91 research outputs found
Return of naturally sourced Pb to Atlantic surface waters
- Author
- A Bollhofer
- A Kumar
- AE Kelly
- AE Noble
- AJ Veron
- AJ Veron
- AM Adams
- AR Baker
- AR Flegal
- AS Goudie
- C Kidd
- C Schlosser
- CF Powell
- CJ Allègre
- DC Ohnemus
- DJ Steding
- E Helmers
- E Ternon
- EA Boyle
- EA Boyle
- F Raes
- G Dulaquais
- G Sarthou
- HB Maring
- HJW De Baar
- I Chiapello
- JF Wu
- JM Pacyna
- JM Prospero
- JO Nriagu
- JO Nriagu
- KA Fomba
- KV Desboeufs
- LJ Spokes
- LY Alleman
- M Kersten
- M Paul
- M Witt
- MD Patey
- Micha J. A. Rijkenberg
- Middag
- MJA Rijkenberg
- MK Reuer
- MP Bacon
- N Huneeus
- R Arimoto
- R Chester
- R Chester
- R Chester
- R Chester
- R Middag
- R Middag
- R Rudnick
- R Schlitzer
- RA Duce
- S Guerzoni
- S Rigaud
- SC Hsu
- TJ Chow
- W Abouchami
- W Abouchami
- Y Asmerom
- Y Ben-Ami
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Anthropogenic emissions completely overwhelmed natural marine lead (Pb) sources during the past century, predominantly due to leaded petrol usage. Here, based on Pb isotope measurements, we reassess the importance of natural and anthropogenic Pb sources to the tropical North Atlantic following the nearly complete global cessation of leaded petrol use. Significant proportions of up to 30-50% of natural Pb, derived from mineral dust, are observed in Atlantic surface waters, reflecting the success of the global effort to reduce anthropogenic Pb emissions. The observation of mineral dust derived Pb in surface waters is governed by the elevated atmospheric mineral dust concentration of the North African dust plume and the dominance of dry deposition for the atmospheric aerosol flux to surface waters. Given these specific regional conditions, emissions from anthropogenic activities will remain the dominant global marine Pb source, even in the absence of leaded petrol combustion
Genome-Wide Transcript Profiling of Endosperm without Paternal Contribution Identifies Parent-of-Origin–Dependent Regulation of AGAMOUS-LIKE36
- Author
- A Becker
- A Bent
- A Erilova
- AE Guitton
- AJ Filson
- AJ Johnston
- AJ Wood
- Alexander Ungru
- AM Chaudhury
- AM Lindroth
- AR Isles
- Arp Schnittger
- Barbara M. Gloeckle
- BH Le
- BY Lin
- C Baroux
- C Josefsson
- C Kohler
- C Kohler
- C Kohler
- Csaba Koncz
- D Haig
- D Wang
- D Zilberman
- DP Barlow
- Ellen D. Andersen
- G Makarevich
- G Makarevich
- G Rios
- GK Smyth
- H Iwakawa
- H Saze
- H Walia
- IH Kang
- IM Morison
- J Goodrich
- JA Jeddeloh
- JD Storey
- JG Steffen
- JN Fitz Gerald
- JP Jackson
- Katrine N. Bjerkan
- L Parenicova
- M Bemer
- M Colombo
- M Gehring
- M Gehring
- M Luo
- Maren Heese
- Mathilde Grelon
- MD Curtis
- MF Portereiko
- MK Nowack
- MK Nowack
- MK Nowack
- MM Lau
- MW Pfaffl
- N Ohad
- P Jullien
- PA Leighton
- Paul E. Grini
- PE Grini
- PE Jullien
- PE Jullien
- PE Jullien
- PE Jullien
- Per Winge
- QA Ngo
- R Feil
- R Kofuji
- R Yadegari
- RA Mosher
- RC Day
- Reidunn B. Aalen
- Reza Shirzadi
- RJ Lawrence
- RJ Scott
- RJ Scott
- S Adams
- S De Bodt
- S de Folter
- S Huang
- S Tiwari
- S Tiwari
- SJ Aw
- SW Chan
- SW Chan
- T Hulsen
- T Kinoshita
- T Kinoshita
- T Murashige
- TF Hsieh
- TM DeChiara
- U Grossniklaus
- W Reik
- X Cao
- X Cao
- X Zhang
- X Zhang
- Y Choi
- Y Kinoshita
- YH Yang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Seed development in angiosperms is dependent on the interplay among different transcriptional programs operating in the embryo, the endosperm, and the maternally-derived seed coat. In angiosperms, the embryo and the endosperm are products of double fertilization during which the two pollen sperm cells fuse with the egg cell and the central cell of the female gametophyte. In Arabidopsis, analyses of mutants in the cell-cycle regulator CYCLIN DEPENDENT KINASE A;1 (CKDA;1) have revealed the importance of a paternal genome for the effective development of the endosperm and ultimately the seed. Here we have exploited cdka;1 fertilization as a novel tool for the identification of seed regulators and factors involved in parent-of-origin–specific regulation during seed development. We have generated genome-wide transcription profiles of cdka;1 fertilized seeds and identified approximately 600 genes that are downregulated in the absence of a paternal genome. Among those, AGAMOUS-LIKE (AGL) genes encoding Type-I MADS-box transcription factors were significantly overrepresented. Here, AGL36 was chosen for an in-depth study and shown to be imprinted. We demonstrate that AGL36 parent-of-origin–dependent expression is controlled by the activity of METHYLTRANSFERASE1 (MET1) maintenance DNA methyltransferase and DEMETER (DME) DNA glycosylase. Interestingly, our data also show that the active maternal allele of AGL36 is regulated throughout endosperm development by components of the FIS Polycomb Repressive Complex 2 (PRC2), revealing a new type of dual epigenetic regulation in seeds
