250 research outputs found
Characteristics of age-friendly bus information
Bus information is an important element to consider when developing and implementing age-friendly bus systems. Little is known regarding the bus information needs and preferences of older people. This study aims to illuminate characteristics of age-friendly bus information. Participant observations with stimulated recall interviews (n=40) were used to identify older peoples' (age 60 and over) perspectives on bus information. The data were analyzed using qualitative content analysis. A printed information location checklist also was conducted. Categorical analysis identified that older people used a variety of information sources including printed information, telephone, Internet, bus drivers, word of mouth, and experience. Positive and negative characteristics of each source were identified. Older people also required a range of levels of information complexity. Popular locations for sourcing printed information included post offices, news agents, tourist information centers, and libraries. Transport providers and policy makers should consider the needs and preferences of older people when providing bus information. Effective information provision requires a range of media, covering a broad spectrum of information complexity and through a variety of locations
Further developments towards a genome-scale metabolic model of yeast
BACKGROUND: To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity. RESULTS: We have expanded the yeast network reconstruction to incorporate many new reactions from the literature and represented these in a well-annotated and standards-compliant manner. The new reconstruction comprises 1102 unique metabolic reactions involving 924 unique metabolites - significantly larger in scope than any previous reconstruction. The representation of lipid metabolism in particular has improved, with 234 out of 268 enzymes linked to lipid metabolism now present in at least one reaction. Connectivity is emphatically improved, with more than 90% of metabolites now reachable from the growth medium constituents. The present updates allow constraint-based analyses to be performed; viability predictions of single knockouts are comparable to results from in vivo experiments and to those of previous reconstructions. CONCLUSIONS: We report the development of the most complete reconstruction of yeast metabolism to date that is based upon reliable literature evidence and richly annotated according to MIRIAM standards. The reconstruction is available in the Systems Biology Markup Language (SBML) and via a publicly accessible database http://www.comp-sys-bio.org/yeastnet/
System-level policies on appropriate opioid use, a multi-stakeholder consensus
Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may help inform organisations such as management structures, government agencies and funding bodies. Methods: We conducted a multi-stakeholder survey using a modified Delphi methodology focusing on policies, at the system level, rather than at the prescriber or patient level. We aimed to provide consensus statements for current developments and priorities for future developments. Results: Twenty-five experts from a variety of fields with experience in acute pain management were invited to join a review panel, of whom 23 completed a modified Delphi survey of policies designed to improve the safety and quality of opioids prescribing for acute pain in the secondary care setting. Strong agreement, defined as consistent among> 75% of panellists, was observed for ten statements. Conclusions: Using a modified Delphi study, we found agreement among a multidisciplinary panel, including patient representation, on prioritisation of policies for system-level interventions, to improve governance, pain management, patient/consumers care, safety and engagement.Publisher PDFPeer reviewe
The twilight of the Liberal Social Contract? On the Reception of Rawlsian Political Liberalism
This chapter discusses the Rawlsian project of public reason, or public justification-based 'political' liberalism, and its reception. After a brief philosophical rather than philological reconstruction of the project, the chapter revolves around a distinction between idealist and realist responses to it. Focusing on political liberalism’s critical reception illuminates an overarching question: was Rawls’s revival of a contractualist approach to liberal legitimacy a fruitful move for liberalism and/or the social contract tradition? The last section contains a largely negative answer to that question. Nonetheless the chapter's conclusion shows that the research programme of political liberalism provided and continues to provide illuminating insights into the limitations of liberal contractualism, especially under conditions of persistent and radical diversity. The programme is, however, less receptive to challenges to do with the relative decline of the power of modern states
COMAP Early Science: III. CO Data Processing
We describe the first season COMAP analysis pipeline that converts raw
detector readouts to calibrated sky maps. This pipeline implements four main
steps: gain calibration, filtering, data selection, and map-making. Absolute
gain calibration relies on a combination of instrumental and astrophysical
sources, while relative gain calibration exploits real-time total-power
variations. High efficiency filtering is achieved through spectroscopic
common-mode rejection within and across receivers, resulting in nearly
uncorrelated white noise within single-frequency channels. Consequently,
near-optimal but biased maps are produced by binning the filtered time stream
into pixelized maps; the corresponding signal bias transfer function is
estimated through simulations. Data selection is performed automatically
through a series of goodness-of-fit statistics, including and
multi-scale correlation tests. Applying this pipeline to the first-season COMAP
data, we produce a dataset with very low levels of correlated noise. We find
that one of our two scanning strategies (the Lissajous type) is sensitive to
residual instrumental systematics. As a result, we no longer use this type of
scan and exclude data taken this way from our Season 1 power spectrum
estimates. We perform a careful analysis of our data processing and observing
efficiencies and take account of planned improvements to estimate our future
performance. Power spectrum results derived from the first-season COMAP maps
are presented and discussed in companion papers.Comment: Paper 3 of 7 in series. 26 pages, 23 figures, submitted to Ap
COMAP Early Science: VII. Prospects for CO Intensity Mapping at Reionization
We introduce COMAP-EoR, the next generation of the Carbon Monoxide Mapping
Array Project aimed at extending CO intensity mapping to the Epoch of
Reionization. COMAP-EoR supplements the existing 30 GHz COMAP Pathfinder with
two additional 30 GHz instruments and a new 16 GHz receiver. This combination
of frequencies will be able to simultaneously map CO(1--0) and CO(2--1) at
reionization redshifts () in addition to providing a significant
boost to the sensitivity of the Pathfinder. We examine a set of
existing models of the EoR CO signal, and find power spectra spanning several
orders of magnitude, highlighting our extreme ignorance about this period of
cosmic history and the value of the COMAP-EoR measurement. We carry out the
most detailed forecast to date of an intensity mapping cross-correlation, and
find that five out of the six models we consider yield signal to noise ratios
(S/N) for COMAP-EoR, with the brightest reaching a S/N above 400.
