Video: Board Certification: Reaching the Pinnacle of Practice

Course Outline & Timeline Registration & Continental Breakfast: 7:30 to 7:55 am Atrium & Lecture Room Welcome & Introduction: 7:55 to 8:00 am Elena Rose Minicucci, J.D., Director of Alumni Relations, NSU Shepard Broad Law Center Welcome Introduce Professor Donna Carol Litman, and attorneys Sheryl Moore, Steven Farbman, Todd Weicholz, and William Snyder, LL.M. Seminar Presentation 8:00 am to 9:15 am Professor Donna Carol Litman - Moderator Nova Southeastern University Shepard Broad Law Center Fort Lauderdale, FL Florida Bar Board Certified in Tax Law Professor Litman will lead the discussion among the other Board Certified attorneys listed above. The Discussion will cover the following: Overview of Board Certification – Requirements Rules Regulating Board Certification – in general Handout: Rule 6-3.5 “Standards for Certification” (general) Handout: Rule 6-3.6 “Recertification” (general) Revocation of Certification – Once Certified, lawyer may lose Certification for certain reasons such as: if the area of practice ceases to be certified; if disciplinary action is taken against the lawyer pursuant to Rules Regulating The Florida Bar; if the lawyer commits a crime; misrepresentation by the lawyer; failure to abide by the rules and regulations governing the program; other lawyer misconduct. Handout: Rule 6-3.8 “Revocation of Certification” 6 Ethics – Rules Regulating The Florida Bar Rule 6-3.9 “Manner of Certification” attorney and law firm must comply with this rule for all advertising, website, business cards, office sign; limitation on use of terms: “Specialist” or “Board Certified” or “Expert” or “B.C.S.” Handout: Rule 6-3.9 “Manner of Certification” & 4-7.14(a)(4) “Potentially Misleading Advertisements” Practice Areas – Board Certification in Florida offers twenty-four practice areas in which to become Board Certified Handout: “Florida’s 24 Legal Specialty Areas” from The Florida Bar Five Specific Board Certification Practice areas discussed below by speakers who are Board Certified in their practice areas: Tax Law Certification: Donna Carol Litman, Esq. Requirements as set forth in Rule 6-5 “Standards for Certification of a Board Certified Tax Lawyer” Handout: Rule 6-5 (including 6-5.1 through 6-5.4) Discussion of Article: Board Certification: The View From the Bench…and Beyond” by George W. Maxwell, III, 77 APR Fla. B.J. 34 (April 2003) – how Judges view Board Certified attorneys Marital & Family Law Certification: Sheryl Moore, Esq. Requirements as set forth in Rule 6-6 “Standards for Board Certification in Marital & Family Law” Handout: Rule 6-6 (including 6-6.1 through 6-6.5) – lawyers and judicial officers included Case Law and/or Ethical Considerations – The Florida Bar v. Morse 784 So. 2d 414 (Fla. 2001) dealing with revocation of Board Certification in Marital & Family Law for failure to provide diligent and competent representation to client Civil Trial Certification: Steven S. Farbman, Esq. Requirements as set forth in Rule 6-4 “Standards for Certification of a Board Certified Civil Trial Lawyer” Handout: Rule 6-4 (including 6-4.1 through 6-4.4) Case Law and/or Ethical Considerations – Rules Regulating The Florida Bar, Chapter 4 – 1.5 Fees and Costs for Legal Services (including Contingency Fee Agreements) and Art. 1 Sec. 26 The Florida Constitution, “Claimant’s Right to Fair Compensation” Criminal Trial Certification: Todd Weicholz, Esq. Requirements as set forth in Rule 6-8 “Standards for Certification of a Board Certified Criminal Lawyer” Handout: Rule 6-8 (including 6-8.1 through 6-8.4) Case Law and/or Ethical Considerations – 4-7.18 “Direct Contact with Prospective Clients” especially relevant to criminal defense matters Wills, Trusts & Estates Certification: William Snyder, LL.M, Esq. Requirements as set forth in Rule 6-7 “Standards For Certification of a Board Certified Wills, Trusts, and Estates Lawyer” 7 Handout: Rule 6-7 (including 6-7.1 through 6-7.4) Case Law & Ethical Considerations - Rules Regulating the Florida Bar – Chapter 4 – 7.13 “Deceptive and Inherently Misleading Advertisements” especially regarding experience and special expertise Professor Donna Carol Litman, Esq. 9:15 to 9:30 am General Question & Answer Session with Seminar Attendees & Board Certified Speakers: Sheryl Moore, Esq., Steven S. Farbman, Esq., Todd Weicholz, Esq., and William Snyder, LL.M., Esq. Seminar ends at 9:30 a

of Education or Offices within it. NCEO Core Staff

assessment: Results of a comparative study (Technical Report 64). Minneapolis, MN: University of Minnesota, National Center on Educationa

Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

Background Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response. Methods We did hierarchical cluster analysis using five common symptoms associated with primary Sjögren's syndrome (pain, fatigue, dryness, anxiety, and depression), followed by multinomial logistic regression to identify subgroups in the UK Primary Sjögren's Syndrome Registry (UKPSSR). We assessed clinical and biological differences between these subgroups, including transcriptional differences in peripheral blood. Patients from two independent validation cohorts in Norway and France were used to confirm patient stratification. Data from two phase 3 clinical trials were similarly stratified to assess the differences between subgroups in treatment response to hydroxychloroquine and rituximab. Findings In the UKPSSR cohort (n=608), we identified four subgroups: Low symptom burden (LSB), high symptom burden (HSB), dryness dominant with fatigue (DDF), and pain dominant with fatigue (PDF). Significant differences in peripheral blood lymphocyte counts, anti-SSA and anti-SSB antibody positivity, as well as serum IgG, κ-free light chain, β2-microglobulin, and CXCL13 concentrations were observed between these subgroups, along with differentially expressed transcriptomic modules in peripheral blood. Similar findings were observed in the independent validation cohorts (n=396). Reanalysis of trial data stratifying patients into these subgroups suggested a treatment effect with hydroxychloroquine in the HSB subgroup and with rituximab in the DDF subgroup compared with placebo. Interpretation Stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments. Our data have important implications for clinical management, trial design, and therapeutic development. Similar stratification approaches might be useful for patients with other chronic immune-mediated diseases. Funding UK Medical Research Council, British Sjogren's Syndrome Association, French Ministry of Health, Arthritis Research UK, Foundation for Research in Rheumatology

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Labor Force Participation of Rural Farm, Rural Nonfarm, and Urban Women: A Panel Update

In this paper, we analyze the paid labor force participation rates and continuity patterns of rural farm, rural nonfarm, and urban women. Specifically, we trace the labor force participation of a panel of approximately 800 women in Nebraska from 1977 to 1985. This paper has a twofold purpose. First, we examine changes in the work status of the cohort of Nebraska women during the farm crisis years. Second, we identify individual factors influencing labor force participation and continuity, contrasting all three residential groups of women. A loglinear model isolates differences in participation rates for rural and urban women as well as for rural farm and rural nonfarm women during the 1977, 198 1, and 1985 panel years. A discriminant analysis then ascertains the nonlinear relationships in women\u27s work histories for the same time period. A comparison of continuous, discontinuous, and nonparticipatory labor force patterns illustrates that rural women, and farm women in particular, entered the wage labor force in disproportionate numbers during the farm crisis years. The farm crisis provides a framework for discussing accelerated participation rates and changes in the effects of individual human capital characteristics. Increases in participation rates are most evident among married farm women with discontinuous parttime work histories. Over the three data points, the effect of preschool children on labor work force participation was attenuated for farm women and higher education levels became less salient in predicting labor force participation rates for both rural and urban women

The Contexts of Housework and the Paid Labor Force: Women’s Perceptions of the Demand Levels of Their Work

This research explores the work perceptions, both physical and mental, of women. The research finds that women’s perceptions of waged and nonwaged labor differ greatly depending on the work environment. Perceptions of physical demands of waged labor are almost solely dependent on the type of paid labor women engage in. For homeworkers, perceptions of physical labor are influenced primarily by the number of hours invested in housework. The mental demands of waged and nonwaged labor are also perceived differently. Women in the waged economy report significantly higher mental demands than do homeworkers. This too varies across labor segments. The closest parallel between physical and mental demand perceptions is between homeworkers and women in the service sector of the waged economy. Overall the assumption that women perceive their work roles in the waged market and the home market similarly is negated