The gamma-ray burst monitor for Lobster-ISS

Lobster-ISS is an X-ray all-sky monitor experiment selected by ESA two years ago for a Phase A study (now almost completed) for a future flight (2009) aboard the Columbus Exposed Payload Facility of the International Space Station. The main instrument, based on MCP optics with Lobster-eye geometry, has an energy passband from 0.1 to 3.5 keV, an unprecedented daily sensitivity of 2x10^{-12} erg cm^{-2}s$^{-1}, and it is capable to scan, during each orbit, the entire sky with an angular resolution of 4--6 arcmin. This X-ray telescope is flanked by a Gamma Ray Burst Monitor, with the minimum requirement of recognizing true GRBs from other transient events. In this paper we describe the GRBM. In addition to the minimum requirement, the instrument proposed is capable to roughly localize GRBs which occur in the Lobster FOV (162x22.5 degrees) and to significantly extend the scientific capabilities of the main instrument for the study of GRBs and X-ray transients. The combination of the two instruments will allow an unprecedented spectral coverage (from 0.1 up to 300/700 keV) for a sensitive study of the GRB prompt emission in the passband where GRBs and X-Ray Flashes emit most of their energy. The low-energy spectral band (0.1-10 keV) is of key importance for the study of the GRB environment and the search of transient absorption and emission features from GRBs, both goals being crucial for unveiling the GRB phenomenon. The entire energy band of Lobster-ISS is not covered by either the Swift satellite or other GRB missions foreseen in the next decade.Comment: 6 pages, 4 figures. Paper presented at the COSPAR 2004 General Assembly (Paris), accepted for publication in Advances in Space Research in June 2005 and available on-line at the Journal site (http://www.sciencedirect.com/science/journal/02731177), section "Articles in press

Lyman Alpha Emitter Evolution in the Reionization Epoch

Combining cosmological SPH simulations with a previously developed Lyman Alpha production/transmission model and the Early Reionization Model (ERM, reionization ends at redshift z~7), we obtain Lyman Alpha and UV Luminosity Functions (LFs) for Lyman Alpha Emitters (LAEs) for redshifts between 5.7 and 7.6. Matching model results to observations at z~5.7 requires escape fractions of Lyman Alpha, f_alpha=0.3, and UV (non-ionizing) continuum photons, f_c=0.22, corresponding to a color excess, E(B-V)=0.15. We find that (i) f_c increases towards higher redshifts, due the decreasing mean dust content of galaxies, (ii) the evolution of f_alpha/f_c hints at the dust content of the ISM becoming progressively inhomogeneous/clumped with decreasing redshift. The clustering photoionization boost is important during the initial reionization phases but has little effect on the Lyman Alpha LF for a highly ionized IGM. Halo (stellar) masses are in the range 10.0 < \log M_h < 11.8 (8.1 < \log M_* < 10.4) with M_h \propto M_*^{0.64}. The star formation rates are between 3-120 solar masses per year, mass-weighted mean ages are greater than 20 Myr at all redshifts, while the mean stellar metallicity increases from Z=0.12 to 0.22 solar metallicity from z~7.6 to z~5.7; both age and metallicity positively correlate with stellar mass. The brightest LAEs are all characterized by large star formation rates and intermediate ages (~200 Myr), while objects in the faint end of the Lyman Alpha LF show large age and star formation rate spreads. With no more free parameters, the Spectral Energy Distributions of three LAE at z~5.7 observed by Lai et al. (2007) are well reproduced by an intermediate age (182-220 Myr) stellar population and the above E(B-V) value.Comment: 13 pages, 9 figures, accepted to MNRA

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Wses Jerusalem Guidelines For Diagnosis And Treatment Of Acute Appendicitis

Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.1

Three New Trixane Glycosides Obtained From The Leaves Of Jungia Sellowii Less. Using Centrifugal Partition Chromatography

Jungia sellowii (Asteraceae) is a shrub that grows in Southern Brazil and polar extract of its leaves presents anti-inflammatory properties. Cyperane, guaiane, nortrixane, and trixane sesquiterpene types were reported as the main metabolites in Jungia species. This work aims to describe the isolation and identification of sesquiterpenes in the leaves of J. sellowii using liquid-liquid partition and centrifugal partition chromatography. Thus, the crude extract of fresh leaves of J. sellowii was partitioned with hexane, dichloromethane, ethyl acetate and butanol, respectively. The butanol fraction was then subjected to a selected ternary system optimized for the CPC (centrifugal partition chromatography): ethyl acetate-ethanol-water (9:2:10, v/v/v). The separation was carried out isocratically at a flow rate of 25 mL/min at 1200 rpm, affording seven fractions A to G. TLC of fractions B, C and F displayed a single spot corresponding to three new glycosylated sesquiterpenoids. Their structures were established by using spectroscopic data in comparison to those reported in the literature. Furthermore, the isolates were evaluated for their leishmanicidal and cytotoxic effects. No cytotoxic effect was observed against the three cancer cell lines (HL60, JURKAT and REH), but compound 1 showed a weak antiprotozoal activity. Liquid-liquid partition and CPC turned to be a versatile technique of glycoside purification which is environmentally friendly and requires a limited amount of organic solvents.12674683FP7-PEOPLE-IRSES Marie Curie Actions, program "ChemBioFight'' [269031

