Redistributing Power in Mississippi: The Reversal of Section 4 of the Voting Rights Act

Recently, the U.S. Supreme Court declared Section 4 of the Voting Rights Act of 1965 unconstitutional, essentially defanging preclearance requirements of Section 5 and leaving racial and other previously disenfranchised minorities unprotected. Using social contract theory as the theoretical framework, empirical field study research was used to examine whether the Voting Rights Act has achieved the results in Mississippi that the Supreme Court’s decision to revoke Section 4 has assumed. Data were collected on race-specific voter registration and voting data, measures of vote discrimination, litigations and Mississippi legislative activity regarding voting rights. Findings indicate that the gap between minority and non-minority voter registration and voting has improved. However, other measures of vote discrimination show that Mississippi has a higher noncompliance rate than any of the other 1965 covered jurisdictions. These findings suggest that the decision in Shelby v. Holder may be premature, particularly as it relates to Mississippi. A Congressional remedy is needed to ensure that Black Mississippians have unfettered opportunities to exercise their Constitutional right to vote and sustain the gains in political power resulting from the protection afforded under Section 4 of the Voting Rights Act

Employees' responsibilities in a knowledge retention strategy: a Ugandan case study

When people join organisations, they come with their experiences, skills and expertise and they gain further knowledge as they execute their duties. Employees may write reports, research papers, and books; others may capture their expertise in expert systems. However, whatever is captured in these forms is modest compared to employees’ total knowledge. When they leave their employment, they carry with them most of their knowledge, resulting in loss of organisational intellectual asset and erosion of organisational memory thus negatively impacting on learning and innovation. Tacit knowledge is more vulnerable than explicit knowledge to being lost. An exploratory study was conducted in the Ugandan National Agricultural Research organisation (NARO) to identify strategies that can be implemented to minimise loss of tacit knowledge. One of the research questions this study addressed was ‘how can individual employees help NARO to minimise knowledge loss?’ This paper presents results from thirty six focus groups and highlights mandatory retirement, resignation, termination of contract, death, and absconding as the major reasons for tacit knowledge being lost from the organisation; it also identifies eight responsibilities for individual employees in minimising knowledge loss from the organisation. These responsibilities are: develop a spirit and attitude to sharing knowledge; capture and document processes, experiences and results; mentoring others and willingness to learn; being result-oriented and having passion for the job; be an effective team player; seek opportunities to acquire and improve knowledge; being open, transparent and trusted; and applying acquired knowledge. Whereas the authors acknowledge that management is responsible for ensuring that individual employees exercise their responsibilities in helping the organisation to minimise knowledge loss, it is not a focus of this paper to present and discuss such management responsibilities. Undertaking the responsibilities effectively requires an enabling organisational environment. Such an environment is likely to encourage employees to engage themselves in a positive behaviour of knowledge sharing so that even when an employee who is knowledgeable in a particular aspect leaves the organisation there will be some other employees with such expertise if it is shared within organisational teams or employee groups

The partially alternating ternary sum in an associative dialgebra

The alternating ternary sum in an associative algebra, $abc - acb - bac + bca + cab - cba$, gives rise to the partially alternating ternary sum in an associative dialgebra with products $\dashv$ and $\vdash$ by making the argument $a$ the center of each term: $a \dashv b \dashv c - a \dashv c \dashv b - b \vdash a \dashv c + c \vdash a \dashv b + b \vdash c \vdash a - c \vdash b \vdash a$. We use computer algebra to determine the polynomial identities in degree $\le 9$ satisfied by this new trilinear operation. In degrees 3 and 5 we obtain $[a,b,c] + [a,c,b] \equiv 0$ and $[a,[b,c,d],e] + [a,[c,b,d],e] \equiv 0$; these identities define a new variety of partially alternating ternary algebras. We show that there is a 49-dimensional space of multilinear identities in degree 7, and we find equivalent nonlinear identities. We use the representation theory of the symmetric group to show that there are no new identities in degree 9.Comment: 14 page

On the challenges and opportunities facing fish biology: a discussion of five key knowledge gaps

