936 research outputs found
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.
- Author
- A Alexa
- A Bairoch
- A Bernsel
- A Bernsel
- A Creasey
- A Garg
- A Krogh
- AB Vaidya
- AE Lobley
- AJ Link
- AL Beetsma
- AM Talman
- Andrea Ecker
- Arthur M Talman
- B Maclean
- B Wickstead
- B Wickstead
- BF Mitchell
- BH Gibbons
- Ceereena Ubaida-Mohien
- CJ Brokaw
- CJ Janse
- CL Gatlin
- CS Yu
- CU Mohien
- DA van Schalkwyk
- David R Graham
- DL Tabb
- DM Baron
- DN Perkins
- E Deligianni
- EF Smith
- Georges K Christophides
- J Stumpff
- JA Vizcaino
- JE Elias
- John R Yates
- Judith H Prieto
- K Lal
- K Lal
- K Pfister
- K Slavic
- KC Chou
- L Fox
- LA Kelley
- LJ Briggs
- LY Geer
- M Aikawa
- M Aikawa
- M Aikawa
- M Bern
- M Krisfalusi
- M Oberholzer
- M Punta
- M Sakato
- Mara Lawniczak
- Mark N Wass
- Michael JE Sternberg
- ML Gupta
- MN Wass
- MP Washburn
- MR van Dijk
- N Edwards
- N Hall
- N Okamoto
- O Billker
- P Horton
- P Yang
- PC Bradbury
- R Carter
- R Craig
- R Tewari
- R Yokoyama
- RC Gentleman
- RE Sinden
- RE Sinden
- RE Sinden
- RE Sinden
- Rebecca S Stanway
- Rhoel R Dinglasan
- RM Tombes
- Robert E Sinden
- Roland Frank
- S Briesemeister
- S Eksi
- S Eksi
- S Hunter
- S Tanner
- Sanjeev Krishna
- Sara Marques
- SC Dawson
- SF Altschul
- SM Khan
- SM King
- T Hawkins
- T Joet
- Tao Xu
- U Straschil
- W Daher
- WCL Ford
- Y Benjamini
- YJ Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway of energy metabolism that power motility, a feature that facilitates gamete encounter and fertilization, is unknown.
METHODS: Plasmodium berghei microgametes were purified and analysed by whole-cell proteomic analysis for the first time. Data are available via ProteomeXchange with identifier PXD001163.
RESULTS: 615 proteins were recovered, they included all male gamete proteins described thus far. Amongst them were the 11 enzymes of the glycolytic pathway. The hexose transporter was localized to the gamete plasma membrane and it was shown that microgamete motility can be suppressed effectively by inhibitors of this transporter and of the glycolytic pathway.
CONCLUSIONS: This study describes the first whole-cell proteomic analysis of the malaria male gamete. It identifies glycolysis as the likely exclusive source of energy for flagellar beat, and provides new insights in original features of Plasmodium flagellar organization
Molecular characterization of Vibrio cholerae outbreak strains with altered El Tor biotype from southern India
- Author
- A Dalsgaard
- A Huq
- A Safa
- A. K. Goel
- AK Goel
- AK Goel
- AK Mukhopadhyay
- AK Tamrakar
- AS Faruque
- B Hochhut
- BV Krishna
- CM Collis
- DV Singh
- F Sabeena
- GB Nair
- GB Nair
- GD Recchia
- H Kazama
- IG Rivera
- J Versalovic
- JB Kaper
- JG Coote
- JW Beaber
- JW Beaber
- KH Chow
- KJ Shaw
- M Ansaruzzaman
- M Iwanaga
- M. Jain
- MK Waldor
- MR Pourshafie
- MV Jesudason
- O Olsvik
- P Garg
- P Kumar
- P. Kumar
- RM Hall
- S. C. Jiang
- SM Faruque
- W Lin
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2009
- Field of study
Forty-four Vibrio cholerae isolates collected over a 7-month period in Chennai, India in 2004 were characterized for gene traits, antimicrobial susceptibility and genomic fingerprints. All 44 isolates were identified as O1 El Tor Ogawa, positive for various toxigenic and pathogenic genes viz. ace, ctxB, hlyA, ompU, ompW, rfbO1, rtx, tcpA, toxR and zot. Nucleotide sequencing revealed the presence of cholera toxin B of classical biotype in all the El Tor isolates, suggesting infection of isolates by classical CTXΦ. Antibiogram analysis showed a broad-spectrum antibiotic resistance that was also confirmed by the presence of resistant genes in the genomes. All isolates contained a class 1 integron and an SXT constin. However, isolates were sensitive to chloramphenicol and tested negative for the chloramphenicol resistant gene suggesting a deletion in SXT constin. Fingerprinting analysis of isolates by ERIC- and Box PCR revealed similar DNA patterns indicating the clonal dissemination of a single predominant V. cholerae O1 strain throughout the 2004 outbreak in Chennai
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
- Author
- A Aouacheria
- A Aouacheria
- A Aranovich
- A Ashkenazi
- A Ashkenazi
- A Ashkenazi
- A Bernet
- A Buque
- A Chiche
- A Conte
- A Costanzo
- A Crockford
- A Degterev
- A Degterev
- A Dey
- A Gast
- A Gross
- A Hakkim
- A Hamacher-Brady
- A Hunger
- A Kaczmarek
- A Kamb
- A Koenig
- A Kotschy
- A Letai
- A Linkermann
- A Linkermann
- A Linkermann
- A Linkermann
- A Mousa
- A Muir
- A Mukherjee
- A Nilsson
- A Oberst
- A Oberst
- A Pagotto
- A Pyakurel
- A Rongvaux
- A Rubartelli
- A Sahaboglu
- A Seiler
- A Serrano-Puebla
- A Shamas-Din
- A Sistigu
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Sumoza-Toledo
- A Sundararaman
- A Tittarelli
- A Trautmann
- A Villunger
- A Witt
- A Zychlinsky
- AA Fatokun