From Sea to Sea: Canada's Three Oceans of Biodiversity
- Author
- A Lapoussière
- A Mann
- A Riedel
- A Sournia
- A Willey
- AD Sekerak
- AD Sekerak
- AE Collin
- AE Radulovici
- AG Huntsman
- AJ Read
- AK Hamilton
- AM Springer
- AS Bursa
- AS Bursa
- AS Bursa
- AS Bursa
- AS Bursa
- AS Bursa
- AØ Mooers
- B Konar
- B O'Connell
- B Worm
- B Worm
- B Worm
- BE Lavaniegos
- BE Lavaniegos
- BG Sanderson
- BJ Burd
- BJ Burd
- BJ Burd
- BW Coad
- C Iselin
- C Lovejoy
- C Lovejoy
- C Lovejoy
- C Mora
- C Sheppard
- CB Field
- Christopher W. McKindsey
- CL Griffiths
- CM Fraser
- CM Roberts
- Connie Lovejoy
- CT Shih
- D Gilbert
- D Gilbert
- D Knox
- D Piepenburg
- D Thomson
- David J. Garbary
- David L. Mackas
- DE McAllister
- DH Thomson
- DJ Garbary
- DJ Wildish
- DJ Wildish
- DL Mackas
- DL Mackas
- DL Peer
- DR Zeller
- DU Hooper
- E Bourget
- E Vanden Berghe
- EB Colbourne
- EC Carmack
- EC Carmack
- EF DeLong
- EG Atkinson
- EG Atkinson
- EL Bousfiel
- Ellen L. Kenchington
- ELR Kenchington
- ELR Kenchington
- F Boero
- F McLaughlin
- F Straneo
- FJ Meuter
- FJ Saucier
- G Citarella
- G Desrosiers
- G Power
- G Prefontaine
- G Seidenfaden
- GJ Vermeij
- GM Buchanan
- GR South
- GR South
- GW Saunders
- H Bain
- H Thurston
- H Whitehead
- HJ Squires
- I Lubinsk
- I Manton
- I Manton
- I Manton
- I Rombouts
- IF Whiteaves
- J Brunel
- J Geraci
- J Grøntved
- J Harwood
- J Payne
- J Prena
- J Prena
- J Schipper
- J-F St-Pierre
- JA Devine
- JA Hutchings
- JA Percy
- JAD Fisher
- JAD Fisher
- JC Briggs
- JC Stroeve
- JD Barrie
- JD Reynolds
- JD Witman
- Jean-Marc Gagnon
- JF Caddy
- JFL Hart
- JL Hart
- JL Martin
- JL Martin
- JL Martin
- JM Sieburth
- John R. Nelson
- Jonathan A. D. Fisher
- JP Coakley
- JP Grime
- JR Forbes
- JR Forbes
- JS Gray
- JT Anderson
- JW Loder
- JW Wacasey
- JW Wacasey
- JW Wacasey
- JW Wacasey
- K Banse
- K Conlan
- K Denman
- K Dunton
- K Lüning
- K-K Liu
- KD Baker
- KE Bernt
- KM Kovacs
- KT Frank
- L Airoldi
- L Bosse
- L Bérard-Therriault
- L Margolis
- L Robba
- L-A Henry
- Laurence Piché
- LE Wells
- M Bourque
- M Cusson
- M Harvey
- M Lebeuf
- M Loreau
- M Poulin
- M Poulin
- M Różańska
- M Starr
- MA Rossong
- MA Tovar-Hernandez
- MA Tovar-Hernandez
- MD Spalding
- ME Garneau
- MG Foy
- Michel Harvey
- Michel Poulin
- MJ Arseneau
- MJ Costello
- MJ Kaiser
- ML Sogin
- MPM Reddy
- MR Robertson
- Mélanie Levesque
- N Bano
- N Daugbjerg
- N Daugbjerg
- N Polunin
- N Simard
- N Simon
- N Vørs
- NA Sloan
- NL Shackell
- OA Jørgensen
- P Bouchet
- P Brunel
- P Brunel
- P Tett
- PA Quijon
- PA Quijón
- PA Ramey
- Paul V. R. Snelgrove
- PC Reid
- PE Galand
- PE Galand
- PE Galand
- PE Galand
- PE Galand
- PG Falkowski
- Philippe Archambault
- Pierre Pepin
- PK Dayton
- PL Stewart
- PL Tyack
- PS Ross
- PS Ross
- PVR Snelgrove
- PVR Snelgrove
- PVR Snelgrove
- PW Gabrielson
- R Gradinger
- R Massana
- R Terrado
- R Terrado
- RA Myers
- RE Thomson
- RE Thomson
- RE Waters
- RF Scagel
- RFG Ormond
- RKS Lee
- RN Hughes
- RO Brinkhurs
- RO Brinkhurst
- RT Wilce
- S Hill
- S Hill
- S Hill
- S Lessard
- S Lindstrom
- S Lindstrom
- S Lindstrom
- S Rutherford
- SF Cross
- SIC Hsiao
- SIC Hsiao
- SIC Hsiao
- SIC Hsiao
- SIC Hsiao
- SIC Hsiao
- SIC Hsiao
- SL Perry
- SM Adl
- T Mosquin
- TA Norton
- Tamara Natasha Romanuk
- TE McDonald
- V Smetacek
- V Tunniclife
- VM Davidson
- Véronique Lesage
- W Adams
- W Adey
- W Fennel
- WB Scott
- WR Crawford
- WR Crawford
- WS Johnson
- Y Jean
- Publication venue
- Public Library of Science
- Publication date
- 01/08/2010
- Field of study