Many fish species face increasing challenges associated with climate change and overfishing. At the same time, aquaculture is becoming vital for food security. Gaining a deeper understanding of the basic biology of fish is therefore more important than ever. Here we synthesize and summarize key questions, opportunities and challenges in fish biology highlighted during a round‐table discussion at the 50th Anniversary Symposium of The Fisheries Society of the British Isles, held at the University of Exeter, U.K., in July 2017. We identified several knowledge gaps but also key opportunities for fish biology to inform food security, for collective behaviour, evolutionary history and trait correlations to predict responses to environmental change and for novel analytical approaches to mine existing data sets. Overall, more integrative approaches through stronger collaborations across different fields are needed to advance our understanding of the basic biology of fish

The thick-bedded tail of turbidite thickness distribution as a proxy for flow confinement: examples from Tertiary basins of central and northern Apennines (Italy)

This study reviews the thickness statistics of non-channelized turbidites from four tertiary basins of Central-Northern Apennines (Italy), where bed geometry and sedimentary character have been previously assessed. Though very different in terms of size and, arguably, character of feeder system, these basins share a common stratigraphic evolution consisting in transition from an early ponded to a late unconfined setting of deposition. Based on comparison of thickness subsets from diverse locations and stratigraphic heights within the studied turbidite fills, this paper seeks to answer the following questions: i) how data collection procedures and field operational constraints (e.g. measure location, outcrop quality, use of thicknesses data from single vs. multiple correlative sections, stratigraphic thickness of the study interval) can affect statistics of sample data? ii) how depositional controls of confined vs. unconfined turbidite basins can result in different thickness-frequency distributions?; and iii) is there in thickness statistics a ‘flow confinement’ signature which can be used to distinguish between confined and unconfined turbidites? Results suggest that: i) best practices of data collection are crucial to a meaningful interpretation of sample data statistics, especially in presence of stratigraphic and spatial trends of turbidite bed thickness; ii) a systematic bias against cm-thick Tcd Bouma sequence turbidites exists in sample data, which can result in the low-end tail of empirical thickness-frequency distributions to depart significantly from the actual distribution of turbidite thickness; and iii) thickness statistics of beds starting with a basal Ta/Tb Bouma division bear a coherent relationship to the transition from ponded to unconfined depositional settings, consisting in reduction of variance and mean and, consequently, parameters, or even type, of best fit model distribution. This research highlights the role of flow stripping, sediment by-pass and bed geometry in altering the initial thickness distribution of ponded turbidites and suggests how fully ponded mini-basins represent the ideal setting for further research linking turbidite thickness statistics and frequency distribution of parent flow volumes

Mixed planar and network single-facility location problems

We consider the problem of optimally locating a single facility anywhere in a network to serve both on-network and off-network demands. Off-network demands occur in a Euclidean plane, while on-network demands are restricted to a network embedded in the plane. On-network demand points are serviced using shortest-path distances through links of the network (e.g., on-road travel), whereas demand points located in the plane are serviced using more expensive Euclidean distances. Our base objective minimizes the total weighted distance to all demand points. We develop several extensions to our base model, including: (i) a threshold distance model where if network distance exceeds a given threshold, then service is always provided using Euclidean distance, and (ii) a minimax model that minimizes worst-case distance. We solve our formulations using the “Big Segment Small Segment” global optimization method, in conjunction with bounds tailored for each problem class. Computational experiments demonstrate the effectiveness of our solution procedures. Solution times are very fast (often under one second), making our approach a good candidate for embedding within existing heuristics that solve multi-facility problems by solving a sequence of single-facility problems. © 2016 Wiley Periodicals, Inc. NETWORKS, Vol. 68(4), 271–282 2016

ENIGMA-anxiety working group : Rationale for and organization of large-scale neuroimaging studies of anxiety disorders

Altres ajuts: Anxiety Disorders Research Network European College of Neuropsychopharmacology; Claude Leon Postdoctoral Fellowship; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 44541416-TRR58); EU7th Frame Work Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw, 10-000-1002); Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, MH002781); National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, ZIA-MH-002782); SA Medical Research Council; U.S. National Institutes of Health grants (P01 AG026572, P01 AG055367, P41 EB015922, R01 AG060610, R56 AG058854, RF1 AG051710, U54 EB020403).Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field