- AA Mailleux
- Aaron Ciechanover
- AB Pardee
- Abhishek D. Garg
- AC Bellail
- AC Schinzel
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- Adi Kimchi
- AE Alsop
- AE Feldstein
- AJ Schile
- AL Anding
- AL Genevois
- Alexey V. Antonov
- AM Chinnaiyan
- AM Distefano
- AM Dudek
- AM Verhagen
- AN Antony
- AN Barclay
- Ana J. García-Sáez
- Andreas Linkermann
- Andreas Strasser
- Andreas Villunger
- Andrew Oberst
- Andrew Thorburn
- Antonella Sistigu
- AP West
- AR Delbridge
- AT Schneider
- AT Ting
- AT Ting
- Atan Gross
- AV Follis
- AV Jacobsen
- AV Vaseva
- AV Vaseva
- AW Roberts
- B Antonsson
- B Aslan
- B Conradt
- B Fadeel
- B Gerlach
- B Gibert
- B Gooptu
- B McDonald
- B Schellenberg
- B Van Do
- B Xia
- BA Carlson
- BA Hilton
- BA Napier
- BB Aggarwal
- BC Barnhart
- Bertrand Joseph
- Beth Levine
- BG Childs
- BG Childs
- BG Childs
- BG Lambrus
- BG Yipp
- Boris Turk
- Boris Zhivotovsky
- BP Eckelman
- BP Eckelman
- BR Stockwell
- Brent R. Stockwell
- Brian D. Dynlacht
- BT Cookson
- C Bergmann
- C Dominguez-Brauer
- C Du
- C Frezza
- C Gerle
- C Guenebeaud
- C Gunther
- C Gunther
- C Helmke
- C Hernandez
- C Hockings
- C Lood
- C Lopez-Garcia
- C Lopez-Otin
- C Lopez-Otin
- C Louandre
- C Louandre
- C Nelson
- C Oberle
- C Piot
- C Rogers
- C Scaffidi
- C Vanpouille-Box
- C White
- C Xie
- Carlos López-Otín
- Carmen Garrido
- Catherine Brenner
- CC Wu
- CD Simpson
- CD Wiley
- Cecilia M.P. Rodrigues
- CF Wenceslau
- Christoph Borner
- CJ Kearney
- CK Ea
- CK Lam
- CK McPhee
- CL Buchheit
- CL Buchheit
- CL Buchheit
- CL Case
- Claudio Hetz
- CM Henry
- CN Casson
- Colin S. Duckett
- CP Baines
- CP Baines
- CP Dillon
- CP Dillon
- CP Dillon
- Cristina Muñoz-Pinedo
- CT Tan
- D Brenner
- D Brough
- D Chen
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- D Goldschneider
- D Kranz
- D Li
- D Malin
- D Martin-Sanchez
- D Merino
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- D Piani
- D Ren
- D Stojkov
- D Tang
- D Tang
- D Vercammen
- D Vercammen
- D Wallach
- D Weaver
- D Yang
- DA Flusberg
- DA Rodriguez
- Daniel J. Klionsky
- Daolin Tang
- David C. Rubinsztein
- David M. Pereira
- David W. Andrews
- David Wallach
- DC Gray
- DH Cho
- Didac Carmona-Gutierrez
- Dieter Adam
- DJ Baker
- DJ Baker
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- DL Vaux
- DM Moquin
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- Domagoj Vucic
- Douglas R. Green
- DR Green
- DR Green
- DR Green
- DR Green
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- DR Green
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- DV Krysko
- E Arama
- E Basso
- E Buytaert
- E Candi
- E Fouquerel
- E Gavathiotis
- E Gavathiotis
- E Giampazolias
- E Kip
- E Lachaier
- E Lafont
- E Meunier
- E Perez
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- E Zandi
- E Zandi
- EA Miao
- Edward A. Miao
- EF Lee
- EH Cheng
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- EJ Park
- Eleonora Candi
- Eli Arama
- Emad S. Alnemri
- Emily H. Cheng
- Emre Sayan
- Enrico Lugli
- Eric H. Baehrecke
- Erwin F. Wagner
- Evripidis Gavathiotis
- EY Bassoy
- Eyal Gottlieb
- F Basit
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- H Yang
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- H Yuan
- H Zhang
- H Zhang
- HA Park
- Hamsa Puthalakath
- Hans-Uwe Simon
- HC Chen
- HE Kamber Kaya
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- SB Berger
- SB Ma
- SB Willingham
- Scott J. Dixon
- Scott W. Lowe
- SE Kim
- SE Kim
- Seamus J. Martin
- SH Baek
- Sharad Kumar
- Shazib Pervaiz
- Shigekazu Nagata
- Simone Fulda
- SJ Clarke
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Gardai
- SJ Martin
- SJ Riedl
- SJ Wang
- SJ Yu
- SK Dasari
- SL Petersen
- SL Thompson
- SL Wong
- SM Frisch
- SM Harding
- SM Kallenberger
- SM Kavuri
- SM Man
- SM Man
- SM Man
- Sonia Melino
- SR Clark
- SR Woo
- Stephen W.G. Tait
- Stuart A. Aaronson
- Stuart A. Lipton
- SW Tait
- SW Tait
- SW Tait
- SW Yu
- SW Yu
- T Bergsbaken
- T Eggert
- T Eisenberg
- T Kamijo
- T Kirkegaard
- T Kirkegaard
- T Konig
- T Kuriakose
- T Kurz
- T Kurz
- T Kurz
- T Kuwana
- T Li
- T Lindsten
- T Mizuta
- T Moldoveanu
- T Moldoveanu
- T Motte Rouge de La
- T Nakagawa
- T Panaretakis
- T Panaretakis
- T Piyush
- T Raveh
- T Saleh
- T Shibue
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Varanita
- T Vervliet
- T Xu
- T Xu
- T Zhang
- TA Fuchs
- TB Kang
- TC Cheng
- Ted M. Dawson
- Theocharis Panaretakis
- Thomas Kaufmann
- Thomas Rudel
- TJ Daish
- TJ Sargeant
- TK Chang
- TL Haas
- TM Fu
- TM Ng
- Tom Luedde
- Tom Vanden Berghe
- TP Garner
- TS Luongo
- TS Luongo
- TT Cung
- TT Renault
- TV Denisenko
- TV Lee
- TW Kang
- U Fischer
- Ute M. Moll
- V Brinkmann
- V Brinkmann
- V Giorgio
- V Giorgio
- V Giorgio
- V Hornung
- V Izzo
- V Kondylis
- V Labi
- V Papayannopoulos
- V Purvanov
- V Sica
- V Turk
- V Turk
- VA Rathinam
- Valina L. Dawson
