Commissioning and Calibration of the ALICE TPC

ALICE (A Large Ion Collider Experiment) is the dedicated heavy ion experiment at the Large Hadron Collider at CERN. The main tracking device of ALICE is a large volume TPC. The milestones of the TPC commissioning as well as the current status of the detector calibration are presented. The obtained resolutions in transverse momentum, position as well as in specific energy loss (dE/dx) are presented and results from noise and electron drift velocity measurements are addressed.Comment: 4 pages, 4 figures- To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

Measurements of ion mobility in argon and neon based gas mixtures

As gaseous detectors are operated at high rates of primary ionisation, ions created in the detector have a considerable impact on the performance of the detector. The upgraded ALICE Time Projection Chamber (TPC) will operate during LHC Run$\,3$ with a substantial space charge density of positive ions in the drift volume. In order to properly simulate such space charges, knowledge of the ion mobility $K$ is necessary. To this end, a small gaseous detector was constructed and the ion mobility of various gas mixtures was measured. To validate the corresponding signal analysis, simulations were performed. Results are shown for several argon and neon based mixtures with different $\textrm{CO}_2$ fractions. A decrease of $K$ was measured for increasing water content.Comment: 3 pages, 2 figure

Drift velocity and gain in argon- and xenon-based mixtures

We present measurements of drift velocities and gains in gas mixtures based on Ar and Xe, with CO2, CH4, and N2 as quenchers, and compare them with calculations. In particular, we show the dependence of Ar- and Xe-CO2 drift velocities and gains on the amount of nitrogen contamination in the gas, which in real experiments may build up through leaks. A quantification of the Penning mechanism which contributes to the Townsend coefficients of a given gas mixture is proposed.Comment: 11 pages, 7 figures, accepted for publication in Nucl.Instrum.Meth. A. Data files available at http://www-alice.gsi.de/tr

A comprehensive study of rate capability in Multi-Wire Proportional Chambers

Systematic measurements on the rate capability of thin MWPCs operated in Xenon, Argon and Neon mixtures using CO2 as UV-quencher are presented. A good agreement between data and existing models has been found, allowing us to present the rate capability of MWPCs in a comprehensive way and ultimately connect it with the mobilities of the drifting ions.Comment: 29 pages, 18 figure

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Gut Microbial Antigenic Mimicry in Autoimmunity

The gut microbiota plays a major role in the developmental biology and homeostasis of cells belonging to the adaptive and innate arms of the immune system. Alterations in its composition, which are known to be regulated by both genetic and environmental factors, can either promote or suppress the pathogenic processes underlying the development of various autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes and rheumatoid arthritis, to just name a few. Cross-recognition of gut microbial antigens by autoreactive T cells as well as gut microbe-driven alterations in the activation and homeostasis of effector and regulatory T cells have been implicated in this process. Here, we summarize our current understanding of the positive and negative associations between alterations in the composition of the gut microbiota and the development of various autoimmune disorders, with a special emphasis on antigenic mimicry

Measurement of spark probability of GEM detector for CBM muon chamber (MUCH)

The stability of triple GEM detector setups in an environment of high energetic showers is studied. To this end the spark probability in a shower environment is compared to the spark probability in a pion beam.Comment: 5 pages, 10 figure