We show that, for these models, COMAP-EoR can make a detailed measurement of
the cosmic molecular gas history from , as well as probe the
population of faint, star-forming galaxies predicted by these models to be
undetectable by traditional surveys. We show that, for the single model that
does not predict numerous faint emitters, a COMAP-EoR-type measurement is
required to rule out their existence. We briefly explore prospects for a
third-generation Expanded Reionization Array (COMAP-ERA) capable of detecting
the faintest models and characterizing the brightest signals in extreme detail.Comment: Paper 7 of 7 in series. 19 pages, 10 figures, to be submitted to Ap
COMAP Early Science: VI. A First Look at the COMAP Galactic Plane Survey
We present early results from the COMAP Galactic Plane Survey conducted
between June 2019 and April 2021, spanning in Galactic
longitude and |b|<1.\!\!^{\circ}5 in Galactic latitude with an angular
resolution of . The full survey will span -
and will be the first large-scale radio continuum survey at
GHz with sub-degree resolution. We present initial results from the first part
of the survey, including diffuse emission and spectral energy distributions
(SEDs) of HII regions and supernova remnants. Using low and high frequency
surveys to constrain free-free and thermal dust emission contributions, we find
evidence of excess flux density at GHz in six regions that we interpret
as anomalous microwave emission. Furthermore we model UCHII contributions using
data from the GHz CORNISH catalogue and reject this as the cause of the
GHz excess. Six known supernova remnants (SNR) are detected at GHz,
and we measure spectral indices consistent with the literature or show evidence
of steepening. The flux density of the SNR W44 at GHz is consistent with
a power-law extrapolation from lower frequencies with no indication of spectral
steepening in contrast with recent results from the Sardinia Radio Telescope.
We also extract five hydrogen radio recombination lines to map the warm ionized
gas, which can be used to estimate electron temperatures or to constrain
continuum free-free emission. The full COMAP Galactic plane survey, to be
released in 2023/2024, will be an invaluable resource for Galactic
astrophysics.Comment: Paper 6 of 7 in series. 28 pages, 10 figures, submitted to Ap
COMAP Early Science: IV. Power Spectrum Methodology and Results
We present the power spectrum methodology used for the first-season COMAP
analysis, and assess the quality of the current data set. The main results are
derived through the Feed-feed Pseudo-Cross-Spectrum (FPXS) method, which is a
robust estimator with respect to both noise modeling errors and experimental
systematics. We use effective transfer functions to take into account the
effects of instrumental beam smoothing and various filter operations applied
during the low-level data processing. The power spectra estimated in this way
have allowed us to identify a systematic error associated with one of our two
scanning strategies, believed to be due to residual ground or atmospheric
contamination. We omit these data from our analysis and no longer use this
scanning technique for observations. We present the power spectra from our
first season of observing and demonstrate that the uncertainties are
integrating as expected for uncorrelated noise, with any residual systematics
suppressed to a level below the noise. Using the FPXS method, and combining
data on scales we estimate , the first direct 3D
constraint on the clustering component of the CO(1-0) power spectrum in the
literature.Comment: Paper 4 of 7 in series. 18 pages, 11 figures, as accepted in Ap
A hard x-ray photoemission study of transparent conducting fluorine-doped tin dioxide
Fluorine-doped tin oxide (FTO) is a commercially
successful transparent conducting oxide with very good electrical
(resistivities < 1×103 Ω·cm) and optical properties (transmittance
> 85%). These properties coupled with cheap and large-scale
deposition on float-glass lines means FTO has found commercial
use in, for example, low emissivity windows and solar cells.
However, despite its widespread application, a detailed
understanding is lacking of the doping and defects in FTO.
Recent work [1] has suggested that the fluorine interstitial plays
a major role in limiting the conductivity of FTO. Here we present
synchrotron radiation high energy x-ray photoemission
spectroscopy (XPS) of the fluorine 1s core level of FTO films
without in situ surface preparation. This probes deeper than
standard XPS and shows that the fluorine interstitial is present
not just at the surface of the films and is not an artefact of argon
ion sputtering for surface preparation
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