60 research outputs found
Boxes and Quilts? I Thought This Was College! Utilizing Pedagogical tools to Access Students\u27 Sociocultural Selves
- Publication venue
- Digital Commons@Georgia Southern
- Publication date
- 01/04/2013
- Field of study
This reflection on practice discusses action research involving two pedagogical tools, identity boxes and culture quilts, which utilize the praxis of culturally responsive pedagogy. These tools were used to build classroom community and help students examine how their lives and education reflected “cultural themes of the society, personal themes, institutional themes, and social histories” (Creswell, 1998, p. 49). A qualitative examination of student response to the use of these tools indicated a strengthening of classroom community and the beginning of a transformative openness to, and critical examination of, cultural concepts based in what the authors term differentialities
Boxes and Quilts? I Thought This Was College! Utilizing Pedagogical tools to Access Students\u27 Sociocultural Selves
- Publication venue
- Digital Commons@Georgia Southern
- Publication date
- 01/04/2013
- Field of study
This reflection on practice discusses action research involving two pedagogical tools, identity boxes and culture quilts, which utilize the praxis of culturally responsive pedagogy. These tools were used to build classroom community and help students examine how their lives and education reflected “cultural themes of the society, personal themes, institutional themes, and social histories” (Creswell, 1998, p. 49). A qualitative examination of student response to the use of these tools indicated a strengthening of classroom community and the beginning of a transformative openness to, and critical examination of, cultural concepts based in what the authors term differentialities
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Aksentijevich Alexandra
- Al Harthi Fawz
- Al Mutairi Amal
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Andrews Shea J.
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Anne Feng Yen-Chen
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Aprile von Hohenstaufen Kathrin
- Arabi Yaseen M.
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Arthur Timothy D.
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- Azarzar Samira
- Åsvold Bjørn Olav
- Bachetti Tiziana
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Bibert Stéphanie
- Biscarini Filippo
- Blay Natalia
- Bochud Pierre-Yves
- Boillat Noémie
- Bottà Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bradford Yuki
- Branka Vulesevic Nardin Rezk
- Brassard Nathalie
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Cal-Sabater Paloma de la
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
- Caulfield Mark J.
- Cárcel-Márquez Jara
- Ceri Stefano
- Chamnanphon Monpat
- Chan Georgia
- Chang Xiao
- Chang Xiao
- Chariyavilaskul Pajaree
- Charney Alexander W.
- Chasman Daniel I.
- Chassé Michaël
- Chaudhary Kumardeep
- Chavan Sameer
- Chen Hung-Hsin
- Cheng Nathan
- Chetruengchai Wanna
- Chittoor Geetha
- Cho Judy H.
- Cho Kelly
- Choi Sam
- Churchhouse Claire
- Chwialkowska Karolina
- Claassen Sabine
- Claringbould Annique
- Coignet Marie
- Coiro Gabriella
- Collins Brett L.
- Colobrán Roger
- Colombo Riccardo
- Conticini Edoardo
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Corridi Marta
- Cortés Beatriz
- Cossarizza Andrea
- Coto Eliecer
- Coviello Domenico A.
- CRiPSI null
- Croci Leonardo
- Croci Susanna
- Crook Derrick W.
- Crooks Kristy
- Crotti Lia
- Cullell Natalia
- Cusick Caroline
- Daga Sergio
- Dalmau David
- Daly Mark
- Danesh John
- Darcis Gilles
- Daya Michelle
- de Cid Rafael
- de Felipe Mimbrera Alicia
- de geus Eco (E. J. C. )
- De Vivo Oreste
- DeDiego Marta L.
- Deelen Patrick
- Dei Simona
- Della Monica Matteo
- Desanctis Elena
- Di Angelantonio Emanuele
- Di Biagio Antonio
- Di Domenico Paolo
- Di Pietro Massimo
- Di Sarno Laura
- Dietl Beatriz
- Do Ron
- Dobaño Carlota
- Doddato Gabriella
- Domingo Carlos
- Domínguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- D’Alessandro Miriana
- D’Antonio Matteo
- D’Antonio-Chronowska Agnieszka
- D’Arminio Monforte Antonella
- D’Mellow Kenton
- Earle Sarah G.
- Eid Mohammed A.
- El-Jawhari Jehan J.
- El-Lawaty Walaa M.
- El-shanshory Mohamed R.
- El-Sherbiny Yasser M.
- Elhadidy Tamer A.
- Elnagdy Marwa H.
- Eltoukhy Madonna M.
- Emiliozzi Arianna
- Emma Duncan
- Erard Véronique
- Esko Tõnu
- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- Farré Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
- Fawns-Ritchie Chloe
- Fawzy Mohammad S.
- Felemban Walaa A.
- Feri Marco
- Fernandez-Cadenas Israel
- Ferreira Manuel A. R.
- Ferri Claudio
- FHoGID null
- Finer Sarah
- FinnGen null
- Finucane Hilary
- Fiorentino Giuseppe
- Fiz-López Aida
- Forgetta Vincenzo
- Forgetta Vincenzo
- Fowler Tom
- Francesco Bianchi Antonio Perrella
- Franchi Federico
- Francisci Daniela
- Franco Giulianini
- Frazer Kelly A.