- VE Kagan
- VI Maltez
- Vincenzo De Laurenzi
- Vincenzo D’Angiolella
- Vishva M. Dixit
- VL Dawson
- VS Marsden
- VS Viswanathan
- W Chen
- W He
- W Hou
- W Lu
- W Zhou
- Wafik S. El-Deiry
- Walter Malorni
- WC Yeh
- WD Cook
- Will Wood
- William J. Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WP Roos
- WS Hambright
- WS Yang
- WS Yang
- WS Yang
- WS Yang
- WT He
- X Chen
- X Chen
- X Hu
- X Jiang
- X Li
- X Liu
- X Liu
- X Luo
- X Qu
- X Song
- X Sun
- X Sun
- X Sun
- X Sun
- X Wang
- X Wang
- X Zhang
- XM Yin
- XM Yin
- XM Zhao
- XN Wu
- Y Aachoui
- Y Aachoui
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Fernandez-Marrero
- Y Fuchs
- Y Fuchs
- Y Ishizaki
- Y Ito
- Y Lee
- Y Li
- Y Li
- Y Liu
- Y Liu
- Y Luo
- Y Ma
- Y Ma
- Y Morizane
- Y Ou
- Y Pang
- Y Rong
- Y Shlyakhtina
- Y Subburaj
- Y Suzuki
- Y Tsujimoto
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Xie
- Y Xie
- Y Xie
- Y Zaltsman
- Y Zermati
- Y Zhang
- Y Zheng
- Y Zhu
- Y Zhu
- YB Chen
- YC Hou
- YH Liao
- YI Nakajima
- Ying Wang
- YN Gong
- Yoshihide Tsujimoto
- YS Cho
- Yufang Shi
- Z Cai
- Z Cai
- Z Wang
- Z Wang
- Z Xu
- Z You
- Z Zhang
- Z Zhong
- Zahra Zakeri
- ZG Liu
- ZN Oltvai
- ZT Schafer
- ZX Chen
- ZX Chen
- Publication venue
- Cell Death Differ
- Publication date
- 01/01/2018
- Field of study
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
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- Annessi V
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- Economopoulou P
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- Efthimiou M
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- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
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- Emile Sameh
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- Federico Pipitone NS
- Feo C
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- Ferraz I
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- Zografos C
- Zonta S
- Zourntou S
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdoli Amir
- Abebe Haimanot
- Abedi Aidin
- Abidi Hassan
- Abolhassani Hassan
- Abu-Gharbieh Eman
- Abubaker Ali Hiwa
- Achappa Basavaprabhu
- Acuna Juan Manuel
- Adedeji Isaac Akinkunmi
- Adegboye Oyelola A
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afzal Muhammad Sohail
- Aghaie Meybodi Mohamad
- Ahadinezhad Bahman
- Ahinkorah Bright Opoku
- Ahmad Sajjad
- Ahmadi Sepideh
- Ahmed Rashid Tarik
- Ahmed Salih Yusra
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Akalu Gizachew Taddesse
- Al Hamad Hanadi
- Al-Maweri Sadeq Ali
- Al-Raddadi Rajaa M
- Alahdab Fares
- AlAmodi Abdulhadi A
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alem Adugnaw Zeleke
- Alem Dejene Tsegaye
- Alemayehu Yosef
- Alhalaiqa Fadwa Naji
- Alhassan Robert Kaba
- Ali Saqib
- Alicandro Gianfranco
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Alluri Sunitha
- Almasri Nihad A
- Almustanyir Sami
- Alvarez Elysia M
- Alvis-Guzman Nelson
- Ameyaw Edward Kwabena
- Amini Saeed
- Amu Hubert
- Ancuceanu Robert
- Andrei Catalina Liliana
- Andrei Tudorel
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anvari Davood
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Argaw Ayele Mamo
- Ariffin Hany
- Arshad Muhammad
- Arulappan Judie
- Aryannejad Armin
- Asemi Zatollah
- Asghari Jafarabadi Mohammad
- Atashzar Mohammad Reza
- Atorkey Prince
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Awedew Atalel Fentahun
- Ayala Quintanilla Beatriz Paulina
- Ayele Alemu Degu
- Ayen Solomon Shitu
- Azab Mohammed A
- Azadnajafabad Sina
- Azami Hiva
- Azangou-Khyavy Mohammadreza
- Azari Jafari Amirhossein
- Azarian Ghasem
- Azzam Ahmed Y
- Bahadory Saeed
- Bai Jianjun
- Baig Atif Amin
- Baker Jennifer L
- Banach Maciej
- Barone-Adesi Francesco
- Barr Ronald D
- Barra Fabio
- Barrow Amadou
- Basaleem Huda
- Batiha Abdul-Monim Mohammad
- Behzadifar Masoud
- Bekele Niguss Cherie
- Belete Rebuma
- Belgaumi Uzma Iqbal
- Bell Arielle Wilder
- Berhie Alemshet Yirga
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhakta Nickhill
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhaskar Sonu
- Bhattacharyya Krittika
- Bhojaraja Vijayalakshmi S
- Bibi Sadia
- Bijani Ali
- Biondi Antonio
- Birara Setognal
- Bjørge Tone
- Bleyer Archie
- Bolarinwa Obasanjo Afolabi
- Bolla Srinivasa Rao
- Boloor Archith
- Braithwaite Dejana
- Brenner Hermann
- Bulamu Norma B
- Burkart Katrin
- Bustamante-Teixeira Maria Teresa
- Butt Nadeem Shafique
- Butt Zahid A
- Bärnighausen Till Winfried
- C. La Vecchia
- Caetano dos Santos Florentino Luciano
- Cao Chao
- Cao Yin
- Carreras Giulia
- Catalá-López Ferrán
- Cembranel Francieli
- Cerin Ester
- Chakinala Raja Chandra
- Chakraborty Promit Ananyo
- Chattu Vijay Kumar
- Chaturvedi Pankaj
- Chaurasia Akhilanand
- Chavan Prachi P
- Chimed-Ochir Odgerel
- Choi Jee-Young Jasmine
- Christopher Devasahayam J
- Chu Dinh-Toi
