5 research outputs found
P34 98. Leiomiomatosis con diseminación intravascular: Desde el útero a cavidades cardíacas y pulmón
ObjetivosLa leiomiomatosis uterina es un tumor mesenquimal poco frecuente, benigno, caracterizado por la proliferación de músculo liso en la luz vascular. Suele presentarse en mujeres de edad media, y presenta una enorme tendencia a la extensión intravascular y cardíaca. El tratamiento principalmente es quirúrgico para reducción de la masa tumoral, asociándose un bloqueo hormonal.MétodoPresentamos el caso de una mujer de 39 años, asintomática, con una plaquetopenia en estudio. Al realizarse una ecografía abdominal, se detecta una tumoración uterina de gran tamaño. La tomografía computarizada toracoabdominal objetivó extensión intravascular, a través de vena cava, extensión cardíaca hasta aurícula y ventrículo derecho, válvula tricúspide y arteria pulmonar hasta lechos parenquimatosos pulmonares.El tratamiento incluyó la realización de una histerectomía y doble anexectomía, asociándose una resección tumoral con acceso abdominal por laparotomía media desde cava inferior, y cirugía cardíaca con parada cardiocirculatoria, hipotermia profunda y perfusión anterógrada vía axilar, para resección tumoral intracardíaca.ResultadosLa evolución postoperatoria fue favorable. El estudio anatomopatológico diagnosticó una leiomiomatosis uterina con diseminación intravascular y cardíaca.ConclusionesLa leiomiomatosis uterina es una tumoración benigna con enorme tendencia a la extensión intravascular y cardíaca. Su tratamiento incluye resección tumoral y bloqueo hormonal de por vida, en mujeres jóvenes, generalmente. El tratamiento quirúrgico para resección tumoral exige control eco-cardiográfico para comprobar la completa resección del mismo
ESTUDIO COMPARATIVO DE LA NEOPLASIA AVANZADA DE COLON EN LA POBLACION GENERAL Y EN LOS PACIENTES CON ANTECEDENTES FAMILIARES DE CANCER COLORRECTAL SEGUN INTERVALOS DE EDAD
Vardenafil improves erectile function in men with erectile dysfunction irrespective of disease severity and disease classification
Background. Vardenafil (Levitra\uae) is a potent and selective phosphodiesterase 5 (PDE5) inhibitor used in the management of erectile dysfunction (ED). This retrospective subgroup analysis assessed the effectiveness of vardenafil treatment in men with ED of different baseline severity and disease classification. Methods. Data from two pi votal, randomized, double-blind, placebo-controlled clinical trials enrolling men from the general ED population who received placebo or vardenafil 5 mg, 10 mg, or 20 mg during a 12-week treatment period were retrospectively analysed, stratifying by psychogenic, organic, and mixed ED disease classification as determined by the investigator. Efficacy endpoints included the International Index of Erectile Function (IIEF)-Erectile Function (EF) domain score, per-patient diary response rates to questions on penile insertion [Sexual Encounter Profile (SEP-2)] and maintenance of erection (SEP-3) and rates of positive response to the Global Assessment Question (GAQ). Results. Data from 1,385 men who received at least one dose of study medication and had pre-and post-baseline measures of efficacy available (intent-to-treat population) are presented. At baseline 37-41% of patients had severe ED, 30-34% moderate, 22% mild-to-moderate and 6-8% mild ED. At baseline, 46-51% of patients were considered to have an organic cause for ED, 13-16% psychogenic ED, and 36-38% mixed classification of ED. For all classifications and for mild-to-moderate to severe ED, men treated with 10 or 20 mg of vardenafil showed statistically and clinically significant improvements (P < 0.001) in IIEF-EF scores, diary response rates to the SEP-2 and SEP-3 questions, and GAQ as compared with those given placebo. The greatest improvements relative to placebo were noted in patients with more severe ED. The most common treatment-emergent adverse events were headache, flushing, rhinitis, dyspepsia, and were dose-related, mostly mild to moderate in intensity and consistent with the class. Conclusions. Vardenafil improv es EF in men with ED irrespective of investigator-determined classification and baseline ED severit
Transverse momentum spectra of charged particles in proton-proton collisions at 1as=900 GeV with ALICE at the LHC
The inclusive charged particle transverse momentum distribution is measured in proton-proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|\u3b7|<0.8) over the transverse momentum range 0.15<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |\u3b7|<0.8 is \u3008pT\u3009INEL=0.483\ub10.001 (stat.)\ub10.007 (syst.) GeV/c and \u3008pT\u3009NSD=0.489\ub10.001 (stat.)\ub10.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger \u3008pT\u3009 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET. \ua9 2010