- Frediani Bruno
- Free Robert C.
- Frippiat Frederic
- Frithiof Robert
- Frullanti Elisa
- Furini Simone
- Gabbi Chiara
- Gabrieli Arianna
- Gaddis Michael
- Galván-Femenía Iván
- Ganna Andrea
- Ganna Andrea
- Garcia-Aymerich Judith
- García-Clemente Marta
- García-Madrona Sebastian
- Gass Matthew C.
- Gatti Francesca
- Gaziano J. Michael
- Genes &
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
- Gignoux Christopher R.
- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot Stéphanie
- Goldstein Jacqueline I.
- Gomez Juan
- González-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyatt Anna L.
- Guzman Charlotte
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Health Research Team null
- Hegazy Mohamed A. F.
- Helgeland Øyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- Hultström Michael
- Hunt Karen A.
- Huynen Pascale
- Hveem Kristian
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- Jiménez-Xarrié Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kallaste Anne
- Kamdar Dhryata
- Kanai Masahiro
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerr Shona M.
- Khafaga Walid T.
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- La Rovere Maria Teresa
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- Läll Kristi
- Leader Joseph B.
- Lee Paul H.
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Levy Tess
- Léonard Philippe
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- Llucià-Carol Laia
- Lo Rizzo Caterina
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- Mandalà Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Marcantonio Simona
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Marike Boezen Lude Franke
- Martin Alicia R.
- Martin Hilary C.
- Martinelli Enrico
- Martí-Fàbregas Joan
- Martín-Nalda Andrea
- Martínez Alba Parra
- Masjuan Jaime
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Matsui Hiroko
- Mazzei Maria Antonietta
- Márquez Leonardo
- Mägi Reedik
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- Menéndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoit
- Moahmed Hanteera S.
- Mohamed Attia A. S.
- Mohseni Moghaddam Seyed Behrooz
- Mondelli Mario Umberto
- Montagnani Francesca
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- Muiño Elena
- Murphy Shawn N.
- Mussini Cristina
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Nakanishi Tomoko
- Neale Benjamin M.
- Nencioni Cesira
- Neofytos Dionysios
- Nguyen Huy
- Nguyen Jennifer P.
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel (M. G. )
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
- Nussle Semira Gonseth
- Odhams Christopher A.
- Ognibene Agostino
- Okasha Kamal
- Oliveira Maureen
- Ori Anil P. S.
- O’Connell Anne Marie
- O’Donnell Christopher J.
- O’Reilly Paul
- P-PredictUs null
- Paciosi Francesco
- Paciosi Francesco
- Packer Richard J.
- Palmer Duncan S.
- Palmieri Maria
- Palotie Aarno
- Pancrazzi Alessandro
- Panese Sandro
- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
- Pathak Gita A.
- Pathak Gita A.
- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson Pärt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
- Porteous David J.
- Poscente Monica
- Preuss Michael
- Przychodzen Bartlomiej P.
- Putchareon Opass
- Puthanakit Thanyawee
- Puusepp Mairo
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- RegCOVID null
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
- Richards J. Brent
- Richmond Anne
- Richmond Anne
- Rico Veronica
- Ridker Paul M.
- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
- Ritchie Marylyn D.
- Riva Agostino
- Rivolta Carlo
- Rizzi Marco
- Roberts Genevieve
- Robles Veronica
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-Jaén Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sarma Gopal
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
- Scotton Pier Giorgio
- Sealfon Stuart C.
- Sebastian Zöllner Brooke Wolford
- Sebra Robert P.
- Seed Cotton
- Segala Francesco Vladimiro
- Segura Tomás
- SeroCOVID null
- Serra-Llovich Alex
- Serrano-Heras Gemma
- Sesso Howard D.
- Shahin Doaa
- Sharififard Bahareh
- Shaw Douglas M.
- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
- Sloofman Laura G.
- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh Noémie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- Thys Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David A.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Villalonga Joan Montaner
- Vincenti Antonella
- Voide Cathy
- Von Frenckell Christian
- Vonk Judith. M.
