55 research outputs found
Progress report on the ground-water resources of the Las Vegas Artesian Basin, Nevada
- Publication venue
- Digital Scholarship@UNLV
- Publication date
- 01/03/1945
- Field of study
Whether the tremendously increased population acquired by Las Vegas in the years 1940 to 1942 will be retained cannot at present be foretold. However, the valley will undoubtedly be expected to support a considerably larger population than it did at any time prior to 1940, and continually increasing demands on the water supply for innumerable pcacetimc activities must be anticipated. Therefore, a sound evaluation of tho ground water resources of Las Vegas Valley is directly in line with the other wisely progressive planning programs which are now operating or are taking shape in the valley as well as in the entire State of Nevada
Water levels and artesian pressure in wells in Las Vegas Valley and in other valleys in Nevada, 1913-1945
- Publication venue
- Digital Scholarship@UNLV
- Publication date
- 01/01/1947
- Field of study
The rock formations of the earth are great natural reservoirs in which a part of the water derived from rain and snow is stored. Water levels and artesian pressure in wells register the stages of these natural reservoirs. The changes in water levels or artesian pressure are indicative of the depletion or replenishment of the natural reservoirs. Systematic and periodic measurements of water levels and artesian pressure in wells have been made in Nevada, by State and Federal agencies from time to time. However, only a few of these measurements have ever been published. Under the cooperative arrangement between the State Engineer of Nevada and the Director of the U.S. Geological Survey, Department of the Interior, beginning in July 1944, a considerable effort was made to assemble and compile the authentic available records of measurements for publication. Such a compilation provides a permanent record, readily available, for future reference. The result of this compilation is set forth in this report. It is the third in the series of Nevada Water Resources Bulletins prepared by the U. S. Department of Interior, Geological Survey, in cooperation with the State Engineer
Association of vitamin D status with arterial blood pressure and hypertension risk : a mendelian randomisation study
- Author
- Acharya Jayshree
- Ahluwalia Tarunveer Singh
- Alves Alexessander Couto
- Arden Nigel
- Bandinelli Stefania
- Berry Diane J
- Billings Liana K
- Brenner Hermann
- Byberg Liisa
- Campbell Harry
- Caroline Hayward
- Cavadino Alana
- Cohorts for Heart and Aging Research in Genomic Epidemiology (CH
- Cooper Cyrus
- Cooper Jackie A
- de Boer Rudolf A
- de Borst Martin H
- Dieffenbach Aida Karina
- Dupuis Josée
- Eriksson Joel
- Eriksson Johan G
- Florez Jose C
- Fraser Ross M
- Frayling Timothy M
- Global Blood Pressure Genetics (Global BPGen) consortium
- Grimnes Guri
- Hagström Emil
- Hardy Rebecca
- Hartman Catharina A
- Heerspink Hiddo J Lambers
- Heinrich Joachim
- Hernandez Dena G
- Herzig Karl-Heinz
- Hingorani Aroon D
- Houston Denise K
- Huffman Jennifer E
- Humphries Steve E
- Hyppönen Elina
- Ingelsson Erik
- International Consortium for Blood Pressure (ICBP)
- Jablonski Kathleen A
- Jameson Karen
- Jorde Rolf
- Jula Antti
- Järvelin Marjo-Riitta
- Karlsson Magnus
- Kivimaki Mika
- Kleber Marcus E
- Kritchevsky Stephen B
- Kuh Diana
- Kumari Meena
- Lahti Jari
- Laitinen Jaana
- Langdahl Bente Lomholt
- Lehtimäki Terho
- LifeLines Cohort Study investigators
- Lind Lars
- Ljunggren Osten
- Lohman Kurt K
- Lorentzon Mattias
- Lu Chen
- Mangino Massimo
- McCarthy Mark I
- McLachlan Stela
- Melhus Håkan
- Mellström Dan
- Michaëlsson Karl
- März Winfried
- Navarro Pau
- Navis Gerjan
- Nolte Ilja M
- Ohlsson Claes
- Osmond Clive
- Pasko Dorota
- Paternoster Lavinia
- Penninx Brenda W
- Pilz Stefan
- Polasek Ozren
- Pouta Anneli
- Power Chris
- Price Jacqueline F
- Raitakari Olli
- Rejnmark Lars
- Ripatti Samuli
- Rudan Igor
- Salomaa Veikko
- Saum Kai-Uwe
- Schöttker Ben
- Sebert Sylvain
- Snieder Harold
- Spector Tim D
- Stolk Ronald P
- Sørensen Thorkild IA
- Theodoratou Evropi
- Thiering Elisabeth
- Tiesler Carla MT
- Tikkanen Emmi
- Tzoulaki Ioanna
- van der Harst Pim
- van der Most Peter J
- Vimaleswaran Karani S
- Vitart Veronique
- Wang Thomas J
- Whittaker John C
- Wilson James F
- Wong Andrew
- Wright Alan F
- Zgaga Lina
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Rheumatoid arthritis - treatment: 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis
- Author
- Ahmad Yasmeen
- Al-Kashi Adam
- Alten Rieke
- Andres Roman Ivorra Jose
- Aranda Richard
- Aranda Richard
- Ashcroft Darren M.
