327 research outputs found
Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk.
- Author
- A Crawford
- A Jemal
- A Meindl
- A Steinbrecher
- A Tjonneland
- Anne TjĂžnneland
- C Meplan
- C Meplan
- C Meplan
- C Meplan
- Catherine MĂ©plan
- CB Ambrosone
- CW Elston
- D Ratnasinghe
- D Roy
- DF Easton
- DG Cox
- DG Cox
- E Jablonska
- EJ Ha
- FP Bellinger
- G Bermano
- G Ravn-Haren
- G Riscuta
- Gitte Ravn-Haren
- J Ahn
- J Hesketh
- J Hu
- J Wang
- JA Knight
- JA Mobley
- JB Lopez-Saez
- JD Yager
- John Hesketh
- K Charalabopoulos
- L Forsberg
- L Serra-Majem
- L Vera-Ramirez
- Lars Ove Dragsted
- M Udler
- MB Terry
- ML Cooper
- MP Rayman
- PM Campeau
- R Brigelius-Flohe
- RD Hansen
- RF Burk
- RK Petersen
- S Benzon Larsen
- S Loft
- S Peng
- S Villette
- SA Miller
- SM Tsai
- U Vogel
- U Vogel
- Ulla Vogel
- William B. Coleman
- X Zhou
- Y Hu
- Y Saito
- YJ Hu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear. In this report, a study population including 975 Danish cases and 975 controls matched for age and hormone replacement therapy (HRT) use was genotyped for five functional single nucleotide polymorphisms (SNPs) in SEPP1, GPX1, GPX4 and the antioxidant enzyme SOD2 genes. The influence of genetic polymorphisms on breast cancer risk was assessed using conditional logistic regression. Additionally pre-diagnosis erythrocyte GPx (eGPx) activity was measured in a sub-group of the population. A 60% reduction in risk of developing overall BC and ductal BC was observed in women who were homozygous Thr carriers for SEPP1 rs3877899. Additionally, Leu carriers for GPX1 Pro198Leu polymorphism (rs1050450) were at âŒ2 fold increased risk of developing a non-ductal BC. Pre-diagnosis eGPx activity was found to depend on genotype for rs713041 (GPX4), rs3877899 (SEPP1), and rs1050450 (GPX1) and on HRT use. Moreover, depending on genotype and HRT use, eGPx activity was significantly lower in women who developed BC later in life compared with controls. Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to ÎČ-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Our data thus suggest a role of selenoproteins in BC development
Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death
- Author
- A Wilgoss
- B Rajagopalan
- B Tang
- BC Stong
- Chengyuan Tang
- CK Abrams
- CM Haynes
- CM Hunzeker
- D Fuchs-Telem
- D Tattersall
- DA Gerido
- Danling Wang
- DJ Muller
- G Mese
- G Richard
- G Richard
- GM Essenfelder
- H Li
- H Takeuchi
- H Xiong
- HB Zhao
- HE Burrell
- HP Harding
- J Thimm
- JA Orellana
- JC Saez
- JE Contreras
- JH Xia
- Jieqiong Tan
- Jingwei Chi
- JM Gomez-Hernandez
- JR Lee
- JR Montgomery
- K Schulze-Osthoff
- K Xia
- Li Li
- LQ He
- M Boyce
- MA Retamal
- Mujun Liu
- N Lopez-Bigas
- P Golstein
- P Vandenabeele
- Qian Pan
- RA Pearson
- S Chakravarthi
- S Diestel
- S Pillai
- WL Di
- Xiao-Jiang Li
- Zhuohua Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic characteristics. Inhibition of hemichannel activity by a connexin hemichannel inhibitor or high extracellular calcium suppresses Cx31R42P-induced cell death. Expression of Cx31R42P induces ER stress resulting in reactive oxygen species (ROS) production, in turn, to regulate gating of Cx31R42P hemichannels and Cx31R42P induced cell death. Moreover, Cx31R42P hemichannels play an important role in mediating ATP release from the cell. In contrast, no hemichannel activity was detected with cells expressing wildtype Cx31. Together, the results suggest that Cx31R42P forms constitutively active hemichannels to promote necrotic cell death. The Cx31R42P active hemichannels are likely resulted by an ER stress mediated ROS overproduction. The study identifies a mechanism of EKV pathogenesis induced by a Cx31 mutant and provides a new avenue for potential treatment strategy of the disease
Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries : Analysis from the RIETE registry
- Author
- Adarraga MD
- Aibar MA
- Alatri A
- Alfonso M
- Alvarez F
- Antonucci G
- Arcelus J
- Ballaz A
- Banos P
- Barba R
- Barillari G
- Barron M
- Barron-Andres B
- Bascunana J
- Bertoletti L
- Bilora F
- Blanco-Molina A
- Bortoluzzi C
- Bounameaux H
- Braester A
- Brandolin B
- Brenner B
- Bucherini E
- Bura-Riviere A
- Calanca L
- Camerota A
- Camon AM
- Carles Sahuquillo Joan
- Cattabiani C
- Chasco L
- Ciammaichella M
- Cruz AJ
- de Miguel J
- del Toro J
- Dentali F
- Dentali Francesco
- Di Micco P
- di Micco Pierpaolo
- Diaz-Pedroche MC
- Diaz-Peromingo JA
- Duce R
- Ellis M
- Escribano JC
- Falga C
- Falvo N
- Farge-Bancel D
- Fernandez-Aracil C
- Fernandez-Capitan C
- Fidalgo Angeles
- Fidalgo MA
- Font C
- Font L
- Garcia MA
- Garcia-Bragado F
- Garcia-Morillo M
- Garcia-Raso A
- Gavin O
- Gaya I
- Gibietis V
- Giorgi-Pierfranceschi M
- Gomez C
- Gomez V
- Gonzalez J
- Grandone E
- Grau E
- Guijarro R
- Gutierrez J
- Hernandez-Blasco L
- Hernandez-Comes G
- Hernando E
- Hij A
- Hirmerova J
- Imbalzano E
- Jara-Palomares L
- Jaras MJ
- Jimenez D
- Jimenez David
- Jimenez R
- Joya MD
- Lessiani G
- Lima J
- Llamas P
- Lobo JL
- Lopez-Jimenez L
- Lopez-Reyes R
- Lopez-Saez JB
- Lopez-Saez Juan Bosco
- Lorente MA
- Lorenzo A
- Lumbierres M
- Madridano O
- Maestre A
- Maestre Ana
- Mahe I
- Maida R
- Maly R
- Marchena PJ
- Martin M
- Martin-Martos F
- Martin-Romero M
- Martinez C
- Mastroiacovo D
- Mastroiacovo Daniela
- Mazzolai L
- Monreal M
- Monreal Manuel
- Morales M
- Moustafa F
- Nieto JA
- Nieto S
- Nunez A
- Nunez MJ
- Odriozola M
- Olivares MC
- Otalora S
- Otero R
- Pace F
- Pardo V
- Pedrajas JM
- Pellejero G
- Perez-Ductor C
- Peris ML
- Pesavento R
- Pinelli M
- Poggio R
- Pons I
- Porras JA
- Pozo R
- Prandoni P
- Quere I
- Quintavalla R
- Ramirez L
- Reyes R
- Riera-Mestre A
- Riesco D
- Rivas A
- Rocci A
- Rodriguez-Davila MA
- Rosa V
- Ruiz-Artacho P
- Sahuquillo JC
- Sala-Sainz MC
- Salgado E
- Samperiz A
- Sanchez GT
- Sanchez-Martinez R
- Siniscalchi C
- Skride A
- Skride Andris
- Soler S
- Soler Silvia
- Surinach JM
- Tiraferri E
- Tolosa C
- Tonello D
- Torres M
- Trujillo-Santos J
- Tzoran I
- Uresandi F
- Usandizaga E
- Valero B
- Valle R
- Vanassche T
- Vandenbriele C
- Vela J
- Verhamme P
- Verhamme Peter
- Vicente MP
- Vilar C
- Villalobos A
- Visona A
- Vitola B
- Wells P
- Yoo HHB
- Zdraveska M
- Publication venue
- 'European Respiratory Society (ERS)'
- Publication date
- 01/01/2019
- Field of study
publishersversionPeer reviewe
Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression
- Author
- A Emaus
- AH Eliassen
- AM Kucharska-Newton
- AP Hoyer
- AS Furberg
- B Pan
- B Pan
- B Pan
- BJ Martin
- C Danilo
- C Ginestier
- Catarina Rodrigues dos Santos
- CC Zielinski
- CJ Antalis
- CJ Antalis
- CM Kitahara
- D Lingwood
- D Smith
- DK Nomura
- DS Babina IS
- E de Azambuja
- E Steinhagen-Thiessen
- EJ Kim
- ER Nelson
- F Bray
- F Jin
- FM Blows
- G Llaverias
- G Orr
- G Ray
- GC Kabat
- GK Hansson
- H Iso
- H Kritz
- H Tulinius
- IA Bani
- Isabel Fonseca
- J He
- JA Kaye
- JB Lopez-Saez
- JBM Costa
- JC Mendes de Almeida
- JD Yager
- JL Khatcheressian
- JSH Ferlay
- JW Clendening
- K Hasija
- KE Abdelsalam
- LA Pires
- LC Pina
- LJ Vatten
- M Ferraroni
- M Gaard
- M Ha
- M Lund EB