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- Zucchi Patrizia
- Zyndorf Marissa
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study
- Author
- Adeline Gerard
- Adem Bytyqi
- Aggeliki Pandazi
- Ahmed Abdel-Razek
- Ahmed Chishti
- Ahmed Mostafa El-Shaarawy
- Alar Sormus
- Alastair Rose
- Albert Prades
- Alberto Lisi
- Alberto Zangrillo
- Aleksandra Lazukic
- Alena Breidablik
- Alenka Spindler-Vesel
- Alessandro Bacuzzi
- Alexander Kulikov
- Alexander Lugovoy
- Alexandre Molin
- Alexandru Bogdan Prodan
- Alexey Gritsan
- Alexey Ovezov
- Ali Saltali
- Alice Werger
- Alida Moise
- Alistair Cain
- Alyson Andrew
- Amanda Datson
- Ambra Licia Di Parma
- Amir Rafi
- Amir Shafi-Kabir
- Ana de Abajo Larriba
- Ana Fernandez- Bustamante
- Ana Maria Petcu
- Ana Pekle-Golez
- Ana Ricardo
- Andre Gottschalk
- Andrea Bell
- Andrea Brunelli
- Andrea Cortegiani
- Andreas Gueldner
- Andreas Reske
- Andrew Donovan
- Andrey Babayants
- Andrey Lubnin
- Andriy Grynyuk
- Andriy Mazur
- Anette Bundy
- Angela Almagro
- Angela Monteirosa
- Angelo Gratarola
- Ann De Bruyne
- Anna Fouracres
- Anna Marija Pavicic
- Annamaria Campanile
- Anne Duvekot
- Annika Aun
- Antoine Petit
- Antonella Marrella
- Antonino Giarratano
- Antonio Martínez Simon
- Antonio Zilic
- Antonis Andreou
- Arieh Eden
- Ashok Das
- Ashok Raj
- Audrey Pospiech
- Aurika Karbonskiene
- Bahar Kuvaki
- Barbka Novak-Supe
- Bas in ‘t Veld
- Baturay Kansu Kazbek
- Bea Bastin
- Ben Creagh-Brown
- Ben Schwerdtfeger
- Ben Shelley
- Benedikt Pannen
- Benoit Plichon
- Bernhard Urbanek
- Binnekade Jan M
- Bjorn Heyse
- Branka Maldini
- Branka Mazul-Sunko
- Branka Strazisar
- Branwen Ellison
- Brigitte Leva
- Cait Goodall
- Carlo Alberto Volta
- Carlos Ferrando
- Carlos Puigbo
- Catalin-Traian Guran
- Caterina Valeria Pesce
- Ceren Sanlikarip
- Cesar Aldecoa Alvares-Santullano
- Charley Higham
- Charlotte Severijns
- Christa Boer
- Christian Nestler
- Christopher Uhlig
- Christos Nouris
- Chryssa Pourzitaki
- Claire West
- Clare Jackson
- Colin Barrett
- Concezione Tommasino
- Corrado Liperi
- Cristina Saiz Ruiz
- Dalip Muhardri
- Dan Corneci
- Dan Costea
- Dana Tomescu
- Daniel Ferreira
- Daniela Filipescu
- Daniela La Bella
- Daniele Sances
- Danielle Franklin
- Darija Azenic-Venzera
- Daryl Kor
- David Kahn
- David Portch
- David Rogerson
- Davide D'antini
- Debbie Fuller
- Deborah Clements
- Dejana Djonoviċ- Omanoviċ
- Demet Sulemanji
- Denny Tran Thiem
- Diana Westerheide
- Dimitri Dylst
- Dimitrios Valsamidis
- Dimitris Karapanos
- Diogo Martins
- Dmitri Bystritski
- Dubravka Ivic
- Dunja Mihajlovic
- Egle Kontrimaviciute
- Eiko Herodes
- Elaine Rogers
- Elena Sardo
- Elisa Brugnoni
- Elisabeth Andersson
- Elizabeth Homan
- Elizabeth Luzier
- Emily Calton
- Emmanuel Futier
- Emmanuel Marret
- Emre Camci
- Enrique Moret
- Erick Morais
- Erika Salciute
- Ernesto Pastor
- Eyup Aydogan
- Fatma Mine Karaman
- Fatma Nur Akgun
- Fatos Sada
- Federica Scavonetto
- Felicity Mackenzie
- Ferim Gunenc
- Fernande Lois
- Fevzi Toraman
- Filippo Bressan
- Foteini Zafeiropoulou
- Francesca Montalto
- Francesca Rapido
- Francesco Bona
- Francis Joseph Borg
- Francisco Hidalgo Martinez
- Frederic Rodenas
- Frode Fjellanger
- Gabija Tomkute
- Gabriela Droc
- Gabriele Sales
- Galina Gritsan
- Gama de Abreu Marcelo
- Gary Mills
- Gary Minto
- Gecaj-Gashi Agreta
- Georgia Tsaousi
- Georgios Antholopoulos
- Georgios Gkiokas
- Gerd Struber
- Gianluca Castellani
- Gianluca Spano
- Gianmarco Giacoletto
- Gilda Cinnella
- Giorgia Cerati
- Giovanni Landoni
- Gisela Perez
- Giulia Pellerano
- Giuseppe Musella
- Giuseppe Servillo
- Glória Tareco
- Goncalves Castro
- Gorjana Erceg
- Guy Rousseau
- Hana Harazim
- Hans Gombotz
- Hany Yassin
- Hedenstierna Goran
- Helen Roberts