Evaluating and understanding biodiversity in marine ecosystems are both necessary and challenging for conservation. This paper compiles and summarizes current knowledge of the diversity of marine taxa in Canada's three oceans while recognizing that this compilation is incomplete and will change in the future. That Canada has the longest coastline in the world and incorporates distinctly different biogeographic provinces and ecoregions (e.g., temperate through ice-covered areas) constrains this analysis. The taxonomic groups presented here include microbes, phytoplankton, macroalgae, zooplankton, benthic infauna, fishes, and marine mammals. The minimum number of species or taxa compiled here is 15,988 for the three Canadian oceans. However, this number clearly underestimates in several ways the total number of taxa present. First, there are significant gaps in the published literature. Second, the diversity of many habitats has not been compiled for all taxonomic groups (e.g., intertidal rocky shores, deep sea), and data compilations are based on short-term, directed research programs or longer-term monitoring activities with limited spatial resolution. Third, the biodiversity of large organisms is well known, but this is not true of smaller organisms. Finally, the greatest constraint on this summary is the willingness and capacity of those who collected the data to make it available to those interested in biodiversity meta-analyses. Confirmation of identities and intercomparison of studies are also constrained by the disturbing rate of decline in the number of taxonomists and systematists specializing on marine taxa in Canada. This decline is mostly the result of retirements of current specialists and to a lack of training and employment opportunities for new ones. Considering the difficulties encountered in compiling an overview of biogeographic data and the diversity of species or taxa in Canada's three oceans, this synthesis is intended to serve as a biodiversity baseline for a new program on marine biodiversity, the Canadian Healthy Ocean Network. A major effort needs to be undertaken to establish a complete baseline of Canadian marine biodiversity of all taxonomic groups, especially if we are to understand and conserve this part of Canada's natural heritage
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
- Carreiro De Freitas AV
- Castro Mollo M
- Cengiz Y
- Cengiz Y
- Ceriani C
- Chachulski W
- Chambers A
- Chan E
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
- Chiu SMY
- Choi J
- Chong BFHK
- Chong CL
- Chong HY
- Chowdhury A
- Chun A
- Chun T
- Chung S
- Cirocchi R
- Clark DJ
- Clark T
- Clement KD
- Clements JM
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Cocker DM
- Collaborative G
- Colombani J-F
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Coomber R
- Corro-Diaz Gonzalez S
- Costa-Maia J
- Court E
- Cragg J
- Cross K
- Cruz H
- Cucumazzo S
- Currow C
- D'aguzan N
- D'amours SK
- D'cruz R
- D'Souza R
- Da Silva LA
- Dabessa D
- Dablouk M
- Dablouk MO
- Dal Canto M
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daqeeq A
- Dar M
- Darweesh M
- Das A
- Das K
- Das S
- Davenport R
- Davies J
- Dawnay G
- Dawoud H
- De Bono P
- De Sousa AV
- Dean R
- Deckelbaum DL
- Decker E
- Deichsel F
- Dempster E
- Deputy M
- Dervenis C
- Despotidis V
- Desta S
- Devadasar GH
- Dharamshi HA
- Di Franco F
- Di Saverio S
- Diab A
- Diaconescu I-B
- Dias S
- Diaz-Zorrilla C
- Dickfos M
- Dickson L
- Dindyal S
- Domini E
- Donoghue D
- dos Santos DV
- Doughan S
- Doughty J
- Drake TM
- Driscoll A
- Du Plessis D
- Dubois A
- Duffy L
- Dwydar A
- Ebdewi H
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eisner L
- El Ashal G
- El Deen KN
- El Gendy A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Hamouly AS
- El-Kashef H
- El-Ma'doul AS
- El-Rabaa S
- El-Shahat NS
- El-Sheemy H
- Elabdin HZ
- Elashmawy M
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbatahgy A
- Elbermawy M
- Eldamaty L
- Elebute O
- Elena G
- Elfeki H
- Elfil M
- Elfouly N
- Elfouly Y
- Elgebaly A
- Elgendy FI
- Elhendawy AOA
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkhadrawi M
- Elkholy A
- Elkolaly SS
- Elkorashy AM
- Elmelegy R
- Elnemr AE
- Elsawahly DME
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elshaer K
- Elshaer M
- Elshafay AE
- Elshanwany S
- Elsheikh S
- Elsherbiny AS
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Escobar EG
- Estupinian S
- Etchill E
- Etman M
- Eysa A
- Eyssartier E
- Faccincani R
- Fadel A
- Fahiem A
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fakher R
- Farah A
- Faraz A
- Farhad M
- Farinella E
- Farooq T
- Farquharson A
- Fattah AA
- Faturoti O
- Faure A
- Fautz T
- Fawzy A
- Felipe CO
- Fergusson S
- Fergusson SJ
- Fermani C
- Fernandez-Bueno F
- Fievet L
- Findlay-Cooper K
- Firdouse M
- Fitzgerald JEF
- Forno W
- Fouad A
- Fouad D
- Fowler AJ
- Fozard T
- Frade F
- Fraga GP
- Francois-Coridon H
- Freitas AV
- Frisk B
- Fujii F
