Foreseeing the Impact of the Proposed AI Act on the Sustainability and Safety of Critical Infrastructures

The AI Act has been recently proposed by the European Commission to regulate the use of AI in the EU, especially on high-risk applications, i.e. systems intended to be used as safety components in the management and operation of road traffic and the supply of water, gas, heating and electricity. On the other hand, IEC 61508, one of the most adopted international standards for safety-critical electronic components, seem to mostly forbid the use of AI in such systems. Given this conflict between IEC 61508 and the proposed AI Act, also stressed by the fact that IEC 61508 is not an harmonised European standard, with the present paper we study and analyse what is going to happen to industry after the entry into force of the AI Act. In particular, we focus on how the proposed AI Act might positively impact on the sustainability of critical infrastructures by allowing the use of AI on an industry where it was previously forbidden. To do so, we provide several examples of AI-based solutions falling under the umbrella of IEC 61508 that might have a positive impact on sustainability in alignment with the current long-term goals of the EU and the Sustainable Development Goals of the United Nations, i.e., affordable and clean energy, sustainable cities and communities

Computing performability measures in Markov chains by means of matrix functions

We discuss the efficient computation of performance, reliability, and availability measures for Markov chains; these metrics, and the ones obtained by combining them, are often called performability measures. We show that this computational problem can be recasted as the evaluation of a bilinear forms induced by appropriate matrix functions, and thus solved by leveraging the fast methods available for this task. We provide a comprehensive analysis of the theory required to translate the problem from the language of Markov chains to the one of matrix functions. The advantages of this new formulation are discussed, and it is shown that this setting allows to easily study the sensitivities of the measures with respect to the model parameters. Numerical experiments confirm the effectiveness of our approach; the tests we have run show that we can outperform the solvers available in state of the art commercial packages on a representative set of large scale examples

Chord catalogs and Estrada classes: partially ordered set approach

Combinatorial properties of catalogs of chords studied according to their partially order structure

Supporting CPS Modeling Through a New Method for Solving Complex Non-holomorphic Equations

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Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Search for a light pseudoscalar Higgs boson produced in association with bottom quarks in pp collisions at root s=8 TeV

Peer reviewe