- Helen Scholes
- Helfried Metzler
- Hemmes Sabrine N T
- Hermann Wrigge
- Hiesmayr Michael
- Hisham Hosny Abdelwahab
- Hol Liselotte
- Hollmann Markus W
- Hrvoje Vinkovic
- Ib Jammer
- Ines Arpino
- Inga Mladic-Batinica
- Ioana Cristina Grintescu
- Ioana Marina Grintescu
- Ioana Popescu Garotescu
- Iole Brunetti
- Iorel Gherghina
- Irene Wiersma
- Irina Grosu
- Irina Komissarova
- Iulia Cindea
- Ivan Kostadinov
- Ivan Mirkovic
- Ivana Oputric
- Ivana Volfova
- Jaber Samir
- Jadranka Pavicic Saric
- Jale Maral
- James Limb
- Jan Brujevic
- Jan Poelaert
- Jane Montgomery
- Janet Palmer
- Jannicke Mellin-Olsen
- Jasmina Markovic-Bozi
- Jasmina Pejakovic
- Jasminka Kopic
- Jasper De Jong
- Jaume Canet
- Jayne Foot
- Jaysimha Susarla
- Jens Hering
- Jens Krassler
- Jeroen van Melkebeek
- Jesus Rico
- Jill Deane
- Joana Amaral
- Johann Geib
- John Williams
- John Xuereb
- Jonathan Paddle
- Jose Antonio de Andrés Ibañez
- Jose Tatay Vivo
- Josep Fava
- Josip Zunic
- Julie Colley
- Juraj Sprung
- Jurgen Van Limmen
- Juri Karjagin
- Juri Oganjan
- Kaili Sarapuu
- Kamil Hudacek
- Karen Simeson
- Karginova Zalina
- Kassiani Theodoraki
- Katarina Bruncakova
- Katarina Liskova
- Katerina Jirmanova
- Katerina Vitkova
- Katharina Skirstad Hodt
- Kazimir Juricic
- Konstantinos Stroumpoulis
- Krishnan Kodaganallur
- Lars Gillberg
- Laura Pasin
- Laura Pistidda
- Leanne Welch
- Lenka Polakovicova
- Liliana Mirea
- Lisa Wayman
- Luc De Baerdemaeker
- Luca Brazzi
- Luca Montagnani
- Lucia Mirabella
- Lucia Stancombe
- Lucia Zamidei
- Lucian Horhota
- Lucy Brown
- Luigi Beretta
- Luigi Delunas
- Luigi Giancarlo
- Luiz Fernando
- Lynn Everett
- Madalina Dutu
- Magda Riciu
- Mahdy Abdelhady
- Maka Zuleika
- Manuel Granell
- Manuel Vico Avalos
- Mar Sendra
- Marc Solier
- Marcel Gama de Abreu
- Marco Baciarello
- Marco Venturino
- Marco Verri
- Marcos Vidal Melo
- Marcus J
- Marcus Schultz
- Margaret Szewczyk
- Mari Carmen Unzueta
- Maria de Lurdes
- Maria Jose Yepes Temino
- Maria Nadolski
- Maria Vargas
- Maria Zelinkova
- Marian Irinel Tudoroiu
- Mariana Correia
- Marie-Claire van Malderen
- Marina Juros-Zovko
- Marina Soro
- Mario Defez
- Marios-Konstantinos Tasoulis
- Mark Pulletz
- Markus Hollmann
- Marta Eugenia Sassone
- Martin Scharffenberg
- Martin Weiss
- Martina Kosinova
- Matea Bogdanovic Dvorscak
- Matthew Rucklidge
- Maud Beran
- Maudrian Burton
- Maureen Bezzina
- Maurizio Solca
- Maximilian Schaefer
- Merilin Mall
- Michael Hiesmayr
- Michael Lundberg
- Michal Drab
- Michela Generali
- Michele De Michele
- Mihai Popescu
- Mihaly Veres
- Mills Gary H
- Minca Voje
- Mine Yildiz
- Mirja Konrad
- Mirna Sehovic
- Miroljub Jovanov
- Mladen Carev
- Mohamed Magdy
- Mohamed Mahran
- Mona Momeni
- Monir Jawad
- Moses Chikungwa
- Mrutyunjaya Rambhatla
- Murat Yilmaz
- Mónica Rodriguez Nunez
- Natalia Anipchenko
- Natasa Dropulic
- Nathalie Roels
- Necmiye Hadimioglu
- Nenad Karanovic
- Nesil Coskunfirat
- Neval Boztug
- Nicholas Boyd
- Nijbroek Sunny G
- Nukhet Sivrikoz
- Nuzhet Mert Senturk
- Oguzhan Arun
- Oleg Korolkov
- Olga Smekalova
- Onur Selvi
- Otto Mohr
- Ozgur Senturk
- Pablo Monedero
- Panagiota Florou
- Paola Morelli
- Paolo Pelosi
- Paolo Severgnini
- Parizade Raymode
- Pasquale Raimondo
- Patrice Forget
- Paul Dennesen
- Paula Dzurnakova
- Pauline Mercer
- Pavel Prokoshev
- Peeter Kivik
- Pelosi Paolo
- Petar Miskovic
- Peter Carvalho
- Peter Kienbaum
- Peter Spieth
- Petr Stourac
- Philip Watt
- Philipp Simon
- Piet Wyffels
- Povilas Miliauskas
- Putensen Christian
- Rachel Walker
- Radek Filipsky
- Radovan Dudas
- Raquel Martinez
- Renatas Tikuisis
- Reuven Pizov
- Riccardo Ragazzi
- Rienk van Beek
- Roberto Dossi
- Roberto Zoppellari
- Rocio Perez
- Rosanna Sileo
- Ruby Molina
- Rupert Pearse
- Ruta Aukstakalniene