- Atkinson Francesca
- Atzeni Fabiola
- Baker D.
- Baraf Herbert
- Baratelle A.
- Bathon J.
- Bathon Joan
- Becker Jean-Claude
- Becker Jean-Claude
- Behrens Frank
- Beirne Paul
- Bernasconi Corrado
- Beutler A.
- Bingham Clifton
- Bingham Sarah J.
- Blackler Laura
- Blunn Karina J.
- Bolce R.
- Breedveld Ferdinand C.
- Breslin Anne
- Buch Maya
- Burgos-Vargas Ruben
- Burke Laura
- Burkhardt Harald
- Burmester Gerd
- Bykerk Vivian P.
- Chai Akiko
- Chernajovsky Yuti
- Chung Carol Y.
- Cifaldi Mary
- Cohen Roger
- Cohen Stanley B.
- Conaghan P. G.
- Covucci Allison
- Curtis Jeffrey
- Curtis Jeffrey
- Curtis Jeffrey
- Dass Shouvik
- Davies Rebecca
- De Bari Cosimo
- De Silva Chulanie
- Decktor D.
- Dehoratius R.
- Delaet Ingrid
- Dell'Accio Francesco
- Dennison Elaine
- Dougados Maxime
- Dougados Maxime
- Doyle M. K.
- Dudler Jean
- Durez Patrick
- Ehrenstein Michael R.
- El-Kadi H.
- Elashoff M.
- Elegbe Ayanbola
- Ellis Shawn D.
- Eltawil Noha
- Emery P.
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Eveslage Maria
- Fan H.
- Farmer Pamela
- Faurholm Bjarne
- Fichtner Andreas
- Fleischmann R.
- Fleischmann R.
- Fleischmann R.
- Fleischmann Roy
- Fleischmann Roy M.
- Fleischmann Roy M.
- Fuji Takeshi
- Furst Dan
- Furst Daniel E.
- Furst Daniel E.
- Galloway James
- Genant Harry
- Genovese M.
- Genovese M. C.
- Genovese M. C.
- Genovese Mark C.
- Genovese Mark C.
- Goldman J.
- Goldring Mary
- Gomez-Reino Juan
- Gould David
- Gujrathi Sheila
- Gullick Nicola J.
- Gullick Nicola J.
- Guo Yonghua
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Hamilton Jennifer
- Haraoui Boulos
- Haraoui Boulos
- Heatley Rebecca
- Herzer Peter
- Heycock Carol
- Hochberg Marc
- Hogan Vanessa
- Holweg Cecile
- Hsia E. C.
- Hsia E. C.
- Hsia E. C.
- Hughes Chris
- Hutchinson David G.
- Hyrich Kimme
- Hyrich Kimme L.
- Iaremenko Oleg
- Ince Akgun
- Jameson Karen
- Jones Tim
- Kahan Andre
- Kary Sonja
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kellner H.
- Kelly Clive
- Kelly Sheila
- Keystone E.
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Khan Nadar
- Khanna Dinesh
- Khraishi Majed
- Kiely Patrick
- Kim L.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirkham Bruce W.
- Kleinert Stefan
- Knight Gregory D.
- Koehm Michaela
- Kremer J.
- Kremer Joel M.
- Krummel-Lorenz Brigitte
- Kummerfeld Sarah
- Kupper Hartmut
- Kupper Hartmut
- Kvien Tore
- Landewe Robert
- Landewe Robert
- Landewe Robert
- Lawson Richard
- Le Bars Manuela
- Lehane Patricia
- Leirisalo-Repo M.
- Li Tracy
- Liebhaber Anke
- Listing Joachim
- Liu H.
- Lloyd Lois A.
- Long Simon G.
- Luggen Michael
- Lugli Helena
- Luijtens Kristel
- Luijtens Kristel
- Lunt Mark
- Lunt Mark
- Luo Allison
- Macey Katherine M.
- Malamet Raymond
- Malik Saadia
- Manzo Antonio
- Mariette Xavier
- Marrelli Alessandra
- Matteson E. L.
- Matteson E. L.
- Matteson Eric L.
- Matucci Cerenic Marco
- McDowell Jackie
- Mela Christopher M.