Cell-based sensors for quantifying the physiological impact of microsystems

2012 January 1Microsystems are increasingly used in the manipulation, patterning and sorting of cells. Critical to the widespread adoption of these new technologies is development of an understanding of their impact on cellular physiology. Here we show the integration of a cell-based sensor, a microfabricated electrical screening platform, and quantitative imaging to enable the first large-scale physiological screens of the impact of microsystems on cells. To perform physiological screening, we developed a cell-based sensor that reports on stress-mediated transcription (via Heat Shock Factor 1 induced expression of GFP). This cell-based sensor was quantitatively characterized using automated imaging. The integration of this quantitative physiological sensor with a microfabricated system enabled the execution of multiplexed screens across electric field strength, frequency, and application duration. Voltage sweeps indicate increasing physiological stress with increasing voltage due to Joule heating, while frequency sweeps indicate increased stress at lower frequencies (1 MHz) due to generation of reactive species at lower frequencies. Combined voltage and frequency sweeps enable the generation of complex maps of physiological state.National Institutes of Health (U.S.) (Grant RR199652)National Institutes of Health (U.S.) (Grant EB005753

Strengthening Of Porcelain Provided By Resin Cements And Flowable Composites

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)This study evaluated the effect of mechanical properties of resin-based luting agents on the strength of resin-coated porcelain. The luting agents tested were two flowable resin composites (Filtek Z350 Flow and Tetric-N Flow), a light-cured resin cement (Variolink Veneer [VV]), and a dual-cured resin cement (Variolink II) in either light-cured (base paste) or dualcured (base + catalyst pastes [VD]) mode. Flexural strength (sigma(f)) and modulus of elasticity (E-f) of the luting agents were measured in three-point bending mode (n=5). Porcelain discs (Vita VM7) were tested either untreated (control) or acid etched, silanized, and coated with the luting agents. Biaxial flexural strength (sigma(bf)) of the porcelain discs was tested using a ball-onring setup (n=30). The sigma(bf) of the resin-coated specimens was calculated at z-axial positions for multilayer specimens in the ball-on-ring test: position z = 0 (ceramic surface at the bonded interface) and position z = -t(2) (luting agent surface above ring). The sigma(f) and E-f data were subjected to analysis of variance and the Student-Newman-Keuls test (alpha=0.05). A Weibull analysis was performed for sigma(bf) data. Weibull modulus (m) and characteristic strength (sigma(0)) were calculated. Linear regression analyses investigated the relationship between mechanical properties of the luting agents and the strengthening of porcelain. VD had higher and VV had lower mechanical strength than the other materials. At z = 0, all resin-coated groups had higher sigma(bf) than the control group. No significant differences between the luting agents were observed for sigma(bf) and sigma(0). At z = -t(2), VD had the highest sigma(bf) and sigma(0), whereas VV had the poorest results. No significant differences in m were observed across groups. A linear increase in flexural strength of the porcelain was associated with increased sigma(f) and E-f of the luting agents at position z = -t(2). In conclusion, resin coating and use of luting agents with better physical properties generally improved the mechanical performance of porcelain.41179188FAPERGS/Brazil [0902063]CNPq/Brazil [503897/2012-4]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Direct photon elliptic flow in Pb-Pb collisions at root s(NN)=2.76 TeV

The elliptic flow of inclusive and direct photons was measured at mid-rapidity in two centrality classes 0-20% and 20-40% in Pb-Pb collisions at root s(NN) = 2.76 TeV by ALICE. Photons were detected with the highly segmented electromagnetic calorimeter PHOS and via conversions in the detector material with the e(broken vertical bar)e pairs reconstructed in the central tracking system. The results of the two methods were combined and the direct-photon elliptic flow was extracted in the transverse momentum range 0.9 < p(T) < 6.2 GeV/c. A comparison to RHIC data shows a similar magnitude of the measured direct-photon elliptic flow. Hydrodynamic and transport model calculations are systematically lower than the data, but are found to be compatible. (C) 2018 The Author. Published by Elsevier B.V.Peer reviewe

Study of B Meson Production in p plus Pb Collisions at root s(NN)=5.02 TeV Using Exclusive Hadronic Decays

Peer reviewe

Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light

Current interferometric gravitational-wave detectors are limited by quantum noise over a wide range of their measurement bandwidth. One method to overcome the quantum limit is the injection of squeezed vacuum states of light into the interferometer’s dark port. Here, we report on the successful application of this quantum technology to improve the shot noise limited sensitivity of the Advanced Virgo gravitational-wave detector. A sensitivity enhancement of up to 3.2±0.1  dB beyond the shot noise limit is achieved. This nonclassical improvement corresponds to a 5%–8% increase of the binary neutron star horizon. The squeezing injection was fully automated and over the first 5 months of the third joint LIGO-Virgo observation run O3 squeezing was applied for more than 99% of the science time. During this period several gravitational-wave candidates have been recorded