- Ruxandra Copotoiu
- Ruxandra Fota
- Sabrine Hemmes
- Salvatore Grasso
- Samir el Kafraw
- Samir Jaber
- Sanda-Maria Copotoiu
- Sandeep Kusre
- Sandeep Varma
- Sandrine Damster
- Santi Maurizio Raineri
- Sara Rodrigues
- Sara Sher
- Sarah Gibb
- Sarah Moreton
- Savino Spadaro
- Schmid Werner
- Schultz
- Selma Pernar
- Semih Kucukguclu
- Semra Kucukgoncu
- Septimiu Gheorghe Moldovan
- Sergei Fedorov
- Sergiy Vorotyntsev
- Serpa Neto Ary
- Serpil Ustalar Ozgen
- Severgnini Paolo
- Seyda Canli
- Shivarajan Algarsamy
- Silvius Negoita
- Simon Davies
- Simone Merzky
- Sipylaite Jurate
- Slavica Kvolik
- Sofia Appleton
- Sonja Skiljic
- Sopio Peradze
- Stanley Wutai
- Stefan de Hert
- Stefan Ivars
- Stefano Pezzatto
- Stefano Tredici
- Stephanie Jones
- Stephen Mowat
- Stijn van de Velde
- Suat Sanli
- Sudhakar Marri
- Suresh Venkatesh
- Susan Yates
- Susana Cadilha
- Suzana Parente
- Swart Pien
- Tanja Goranovic
- Tanja Treschan
- Tarek Metwally
- Tatiana Sidiropoulou
- Tatyana Kapkan
- Thais Creary
- Thea Koch
- Thomas Bluth
- Thomas Kiss
- Thomas Smith
- Thomas Wegscheider
- Toby Weingarten
- Tom Jacobs
- Tomas Kolacek
- Tomislav Radocaj
- Valentina Tarzia
- Valery Likhvantsev
- Vedran Frkovic
- Veerle van Mossevelde
- Vesna Novak-Jankovic
- Vicari Sottosanti
- Victoria Barsan
- Victoria Moral
- Vidal Melo Marcos F
- Villiam Sobona
- Vincenzo Russotto
- Vittoria Bartolini
- Werner Schmid
- Wolfgang Kroell
- Wrigge Hermann
- Yeo Tze
- Yigal Leykin
- Yousif Saeed
- Zeljka Gavranovic
- Zerrin Sungur
- Zivile Teberaite
- Zsolt Tolcser
- Zuleyha Kazak Bengisun
- Zuzana Kusnierikova
- Şule Ozbilgin
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P < 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
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- Eiriksdottir Gudny
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- Elliott Paul
- Ellis Stephen G.
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- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
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- Esko Tõnu
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- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
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- Felix Stephan B.
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- Ferreir Teresa
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- Fisher Eva
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- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
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- Jukema J. Wouter
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- Kinnunen Leena
- Klopp Norman
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- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
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- Leander Karin
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- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
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- Linksted Pamela
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- Loley Christina
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- Lua Jian'an
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- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
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- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
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- Nilsson Peter
- Nisbet James
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- Nyholt Dale R.
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- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
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- Owen Katharine R.
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- Pankow James S.
