Space Shuttle Orbiter Structures and Mechanisms

The Space Shuttle Orbiter has performed exceptionally well over its 30 years of flight experience. Among the many factors behind this success were robust, yet carefully monitored, structural and mechanical systems. From highlighting key aspects of the design to illustrating lessons learned from the operation of this complex system, this paper will attempt to educate the reader on why some subsystems operated flawlessly and why specific vulnerabilities were exposed in others. Specific areas to be covered will be the following: high level configuration overview, primary and secondary structure, mechanical systems ranging from landing gear to the docking system, and windows

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Guidelines for Managing Lesser Prairie-Chicken Populations and Their Habitats

Lesser prairie-chicken (Tympanuchus paidicinctus) populations have declined by \u3e90% since the 1800s. These declines have concerned both biologists and private conservation groups and led to a petition to list the lesser prairie-chicken as threatened under the Endangered Species Act. Most of the land in the current range of the lesser prairie-chicken is privately owned, and declines have been primarily attributed to anthropogenic factors. Conversion of native rangeland to cropland and excessive grazing have been implicated as leading causes in the species\u27 decline. Periodic drought probably has exacerbated these problems. Little research on habitat requirements was conducted prior to 1970. Despite recent advances in the knowledge of lesser prairie-chicken ecology, no comprehensive guidelines for management of the species have been published. In these guide- lines, we provide a synopsis of our current knowledge of lesser prairie-chicken habitat requirements and suggest management strategies to monitor, maintain, and enhance lesser prairie-chicken populations

Active Regulation of Altitude as a Function of Optical Texture

Institute of Aviation, University of Illinois, Urbana, Illinois Two empirical studies are reported that examine active regulation of altitude as a function of the type of ground texture. Three ground textures were examined: lines perpendicular to the direction of motion, lines parallel to the direction of motion, and the combination (i.e., square or checkerboard texture). Although subjects only controlled altitude, disturbances were: introduced on three axes: vertical, lateral, and fore-aft. The re8ults show a clear advantage for texture parallel to the direction of motion. However, in considering these results in the context of previous research on altitude control, the argument is made that there is no compelling evidence that suggests either parallel (splay) or perpendicular (density) texture is privileged with regard to altitude control. Rather, the most effective display for altitude control will be the one t-hat best isolates the optical activity associated with changing altitude from the optical activity arising from other sources of disturbance (such as forward locomotion). Such a display will make it easier for the observer to distinguish and respond specifically to the disturbances of altitude

Active Regulation of Altitude as a Function of Optical Texture

Institute of Aviation, University of Illinois, Urbana, Illinois Two empirical studies are reported that examine active regulation of altitude as a function of the type of ground texture. Three ground textures were examined: lines perpendicular to the direction of motion, lines parallel to the direction of motion, and the combination (i.e., square or checkerboard texture). Although subjects only controlled altitude, disturbances were: introduced on three axes: vertical, lateral, and fore-aft. The re8ults show a clear advantage for texture parallel to the direction of motion. However, in considering these results in the context of previous research on altitude control, the argument is made that there is no compelling evidence that suggests either parallel (splay) or perpendicular (density) texture is privileged with regard to altitude control. Rather, the most effective display for altitude control will be the one t-hat best isolates the optical activity associated with changing altitude from the optical activity arising from other sources of disturbance (such as forward locomotion). Such a display will make it easier for the observer to distinguish and respond specifically to the disturbances of altitude

Alternative Displays for Discrete Movement Control

This research examined performance in a single-axis discrete positioning task using three different mappings for the visual display of the movement space. In a normal display condition, displayed distance was proportional to actual distance. In a split-screen condition, 66.5% of the initial distance to the target was mapped into 50% of the visual space and 33.5% of the distance (containing the target) was mapping into the remaining 50% of visual space. Finally, in a log screen condition there was a logarithmic mapping from actual to visual space. The split-screen and log screen conditions resulted in magnification of the space containing the target and compression of space distance from the target. Results for movement time (MT) showed a significant effect of target width. MTs were longer for smaller targets. Performance with normal and log screens was equivalent in terms of overall level and in terms of rate of increase in MT with reduction in target size. A smaller rate of increase, however, was found for the split-screen display. MTs for the smallest target were faster with the split-screen display. Evidence suggests that fewer corrective movements were required for the smaller targets when using the split screen