114 research outputs found
Satisfacción de los pacientes sometidos a intervenciones de cirugía menor en atención primaria
Coming full circle: constructing a [Gd6] wheel dimer by dimer and the importance of spin topology
© 2017 The Royal Society of Chemistry. The syntheses, structures, magnetic and thermodynamic properties of three related triethanolamine-based Gd III complexes are described. The smallest, a dimer ([Gd 2 ]), can be viewed as the subunit from which the two larger complexes, a linear tetramer ([Gd 2 ] 2 ) and a cyclic hexamer ([Gd 2 ] 3 ), are composed by further deprotonation of the triethanolamine ligand. In all cases, nearest neighbour magnetic ions are weakly correlated by antiferromagnetic isotropic exchange, whose strength does not change significantly from one complex to another; J ranging from -0.10 to -0.13 cm -1 . Therefore, rather than the strength of the coupling, it is the spin topology that is the dominant factor in determining the differences between the physical properties-specifically, the nuclearity and the transition from open (dimer and tetramer) to cyclic (hexamer) boundary conditions. Indeed the hexanuclear wheel reaches the continuum limit of classical Heisenberg spin chains. In terms of the magnetocaloric properties, the smaller the nuclearity, the larger the magnetic entropy and adiabatic temperature changes
Efficacy of a strategy for implementing a guideline for the control of cardiovascular risk in a primary healthcare setting: the SIRVA2 study a controlled, blinded community intervention trial randomised by clusters
This work describes the methodology used to assess a strategy for implementing clinical practice guidelines (CPG) for cardiovascular risk control in a health area of Madrid
A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007
We present the results of the first search for gravitational wave bursts
associated with high energy neutrinos. Together, these messengers could reveal
new, hidden sources that are not observed by conventional photon astronomy,
particularly at high energy. Our search uses neutrinos detected by the
underwater neutrino telescope ANTARES in its 5 line configuration during the
period January - September 2007, which coincided with the fifth and first
science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed
for candidate gravitational-wave signals coincident in time and direction with
the neutrino events. No significant coincident events were observed. We place
limits on the density of joint high energy neutrino - gravitational wave
emission events in the local universe, and compare them with densities of
merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at
http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access
area to figures, tables at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000
Does accreditation stimulate change? A study of the impact of the accreditation process on Canadian healthcare organizations
<p>Abstract</p> <p>Background</p> <p>One way to improve quality and safety in healthcare organizations (HCOs) is through accreditation. Accreditation is a rigorous external evaluation process that comprises self-assessment against a given set of standards, an on-site survey followed by a report with or without recommendations, and the award or refusal of accreditation status. This study evaluates how the accreditation process helps introduce organizational changes that enhance the quality and safety of care.</p> <p>Methods</p> <p>We used an embedded multiple case study design to explore organizational characteristics and identify changes linked to the accreditation process. We employed a theoretical framework to analyze various elements and for each case, we interviewed top managers, conducted focus groups with staff directly involved in the accreditation process, and analyzed self-assessment reports, accreditation reports and other case-related documents.</p> <p>Results</p> <p>The context in which accreditation took place, including the organizational context, influenced the type of change dynamics that occurred in HCOs. Furthermore, while accreditation itself was not necessarily the element that initiated change, the accreditation process was a highly effective tool for (i) accelerating integration and stimulating a spirit of cooperation in newly merged HCOs; (ii) helping to introduce continuous quality improvement programs to newly accredited or not-yet-accredited organizations; (iii) creating new leadership for quality improvement initiatives; (iv) increasing social capital by giving staff the opportunity to develop relationships; and (v) fostering links between HCOs and other stakeholders. The study also found that HCOs' motivation to introduce accreditation-related changes dwindled over time.</p> <p>Conclusions</p> <p>We conclude that the accreditation process is an effective leitmotiv for the introduction of change but is nonetheless subject to a learning cycle and a learning curve. Institutions invest greatly to conform to the first accreditation visit and reap the greatest benefits in the next three accreditation cycles (3 to 10 years after initial accreditation). After 10 years, however, institutions begin to find accreditation less challenging. To maximize the benefits of the accreditation process, HCOs and accrediting bodies must seek ways to take full advantage of each stage of the accreditation process over time.</p
Spatial memory in the grey mouse lemur (Microcebus murinus)