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- Park Ju-Hyun
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- Parts Leopold
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- Pascoe Laura
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- Payne Felicity
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- Pedersen Oluf
- Pellikka Niina
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- Rice Catherine
- Ridderstråel Martin
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- Rief Winfried
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- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
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- Sampietro M. Lourdes
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- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
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- Boomsma Dorret I
- Borecki Ingrid
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- Bornstein Stefan R
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- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
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- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
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- Carty Cara
- Casas Juan P
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- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
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- Center Jacqueline R
- Cesana Giancarlo
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- Chang Hsing-Yi
- Chang Yen-Pei C
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- Chen Han
- Chen Ida
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- Chen Ming-Huei
- Chen Wei
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- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
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- Cimponeriu Dan
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- Heikkilä Kauko
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- Heliövaara Markku
- Helmer Catherine
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- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
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- Hercberg Serge
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- Herrera Lizbeth
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- Willenborg Christina
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- Wilsgaard Tom
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- Wilson Scott G
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- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
- Author
- Abate Degu
- Abate Kalkidan Hassen
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdela Jemal
- Abdelalim Ahmed
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Molla
- Abebe Zegeye
- Abil Olifan Zewdie
- Aboyans Victor
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen M E
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Pawan
- Ackerman Ilana N
- Adamu Abdu A
- Adebayo Oladimeji M
- Adekanmbi Victor
- Ademi Zanfina
- Adetokunboh Olatunji O
- Adib Mina G
- Adsuar Jose C
- Afanvi Kossivi Agbelenko
- Afarideh Mohsen
- Afshin Ashkan
- Agarwal Gina
- Agesa Kareha M
- Aggarwal Rakesh
- Aghayan Sargis Aghasi
- Agrawal Anurag
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Ahmed Sayem
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Alahdab Fares
- Alam Khurshid
- Alam Tahiya
- Alashi Alaa
- Alavian Seyed Moayed
- Alene Kefyalew Addis
- Alijanzadeh Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Alonso Jordi
- Alsharif Ubai
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Aminde Leopold N
- Amini Erfan
- Amiresmaili Mohammadreza
- Ammar Walid
- Amoako Yaw Ampem
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Androudi Sofia
- Animut Megbaru Debalkie
- Anjomshoa Mina
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T
- Anwari Palwasha
- Arabloo Jalal
- Aremu Olatunde
- Arora Amit
- Arora Megha
- Artaman Al
- Aryal Krishna K
- Asayesh Hamid
- Ataro Zerihun
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide F G A
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Ayer Rakesh
- Azzopardi Peter S
- Babazadeh Arefeh
- Badali Hamid
- Balakrishnan Kalpana
- Bali Ayele Geleto
- Banach Maciej
- Banoub Joseph Adel Mattar
- Barac Aleksandra
- Barboza Miguel A
- Barker-Collo Suzanne Lyn
- Barquera Simon
- Barrero Lope H
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Bayu Begashaw
- Bekru Eyasu Tamru
- Belachew Abate Bekele
- Belay Yihalem Abebe
- Bell Michelle L
- Bello Aminu K
- Bennett Derrick A
- Bensenor Isabela M
- Berhane Adugnaw
- Bernabe Eduardo
- Bernstein Robert S
- Beuran Mircea
- Beyranvand Tina
- Bhala Neeraj
- Bhatt Samir
- Bhaumik Soumyadeep
- Bhutta Zulfiqar A
- Biadgo Belete
- Biehl Molly H
- Bijani Ali
- Bikbov Boris
- Bilano Ver
- Bililign Nigus
- Bin Sayeed Muhammad Shahdaat
- Bisanzio Donal
- Bjørge Tone
- Bleyer Archie
- Bobasa Eshetu Mulisa
- Bou-Orm Ibrahim R
- Boufous Soufiane
- Bourne Rupert
- Brady Oliver J
- Brant Luisa C
- Brayne Carol
- Brazinova Alexandra
- Breitborde Nicholas J K
- Brenner Hermann
- Briant Paul Svitil
- Briko Andrey Nikolaevich
- Britton Gabrielle