- Chung Michael T
- Compton Kelly
- Conde Joao
- Costa Vera Marisa
- D'Amico Emanuele
- Da'ar Omar B
- Dadras Omid
- Dahlawi Saad M A
- Dai Xiaochen
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Daneshpajouhnejad Parnaz
- Darwish Amira Hamed
- Daryani Ahmad
- De la Hoz Fernando Pio
- Dean Frances E
- Debela Sisay Abebe
- Demie Takele Gezahegn G
- Demissie Getu Debalkie
- Demissie Zeleke Geto
- Denova-Gutiérrez Edgar
- Derbew Molla Meseret
- Desai Rupak
- Desta Abebaw Alemayehu
- Dhamnetiya Deepak
- Dharmaratne Samath Dhamminda
- Dhimal Mandira Lamichhane
- Dhimal Meghnath
- Dianatinasab Mostafa
- Didehdar Mojtaba
- Diress Mengistie
- Djalalinia Shirin
- Do Huyen Phuc
- Doaei Saeid
- Dorostkar Fariba
- dos Santos Wendel Mombaque
- Drake Thomas M
- Ekholuenetale Michael
- El Sayed Zaki Maysaa
- El Sayed Iman
- El Tantawi Maha
- El-Abid Hassan
- El-Jaafary Shaimaa I
- Elbahnasawy Mostafa Ahmed
- Elbarazi Iffat
- Elhabashy Hala Rashad
- Elhadi Muhammed
- Enyew Daniel Berhanie
- Erdomaeva Yana Arturovna
- Erkhembayar Ryenchindorj
- Eshrati Babak
- Eskandarieh Sharareh
- Faisaluddin Mohammed
- Fares Jawad
- Farooque Umar
- Fasanmi Abidemi Omolara
- Fatima Wafa
- Ferreira de Oliveira José Miguel P
- Ferrero Simone
- Ferro Desideri Lorenzo
- Fetensa Getahun
- Filip Irina
- Fischer Florian
- Fisher James L
- Fitzmaurice Christina
- Force Lisa M
- Foroutan Masoud
- Fu Weijia
- Fukumoto Takeshi
- Gaal Peter Andras
- Gad Mohamed M
- Gaewkhiew Piyada
- Gallus Silvano
- Garg Tushar
- Gebremeskel Teferi Gebru
- Gemeda Belete Negese Belete
- Getachew Tamiru
- Ghafourifard Mansour
- Ghamari Seyyed-Hadi
- Ghashghaee Ahmad
- Ghassemi Fariba
- Ghith Nermin
- Gholami Ali
- Gholizadeh Navashenaq Jamshid
- Gilani Syed Amir
- Ginindza Themba G
- Gizaw Abraham Tamirat
- Glasbey James C
- Goel Amit
- Golechha Mahaveer
- Goleij Pouya
- Golinelli Davide
- Gopalani Sameer Vali
- Gorini Giuseppe
- Goudarzi Houman
- Goulart Bárbara Niegia Garcia
- Grada Ayman
- Gubari Mohammed Ibrahim Mohialdeen
- Guerra Maximiliano Ribeiro
- Guha Avirup
- Gunasekera D Sanjeeva
- Gupta Bhawna
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Haddadi Rasool
- Hafezi-Nejad Nima
- Hailu Alemayehu
- Haj-Mirzaian Arvin
- Halwani Rabih
- Hamadeh Randah R
- Hambisa Mitiku Teshome
- Hameed Sajid
- Hamidi Samer
- Haque Shafiul
- Hariri Sanam
- Haro Josep Maria
- Harvey James D
- Hasaballah Ahmed I
- Hasan S M Mahmudul
- Hashemi Seyedeh Melika
- Hassan Treska S
- Hassanipour Soheil
- Hay Simon I
- Hayat Khezar
- Hebo Sultan H
- Heidari Golnaz
- Heidari Mohammad
- Henrikson Hannah Jacqueline
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Heyi Demisu Zenbaba
- Hezam Kamal
- Hole Michael K
- Holla Ramesh
- Horita Nobuyuki
- Hossain Md Mahbub
- Hossain Mohammad Bellal
- Hosseini Mohammad-Salar
- Hosseini Mostafa
- Hosseinzadeh Ali
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Hsairi Mohamed
- Huang Junjie
- Hussein Nawfal R
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Innos Kaire
- Irham Lalu Muhammad
- Islam Rakibul M
- Islam Sheikh Mohammed Shariful
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Jacob Louis
- Jadidi-Niaragh Farhad
- Jain Vardhmaan
- Jakovljevic Mihajlo
- Janghorban Roksana
- Javadi Mamaghani Amirreza
- Jayaram Shubha
- Jayawardena Ranil
- Jazayeri Seyed Behzad
- Jebai Rime
- Jha Ravi Prakash
- John-Akinola Yetunde O
- Joo Tamas
- Joseph Nitin
- Joukar Farahnaz
- Jürisson Mikk
- Kaambwa Billingsley
- Kabir Ali
- Kalankesh Leila R
- Kaliyadan Feroze
- Kamal Zul
- Kamath Ashwin
- Kandel Himal
- Kar Sitanshu Sekhar
- Karaye Ibraheem M
- Karimi Amirali
- Kassa Bekalu Getnet
- Kauppila Joonas H
- Keegan Theresa H M
- Kemp Bohan Phillip M
- Kengne Andre Pascal
- Kerbo Amene Abebe
- Ketterl Tyler G
- Keykhaei Mohammad
- Khader Yousef Saleh
- Khajuria Himanshu
- Khalili Nastaran
- Khalili Neda
- Khan Ejaz Ahmad
- Khan Gulfaraz
- Khan Maseer
- Khan Md Nuruzzaman
- Khan Moien AB
- Khanali Javad
- Khayamzadeh Maryam
- Khosravizadeh Omid
- Khubchandani Jagdish
- Khundkar Roba
- Kim Min Seo
- Kim Yun Jin
- Kisa Adnan
- Kisa Sezer
- Kissimova-Skarbek Katarzyna
- Kocarnik Jonathan M
- Kolahi Ali-Asghar
- Kopec Jacek A
- Koteeswaran Rajasekaran
- Koulmane Laxminarayana Sindhura Lakshmi
- Koyanagi Ai
- Kugbey Nuworza
- Kumar G Anil
- Kumar Nithin
- Kutluk Tezer
- Kwarteng Alexander
- Lan Qing
- Landires Iván
- Lasrado Savita
- Lauriola Paolo
- Ledda Caterina
- Lee Sang-woong
- Lee Wei-Chen
- Lee Yeong Yeh
- Lee Yo Han
- Leigh James
- Leong Elvynna
- Li Bingyu
- Li Jiarui
- Li Ming-Chieh
- Lim Stephen S
- Liu Xuefeng
- Lobo Stany W
- Loureiro Joana A
- Lu Dan
- Lugo Alessandra
- Lunevicius Raimundas
- Magdy Abd El Razek Hassan
- Magdy Abd El Razek Muhammed
- Mahmoudi Morteza
- Majeed Azeem
- Makki Alaa
- Male Shilpa
- Malekpour Mohammad-Reza
- Malekzadeh Reza
- Malik Ahmad Azam
- Malogolowkin Marcio Henrique
- Mamun Mohammed A
