Book History, Women, and the Canon: Theorizing Feminist Bibliography

This paper revises book history's historiography to account for feminist inquiry

“She writes like a Woman”: Paratextual Marketing in Delarivier Manley’s Early Career

Delarivier Manley has long been discussed as a sensational and successful Tory political satirist of the early eighteenth century. In the late seventeenth century, however, she associated with Whigs, experimented with genres, and tested different techniques for marketing her texts. Mimicking the methods of celebrity actresses, Manley used paratextual addresses to engage public interest in a carefully curated identity, creating a commodity in her persona that she would employ throughout her career. This paper traces her developing persona in her first three publications: Letters Writen by Mrs. Manley, The Lost Lover, and The Royal Mischief. Although these texts are not explicitly political satire, they nevertheless explicate the preliminary and halting machinations of an astute businesswoman and the marketing tactics Manley would employ throughout her career. The result is a more complete and nuanced picture of Manley’s commercial authorship

Viola pubescens var. eriocarpa (Schwein.) N.H.Russell

https://thekeep.eiu.edu/herbarium_specimens_byname/20202/thumbnail.jp

Characterization of Microtubule Organizing Centers in the genus Protostelium, Including Evolutionary Implications

Microtubule organizing centers (MTOCs) are cellular regions of microtubule nucleation. The best known MTOCs are those associated with the centrosome, but several non-centrosomal MTOCs are known in eukaryotes, especially in land plants. MTOCs are poorly characterized across the breadth of amoebozoan diversity, but are well-known in certain amoebozoan lineages, including the genus of protosteloid slime molds Protostelium. The structure of the MTOC is known for two non-ciliated species, P. nocturnum and P. mycophaga, as well as P. aurantium, which can reversibly become ciliated under appropriate conditions. P. nocturnum and P. mycophaga have acentriolar centrosomal MTOCs while P. aurantium has a centriole-bearing pro-kinetid that differentiates into a kinetid when the cell becomes ciliated. It was previously thought that the MTOCs of P. mycophaga and P. nocturnum were homologous to each other, and were derived from a structure reminiscent of the kinetid of P. aurantium, but recent changes in our understanding of the group’s phylogeny, as well as the realization that most isolates of P. aurantium cannot become ciliated, have called this hypothesis into question. In this thesis, a new strain of P. aurantium was isolated. This strain, which was unable to produce cilia when isolated, was characterized ultrastructurally and found to have an MTOC typical of non-ciliated Protostelium spp. After ultrastructural work was complete, ciliated cells were unexpectedly found in one culture of the new isolate. The significance of these findings, and their implications for the evolutionary history of Protostelium, are discussed

Relational and Incarnational Leadership: A Flattening of the Congregational Hierarchy and a Shared Journey of Faith

The problem addressed in this paper is: How can mainline congregational leadership move a church forward toward health in a postmodern world wherein the mainline Church as a whole is in such serious decline? This problem will be addressed by proposing a model of pastoral leadership that lives relationally and incarnationally with the congregation, flattens the hierarchy, and nurtures key lay leaders who are empowered to: answer their personal call, cultivate intentional relationships, and nurture the congregation into a missional and incarnationally focused living organism. Pastoral leadership, as we will argue, is, therefore, primarily living incarnationally and relationally with a congregation by helping indigenous people find innovative answers to their local and global problems. To present the importance of this style of relational leadership, we will look at: Chapter I - an introduction, by means of a familiar church dialogue and the current state of the mainline Church; Chapter II - The Trinity as a relational model of leadership; Chapter III - Moses as a communal model of leadership; Chapter IVNehemiah as a spiritual leader; Chapter V- Nehemiah as an emotionally intelligent community leader; Chapter VI- John Wesley\u27s leadership as a flattening of the hierarchy and a model of relational leadership, and in Chapter VII - we will investigate corporate leadership as a spiritual model and a flattening hierarchy

What Is Critical Bibliography?

This introduction to the special issue, “New Approaches to Critical Bibliography and the Material Text,” defines critical bibliography as a method that, at the intersection of critical theory and bibliographic study, challenges standard histories of the book and bookish objects. Drawing on feminist studies, critical race studies, postcolonialism, Marxism, queer theory, and disability studies, among others, critical bibliography, the authors argue, calls attention to the structures of oppression upholding the circulation, preservation, and organization of material texts—but also the possibilities of liberation therein. Taking up this method from a variety of fields and periods, the essays in this issue take on the very grounds, definitions, and boundaries of traditional bibliography, asking epistemological and ontological questions that interrogate the material and conceptual construction of bibliographic knowledge itself

Dectin-1 Expression is Altered by Fungal Infection, Polymicrobial Sepsis, and Glucan Administration.