- Brugha Traolach
- Buchbinder Rachelle
- Busse Reinhard
- Butt Zahid A
- Bärnighausen Till Winfried
- Cahuana-Hurtado Lucero
- Campuzano Rincon Julio Cesar
- Cano Jorge
- Carrero Juan J
- Carter Austin
- Carvalho Félix
- Castañeda-Orjuela Carlos A
- Castillo Rivas Jacqueline
- Castro Franz
- Catalá-López Ferrán
- Cercy Kelly M
- Cerin Ester
- Chaiah Yazan
- Chang Jung-Chen
- Charlson Fiona J
- Chattu Vijay Kumar
- Chiang Peggy Pei-Chia
- Chitheer Abdulaal
- Choi Jee-Young J
- Christensen Hanne
- Christopher Devasahayam J
- Chung Sheng-Chia
- Cicuttini Flavia M
- Cirillo Massimo
- Collado-Mateo Daniel
- Cooper Cyrus
- Cortesi Paolo Angelo
- Cortinovis Monica
- Cousin Ewerton
- Criqui Michael H
- Cromwell Elizabeth A
- Cross Marita
- Crump John A
- Cárdenas Rosario
- Daba Alemneh Kabeta
- Dachew Berihun Assefa
- Dadi Abel Fekadu
- Dandona Lalit
- Dandona Rakhi
- Dargan Paul I
- Daryani Ahmad
- Das Gupta Rajat
- Das Neves José
- Dasa Tamirat Tesfaye
- Davitoiu Dragos Virgil
- De La Hoz Fernando Pio
- De Leo Diego
- De Neve Jan-Walter
- De Steur Hans
- Degefa Meaza Girma
- Degenhardt Louisa
- Deiparine Selina
- Demoz Gebre Teklemariam
- Denova-Gutiérrez Edgar
- Deribe Kebede
- Dervenis Nikolaos
- Des Jarlais Don C
- Dey Subhojit
- Dharmaratne Samath D
- Dhimal Meghnath
- Dinberu Mesfin Tadese
- Dirac M Ashworth
- Djalalinia Shirin
- Doan Linh
- Dokova Klara
- Doku David Teye
- Dorsey E Ray
- Doyle Kerrie E
- Driscoll Tim Robert
- Dubey Manisha
- Dubljanin Eleonora
- Duken Eyasu Ejeta
- Duncan Bruce B
- Duraes Andre R
- Ebrahimi Hedyeh
- Ebrahimpour Soheil
- Echko Michelle M
- Edessa Dumessa
- Edvardsson David
- Effiong Andem
- Eggen Anne Elise
- Ehrlich Joshua R
- El Bcheraoui Charbel
- El-Khatib Ziad
- Elyazar Iqbal R F
- Enayati Ahmadali
- Endalifer Melese Linger
- Endries Aman Yesuf
- Er Benjamin
- Erskine Holly E
- Eskandarieh Sharareh
- Esteghamati Alireza
- Esteghamati Sadaf
- Fakhim Hamed
- Faramarzi Mahbobeh
- Fareed Mohammad
- Farhadi Farzaneh
- Farid Talha A
- Farinha Carla Sofia E sá
- Farioli Andrea
- Faro Andre
- Farzadfar Farshad
- Fazaeli Ali Akbar
- Feigin Valery L
- Fentahun Netsanet
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes Joao C
- Ferrari Alize J
- Ferreira Manuela L
- Filip Irina
- Fischer Florian
- Fitzmaurice Christina
- Foigt Nataliya A
- Foreman Kyle J
- Frank Tahvi D
- Fukumoto Takeshi
- Fullman Nancy
- Furtado João M
- Fürst Thomas
- Gakidou Emmanuela
- Gall Seana
- Gallus Silvano
- Ganji Morsaleh
- Garcia-Basteiro Alberto L
- Gardner William M
- Gebre Abadi Kahsu
- Gebremedhin Amanuel Tesfay
- Gebremichael Teklu Gebrehiwo
- Gelano Tilayie Feto
- Geleijnse Johanna M
- Genova-Maleras Ricard
- Geramo Yilma Chisha Dea
- Gething Peter W
- Gezae Kebede Embaye
- Ghadami Mohammad Rasoul
- Ghadiri Keyghobad
- Ghasemi-Kasman Maryam
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- Ghoshal Aloke Gopal
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- Mohammed Shafiu
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- Morrison Shane Douglas
- Moschos Marilita M
- Mousavi Seyyed Meysam
- Mruts Kalayu Brhane
- Muche Achenef Asmamaw
- Muchie Kindie Fentahun
- Mueller Ulrich Otto
- Muhammed Oumer Sada
- Mukhopadhyay Satinath
- Muller Kate
- Mumford John Everett
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- Murthy G V S
- Musa Kamarul Imran
- Mustafa Ghulam
- März Winfried
- Nabhan Ashraf F
- Nagata Chie
- Nagel Gabriele
- Naghavi Mohsen
- Naheed Aliya
- Nahvijou Azin
- Naik Gurudatta
- Najafi Farid
- Nam Hae Sung
- Nangia Vinay
- Nansseu Jobert Richie
- Neamati Nahid
- Negoi Ionut
- Negoi Ruxandra Irina
- Neupane Subas
- Newton Charles Richard James
- Ngunjiri Josephine W
- Nguyen Anh Quynh
- Nguyen Grant
- Nguyen Ha Thu
- Nguyen Huong Lan Thi
- Nguyen Huong Thanh
- Nguyen Long Hoang
- Nguyen Minh
- Nguyen Nam Ba
- Nguyen Son Hoang
- Nichols Emma
- Ningrum Dina Nur Anggraini
- Nixon Molly R
- Nomura Shuhei
- Noroozi Mehdi
- Norrving Bo
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- Nouri Hamid Reza
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- Oh In-Hwan
- Oladimeji Olanrewaju
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- Otstavnov Stanislav S
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- Pesudovs Konrad
- Petzold Max
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- Radfar Amir
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- Rafiei Alireza
- Rahim Fakher
- Rahimi Kazem
- Rahimi Zohreh
- Rahimi-Movaghar Afarin
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Mohammad Hifz Ur
- Rahman Muhammad Aziz
- Rahman Sajjad Ur
- Rai Rajesh Kumar
- Rajati Fatemeh
- Ranjan Prabhat
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- Resnikoff Serge
- Rezaei Satar
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- Roever Leonardo
- Ronfani Luca
- Roshandel Gholamreza
- Rostami Ali
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- Rothenbacher Dietrich
- Rubagotti Enrico
- Sachdev Perminder S
- Sadat Nafis
- Sadeghi Ehsan
- Saeedi Moghaddam Sahar
- Safari Hosein
- Safari Yahya
- Safari-Faramani Roya
- Safdarian Mahdi
- Safi Sare
- Safiri Saeid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi Haniye Sadat
- Salam Nasir