- Manafi Navid
- Mansour-Ghanaei Fariborz
- Mansouri Borhan
- Mansournia Mohammad Ali
- Martini Santi
- Masoumi Seyedeh Zahra
- Matei Clara N
- Mathur Manu Raj
- Mathur Prashant
- McAlinden Colm
- Mehrotra Ravi
- Mendoza Walter
- Menezes Ritesh G
- Mentis Alexios-Fotios A
- Meretoja Tuomo J
- Mersha Amanual Getnet
- Mesregah Mohamed Kamal
- Mestrovic Tomislav
- Miao Jonasson Junmei
- Miazgowski Bartosz
- Michalek Irmina Maria
- Miller Ted R
- Mingude Alemu Basazin
- Mirmoeeni Seyyedmohammadsadeq
- Mirzaei Hamed
- Misra Sanjeev
- Mithra Prasanna
- Mohammad Karzan Abdulmuhsin
- Mohammadi Mokhtar
- Mohammadi Seyyede Momeneh
- Mohammadian-Hafshejani Abdollah
- Mohammadpourhodki Reza
- Mohammed Arif
- Mohammed Shafiu
- Mohammed Teroj Abdulrahman
- Moka Nagabhishek
- Mokdad Ali H
- Molokhia Mariam
- Momtazmanesh Sara
- Monasta Lorenzo
- Moni Mohammad Ali
- Moradi Ghobad
- Moradi Yousef
- Moradzadeh Maliheh
- Moradzadeh Rahmatollah
- Moraga Paula
- Morrison Shane Douglas
- Mostafavi Ebrahim
- Mousavi Khaneghah Amin
- Mpundu-Kaambwa Christine
- Mubarik Sumaira
- Murray Christopher J L
- Mwanri Lillian
- Nabhan Ashraf F
- Nagaraju Shankar Prasad
- Nagata Chie
- Naghavi Mohsen
- Naimzada Mukhammad David
- Naldi Luigi
- Nangia Vinay
- Naqvi Atta Abbas
- Narasimha Swamy Sreenivas
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- Soltani-Zangbar Mohammad Sadegh
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- Subedi Ranjeeta
- Sufiyan Mu'awiyyah Babale
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- Tabuchi Takahiro
- Tadbiri Hooman
- Taheri Majid
- Taherkhani Amir
- Takahashi Ken
- Tampa Mircea
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- Tat Vivian Y
- Tavakoli Ahmad
- Tbakhi Abdelghani
- Tehrani-Banihashemi Arash
- Temsah Mohamad-Hani
- Tesfay Fisaha Haile
- Tesfaye Bekele
- Thakur Jarnail Singh
- Thapar Rekha
- Thavamani Aravind
- Thiyagarajan Arulmani
- Thomas Nihal
- Tobe-Gai Ruoyan
- Togtmol Munkhsaikhan
- Tohidast Seyed Abolfazl
- Tohidinik Hamid Reza
- Tolani Musliu Adetola
- Tollosa Daniel Nigusse
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- Traini Eugenio
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- Tusa Biruk Shalmeno
- Ukke Gebresilasea Gendisha
- Ullah Irfan
- Ullah Saif
- Umapathi Krishna Kishore
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Ushula Tolassa Wakayo
- Vacante Marco
- Valadan Tahbaz Sahel
- Vargas Martina T
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- Villeneuve Paul J
- Violante Francesco S
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- Waheed Yasir
- Wang Ning
- Ward Paul
- Weldesenbet Adisu Birhanu
- Wen Yi Feng
- Westerman Ronny
- Winkler Andrea Sylvia
- Wubishet Befikadu Legesse
- Xu Rixing
- Xu Suowen
- Yahyazadeh Jabbari Seyed Hossein
- Yang Lin
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yazie Taklo Simeneh
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yeshaw Yigizie
- Yirdaw Birhanu Wubale
- Yonemoto Naohiro
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yunusa Ismaeel
- Zadnik Vesna
- Zahir Mazyar
- Zahirian Moghadam Telma
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zare Fariba
- Zastrozhin Mikhail Sergeevich
- Zastrozhina Anasthasia
- Zhang Jianrong
- Zhang Zhi-Jiang
- Ziapour Arash
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
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- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
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- Alhabib Khalid F
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- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
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- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
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- Yang Lin
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- Yao Yao
- Ye Pengpeng
- Yesera Gesila Endashaw
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yiğit Arzu
- Yiğit Vahit
- Yip Paul
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- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zandi Milad
- Zandieh Ghazal G Z
- Zanghì Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Kalkidan Hassen
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbasifard Mitra
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdi Parsa
- Abdollahi Mohammad
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abiodun Olumide
- Abiso Temesgen Lera
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas Guimarães
- Abu-Gharbieh Eman
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Abukhadijah Hana Jihad Jihad
- Aburuz Salahdein
- Adane Mesafint Molla
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Aden Bashir
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adha Rishan
- Adibi Amin
- Adnani Qorinah Estiningtyas Sakilah
- Adzigbli Leticia Akua
- Afolabi Aanuoluwapo Adeyimika
- Afolabi Rotimi Felix