- ML Knapp
- ML Kwan
- N Alikhani
- N Cortez-Dias
- N Potischman
- NF Boyd
- NK Yadav
- PG Moorman
- PJ Pussinen
- R Demicheli
- R Ross
- RA Hegele
- RA Hiatt
- RB Wallace
- RJ DeBerardinis
- S Sigismund
- S Strohmaier
- S Trompet
- SA Tornberg
- SB Edge
- SF Nielsen
- SPP Mendis
- SĂ©rgio Dias
- T Agurs-Collins
- V Michalaki
- V Rosato
- WK Owiredu
- WM Cao
- Y Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
- Author
- Aarsland D
- Abramzon Y
- Ahmed S
- Al-Sarraj S
- Albani D
- Albert MS
- Alcolea D
- American Genome Center
- Ansorge O
- Attems J
- Bandres-Ciga S
- Barrett MJ
- Beach TG
- Bekris LM
- Bennett DA
- Besser LM
- Bigio EH
- Black SE
- Blauwendraat C
- Boeve BF
- Bohannan RC
- Brett F
- Brice A
- Brunetti M
- Cairns NJ
- Calvo A
- Canosa A
- Caraway CA
- Chia R
- ChiĂČ A
- Clarimon J
- Clark L
- Cusi D
- Dalgard CL
- Dawson TM
- Dickson DW
- Diez-Fairen M
- Ding J
- Duyckaerts C
- Eicher J
- Faber K
- Ferman T
- Ferrari R
- Ferrucci L
- Flanagan ME
- Floris G
- Foroud TM
- Fortea J
- Galasko D
- Gan-Or Z
- Gasser T
- Geiger JT
- Gentleman S
- Ghetti B
- Gibbs JR
- Goate A
- Goldstein DS
- GonzĂĄlez-Aramburu I
- Graff-Radford NR
- Grassano M
- Gustavsson E
- Halliday GM
- Hardy JA
- Hernandez DG
- Hodges AK
- Honig LS
- Infante J
- Jaunmuktane Z
- Kaiser SM
- Kaufmann H
- Keith J
- Kim RC
- Klein G
- KrĂŒger R
- Kukull WA
- Kuzma A
- Lage C
- Landi F
- Lashley T
- Lemstra A
- Lesage S
- Leverenz JB
- LleĂł A
- Logroscino G
- Londos E
- Lopez G
- Love S
- Makarious MB
- Mao Q
- Marder K
- Masellis M
- Masliah E
- May P
- McKeith IG
- Monuki ES
- Moore A
- Mora G
- Morenas-Rodriguez E
- Morgan K
- Morris CM
- Morris HR
- Morris JC
- Myllykangas L
- Nalls MA
- Newell KL
- Norcliffe-Kaufmann L
- Oinas M
- Palma J-A
- Palmer L
- Parkkinen L
- Pastor P
- Perkins M
- Pickering-Brown S
- Pletnikova O
- Portley MK
- Renton AE
- Resnick SM
- Reynolds RH
- RodrĂguez-RodrĂguez E
- Rogaeva E
- Rosenthal LS
- Ross OA
- Ryten M
- Sabir MS
- Saez-Atienzar S
- Salvi E
- Sanchez-Juan P
- Santana I
- Scherzer CR
- Scholz SW
- Schulte C
- Serrano GE
- Shah Z
- Shakkottai VG
- Sidransky E
- Singleton AB
- St George-Hyslop P
- Stone DJ
- Tanaka T
- Tayebi N
- Thomas AJ
- Tienari PJ
- Tilley BS
- Topol EJ
- Torkamani A
- Traynor BJ
- Troakes C
- Trojanowski JQ
- Troncoso JC
- Van Deerlin VM
- Viollet C
- Walton RL
- Warner TT
- Woltjer R
- Wszolek ZK
- Xiromerisiou G
- Publication venue
- Publication date
- 01/03/2021
- Field of study
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
- Author
- A Abeliovich
- A Beilina
- A Elbaz
- A Gardet
- A Grunewald
- A Kumar
- A Mamais
- A Salasova
- A Schaffner
- A Trancikova
- A Trancikova
- A Witoelar
- A Zimprich
- A Zimprich
- AB West
- AB West
- AH Schapira
- AJ Schwab
- AM Arranz
- AM Schreij
- B Dehay
- B Kim
- BA Matikainen-Ankney
- BJ Ryan
- BM Law
- C Bedford
- C Manzoni
- C Manzoni
- C Manzoni
- C Manzoni
- C Paisan-Ruiz
- C Stark
- C Tapia-Rojas
- C van der Merwe
- C Vilarino-Guell
- CC Ho
- CE Krebs
- CH Hsieh
- CH Hsu
- CH Hsu
- CH Lin
- CH Ng
- CJ Gloeckner
- CJ Gloeckner
- CL Klein
- D Chan
- D Perdiz
- D Wang
- DA Beccano-Kelly
- DA MacLeod
- Daniel C. Berwick
- DC Angeles
- DC Angeles
- DC Berwick
- DC Berwick
- DC Berwick
- DC Berwick
- DC Berwick
- DD Feng
- DL Moore
- DS Schwarz
- E Deyaert
- E Lobbestael
- E Ohta
- E Purlyte
- E Schurr
- E Ungewickell
- ED Plowey
- Elisa Greggio
- Emilie Giaime
- ES Sweet
- F Cicchetti
- F Kawakami
- F Kawakami
- F L'Episcopo
- FR Zhang
- G Guaitoli
- G Piccoli
- George R. Heaton
- H Houlden
- H Jia
- H Mortiboys
- HJ Cho
- HJ Yun
- HL Melrose