Glucans are fungal cell wall PAMPs that promote survival in polymicrobial and candidal sepsis. Dectin-1 is the primary PRR for glucans. The goals of the present study were to characterize 1) the effects of fungal infection on Dectin-1; 2) the effects of polymicrobial sepsis in the presence and absence of glucan on Dectin-1; 3) the effects of systemic administration of glucans on Dectin-1; and 4) the intracellular trafficking of glucans. Mice were either systemically infected with Candida albicans, or made septic by CLP with and without glucan phosphate (GP) injection, or injected with GP. Flow cytometry was performed to assess cell surface Dectin-1 expression. C. albicans sepsis resulted in an increase in the percentage of Dectin-1 positive (Dectin+) blood and splenic leukocytes by increasing the percentage of neutrophils. C. albicans infection increased the percentage of Dectin+ splenic T cells. CLP decreased the percentage of highly Dectin-1 positive leukocytes in the blood by decreasing the percentage of Dectin+ neutrophils. GP treatment in sepsis further decreased the percentages of Dectinhigh blood leukocytes and Dectin+ neutrophils. CLP decreased the percentage of Dectin+ splenic leukocytes by decreasing the percentage of splenic macrophages. GP administration to CLP mice further decreased the percentage of Dectin+ splenocytes by decreasing the percentage of Dectin+ macrophages. Administration of GP resulted in a prolonged decrease in the percentage of Dectinhigh blood leukocytes. The changes in Dectin-1 expression with GP were because of decreases in the percentage of Dectin+ neutrophils and monocytes. In the trafficking studies, macrophages were incubated with fluorescent labeled glucans and then stained for intracellular organelles and signal transduction molecules. Cells were imaged using confocal microscopy. GP is internalized by clathrin and trafficked to the Golgi apparatus. GP internalization is regulated but not dependent on caveolin-1. GP co-localized with SRA, TLR2, and PI3K/p85. The trafficking of laminarin and particulate glucan is similar. We speculate that loss of cell surface Dectin-1 may be important in the protection conferred by glucans in sepsis. Additionally, intracellular trafficking and interaction with signaling components may be important steps in modulation of cellular function by glucan-pattern recognition receptor complexes

Dectin-1 Expression is Altered by Fungal Infection, Polymicrobial Sepsis, and Glucan Administration.

Glucans are fungal cell wall PAMPs that promote survival in polymicrobial and candidal sepsis. Dectin-1 is the primary PRR for glucans. The goals of the present study were to characterize 1) the effects of fungal infection on Dectin-1; 2) the effects of polymicrobial sepsis in the presence and absence of glucan on Dectin-1; 3) the effects of systemic administration of glucans on Dectin-1; and 4) the intracellular trafficking of glucans. Mice were either systemically infected with Candida albicans, or made septic by CLP with and without glucan phosphate (GP) injection, or injected with GP. Flow cytometry was performed to assess cell surface Dectin-1 expression. C. albicans sepsis resulted in an increase in the percentage of Dectin-1 positive (Dectin+) blood and splenic leukocytes by increasing the percentage of neutrophils. C. albicans infection increased the percentage of Dectin+ splenic T cells. CLP decreased the percentage of highly Dectin-1 positive leukocytes in the blood by decreasing the percentage of Dectin+ neutrophils. GP treatment in sepsis further decreased the percentages of Dectinhigh blood leukocytes and Dectin+ neutrophils. CLP decreased the percentage of Dectin+ splenic leukocytes by decreasing the percentage of splenic macrophages. GP administration to CLP mice further decreased the percentage of Dectin+ splenocytes by decreasing the percentage of Dectin+ macrophages. Administration of GP resulted in a prolonged decrease in the percentage of Dectinhigh blood leukocytes. The changes in Dectin-1 expression with GP were because of decreases in the percentage of Dectin+ neutrophils and monocytes. In the trafficking studies, macrophages were incubated with fluorescent labeled glucans and then stained for intracellular organelles and signal transduction molecules. Cells were imaged using confocal microscopy. GP is internalized by clathrin and trafficked to the Golgi apparatus. GP internalization is regulated but not dependent on caveolin-1. GP co-localized with SRA, TLR2, and PI3K/p85. The trafficking of laminarin and particulate glucan is similar. We speculate that loss of cell surface Dectin-1 may be important in the protection conferred by glucans in sepsis. Additionally, intracellular trafficking and interaction with signaling components may be important steps in modulation of cellular function by glucan-pattern recognition receptor complexes