS) and Galaxy and Mass Assembly (GAMA) surveys, combined with 1.4 GHz observations from the MeerKAT International GHz Tiered Extragalactic Exploration (MIGHTEE) survey and Deep Investigation of Neutral Gas Origins (DINGO) projects, we investigate the impact of timescale differences between far-ultraviolet - far-infrared and radio-derived star formation rate (SFR) tracers. We examine how the SED-derived star formation histories (SFH) of galaxies can be used to explain discrepancies in these SFR tracers, which are sensitive to different timescales. Galaxies exhibiting an increasing SFH have systematically higher L$_\mathrm{TIR}$ and SED-derived SFRs than predicted from their 1.4 GHz radio luminosity. This indicates that insufficient time has passed for subsequent supernovae-driven radio emission to accumulate. We show that backtracking the SFR(t) of galaxies along their SED-derived SFHs to a time several hundred megayears prior to their observed epoch will both linearise the SFR-L$_\mathrm{1.4GHz}$ relation and reduce the overall scatter. The minimum scatter in the SFR(t)-L$_\mathrm{1.4GHz}$ is reached at 200 - 300 Myr prior, consistent with theoretical predictions for the timescales required to disperse the cosmic ray electrons responsible for the synchrotron emission.Comment: 23 pages, 13 figures, 2 tables. Accepted for publication in MNRA

DEVILS/MIGHTEE/GAMA/DINGO: the impact of SFR time-scales on the SFR-radio luminosity correlation

The tight relationship between infrared luminosity (LTIR) and 1.4 GHz radio continuum luminosity (L1.4 GHz) has proven useful for understanding star formation free from dust obscuration. Infrared emission in star-forming galaxies typically arises from recently formed, dust-enshrouded stars, whereas radio synchrotron emission is expected from subsequent supernovae. By leveraging the wealth of ancillary far-ultraviolet – far-infrared photometry from the Deep Extragalactic VIsible Legacy Survey and Galaxy and Mass Assembly surveys, combined with 1.4 GHz observations from the Meer Karoo Array Telescope International GHz Tiered Extragalactic Exploration survey and Deep Investigation of Neutral Gas Origin projects, we investigate the impact of time-scale differences between far-ultraviolet – far-infrared and radio-derived star formation rate (SFR) tracers. We examine how the spectral energy distribution (SED)-derived star formation histories (SFHs) of galaxies can be used to explain discrepancies in these SFR tracers, which are sensitive to different time-scales. Galaxies exhibiting an increasing SFH have systematically higher LTIR and SED-derived SFRs than predicted from their 1.4 GHz radio luminosity. This indicates that insufficient time has passed for subsequent supernovae-driven radio emission to accumulate. We show that backtracking the SFR(t) of galaxies along their SED-derived SFHs to a time several hundred megayears prior to their observed epoch will both linearize the SFR–L1.4 GHz relation and reduce the overall scatter. The minimum scatter in the SFR(t)–L1.4 GHz is reached at 200 – 300 Myr prior, consistent with theoretical predictions for the time-scales required to disperse the cosmic ray electrons responsible for the synchrotron emission.This work is based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme ID 179.A-2005 (Ultra-VISTA) and ID 179.A- 2006 (VIDEO) and on data products produced by CALET and the Cambridge Astronomy Survey Unit on behalf of the Ultra-VISTA and VIDEO consortia. Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/IRFU, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l’Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. This work is based in part on data products produced at Terapix available at the Canadian Astronomy Data Centre as part of the Canada-France-Hawaii Telescope Legacy Survey, a collaborative project of NRC and CNRS. The Hyper Suprime-Cam (HSC) collaboration includes the astronomical communities of Japan and Taiwan, and Princeton University. The HSC instrumentation and software were developed by the National Astronomical Observatory of Japan (NAOJ), the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU), the University of Tokyo, the High Energy Accelerator Research Organization (KEK), the Academia Sinica Institute for Astronomy and Astrophysics in Taiwan (ASIAA), and Princeton University. Funding was contributed by the FIRST program from Japanese Cabinet Office, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Japan Society for the Promotion of Science (JSPS), Japan Science and Technology Agency (JST), the Toray Science Foundation, NAOJ, Kavli IPMU, KEK, ASIAA, and Princeton University. MJJ, IHW, and CLH acknowledge generous support from the Hintze Family Charitable Foundation through the Oxford Hintze Centre for Astrophysical Surveys. MJJ acknowledges the support of the STFC consolidated grant [ST/S000488/1] and [ST/W000903/1] and from a UKRI Frontiers Research Grant [EP/X026639/1]. CLH acknowledges support from the Leverhulme Trust through an Early Career Fellowship. ID acknowledges support from INAF Minigrant ”Harnessing the power of VLBA towards a census of AGN and star formation at high redshift”.Peer reviewe