- HL Melrose
- HN Nguyen
- I Agalliu
- I Dikic
- I Marin
- I Martin
- I Russo
- I Russo
- J Alegre-Abarrategui
- J Dusonchet
- J Liao
- J Madero-Perez
- J Madero-Perez
- J Nixon-Abell
- J Nixon-Abell
- J Penney
- J Ruiz-Martinez
- J Schapansky
- J Schapansky
- J Vitte
- J Yan
- JA Korecka
- James Parkinson
- JC Barrett
- JE Ahlskog
- JM Thomas
- JW Langston
- K Gotthardt
- K Haebig
- K Harvey
- K Harvey
- K. Muda
- Kirsten Harvey
- KK Johansen
- L Abel
- L Civiero
- L Parisiadou
- L Pellegrini
- L Pellegrini
- Lina Wauters
- LN Hockey
- M Blanca Ramirez
- M Decressac
- M Gajendran
- M Hamm
- M Nguyen
- M Quadri
- M Verma
- M Xilouri
- M Yue
- MA Shaw
- MD Cirnaru
- ML Hanke
- MN Seaman
- MR Cookson
- MS Islam
- MW Dodson
- N Dzamko
- N Dzamko
- N Shin
- ND Jorgensen
- NG James
- NJ Lavalley
- NL Khan
- O Cooper
- P Davies
- P Gomez-Suaga
- P Gomez-Suaga
- P Marcinek
- P Rivero-Rios
- P Zhang
- PA Lewis
- PG Woodman
- PS Guerreiro
- PY Pan
- R Allegra
- R Chia
- R Inzelberg
- R Lopez de Maturana
- R Lopez de Maturana
- R Saunders-Pullman
- Rajasekharreddy Pala
- RD Mills
- RJ Nichols
- RM Sancho
- S Bandres-Ciga
- S Biskup
- S Edvardson
- S Gehrke
- S Kaushik
- S Matta
- S Saez-Atienzar
- S Sen
- S Tsujii
- S Werner
- SF Soukup
- SJ Cherra 3rd
- SJ Cherra 3rd
- SJ Orenstein
- SK Kalia
- Sonia Azeggagh
- SR Pfeffer
- T Eguchi
- T Kuwahara
- TB Sherer
- TM Dawson
- V Kumar
- VF Taelman
- VK Godena
- X Li
- X Li
- Y Imai
- Y Imai
- Y Li
- Y Ma
- Y Tong
- Y Tong
- Y Xiong
- Y Yuan
- Z Berger
- Z Gan-Or
- Z Liu
- Z Liu
- Z Sheng
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson's disease, a considerable amount of work has gone into uncovering its basic cellular function. This effort has led to the implication of LRRK2 in a bewildering range of cell biological processes and pathways, and probable roles in a number of seemingly unrelated medical conditions. In this review we summarise current knowledge of the basic biochemistry and cellular function of LRRK2. Topics covered include the identification of phosphorylation substrates of LRRK2 kinase activity, in particular Rab proteins, and advances in understanding the activation of LRRK2 kinase activity via dimerisation and association with membranes, especially via interaction with Rab29. We also discuss biochemical studies that shed light on the complex LRRK2 GTPase activity, evidence of roles for LRRK2 in a range of cell signalling pathways that are likely cell type specific, and studies linking LRRK2 to the cell biology of organelles. The latter includes the involvement of LRRK2 in autophagy, endocytosis, and processes at the trans-Golgi network, the endoplasmic reticulum and also key microtubule-based cellular structures. We further propose a mechanism linking LRRK2 dimerisation, GTPase function and membrane recruitment with LRRK2 kinase activation by Rab29. Together these data paint a picture of a research field that in many ways is moving forward with great momentum, but in other ways has not changed fundamentally. Many key advances have been made, but very often they seem to lead back to the same places
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
- Becker M
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr JK
- Belanger-Champagne C
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
- Betancourt C
- Bethke S
- Bevan AJ
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Biedermann D
- Bielski R
- Biesuz NV
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biondi S
- Bjergaard DM
- Black CW
- Black JE
- Black KM
- Blackburn D
- Blair RE
- Blanchard J-B