- Mendelsohn A.
- Mikitenko Ganna
- Mistlin Alan
- Moreland Larry
- Mozaffarian Neelufar
- Mozaffarian Neelufar
- Nikiphorou Elena
- Nishikawa Masataka
- Nissim Ahuva
- Notley Clare A.
- Nurmohamed Michael T.
- Oakley Stephen
- Oezer Uemit
- Owaki Hajime
- Owen Catherine
- Panayi Gabriel
- Pappu Ramesh
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Pavelka Karel
- Pavelka Karel
- Potempa Jan
- Qi Keqin
- Quirke Anne-Marie
- Rahman M. U.
- Rees Jonathon
- Reiss William
- Reynard Mark
- Reynolds Alan
- Ritchlin C.
- Rizzo Warren
- Robles Manuel
- Roy Sanjoy
- Rynne Martin
- Sague S.
- Saravanan Vadivelu
- Scharbatke Eva C.
- Schechtman Joy
- Schiff Michael
- Schiff Michael
- Seed Michael
- Shah Devron
- Shaw Tim
- Sibilia Jean
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Soliman Moetaza M.
- Stancati Andrea
- Strand Vibeke
- Strangfeld Anja
- Subang Christina
- Sweetser Marianne
- Sweetser Marianne T.
- Symmons Deborah
- Taylor Monet
- Taylor Peter
- Taylor Peter
- Teng Onno
- Tony Hans-Peter
- Torbeyns Anne
- Townsend Michael
- Unnebrink Kristina
- van der Heijde D.
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van Laar Jacob M.
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- Venables Patrick
- Vencovsky Jiri
- Vernon Emma
- Vernon Emma
- Vital Edward M.
- Walsh Claire
- Walsh David A.
- Wang J.
- Wasco M. C.
- Watson Kath
- Watson Kath D.
- Watson Kath D.
- Wegner Natalia
- Weinblatt Michael
- Weinblatt Michael
- Westhovens Rene
- Westhovens Rene
- Weyer Gerd
- Williams Richard
- Williams Richard B.
- Williams Sarah
- Winyard Paul
- Xu W.
- Yazici Yusuf
- Young Adam
- Young Adam
- Zain Amir
- Zanetakis E.
- Zink Angela
- Álvaro-Gracia Jose
- Östör Andrew
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50 mg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50 mg/week for over 50 kg, 40 mg/week for 40 to 50 kg and 20 to 30 mg/week for under 40 kg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient died of sepsis caused by decubitus ulcer infection. DAS28-CRP score was decreased from 3.9 to 2.7 significantly. Although CRP was decreased from 1.50 to 0.93 mg/dl, it wasn't significant. Matrix metalloproteinase (MMP)-3 was decreased from 220.0 to 174.2 ng/ml significantly. Glutamate pyruvate transaminase (GPT) was increased from 19 to 35 U/l and number of leukocyte was decreased from 7832 to 6271 significantly. DAS28-CRP, CRP, and MMP-3 were improved significantly with MTX, although they weren't without MTX. Increase of GPT and leukopenia were seen significantly with MTX, although they weren't without MTX. Conclusions: It was reported that the risks of IP caused by LEF in Japanese RA patients were past IP history, loading dose administration and low BW. Addition of low-dose LEF is a potent safe alternative for the patients showing unsatisfactory response to current medicines, but need to pay attention for liver function and infection caused by leukopenia, especially with MTX. Disclosure statement: The authors have declared no conflicts of interes
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
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- Li X
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- Li XB
- Li XF
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- Pan-STARRS
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- Parra A
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- Pearlstone BL
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- Pekeur NW
- Pekowsky L
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- Piccinni OJ
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- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
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- Piron F
- Pirronello V
- Pisanu T
- Pita S
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- Poe M
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- Poolakkil S
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- Popolizio P
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- Principe G
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- Prodi GA
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- Prokoph H
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- Przybylski GT
- Pulone L
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- Quimby RM
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- Ren Z
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- Reposeur T
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- Robinet F
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- Rochester LS
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- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
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- Romero M Dominguez
- Romie JH
- Romoli C
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- Rosell A Carnero
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- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
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- Ryckbosch D
- Rykoff ES
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- Sadler EM
- Sadler EM
- Saffe C
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- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
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- Saldaa M
- Saleem M
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- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
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- Sandrock A
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- Santangelo A
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- Santos EM
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- Sarazin F
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- Sasaki M
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- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
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- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
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- Schlegel DJ
- Schlickeiser R
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- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
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- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
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- Schumacher J
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- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
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- Secco LF
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- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
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- Sengupta AS
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- Sequino V
- Sergeev A
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- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
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- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
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- Shara MM
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- Sharp RG
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- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
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- Siebert MR
- Siegel MH
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- Siemens X
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- Slagmolen BJJ
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- Starling RLC
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
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- Parts Leopold
- Paré Guillaume
- Pascoe Laura
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- Peden John F.
