46,949 research outputs found

    Hepatic stellate cells and parasite-induced liver fibrosis

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    ABSTRACT: Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well investigated over the last few years in a number of liver diseases. The trans-differentiation process can be monitored in vitro by evaluation of biomarkers that are characteristic of normal quiescent hepatic stellate cells or activated myofibroblasts. Two major parasitic diseases associated with liver injury and fibrosis are schistosomiasis and echinococcosis. Recent studies have highlighted a role for activated hepatic stellate cells in both murine and human schistosomiasis as well as demonstrating that schistosome antigens are able to regulate this trans-differentiation process. Study of the hepatic stellate cell and its interaction with parasite-derived antigens may be pivotal in our understanding of the pathology associated with schistosomiasis and other parasitic diseases, including echinococcosis, as well as revealing new information on the trans-differentiation process in this cell type

    Emission characteristics of CO, NOx, SO2 and indications of biomass burning observed at a rural site in eastern China

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    Atmospheric O3, CO, SO2, and NO* y (NO* y ≈ NO + NO2 + PAN + organic nitrates + HNO3 + N2O5 + ⋯) were measured in 1999-2000 at a rural/agricultural site in the Yangtze Delta of China. In this paper we analyze the measurement results to show the emission characteristics of the measured gases and to infer relevant emission ratios. Positive correlations were found between CO and NO* y with a slope (Δ[CO]/Δ[NO* y]) of 36 (ppbv/ppbv) for the winter and nighttime measurements. The ratio is considerably larger than that (≈10 ppbv/ppbv) observed in the industrialized countries. The highest CO/NO* y ratio (30-40 ppbv/ppbv) occurred in September-December 1999 and June 2000. The good correlation between CO and the biomass burning tracer CH3Cl and the lack of correlation with the industrial tracer C2Cl4 suggests that the burning of biofuels and crop residues is a major source for the elevated CO and possibly for other trace gases as well. The average SO2 to NO* y ratio was 1.37 ppbv/ppbv, resulting from the use of relatively high-sulfur coals in China. The measured SO2/NO* y and ΔCO/ΔNO* y were compared with the respective ratios from the current emission inventories for the study region, which indicated a comparable SO2/NOx emission ratio but a large discrepancy for CO/NOx. The observed CO to NO* y ratio was more than 3 times the emission ratio derived from the inventories, indicating the need for further improvement of emission estimates for the rural/agricultural regions in China. Additional research will be needed to study the implications of rural emissions to atmospheric chemistry and climate on both regional and global scales.Department of Civil and Environmental Engineerin

    Epidemiological, clinical and laboratory characteristics of 19 serologically confirmed rickettsial disease in Singapore.

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    AIM: To identify epidemiological, clinical and laboratory features of serologically-proven typhus in the local setting. METHOD & RESULTS: Retrospective study looking at rickettsial serologies done over a six-month period and collection of the epidemological, clinical, laboratory and treatment response data from the case notes of the patients with an ordered rickettsial serology. Twenty of the 35 cases had a positive serology. Of these 20 patients, 18 were already clinically diagnosed as having murine typhus. All except one were males and all were migrant workers. Majority of the patients were construction workers staying in containers where rats abound. The most consistent clinical features were high fever (100%) for a median period of seven days, headache (94%) and cough (47%). The white cell count was usually normal (74%) but thrombocytopenia was common (68%). Transaminitis was also common (90%) with the AST component higher than the ALT in half of the cases. Response to doxycycline therapy was rapid and most (88%) were afebrile by 72 hours. CONCLUSION: Typhus (notably murine type) can be confidently diagnosed from consistent clinical features supported by epidemiological and laboratory clues. Early recognition with the prompt treatment response will result in shorter hospital stay with decreased cost. Serological testing may only prove useful in difficult situations when the clinical diagnosis is less clear
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