- Blanco JE
- Blazek T
- Bloch I
- Blocker C
- Blum W
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Bock C
- Boehler M
- Boeriu OE Vickey
- Boerner D
- Bogaerts JA
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bold T
- Boldea V
- Boldyrev AS
- Bomben M
- Bona M
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Bos K
- Boscherini D
- Bosman M
- Bossio Sola JD
- Boudreau J
- Bouffard J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bracinik J
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Bravo A Gascon
- Brendlinger K
- Brennan AJ
- Brenner L
- Brenner R
- Bressler S
- Bret M Cano
- Bristow TM
- Britton D
- Britzger D
- Brochu FM
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brosamer J
- Brost E
- Broughton JH
- Bruncko D
- Bruneliere R
- Bruni A
- Bruni G
- Brunt BH
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Buescher D
- Buesher V
- Bugge MK
- Bulekov O
- Bullock D
- Burckhart H
- Burdin S
- Burgard CD
- Burghgrave B
- Burka K
- Burke S
- Burmeister I
- Busato E
- Bussey P
- Butler JM
- Butt AI
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund O Bessidskaia
- Cabrera Urban S
- Caforio D
- Cairo VM
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Caloba LP
- Calvet D
- Calvet S
- Calvet TP
- Camarda S
- Camarri P
- Cameron D
- Camincher C
- Campana S
- Campanelli M
- Campoverde A
- Canale V
- Canepa A
- Cantero J
- Cantrill R
- Cao T
- Caprini I
- Caprini M
- Capua M
- Caputo R
- Carbone RM
- Cardarelli R
- Cardillo F
- Carli I
- Carli T
- Carlino G
- Carminati L
- Caron S
- Carquin E
- Carrillo-Montoya GD
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Casolino M
- Casper DW
- Castaneda-Miranda E
- Castelli A
- Castillo Gimenez V
- Castillo I Santoyo
- Castilloa LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
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- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particleâhole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
Search for the direct production of charginos and neutralinos in final states with tau leptons in âs=13 TeV collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Albergh GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
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- van Woerden MC
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- von der Schmitt H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
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- Vukotic I
- Wagner P
- Wagner W
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- Wahlberg H
- Wahrmund S
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- Wang C
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- Wang H
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- Wang J
- Wang Q
- Wang R
- Wang SM
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- Warburton A
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- Wardrope DR
- Washbrook A
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- Wells PS
- Wenaus T
- Wengler T
- Wenig S
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- Werner MD
- Werner P
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- White R
- Whiteson D
- Whitmore BW
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wiglesworth C
- Wiik-Fuchs LAM
- Wildauer A
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- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson JA
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf TMH
- Wolff R
- Wolter MW
- Wolters H
- Wong KH Yau
- Wong VWS
- Worm SD
- Wosiek BK
- Wotschack J
- Wozniak KW