- Afshin Ashkan
- Afyouni Shadi
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agbozo Faith
- Aghamiri Shahin
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Noah
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmed Ali
- Ahmed Anisuddin
- Ahmed Ayman
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Safoora
- Ahmed Syed Anees
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemiju Tomi
- Akkaif Mohammed Ahmed
- Akkala Sreelatha
- Akombi-Inyang Blessing
- Al Awaidy Salah
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-Fatly Bassam
- Al-Gheethi Adel Ali Saeed
- Al-Habbal Khairat
- Al-Marwani Sabah
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Al-Rifai Rami Hani
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Al-Zyoud Walid
- Alahdab Fares
- Alalalmeh Samer O
- Alalwan Tariq A
- Alam Khurshid
- Alam Nazmul
- Alanezi Fahad Mashhour
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- Albakri Almaza
- AlBataineh Mohammad T
- Aldhaleei Wafa A
- Aldridge Robert W
- Alemayohu Mulubirhan Assefa
- Alemu Yihun Mulugeta
- Alhabib Khalid F
- Alhassan Robert Kaba
- Ali Abid
- Ali Amjad
- Ali Beriwan Abdulqadir
- Ali Iman
- Ali Liaqat
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Waad
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Alla François
- Almustanyir Sami
- Alomari Mahmoud A
- Alonso Jordi
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Alrawashdeh Ahmad
- Alrousan Sahel Majed
- Alshahrani Najim Z
- Altaany Zaid
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- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J
- Alwafi Hassan
- Aly Hany
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- Amaechi Uchenna Anderson
- Aman Mohammadi Masous
- Amani Reza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Ammirati Enrico
- Amu Hubert
- Amugsi Dickson A
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- Anderson Jason A
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- Angappan Dhanalakshmi
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- Antriyandarti Ernoiz
- Anuoluwa Boluwatife Stephen
- Anvari Davood
- Anvari Saeid
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- Anwar Sumadi Lukman
- Anwer Razique
- Anyabolo Ekenedilichukwu Emmanuel
- Anyasodor Anayochukwu Edward
- Apostol Geminn Louis Carace
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Aregawi Brhane Berhe
- Aremu Abdulfatai
- Armocida Benedetta
- Arndt Michael Benjamin
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Aruleba Idowu Thomas
- Arumugam Ashokan
- Asbeutah Akram M
- Asgary Saeed
- Asgedom Akeza Awealom
- Ashbaugh Charlie
- Ashemo Mubarek Yesse
- Ashraf Tahira
- Askarinejad Amir
- Assmus Michael
- Astell-Burt Thomas
- Athar Mohammad
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atreya Alok
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Awoke Andargie Abate
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayestas Portugal Carlos
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azevedo Rui M S
- Azhar Gulrez Shah
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- Bansal Hansi
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- Belgaumi Uzma Iqbal
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- Bhala Neeraj
- Bhandari Dinesh
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- Bhat Ajay Nagesh
- Bhat Vivek
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- Bhatti Rajbir
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- Bhutta Zulfiqar A
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- Biswas Raaj Kishore
- Bjørge Tone
- Boachie Micheal Kofi
- Boakye Hosea
- Bockarie Moses John
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bogale Eyob Ketema
- Bolla Srinivasa Rao
- Boloor Archith
- Bonakdar Hashemi Milad
- Boppana Sri Harsha
- Bora Basara Berrak
- Borhany Hamed
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boufous Soufiane
- Bourne Rupert
- Boxe Christopher
- Braithwaite Dejana
- Brant Luisa C
- Brar Amanpreet
- Brauer Michael
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- Mithra Prasanna
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- Skou Søren T
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- Suresh Vinay
- Swain Chandan Kumar
- Szarpak Lukasz
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- Tang Haosu
- Tat Nathan Y
- Taveira Nuno
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- Tian Jing
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- Trabelsi Khaled
- Tran Jasmine T
- Tran Mai Thi Ngoc
- Tran Nghia Minh
- Trico Domenico
- Trihandini Indang
- Troeger Christopher E
- Tromans Samuel Joseph
- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsermpini Evangelia Eirini
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- Udoakang Aniefiok John
- Udoh Arit
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- Verras Georgios-Ioannis