- Furqan MM
- Gadhvi V
- Gaignard E
- Galloway S
- Gamaly E
- Garaycochea O
- Garcia Florez LJ
- Garcia Torres CP
- Garland A
- Gash K
- Gasteratos K
- Gemeah M
- Gemenetzis G
- George R
- Germanos S
- Gerosa A
- Ghandora N
- Ghanem E
- Ghanem S
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Giacci L
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giuliani S
- Giuriato TF
- Glasbey JC
- Glover TE
- Gobin N
- Goh CC
- Gohar ME-SAM
- Gokani S
- Golding D
- Gomaa A
- Gomah M
- Gonzales Stuva JP
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Graffeille V
- Graffieille V
- Grandinetti PP
- Grant A
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Green N
- Griffiths E
- Griffiths M
- Grossart C
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Gumar M
- Gunnarsson U
- Guo W
- Gustafsson U
- Gyanchandani N
- Habeeb MA
- Habeebullah A
- Hache-Marliere M
- Hafez AT
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- Zakir M
- Zalabia MF
- Zamarin K
- Zani A
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- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zhang Z
- Zheng F
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
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- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
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- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
- B Mackenzie
- B Marshall
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- B Oldenburg
- B Poeggeler
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- B Regland
- B Russell
- B Schiessl
- B Shipley
- B Skibska
- B Sturm
- B Thorand
- B Wang
- B Wolff
- B Wolozin
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- B Xu
- B Zhang
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- BA Maddux
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- BS van Asbeck
- BT Mossman
- BV Naidu
- BY Tung
- BØ Palsson
- C Arnaud
- C Beaumont
- C Behl
- C Biondi
- C Bolin
- C Bozzini
- C Breymann
- C Brooksbank
- C Bubici
- C Bubici
- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C García-Ruiz
- C Gasche
- C Gasche
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
QCD and strongly coupled gauge theories : challenges and perspectives
- Author
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
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- Pant BC
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- Parra A
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- Pearlstone BL
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- Pekeur NW
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- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
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- Pirronello V
- Pisanu T
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- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Principe G
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- Prodi GA
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- Prokoph H
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- Przybylski GT
- Pulone L
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- Rojas-Bravo C
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- Salvadori I
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- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
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- Schulz A
- Schulz A
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- Schwalbe SG
- Schwanke U
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- Sciutto SJ
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- Segreto A
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- Seitenzahl IR
- Sekiguchi Y
- Sellers D
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- Sevilla-Noarbe I
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- Shaffer TJ
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- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
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- Shara MM
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- Sharp RG
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- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
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- Shoemaker DH
- Shoemaker DM
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- Siebert MR
- Siegel MH
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- Siemens X
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- Sintes AM
- Siskind EJ
- Slagmolen BJJ