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- Perola Markus
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- Peter M Visscher
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- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
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- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
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- Pouta Anneli
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- Qi Lu
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- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
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- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
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- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
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- Schwarz Peter E H
- Schäfer Arne
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- Scott Laura J.
- Seedorf Udo
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- Sennblad Bengt
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- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
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- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
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- van Rij Andre M.
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- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
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- Borja Judith B
- Bornstein Stefan R
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- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
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- Carlson Olga D
- Carty Cara
- Casas Juan P
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- Caulfield Mark
- Cavalieri Margherita
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- Center Jacqueline R
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- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
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- Chasman Dan
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- Chen Constance
- Chen Han
- Chen Ida
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- Chen Ming-Huei
- Chen Wei
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- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
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- Clarke Robert
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- Curhan Gary
- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
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- Dreisbach Albert W
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- Eury Elodie
- Evangelou Evangelos
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- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
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- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
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- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
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- Fowkes F Gerald R
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- Glorioso Nicola
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- Goessling Wolfram
- Golay Alain
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- Gyllensten Ulf B
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- Hadley David
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- Hayward Caroline
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- Heckbert Susan R
- Hedblad Bo
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- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
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- Hernandez Dena
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- Herrera Lizbeth
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- Witteman Jacqueline C M
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- Wolffenbuttel Bruce H R
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- Wong Tien Y
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- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
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- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Multi-messenger Observations of a Binary Neutron Star Merger
- Author
- (Deeper DWF
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- Abbott B. P.
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- AGILE Team
- Agliozzo C.
- Aguiar O. D.
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- Ahlers M.
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- Aiello L.
- Ain A.
- Ajith P.
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- Angelova S. V.
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- Angus C. R.
- Annis J.
- Ansseau I.
- ANTARES Collaboration
- Antier S.
- Anton G.
- Antonelli L. A.
- Anupama G. C.
- Aoki K.
- Aoki W.
- Appert S.
- Aptekar R. L.
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- Ashton G.
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- AST3
- Aston S. M.
- Astone P.
- AstroSat Cadmium Zinc Telluride Imager Team
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- Atwood W. B.
- Aubert J.-J.
- Aublin J.
- Auffenberg J.
- Aufmuth P.
- Aulbert C.
- AultONeal K.
- Austin C.
- Australia Telescope Compact Array ATCA:
- Australian SKA Pathfinder ASKAP:
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- Avila-Alvarez A.
- Axani S.
- Baar S.
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- Bhagwat S.
- Bhalerao V.
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- Blagorodnova N.
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later
designated GW170817) with merger time 12:41:04 UTC was observed through
gravitational waves by the Advanced LIGO and Advanced Virgo detectors.
The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray
burst (GRB 170817A) with a time delay of ∼ 1.7 {{s}} with respect to
the merger time. From the gravitational-wave signal, the source was
initially localized to a sky region of 31 deg2 at a
luminosity distance of {40}-8+8 Mpc and with
component masses consistent with neutron stars. The component masses
were later measured to be in the range 0.86 to 2.26 {M}ȯ
. An extensive observing campaign was launched across the
electromagnetic spectrum leading to the discovery of a bright optical
transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC
4993 (at ∼ 40 {{Mpc}}) less than 11 hours after the merger by the
One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The
optical transient was independently detected by multiple teams within an
hour. Subsequent observations targeted the object and its environment.
Early ultraviolet observations revealed a blue transient that faded
within 48 hours. Optical and infrared observations showed a redward
evolution over ∼10 days. Following early non-detections, X-ray and
radio emission were discovered at the transient’s position ∼ 9
and ∼ 16 days, respectively, after the merger. Both the X-ray and
radio emission likely arise from a physical process that is distinct
from the one that generates the UV/optical/near-infrared emission. No
ultra-high-energy gamma-rays and no neutrino candidates consistent with
the source were found in follow-up searches. These observations support
the hypothesis that GW170817 was produced by the merger of two neutron
stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and
a kilonova/macronova powered by the radioactive decay of r-process
nuclei synthesized in the ejecta.</p
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
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- Wysocki Daniel
- Xiao Liting
- Yadav N.
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- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamashita K.
- Yamazaki R.
- Yang Fengwei
- Yang Kate Z.
- Yang Le
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yeeles D. W.
- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
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- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
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- Andersen R.
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- Andrea Prodi Giovanni
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- Andrés-Carcasona Marc
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- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
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