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- Villafañe Jorge Hugo
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- Violante Francesco S
- Vlassov Vasily
- Vo Bay
- Vollset Stein Emil
- Volovat Simona Ruxandra
- Vos Theo
- Vujcic Isidora S
- Waheed Yasir
- Wang Cong
- Wang Fang
- Wang Shu
- Wang Yanzhong
- Wang Yuan-Pang
- Wanjau Mary Njeri
- Waqas Muhammad
- Ward Paul
- Waris Abdul
- Wassie Emebet Gashaw
- Weerakoon Kosala Gayan
- Weintraub Robert G
- Weiss Daniel J
- Weiss Eli J
- Weldetinsaa Haftom Legese Legese
- Wells Katherine M
- Wen Yi Feng
- Wiangkham Taweewat
- Wickramasinghe Nuwan Darshana
- Wilkerson Caroline
- Willeit Peter
- Wilson Shadrach
- Wong Yen Jun
- Wongsin Utoomporn
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- Wu Chenkai
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- Xia Juan
- Xiao Hong
- Xu Suowen
- Xu Xiaoyue
- Xu Yvonne Yiru
- Yadav Mukesh Kumar
- Yaghoubi Sajad
- Yamagishi Kazumasa
- Yang Lin
- Yano Yuichiro
- Yaribeygi Habib
- Yasufuku Yuichi
- Ye Pengpeng
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yezli Saber
- Yi Siyan
- Yigzaw Zeamanuel Anteneh
- Yiğit Arzu
- Yin Dehui
- Yip Paul
- Yismaw Malede Berihun
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Zadey Siddhesh
- Zadnik Vesna
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Sojib Bin
- Zandieh Ghazal G Z
- Zanghì Aurora
- Zar Heather J
- Zare Iman
- Zarimeidani Fatemeh
- Zastrozhin Mikhail Sergeevich
- Zeng Youjie
- Zhai Chunxia
- Zhang Anthony Lin
- Zhang Haijun
- Zhang Liqun
- Zhang Meixin
- Zhang Yunquan
- Zhang Zhenyu
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhao Jeff T
- Zhao Xiu-Ju George
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Jingjing
- Zhou Juexiao
- Zhou Shangcheng
- Zhu Bin
- Zhu Lei
- Zhu Zhaohua
- Ziaeian Boback
- Ziafati Makan
- Zielińska Magdalena
- Zimsen Stephanie R M
- Zoghi Ghazal
- Zoller Thomas
- Zumla Alimuddin
- Zyoud Sa'ed H
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 risk–outcome pairs. Pairs were included on the basis of data-driven determination of a risk–outcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each risk–outcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of risk–outcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4–78·8) for child growth failure and 66·3% (60·2–72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bożena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Boren Samuel
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Burns Douglas
- Burns Dustin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Buttignol Michael
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calpas Betty
- Calvelli Valerio
- Calvert Brian
- Calvo Enrique
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Caputo Claudio
- Carlin Roberto
- Carnes Andrew
- Carpinteyro Severiano
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castiñeiras De Saa Juan Ramon
- Castle James
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Celik Ali
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- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
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- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Sunan Kalijaga State Islamic University
- Publication date
- 01/01/2012
- Field of study
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asilar Ece
- Asin Ivan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian Tobias
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Basegmez Suzan
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
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- Volkov Alexey
- Volobouev Igor
- Vormwald Benedikt
- Vorobiev Igor
- Vorobyev Alexey
- Voutilainen Mikko
- Vutova Mariana
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Walczak Marek
- Walia Genius
- Walker Matthew
- Wallny Rainer
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- Waltenberger Wolfgang
- Wan Abdullah Wan Ahmad Tajuddin
- Wang Chunjie
- Wang Dayong
- Wang Fuqiang
- Wang Jian
- Wang Jing
- Wang Michael
- Wang Quan
- Wang Ren-Jie
- Wang Sean-Jiun
- Wang Ta-Wei
- Wang Yanchu
- Wang Zheng
- Waqas Muhammad
- Wardle Nicholas
- Wasserbaech Steven
- Wayand Stefan
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- Weber Hendrik
- Weber Hendrik
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- Wei Hua
- Weiler Thomas
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- Wendland Lauri
- Weng Yao
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- Wetzel James
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- Wickramage Nadeesha
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- Wissing Christoph
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- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Yong
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagozdzinska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Jinzhong