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- Smartt SJ
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- Starling RLC
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- Steele I
- Steele K
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- Stone R
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- Strafella F
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- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
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- Stuver AL
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- Suchyta E
- Sudholz T
- Sugawara Y
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- Sullivan GW
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- Summerscales TZ
- Sun L
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- Supanitsky AD
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- Taboada I
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- Tao C
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- Tao WH
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Lawson criterion for ignition exceeded in an inertial fusion experiment
- Author
- Abu-Shawareb H
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
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- Author
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- Publication venue
- OXFORD UNIV PRESS
- Publication date
- 29/10/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Aamer A
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- Abd El Hameed OS
- Abd El Hamid N
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- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
- Abdel-Wahab NYE
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- Abdelhamed R
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- Madrid Barrientos LA
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- Mohamed M
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- Mohamed MM
- Mohamed O
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- Tharmalingam S
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- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
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- Timothy OK
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- To K
- To K
- Todd KO
- Toeema AG
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- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
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- Tugnoli G
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- Tun AK
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- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
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- Tutino R
- Tverskis Z
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- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
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- Ukwenya Y
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- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
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- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
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- Velasquez R
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- Vendramin E
- Venskutonis D
- Venskutonis D
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- Venugopal C
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- Wold TB
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- Yahaya MT
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- Yaseen TM
- Yau JD
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- Yeung ENW
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- Yifieyeh A
- Yildirim R
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- Ymeri S
- Yoganathan P
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- Yong CO
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- Youssef D
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- Zaa'treh R
- Zachariades D-C
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- Zahran D
- Zakaria E
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- Zani A
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- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
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- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
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- Zimmermann EF
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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