- Salama Joseph S
- Salamati Payman
- Saleem Zikria
- Salimi Yahya
- Salimzadeh Hamideh
- Salomon Joshua A
- Salvi Sundeep Santosh
- Salz Inbal
- Samy Abdallah M
- Sanabria Juan
- Sanchez-Niño Maria Dolores
- Santomauro Damian Francesco
- Santos Itamar S
- Santos João Vasco
- Santric Milicevic Milena M
- Sao Jose Bruno Piassi
- Sardana Mayank
- Sarker Abdur Razzaque
- Sarmiento-Suárez Rodrigo
- Sarrafzadegan Nizal
- Sartorius Benn
- Sarvi Shahabeddin
- Sathian Brijesh
- Satpathy Maheswar
- Sawant Arundhati R
- Sawhney Monika
- Saxena Sonia
- Schaeffner Elke
- Schmidt Maria Inês
- Schneider Ione J C
- Schutte Aletta Elisabeth
- Schwebel David C
- Schwendicke Falk
- Scott James G
- Sekerija Mario
- Sepanlou Sadaf G
- Serván-Mori Edson
- Seyedmousavi Seyedmojtaba
- Shabaninejad Hosein
- Shafieesabet Azadeh
- Shahbazi Mehdi
- Shaheen Amira A
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shamsi Mohammadbagher
- Sharafi Heidar
- Sharafi Kiomars
- Sharif Mehdi
- Sharif-Alhoseini Mahdi
- Sharma Jayendra
- Sharma Rajesh
- She Jun
- Sheikh Aziz
- Shi Peilin
- Shiadeh Malihe Nourollahpour
- Shibuya Kenji
- Shiferaw Mekonnen Sisay
- Shigematsu Mika
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shokoohinia Yalda
- Shokraneh Farhad
- Shoman Haitham
- Shrime Mark G
- Si Si
- Siabani Soraya
- Sibai Abla Mehio
- Siddiqi Tariq J
- Sigfusdottir Inga Dora
- Sigurvinsdottir Rannveig
- Silva Diego Augusto Santos
- Silva João Pedro
- Silveira Dayane Gabriele Alves
- Singam Narayana Sarma Venkata
- Singh Jasvinder A
- Singh Narinder Pal
- Singh Virendra
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Skirbekk Vegard
- Sliwa Karen
- Smith David L
- Smith Mari
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- Sobaih Badr Hasan
- Sobhani Soheila
- Soofi Moslem
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- Soyiri Ireneous N
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T
- Srinivasan Vinay
- Stanaway Jeffrey D
- Starodubov Vladimir I
- Stein Dan J
- Steiner Caitlyn
- Steiner Timothy J
- Stokes Mark A
- Stovner Lars Jacob
- Subart Michelle L
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Sulo Gerhard
- Sunguya Bruno F
- Sur Patrick John
- Sykes Bryan L
- Sylaja P N
- Sylte Dillon O
- Szoeke Cassandra E I
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Tandon Nikhil
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Taveira Nuno
- Taylor Hugh R
- Tehrani-Banihashemi Arash
- Tekalign Tigist Gashaw
- Tekelemedhin Shishay Wahdey
- Tekle Merhawi Gebremedhin
- Temsah Mohamad-Hani
- Temsah Omar
- Terkawi Abdullah Sulieman
- Tessema Belay
- Teweldemedhin Mebrahtu
- Thankappan Kavumpurathu Raman
- Theis Andrew
- Thirunavukkarasu Sathish
- Thomas Nihal
- Tilahun Binyam
- To Quyen G
- Tonelli Marcello
- Topor-Madry Roman
- Torre Anna E
- Tortajada-Girbés Miguel
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Towbin Jeffrey A
- Tran Bach Xuan
- Tran Khanh Bao
- Troeger Christopher E
- Tsadik Afewerki Gebremeskel
- Tsoi Derrick
- Tudor Car Lorainne
- Tyrovolas Stefanos
- Ukwaja Kingsley Nnanna
- Ullah Irfan
- Undurraga Eduardo A
- Updike Rachel L
- Usman Muhammad Shariq
- Uthman Olalekan A
- Vaduganathan Muthiah
- Vaezi Afsane
- Valdez Pascual R
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Venketasubramanian Narayanaswamy
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Wang Yafeng
- Wang Yuan-Pang
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Daniel J
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- West T Eoin
- Westerman Ronny
- Whiteford Harvey A
- Widecka Justyna
- Wijeratne Tissa
- Williams Hywel C
- Wilner Lauren B
- Wilson Shadrach
- Winkler Andrea Sylvia
- Wiyeh Alison B
- Wiysonge Charles Shey
- Wolfe Charles D A
- Woolf Anthony D
- Wyper Grant M A
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yahyazadeh Jabbari Seyed Hossein
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Yasin Jemal
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zadnik Vesna
- Zaidi Zoubida
- Zaman Sojib Bin
- Zamani Mohammad
- Zandian Hamed
- Zar Heather J
- Zenebe Zerihun Menlkalew
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zucker Inbar
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Socio-demographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2)
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
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- Bellard Terell M.
- Bellerby Damian
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- Belter Edward A., Jr.
- Bemrose Richard
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- Benke J
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- Kruchowski Scott S.
- Kube Michael
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- Liyanage Dhammika
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- Lovell Jamie
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- Lowry Stephen
- Lozado Ryan J.
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- Lu Yontao T.
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
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- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdelfatah S
- Abdellatif M
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
- …