122 research outputs found
The Type 2 Diabetes Knowledge Portal: an Open access Genetic Resource Dedicated to Type 2 Diabetes and Related Traits
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate the T2DKP\u27s comprehensiveness by comparing its datasets with those of other repositories. Second, we describe how researchers unfamiliar with human genetic data can begin using and correctly interpreting them via the T2DKP. Third, we describe how existing users can extend their current workflows to use the full suite of tools offered by the T2DKP. We finally discuss the lessons offered by the T2DKP toward the goal of democratizing access to complex disease genetic results
Literary studies and the academy
In 1885 the University of Oxford invited applications for the newly created Merton Professorship of English Language and Literature. The holder of the chair was, according to the statutes, to âlecture and give instruction on the broad history and criticism of English Language and Literature, and on the works of approved English authorsâ. This was not in itself a particularly innovatory move, as the study of English vernacular literature had played some part in higher education in Britain for over a century. Oxford University had put English as a subject into its pass degree in 1873, had been participating since 1878 in extension teaching, of which literary study formed a significant part, and had since 1881 been setting special examinations in the subject for its non-graduating women students. What was new was the fact that this ancient university appeared to be on the verge of granting the solid academic legitimacy of an established chair to an institutionally marginal and often contentious intellectual pursuit, acknowledging the study of literary texts in English to be a fit subject not just for women and the educationally disadvantaged but also for university men
Opera and Hypnosis: Victor Maurelâs Experiments with Verdiâs Otello
One day in his private home on the avenue Bugeaud, in Parisâs sixteenth arrondissement, the famous baritone Victor Maurel hosted a meeting which combined music with hypnotism of a young woman
Vocal Culture in the Age of Laryngoscopy
For several months beginning in 1884, readers of Life, Science, Health, the Atlantic Monthly and similar magazines would have encountered half-page advertisements for a newly patented medical device called the âammoniaphoneâ (Figure 2.1). Invented and promoted by a Scottish doctor named Carter Moffat and endorsed by the soprano Adelina Patti, British Prime Minister William Gladstone and the Princess of Wales, the ammoniaphone promised a miraculous transformation in the voices of its users. It was recommended for âvocalists, clergymen, public speakers, parliamentary men, readers, reciters, lecturers, leaders of psalmody, schoolmasters, amateurs, church choirs, barristers, and all persons who have to use their voices professionally, or who desire to greatly improve their speaking or singing tonesâ. Some estimates indicated that Moffat sold upwards of 30,000 units, yet the ammoniaphone was a flash in the pan as far as such things go, fading from public view after 1886
Unsound Seeds
With this image of a curtain hiding and at the same time heightening some terrible secret, Max Kalbeck began his review of the first Viennese performance of Richard Straussâs Salome. Theodor W. Adorno picked up the image of the curtain in the context of Straussâs fabled skill at composing non-musical events, when he identified the opening flourish of Straussâs Salome as the swooshing sound of the rising curtain. If this is so, the succĂšs de scandale of the opera was achieved, in more than one sense, as soon as the curtain rose at Dresdenâs Semperoper on 10 December 1905.
Critics of the premiere noted that the opera set âboundless wildness and degeneration to musicâ; it brought âhigh decadenceâ onto the operatic stage; a âcomposition of hysteriaâ, reflecting the âdisease of our timeâ, Salome is âhardly music any moreâ.The outrage did not end there
Science, Technology and Love in Late Eighteenth-Century Opera
It is a tale told by countless operas: young love, thwarted by an old manâs financially motivated marriage plans, triumphs in the end thanks to a deception that tricks the old man into blessing the young loversâ union. Always a doddering fool, the old man is often also an enthusiast for knowledge. Such is the case, for instance, in Carlo Goldoniâs comic opera libretto Il mondo della luna (1750), in which Buonafedeâs interest in the moon opens him to an elaborate hoax that has him believe he and his daughters have left Earth for the lunar world; and also in the Singspiel Die LuftbĂ€lle, oder der Liebhaber Ă la Montgolfier (1788), wherein the apothecary Wurm trades Sophie, the ward he intended to marry himself, for a technological innovation that will make him a pioneering aeronaut
Operatic Fantasies in Early Nineteenth-Century Psychiatry
In his celebrated essay on insanity in the Dictionnaire des sciences mĂ©dicales (1816), French psychiatrist Ătienne Esquirol marvelled at the earlier custom of allowing asylum inmates to attend theatrical productions at Charenton
Identifying Public Knowledge, Behavior, and Perception of Native New Zealand Birds
The Wellington City Council and ZEALANDIA seek to better understand public awareness of native birds and conservation efforts so they can better strategize about outreach campaigns in the future. Through interviews with experts in social media, education, and conservation we assessed current approaches to outreach. Through surveys we assessed public awareness of native birds and conservation efforts. We found that current WCC and ZEALANDIA engagements within the community have been successful in educating the public about native birds and there is evidence that using narratives in outreach better connects individuals to the issues. Our recommendations include developing a heightened presence in social media, a potential outreach campaign, and a suggestion for future study
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