Research synthesis of recommended acetabular cup orientations for total hip arthroplasty

Total Hip Arthroplasty (THA) is regarded as one of the most successful surgical procedures of modern times yet continues to be associated with a small but significant complication rate. Many early failures may be associated with poor component positioning with, in particular, acetabular component orientation dependent on the subjective judgement of the surgeon. In this paper, we compare the manufacturers’ instructions on acetabular cup orientation with the literature-based recommended safety zones, by transforming them onto a single, clinically-relevant framework in which the different reference systems, safety guidelines and current instrumentation surgical techniques can be evaluated. The observed limited consensus between reflects ongoing uncertainty regarding the optimum acetabular component positioning that is probably responsible for a significant number of hip dislocations and early revisions. Our analysis suggests a new safety zone - the Strathclyde Safety Zone, SSZ (30° - 55° inclination and 5° - 30° anteversion) - defined in the operative reference frame, that encompasses other safety zones and which, incidentally, holds the majority of manufacturers’ guideline positions

Information Sharing Within a Distributed, Collaborative Design Process: A Case Study

A current research project at the University of Strathclyde is introduced which aims to better understand the role of distributed engineering design in industry and address present problems. The first major industrial case study of the project, completed within a multinational in the oil and gas industry, is then described together with the main research questions. This multinational will be described in the text as company A. The findings are split into three areas depending on the data collection method employed. The main case study issues are investigated through interviews while a profile of current activities and perceptions comes from completed questionnaires. Sampling and analysis of distributed activity over time is served by the completion of daily diaries and direct observation. These combine to increase the understanding of information sharing and collaborative design in a distributed organization. Interviews show the importance of design reuse within the organization contrasting with the pressures of formalizing all parts of a design project. The preponderance of variant design activity is also highlighted along with concerns of continued practice. The questionnaires show that 34% of engineers’ time is spent sourcing relevant information and knowledge and that the most popular sources are company systems followed by personal contact. 18% of work is found to be distributed while colleagues from another location and another floor/department know more 51% and 57% of the time respectively. The detail design phase of a distributed design project is analysed over time which finds that most collaborative work consists of simple information exchange supplementary to the main design activity. Furthermore, concentrated periods of collaborative design are found to follow these information exchange cycles’. Distributed problems are also discussed in the paper, ranging from difficulties with unfamiliar terminology to a lack of visibility at worldwide sites

microRNAs and EMT in mammary cells and breast cancer

MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.Josephine A. Wright, Jennifer K. Richer and Gregory J. Goodal

Scripture and reform

No description supplie