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- Wyatt TR
- Wynne BM
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- Yabsley B
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- Yamaguchi D
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- Yamamoto A
- Yamamoto S
- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki Y
- Yan Z
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- Yang H
- Yang Y
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- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
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- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
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- Young CJS
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fbâ1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ËÏ+1 ËÏâ1 pair production and of Ëϱ1 ËÏ02 and ËÏ+1 ËÏâ1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the Ë ÏL state is set to be halfway between the masses of the Ëϱ1 and the ËÏ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ËÏ+1 ËÏâ1 for a massless ËÏ01. Common Ëϱ1 and ËÏ02 masses up to 760 GeV are excluded in the case of production of Ëϱ1 ËÏ02 and ËÏ+1 ËÏâ1 assuming a massless ËÏ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the Ëϱ1 and the ËÏ01 are also studied by varying the Ë ÏL mass between the masses of the Ëϱ1 and the ËÏ01
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- Author
- Abante J
- Abecassis BS
- Aben N
- Aghamirzaie D
- Ahsen ME
- Aittokallio T
- Akhtari FS
- Al-lazikani B
- Alam T
- Allam A
- Allen C
- Altarawy D
- Alves V
- Amadoz A
- Anchang B
- Angel Pujana M
- Antolin AA
- Ash JR
- Ba-alawi W
- Bagheri M
- Bajic V
- Ball G
- Ballester PJ
- Baptista D
- Bare C
- Bateson M
- Bender A
- Bertrand D
- Boroevich KA
- Bosdriesz E
- Bougouffa S
- Bounova G
- Brouwer T
- Bryant B
- Bulusu KC
- Calaza M
- Calderone A
- Calza S
- Capuzzi S
- Carbonell-Caballero J
- Carlin D
- Carter H
- Castagnoli L
- Celebi R
- Cesareni G
- Chang H
- Chen G
- Chen H
- Chen H
- Cheng L
- Chernomoretz A
- Chicco D
- Cho K-H
- Cho S
- Choi D
- Choi J
- Choi K
- Choi M
- Coker E
- Combinatio A-SD
- Cortes-Ciriano I
- Cserzo M
- Cubuk C
- Curtis C
- Dang CC
- de Almeida MP
- De Cock M
- de Esch I
- de Graaf C
- De Maeyer D
- De Niz C
- de Ruiter JR
- De Troyer E
- Di Veroli GY
- Dijkstra T
- Dopazo J
- Draghici S
- Drosou A
- Dry JR
- Dumontier M
- Ehrhart F
- Eid F-E
- ElHefnawi M
- Elmarakeby H
- Engin HB
- Evelo C
- Falcao AO
- Farag S
- Fawell S
- Fernandez-Lozano C
- Fisch K
- Flobak A
- Fornari C
- Foroushani ABK
- Fotso DC
- Fourches D
- Friend S
- Frigessi A
- Gao F
- Gao X
- Garnett MJ
- Gerold JM
- Gestraud P
- Ghazoui Z
- Ghosh S
- Gillberg J
- Godoy-Lorite A
- Godynyuk L
- Godzik A
- Goldenberg A
- Gomez-Cabrero D
- Gonen M
- Gray H
- Grechkin M
- Guan Y
- Guimera R
- Guinney J
- Guney E
- Haibe-Kains B
- Han Y
- Hase T
- He D
- He L
- Heath LS
- Hellton KH
- Helmer-Citterich M
- Hidalgo MR
- Hidru D
- Hill SM
- Hochreiter S
- Hong S
- Hovig E
- Hsueh Y-C
- Hu Z
- Huang JK
- Huang RS
- Hunyady L
- Hwang J
- Hwang TH
- Hwang W
- Hwang Y
- Isayev O
- Jack J
- Jahandideh S
- Jang IS
- Jeon M
- Ji J
- Jo Y
- Kamola PJ
- Kanev GK
- Kang J
- Karacosta L
- Karimi M
- Kaski S
- Kazanov M
- Khamis AM
- Khan SA
- Kiani NA
- Kim A
- Kim J
- Kim J
- Kim K
- Kim K
- Kim S
- Kim Y
- Kim Y
- Kirk PDW
- Kitano H
- Klambauer G
- Knowles D
- Ko M
- Kohn-Luque A
- Kooistra AJ
- Kuenemann MA
- Kuiper M
- Kurz C
- Kwon M
- Laegreid A
- Lederer S
- Lee H
- Lee J
- Lee YW
- Leppaho E
- Lewis R
- Li J
- Li L
- Liley J
- Lim WK
- Lin C
- Liu Y