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukov Valery
- Zhukova Victoria
- Zolkapli Zukhaimira
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV
Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
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- Sturdy Jared
- Stöver Marc
- Suarez Gonzalez Juan
- Suarez Indara
- Sudic Lucija
- Sulak Lawrence
- Sulimov Valentin
- Sultanov Georgi
- Summers Sioni
- Sumorok Konstanty
- Sun Jian
- Sun Menglei
- Sun Xin
- Sung Kevin
- Sur Nairit
- Susa Tatjana
- Sutar Bajrang
- Suwonjandee Narumon
- Suárez Andrés Ignacio
- Svyatkovskiy Alexey
- Swain Sanjay Kumar
- Swartz Morris
- Syarif Rizki
- Symonds Philip
- Szillasi Zoltan
- Szleper Michal
- Sznajder Andre
- Sánchez Hernández Alberto
- Tabarelli de Fatis Tommaso
- Tadel Matevz
- Takahashi Yuta
- Takasugi Eric
- Tali Bayram
- Talvitie Joonas
- Tambe Norbert
- Tan Ping
- Tan Shao Min
- Tao Junquan
- Tao Zhengcheng
- Tapia Takaki Daniel
- Tapper Alexander
- Tarkovskii Evgenii
- Taroni Silvia
- Tatar Kaya
- Tatarinov Aysen
- Tavernier Stefaan
- Tavolaro Vittorio Raoul
- Taylor Devin
- Taylor Lucas
- Teixeira De Lima Rafael
- Tenchini Roberto
- Teodorescu Liliana
- Terkulov Adel
- Teyssier Daniel
- Thakur Shalini
- Thapa Krishna
- Thea Alessandro
- Theofilatos Konstantinos
- Tholen Heiner
- Thom Julia
- Thomas Laurent
- Thomas Scott
- Thomassen Peter
- Thyssen Filip
- Thüer Sebastian
- Tiko Andres
- Tiras Emrah
- Titov Maksym
- Tkaczyk Slawek
- Tlisov Danila
- Toda Sachiko
- Toldaiev Oleksii
- Tomalin Ian R
- Tomei Thiago
- Toms Maria
- Tonelli Manganote Edmilson José
- Tonelli Guido
- Tonjes Marguerite
- Tonwar Suresh C
- Topakli Huseyin
- Topkar Anita
- Topsis-Giotis Iasonas
- Torassa Ezio
- Toriashvili Tengizi
- Toropin Alexander
- Tosi Mia
- Tosi Nicolò
- Tosi Silvano
- Traczyk Piotr
- Tran Nhan Viet
- Treberer-Treberspurg Wolfgang
- Treille Daniel
- Trevisani Nicolò
- Tricomi Alessia
- Triossi Andrea
- Tripathi Mani
- Trippkewitz Karim Damun
- Trocino Daniele
- Trocsanyi Zoltan Laszlo
- Troendle Daniel
- Troshin Sergey
- Trovato Marco
- Tsai Jui-fa
- Tsamalaidze Zviad
- Tsirou Andromachi
- Tu Zhoudunming
- Tucker Jordan
- Tully Christopher
- Tumasyan Armen
- Tuo Shengquan
- Tuominiemi Jorma
- Tuovinen Esa
- Turkcapar Semra
- Turkewitz Jared
- Turner Mark
- Turner Paul
- Tuuva Tuure
- Tuve Cristina
- Tytgat Michael
- Tyurin Nikolay
- Tzeng Yeng-Ming
- Tziaferi Eirini
- Uchida Kirika
- Ujvari Balazs
- Ulmer Keith
- Ulrich Ralf
- Undleeb Sonaina
- Uplegger Lorenzo
- Uribe Estrada Cecilia
- Usai Emanuele
- Uzunian Andrey
- Vaandering Eric Wayne
- Vadruccio Daniele
- Vai Ilaria
- Vaitkus Juozas
- Valuev Vyacheslav
- Van De Klundert Merijn
- Van Doninck Walter
- Van Driessche Ward
- Van Haevermaet Hans
- Van Hove Pierre
- Van Mechelen Pierre
- Van Mulders Petra
- Van Onsem Gerrit Patrick
- Van Parijs Isis
- Van Remortel Nick
- Van Spilbeeck Alex
- Vander Donckt Muriel
- Vander Velde Catherine
- Vanelderen Lukas
- Vanhoefer Annika
- Vanlaer Pascal
- Varela Joao
- Varelas Nikos
- Varma Mukund
- Vartak Adish
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veckalns Viesturs
- Veelken Christian
- Velasco Mayda
- Velicanu Dragos
- Velkovska Julia
- Venditti Rosamaria
- Ventura Sandro
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Verlage Tobias
- Vernieri Caterina
- Verwilligen Piet
- Verzetti Mauro
- Verzocchi Marco
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Viliani Lorenzo
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vitulo Paolo
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Vormwald Benedikt
- Vorobiev Igor
- Vorobyev Alexey
- Voutilainen Mikko
- Vutova Mariana
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Walczak Marek
- Walia Genius
- Walker Matthew
- Wallny Rainer
- Walsh Roberval
- Waltenberger Wolfgang
- Wan Abdullah Wan Ahmad Tajuddin
- Wang Chunjie
- Wang Dayong
- Wang Fuqiang
- Wang Hui
- Wang Jian
- Wang Jing
- Wang Michael
- Wang Quan
- Wang Ren-Jie
- Wang Sean-Jiun
- Wang Ta-Wei
- Wang Yanchu
- Wang Zheng
- Wang Zhixing
- Waqas Muhammad
- Wardle Nicholas
- Wasserbaech Steven
- Wayand Stefan
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Marc
- Weber Matthias
- Wei Hua
- Weiler Thomas
- Weinberg Marc
- Welke Charles
- Wendland Lauri
- Wertz Sébastien
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Wickramage Nadeesha
- Wilbur Scott
- Williams Thomas
- Williamson Shawn
- Wimpenny Stephen
- Winer Brian L
- Winn Dave
- Wissing Christoph
- Wittich Peter
- Wolf Matthias
- Wolf Roger
- Wolfe Evan
- Wood Darien
- Wood John
- Woodard Anna
- Woods Nathaniel
- Wright Douglas
- Wright Jack
- Wu Zhenbin
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Wöhrmann Clemens
- Würthwein Frank
- Xia Fan
- Xiao Meng
- Xie Si
- Xie Wei
- Xin Yongjie
- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Unki
- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
- …