Wild animals face the challenge of locating feeding sites distributed across broad spatial and temporal scales. Spatial memory allows animals to find a goal, such as a productive feeding patch, even when there are no goal-specific sensory cues available. Because there is little experimental information on learning and memory capabilities in free-ranging primates, the aim of this study was to test whether grey mouse lemurs (Microcebus murinus), as short-term dietary specialists, rely on spatial memory in relocating productive feeding sites. In addition, we asked what kind of spatial representation might underlie their orientation in their natural environment. Using an experimental approach, we set eight radio-collared grey mouse lemurs a memory task by confronting them with two different spatial patterns of baited and non-baited artificial feeding stations under exclusion of sensory cues. Positional data were recorded by focal animal observations within a grid system of small foot trails. A change in the baiting pattern revealed that grey mouse lemurs primarily used spatial cues to relocate baited feeding stations and that they were able to rapidly learn a new spatial arrangement. Spatially concentrated, non-random movements revealed preliminary evidence for a route-based restriction in mouse lemur space; during a subsequent release experiment, however, we found high travel efficiency in directed movements. We therefore propose that mouse lemur spatial memory is based on some kind of mental representation that is more detailed than a route-based network map
Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as fiber size were significantly lower in ob/ob mice compared to wild type littermates, being significantly increased by leptin administration (P<0.001). This effect was associated with an inactivation of the muscle atrophy-related transcription factor forkhead box class O3 (FoxO3a) (P<0.05), and with a decrease in the protein expression levels of the E3 ubiquitin-ligases muscle atrophy F-box (MAFbx) (P<0.05) and muscle RING finger 1 (MuRF1) (P<0.05). Moreover, leptin increased (P<0.01) protein expression levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a regulator of muscle fiber type, and decreased (P<0.05) myostatin protein, a negative regulator of muscle growth. Leptin administration also activated (P<0.01) the regulators of cell cycle progression proliferating cell nuclear antigen (PCNA) and cyclin D1, and increased (P<0.01) myofibrillar protein troponin T. The present study provides evidence that leptin treatment may increase muscle mass of ob/ob mice by inhibiting myofibrillar protein degradation as well as enhancing muscle cell proliferation
Balancing Social and Political Strategies in Emerging Markets: Evidence from India
This article explores the substitution and complementary effects between political and social
strategies on firm performance in the context of an emerging market (EM). Using in-depth,
historical case-study approach, the article investigates how companies integrate political and
social resources in this market. Corporate performance includes traditional measures such as
accounting performance and nonfinancial measures like the ease of doing business. The study
finds that social strategies are stronger enablers of firm long-term performance than political
strategies. The latter have a short-term impact on performance, but their success over time is
limited. The main drawback of reliance on political resources in EMs is the lack of political
stability, fragmented polity, and weak political coalitions. We identify rather limited evidence
of firms using these two strategies as complements. Thus, we suggest that firms should
employ both these strategies in the EM
Potassium : a neglected nutrient in global change
L'article inclou sis apèndixsAim: Potassium (K) is the second most abundant nutrient after nitrogen (N) in plant photosynthetic tissues. Thousands of physiological and metabolic studies in recent decades have established the fundamental role of K in plant function, especially in water use efficiency and economy, and yet macroecological studies have mostly overlooked this nutrient.- Methods: We have reviewed available studies on the contents, stoichiometries and roles of potassium in the soil-plant system and in terrestrial ecosystems. We have also reviewed the impacts of global change drivers on K contents, stoichiometries, and roles. - Conclusions: The current literature indicates that K, at a global level, is as limiting as N and phosphorus (P) for plant productivity in terrestrial ecosystems. K limitation has been seen up to some degree in 70% of all studied terrestrial ecosystems. However, atmospheric K deposition from human activities represents higher amounts than that from natural sources in some areas. We are far from understanding the K fluxes between the atmosphere and land, and the role of anthropogenic activities in these fluxes. The increasing aridity expected in wide areas of the world makes K more critical through its role in water use efficiency. N deposition exerts a strong impact on the ecosystem K-cycle, decreasing K availability and increasing K limitation. Plant invasive success is enhanced by higher soil K availability, especially in environments without strong abiotic stresses. The impacts of other global change drivers, such as increasing atmospheric CO² or changes in land use remain to be elucidated. Current models of the responses of ecosystems and carbon storage to projected global climatic and atmospheric changes are now starting to consider N and P, but they should also consider K, mostly in arid and semiarid ecosystems
Automatización del corte tridimensional de piezas mediante un robot manipulador a partir de un diseño CAD
XXV Jornadas de Automática. Año 2004En este artículo se expone el desarrollo de una
aplicación informática que permite la
automatización del corte de piezas en tres
dimensiones mediante un brazo robótico industrial a
partir de un diseño de las mismas realizado mediante
una herramienta CAD/CAM. Partiendo de un
programa en lenguaje simbólico y de la posición
inicial de la herramienta de corte, el software
desarrollado permite simular la trayectoria de corte
y determinar si todos los puntos de la misma son
alcanzables, en cuyo caso se transmiten al
controlador del manipulador en un formato
comprensible por éste y se ejecuta la trayectoria.Ministerio de Ciencia y Tecnología DPI2001-2424-C02-0
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