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- Low J
- Lysenko A
- Machado D
- Madhukar N
- Malpartida AB
- Mamitsuka H
- Marabita F
- Marchal K
- Marttinen P
- Mason D
- Mason MJ
- Mazaheri A
- Mehmood A
- Mehreen A
- Menden MP
- Michaut M
- Miller RA
- Mitsopoulos C
- Modos D
- Moo K
- Motsinger-Reif A
- Movva R
- Muraru S
- Muratov E
- Mushthofa M
- Nagarajan N
- Nakken S
- Nath A
- Neto EC
- Neuvial P
- Newton R
- Nguyen T
- Ning Z
- Norman T
- Oliva B
- Olsen C
- Palmeri A
- Panesar B
- Papadopoulos S
- Park J
- Park S
- Park S
- Pawitan Y
- Peluso D
- Pendyala S
- Peng J
- Perfetto L
- Pirro S
- Plevritis S
- Politi R
- Poon H
- Porta E
- Prellner I
- Preuer K
- Ramnarine R
- Reid JE
- Reyal F
- Richardson S
- Ricketts C
- Rieswijk L
- Rocha M
- Rodriguez-Gonzalvez C
- Roell K
- Romeo Aznar V
- Rotroff D
- Rukawa P
- Sadacca B
- Saez-Rodriguez J
- Safikhani Z
- Safitri F
- Sales-Pardo M
- Sauer S
- Schlichting M
- Seoane JA
- Serra J
- Shang M-M
- Sharma A
- Sharma H
- Shen Y
- Shiga M
- Shin M
- Shkedy Z
- Shopsowitz K
- Sinai S
- Skola D
- Smirnov P
- Soerensen IF
- Soerensen P
- Song J-H
- Song SO
- Soufan O
- Spitzmueller A
- Steipe B
- Stolovitzky G
- Suphavilai C
- Szalai B
- Tamayo SP
- Tamborero D
- Tang EKY
- Tang J
- Tanoli Z-U-R
- Tarres-Deulofeu M
- Tegner J
- Thommesen L
- Tonekaboni SAM
- Tran H
- Truong A
- Tsunoda T
- Turu G
- Tzeng G-Y
- Van Daele D
- van Engelen B
- van Laarhoven T
- Van Moerbeke M
- van Westen GJP
- Verbeke L
- Videla S
- Vis D
- Vogel R
- Voronkov A
- Votis K
- Walk OBD
- Wang A
- Wang D
- Wang H-QH
- Wang P-W
- Wang S
- Wang W
- Wang X
- Wang X
- Wennerberg K
- Wernisch L
- Wessels L
- Westerman BA
- White SR
- Wijayawardena B
- Willighagen E
- Wolfinger R
- Wurdinger T
- Xie L
- Xie S
- Xu H
- Yadav B
- Yau C
- Yeerna H
- Yin JW
- Yu M
- Yu M
- Yu T
- Yun SJ
- Zakharov A
- Zamichos A
- Zanin M
- Zaslavskiy M
- Zeng L
- Zenil H
- Zhang F
- Zhang P
- Zhang W
- Zhao H
- Zhao L
- Zheng W
- Zoufir A
- Zucknick M
- Publication venue
- Publication date
- 01/01/2019
- Field of study
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZenecaâs large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe
Study of ordered hadron chains with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
- Betancourt C
- Bethani A
- Bethke S
- Bevan AJ
- Beyer J
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bilokon H
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blum W
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
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- Yigitbasi E
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
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- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
The analysis of the momentum difference between charged hadrons in high-energy proton-proton collisions is performed in order to study coherent particle production. The observed correlation pattern agrees with a model of a helical QCD string fragmenting into a chain of ground-state hadrons. A threshold momentum difference in the production of adjacent pairs of charged hadrons is observed, in agreement with model predictions. The presence of low-mass hadron chains also explains the emergence of charge-combination-dependent two-particle correlations commonly attributed to Bose-Einstein interference. The data sample consists of 190 ÎŒbâ1 of minimum-bias events collected with proton-proton collisions at a center-of-mass energy âs=7 TeV in the early low-luminosity data taking with the ATLAS detector at the LHC
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